sel The Fifth Seal: Cries for Vengeance (Selected Scriptures) By feeds.gty.org Published On :: Sun, 25 Feb 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel The Triumph of Obedience (Selected Scriptures) By feeds.gty.org Published On :: Wed, 06 Mar 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel Shepherds Conference Q&A with John MacArthur and John Piper (Selected Scriptures) By feeds.gty.org Published On :: Thu, 07 Mar 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel Christ Is Sufficient for All Your Crises (Selected Scriptures) By feeds.gty.org Published On :: Sun, 05 May 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel The Church’s Singular Focus (Selected Scriptures) By feeds.gty.org Published On :: Sun, 16 Jun 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel Thinking Biblically About Current Events: A Conversation with John MacArthur (Selected Scriptures) By feeds.gty.org Published On :: Sun, 20 Oct 2024 00:00:00 Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.Click the icon below to listen. Full Article
sel A Nation Under God?, Part A (Selected Scriptures) By feeds.gty.org Published On :: Sun, 06 Oct 2024 00:00:00 PST Our Lord said, “If any man will come after Me, let him deny himself, pick up his cross and follow Me.” The church of Jesus Christ, of course, is Full Article
sel A Nation Under God?, Part B (Selected Scriptures) By feeds.gty.org Published On :: Sun, 13 Oct 2024 00:00:00 PST Our Lord said, “If any man will come after Me, let him deny himself, pick up his cross and follow Me.” The church of Jesus Christ, of course, is Full Article
sel Abortion and the Campaign for Immorality (Selected Scriptures) By feeds.gty.org Published On :: Sun, 20 Oct 2024 00:00:00 PST What a privilege and joy it is to worship the Lord here at Grace church. Patricia and I miss it when we’re not here; there&rsqu Full Article
sel Homosexuality and the Campaign for Immorality (Selected Scriptures) By feeds.gty.org Published On :: Sun, 27 Oct 2024 00:00:00 PST Earlier in the service I read from the first chapter of Romans what is really a very, very shocking portion of Scripture just to remind you that Romans cha Full Article
sel We Will Not Bow, Part 2 (Selected Scriptures) By feeds.gty.org Published On :: Sun, 10 Nov 2024 00:00:00 PST The following sermon transcript does not match the video version of the sermon—it matches only the audio version. Here's a brief exp Full Article
sel Engagement with China Is Not an End in Itself By www.eastwestcenter.org Published On :: Tue, 21 Dec 2021 00:55:45 +0000 Engagement with China Is Not an End in Itself Engagement with China Is Not an End in Itself brophyc Mon, 12/20/2021 - 14:55 Dec 21, 2021 Dec 21, 2021 Politics & International Relations Politics & International Relations China China East-West Wire Tagline News, Commentary, and Analysis Home EWC Feeds East-West Wire The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here. For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists. Explore search All Programs All Regions All Topics Release Date Filters Reset filters East-West Wire Tagline News, Commentary, and Analysis Home EWC Feeds East-West Wire The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here. For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists. Explore search All Programs All Regions All Topics Release Date Filters Reset filters Full Article
sel Dan Malesela: Marumo Gallants must not show too much respect to Mamelodi Sundowns By www.iol.co.za Published On :: Thu, 07 Nov 2024 20:47:39 GMT Full Article
sel Bitter ex-wife, who kept father away from child by falsely accusing him of rape, ordered to pay R665,000 in damages By www.iol.co.za Published On :: Tue, 12 Nov 2024 04:22:39 GMT Full Article
sel Thuli Madonsela pushes back against Mbalula's call for spaza shop shutdown, sparking debate on health and economy By www.iol.co.za Published On :: Tue, 12 Nov 2024 04:30:20 GMT Full Article
sel Living Unselfishly By feeds.gty.org Published On :: Sun, 10 Nov 2024 00:00:00 -0800 “If you have bitter jealousy and selfish ambition in your heart, do not be arrogant and so lie against the truth” (James 3:14). A wise person lives for God and others, not for self. Having characterized spiritual wisdom in the preceding verse, James begins to analyze worldly wisdom in verse 14. Worldly wisdom is not of God. It has no relationship to Him, is not obedient to Him, and has no knowledge of His truth. What is the motive of someone who lives according to worldly wisdom? “Bitter jealousy and selfish ambition.” The Greek word translated “bitter” also means “harsh” and is used of bitter, undrinkable water. “Bitter jealousy” carries the idea of a harsh, bitter self-centeredness that produces a resentful attitude toward others. People with bitter jealousy live in a world that focuses on themselves. They react in a jealous manner toward anyone who threatens their territory, accomplishments, or reputation. They resent anyone who threatens to crowd their slice of this world. They consider people who differ from them as implacable enemies. And they are bitterly jealous of anyone who is successful. The Greek term translated “selfish ambition” refers to a personal ambition that creates rivalry, antagonism, or a party spirit. That’s another way of pointing to self. The person who follows human wisdom begins with a “bitter jealousy” that creates an attitude of competition and conflict. Then “selfish ambition” generates a party spirit and bitterness toward others. James is saying that ungodly wisdom is self-centered, and its goal is personal gratification at any cost. What about you? Are you motivated by jealousy and selfish ambition? Be honest in your evaluation. Take a serious inventory of your heart and ask yourself, Am I serving others instead of fulfilling my own desires at the expense of others? Suggestions for Prayer Ask God to convict you when you put yourself before Him and others. Repent of any present situations in which you are doing that very thing. For Further Study Read the following verses: Genesis 37:4; 1 Samuel 18:8; Luke 15:25-30; 22:24. What was the sin in each example? Read and study 1 Corinthians 13:4-7 to learn how the qualities of love are opposite to human wisdom. From Strength for Today by John MacArthur Copyright © 1997. Used by permission of Crossway Books, a division of Good News Publishers, Wheaton, IL 60187, www.crossway.com.Additional ResourcesThe Study Bible (mobile app)Grace to You Sermons (mobile app)John MacArthur’s complete sermon archiveThe MacArthur Study BibleThe complete MacArthur New Testament Commentary series Full Article
sel Embrace self-love this Singles Day: a guide to celebrating you By www.iol.co.za Published On :: Sun, 10 Nov 2024 09:56:06 GMT Full Article
sel Spar distinguishes sell-by and best before dates amid spaza shop food contamination cases By www.iol.co.za Published On :: Tue, 12 Nov 2024 13:23:48 GMT Full Article
sel BIR to monitor online sellers' tax compliance during holiday season By business.inquirer.net Published On :: Wed, 13 Nov 2024 14:14:09 +0800 MANILA, Philippines – The Bureau of Internal Revenue (BIR) will closely monitor the tax compliance of online marketplaces and online sellers during the holiday season, Commissioner Romeo Lumagui Jr. has said. In a statement Wednesday, Lumagui warned that online businesses violating tax laws would be blocked. Section 115 of the National Internal Revenue Code, as […]...Keep on reading: BIR to monitor online sellers' tax compliance during holiday season Full Article
sel Blinken heads to Brussels for urgent talks on Ukraine after Trump win By www.euronews.com Published On :: Tue, 12 Nov 2024 16:18:06 +0100 Blinken heads to Brussels for urgent talks on Ukraine after Trump win Full Article
sel gem hatz diesel manual By english.al-akhbar.com Published On :: gem hatz diesel manual Full Article
sel to write an essay paper about yourself By english.al-akhbar.com Published On :: to write an essay paper about yourself Full Article
sel to write a self concept paper By english.al-akhbar.com Published On :: to write a self concept paper Full Article
sel to write a book in 24 hours 24 hour bestseller series By english.al-akhbar.com Published On :: to write a book in 24 hours 24 hour bestseller series Full Article
sel to make yourself happy and remarkably less disturbable By english.al-akhbar.com Published On :: to make yourself happy and remarkably less disturbable Full Article
sel to write a paper about myself By english.al-akhbar.com Published On :: to write a paper about myself Full Article
sel to write an autobiography essay about yourself By english.al-akhbar.com Published On :: to write an autobiography essay about yourself Full Article
sel to write an autobiography about yourself By english.al-akhbar.com Published On :: to write an autobiography about yourself Full Article
sel Veyseloglu Modern Retail Expansion Project By www.adb.org Published On :: 2024-11-11 The transaction involves a loan of up to $10,000,000 (or the local currency equivalent) to Araz Supermarket LLC (Araz) for the Veyseloglu Modern Retail Expansion Project in Azerbaijan, and technical assistance (TA) of $500,000 for the Building the Capacity of Smallholder Fruit and Vegetable Farmers for Climate-Resilient Farming. Full Article
sel Consumer insecticides are useless for fighting cockroach infestations By www.newscientist.com Published On :: Wed, 14 Aug 2024 16:00:39 +0100 Lab-reared German cockroaches are susceptible to consumer insecticide sprays, allowing manufacturers to pass US regulatory tests, but insects taken from real-world infestations are able to shrug off the products Full Article
sel A selection of elaborate birds' nests from around the world By www.newscientist.com Published On :: Wed, 28 Aug 2024 19:00:00 +0100 These photos showcase some of the intricately created birds' nests found in the Natural History Museum in Tring, UK, home to one of the world's largest ornithological collections Full Article
sel Fish size themselves up in a mirror to decide if they can win a fight By www.newscientist.com Published On :: Wed, 11 Sep 2024 11:00:10 +0100 Cleaner wrasse use their reflection to build a mental image of their body size, which they use to compare themselves to rivals before picking a fight Full Article
sel Watch elephants use a hose to shower themselves – and prank others By www.newscientist.com Published On :: Fri, 08 Nov 2024 16:00:22 +0000 Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water Full Article
sel Self-centred, spoiled and lonely? Examining the only child stereotype By www.newscientist.com Published On :: Wed, 07 Aug 2024 17:00:00 +0100 More and more parents are choosing to only have one child. Here’s what the evidence says about how growing up without siblings affects their personality traits and well-being Full Article
sel Canadian lake selected as site to mark the start of the Anthropocene By www.newscientist.com Published On :: Tue, 11 Jul 2023 19:00:23 +0100 Geologists hoping to declare a new epoch dominated by humanity’s influence on Earth have chosen Crawford Lake in Canada as the location where the start of the Anthropocene is defined Full Article
sel Why hairy animals shake themselves dry By www.newscientist.com Published On :: Thu, 07 Nov 2024 19:00:44 +0000 The brain pathway that causes hairy mammals like mice and dogs to shake themselves dry appears to have more to do with pressure than temperature Full Article
sel Watch elephants use a hose to shower themselves – and prank others By www.newscientist.com Published On :: Fri, 08 Nov 2024 16:00:22 +0000 Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water Full Article
sel In Seniors, 'Fear of Falling' Risky in Itself By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: In Seniors, 'Fear of Falling' Risky in ItselfCategory: Health NewsCreated: 8/20/2010 10:10:00 AMLast Editorial Review: 8/23/2010 12:00:00 AM Full Article
sel Kids Benefit From Doctors' Antismoking Counseling: Experts By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Kids Benefit From Doctors' Antismoking Counseling: ExpertsCategory: Health NewsCreated: 8/26/2013 9:35:00 AMLast Editorial Review: 8/26/2013 12:00:00 AM Full Article
sel Diet, Exercise Counseling Urged for Overweight Americans With Heart Risks By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Diet, Exercise Counseling Urged for Overweight Americans With Heart RisksCategory: Health NewsCreated: 8/26/2014 9:35:00 AMLast Editorial Review: 8/26/2014 12:00:00 AM Full Article
sel 'Goth' Teens Report More Depression, Self-Harm By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: 'Goth' Teens Report More Depression, Self-HarmCategory: Health NewsCreated: 8/27/2015 12:00:00 AMLast Editorial Review: 8/28/2015 12:00:00 AM Full Article
sel Restless Legs Syndrome Might Raise Risk of Suicide, Self-Harm By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Restless Legs Syndrome Might Raise Risk of Suicide, Self-HarmCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/26/2019 12:00:00 AM Full Article
sel Posting All Those Selfies Online Could Backfire, Study Finds By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Posting All Those Selfies Online Could Backfire, Study FindsCategory: Health NewsCreated: 8/29/2019 12:00:00 AMLast Editorial Review: 8/30/2019 12:00:00 AM Full Article
sel Feel Guilty About 'Useless' Leisure Time? Your Mental Health Might Suffer By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Feel Guilty About 'Useless' Leisure Time? Your Mental Health Might SufferCategory: Health NewsCreated: 8/26/2021 12:00:00 AMLast Editorial Review: 8/26/2021 12:00:00 AM Full Article
sel Poor Sleep Can Make Folks Selfish, Study Finds By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Poor Sleep Can Make Folks Selfish, Study FindsCategory: Health NewsCreated: 8/24/2022 12:00:00 AMLast Editorial Review: 8/24/2022 12:00:00 AM Full Article
sel Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease By www.medicinenet.com Published On :: Thu, 18 Aug 2022 00:00:00 PDT Title: Having Ideal Heart Health May Lessen the Risk for Brain Vessel DiseaseCategory: Health NewsCreated: 8/17/2022 12:00:00 AMLast Editorial Review: 8/18/2022 12:00:00 AM Full Article
sel Are Green Mussels Good for You? By www.medicinenet.com Published On :: Fri, 26 Aug 2022 00:00:00 PDT Title: Are Green Mussels Good for You?Category: Health and LivingCreated: 8/26/2022 12:00:00 AMLast Editorial Review: 8/26/2022 12:00:00 AM Full Article
sel Self-Employed Women Are Often Healthier: Study By www.medicinenet.com Published On :: Mon, 8 Aug 2022 00:00:00 PDT Title: Self-Employed Women Are Often Healthier: StudyCategory: Health NewsCreated: 8/8/2022 12:00:00 AMLast Editorial Review: 8/8/2022 12:00:00 AM Full Article
sel Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1 [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Human organic anion transporting polypeptide (OATP) 1B1 and 1B3 are two highly homologous liver-specific uptake transporters. However, 2’,7’-dichlorofluorescein (DCF) is preferably transported by OATP1B1. In the present study, the molecular mechanisms for the selective transport of DCF by OATP1B1 were investigated by constructing and characterizing an array of OATP1B1/1B3 chimeras and site-directed mutagenesis. Our results show that transmembrane domain (TM) 10 is crucial for the surface expression and function of OATP1B1, in which Q541 and L545 play the most important roles in DCF transport. Replacement of TM10 in OATP1B1 with its OATP1B3 counterpart led to OATP1B1’s complete intracellular retention. Q541 and L545 may interact with DCF directly via hydrogen bonding and hydrophobic interactions. The decrease of DCF uptake by Q541A and L545S was due to their reduced binding affinity for DCF as compared with OATP1B1. In addition, Q541 and L545 are also crucial for the transport of estradiol-17β-glucuronide (E17βG) but not for the transport of estrone-3-sulfate (E3S), indicating different interaction modes between DCF/E17βG and E3S in OATP1B1. Taken together, Q541 and L545 in TM10 are critical for OATP1B1-mediated DCF uptake, but their effect is substrate-dependent. SIGNIFICANCE STATEMENT The key TMs and amino acid residues for the selective transport of DCF by OATP1B1 were identified. TM10 is crucial for the surface expression and function of OATP1B1. Within TM10, Q541 and L545 played the most significant roles and affected the function of OATP1B1 in a substrate-dependent manner. This information is crucial for a better understanding of the mechanism of the multispecificity of OATP1B1 and as a consequence the mechanism of OATP1B1-mediated drug–drug interactions. Full Article
sel Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5 [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC50 and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC50 values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms. SIGNIFICANCE STATEMENT These findings provide valuable insight regarding in vitro testing conditions to investigate the metabolism of new drug candidates and help determine drug safety in neonates. The results presented here also clearly demonstrate the effect that probe selection may have on CYP3A cytochrome P450 inhibition studies. Full Article