sel

The Fifth Seal: Cries for Vengeance (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

The Triumph of Obedience (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

Shepherds Conference Q&A with John MacArthur and John Piper (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

Christ Is Sufficient for All Your Crises (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

The Church’s Singular Focus (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

Thinking Biblically About Current Events: A Conversation with John MacArthur (Selected Scriptures)

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.




sel

A Nation Under God?, Part A (Selected Scriptures)

Our Lord said, “If any man will come after Me, let him deny himself, pick up his cross and follow Me.” The church of Jesus Christ, of course, is

 




sel

A Nation Under God?, Part B (Selected Scriptures)

Our Lord said, “If any man will come after Me, let him deny himself, pick up his cross and follow Me.” The church of Jesus Christ, of course, is

 




sel

Abortion and the Campaign for Immorality (Selected Scriptures)

What a privilege and joy it is to worship the Lord here at Grace church. Patricia and I miss it when we’re not here; there&rsqu

 




sel

Homosexuality and the Campaign for Immorality (Selected Scriptures)

Earlier in the service I read from the first chapter of Romans what is really a very, very shocking portion of Scripture just to remind you that Romans cha

 




sel

We Will Not Bow, Part 2 (Selected Scriptures)

The following sermon transcript does not match the video version of the sermon—it matches only the audio version. Here's a brief exp

 




sel

Engagement with China Is Not an End in Itself

Engagement with China Is Not an End in Itself Engagement with China Is Not an End in Itself
brophyc Mon, 12/20/2021 - 14:55

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore




sel

Dan Malesela: Marumo Gallants must not show too much respect to Mamelodi Sundowns




sel

Bitter ex-wife, who kept father away from child by falsely accusing him of rape, ordered to pay R665,000 in damages




sel

Thuli Madonsela pushes back against Mbalula's call for spaza shop shutdown, sparking debate on health and economy




sel

Living Unselfishly

“If you have bitter jealousy and selfish ambition in your heart, do not be arrogant and so lie against the truth” (James 3:14).

A wise person lives for God and others, not for self.

Having characterized spiritual wisdom in the preceding verse, James begins to analyze worldly wisdom in verse 14. Worldly wisdom is not of God. It has no relationship to Him, is not obedient to Him, and has no knowledge of His truth.

What is the motive of someone who lives according to worldly wisdom? “Bitter jealousy and selfish ambition.” The Greek word translated “bitter” also means “harsh” and is used of bitter, undrinkable water. “Bitter jealousy” carries the idea of a harsh, bitter self-centeredness that produces a resentful attitude toward others. People with bitter jealousy live in a world that focuses on themselves. They react in a jealous manner toward anyone who threatens their territory, accomplishments, or reputation. They resent anyone who threatens to crowd their slice of this world. They consider people who differ from them as implacable enemies. And they are bitterly jealous of anyone who is successful.

The Greek term translated “selfish ambition” refers to a personal ambition that creates rivalry, antagonism, or a party spirit. That’s another way of pointing to self. The person who follows human wisdom begins with a “bitter jealousy” that creates an attitude of competition and conflict. Then “selfish ambition” generates a party spirit and bitterness toward others. James is saying that ungodly wisdom is self-centered, and its goal is personal gratification at any cost.

What about you? Are you motivated by jealousy and selfish ambition? Be honest in your evaluation. Take a serious inventory of your heart and ask yourself, Am I serving others instead of fulfilling my own desires at the expense of others?

Suggestions for Prayer

  • Ask God to convict you when you put yourself before Him and others.
  • Repent of any present situations in which you are doing that very thing.

For Further Study

Read the following verses: Genesis 37:4; 1 Samuel 18:8; Luke 15:25-30; 22:24.

  • What was the sin in each example?
  • Read and study 1 Corinthians 13:4-7 to learn how the qualities of love are opposite to human wisdom.



From Strength for Today by John MacArthur Copyright © 1997. Used by permission of Crossway Books, a division of Good News Publishers, Wheaton, IL 60187, www.crossway.com.

Additional Resources




sel

Embrace self-love this Singles Day: a guide to celebrating you




sel

Spar distinguishes sell-by and best before dates amid spaza shop food contamination cases




sel

BIR to monitor online sellers' tax compliance during holiday season

MANILA, Philippines – The Bureau of Internal Revenue (BIR) will closely monitor the tax compliance of online marketplaces and online sellers during the holiday season, Commissioner Romeo Lumagui Jr. has said. In a statement Wednesday, Lumagui warned that online businesses violating tax laws would be blocked. Section 115 of the National Internal Revenue Code, as […]...

Keep on reading: BIR to monitor online sellers' tax compliance during holiday season




sel

Blinken heads to Brussels for urgent talks on Ukraine after Trump win

Blinken heads to Brussels for urgent talks on Ukraine after Trump win




sel

gem hatz diesel manual

gem hatz diesel manual




sel

to write an essay paper about yourself

to write an essay paper about yourself




sel

to write a self concept paper

to write a self concept paper




sel

to write a book in 24 hours 24 hour bestseller series

to write a book in 24 hours 24 hour bestseller series




sel

to make yourself happy and remarkably less disturbable

to make yourself happy and remarkably less disturbable




sel

to write a paper about myself

to write a paper about myself




sel

to write an autobiography essay about yourself

to write an autobiography essay about yourself




sel

to write an autobiography about yourself

to write an autobiography about yourself




sel

Veyseloglu Modern Retail Expansion Project

The transaction involves a loan of up to $10,000,000 (or the local currency equivalent) to Araz Supermarket LLC (Araz) for the Veyseloglu Modern Retail Expansion Project in Azerbaijan, and technical assistance (TA) of $500,000 for the Building the Capacity of Smallholder Fruit and Vegetable Farmers for Climate-Resilient Farming.




sel

Consumer insecticides are useless for fighting cockroach infestations

Lab-reared German cockroaches are susceptible to consumer insecticide sprays, allowing manufacturers to pass US regulatory tests, but insects taken from real-world infestations are able to shrug off the products




sel

A selection of elaborate birds' nests from around the world

These photos showcase some of the intricately created birds' nests found in the Natural History Museum in Tring, UK, home to one of the world's largest ornithological collections




sel

Fish size themselves up in a mirror to decide if they can win a fight

Cleaner wrasse use their reflection to build a mental image of their body size, which they use to compare themselves to rivals before picking a fight




sel

Watch elephants use a hose to shower themselves – and prank others

Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water




sel

Self-centred, spoiled and lonely? Examining the only child stereotype

More and more parents are choosing to only have one child. Here’s what the evidence says about how growing up without siblings affects their personality traits and well-being




sel

Canadian lake selected as site to mark the start of the Anthropocene

Geologists hoping to declare a new epoch dominated by humanity’s influence on Earth have chosen Crawford Lake in Canada as the location where the start of the Anthropocene is defined




sel

Why hairy animals shake themselves dry

The brain pathway that causes hairy mammals like mice and dogs to shake themselves dry appears to have more to do with pressure than temperature




sel

Watch elephants use a hose to shower themselves – and prank others

Asian elephants at Berlin Zoo show impressive skill when using a hose as a tool, and even appear to sabotage each other by stopping the flow of water




sel

In Seniors, 'Fear of Falling' Risky in Itself

Title: In Seniors, 'Fear of Falling' Risky in Itself
Category: Health News
Created: 8/20/2010 10:10:00 AM
Last Editorial Review: 8/23/2010 12:00:00 AM




sel

Kids Benefit From Doctors' Antismoking Counseling: Experts

Title: Kids Benefit From Doctors' Antismoking Counseling: Experts
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM




sel

Diet, Exercise Counseling Urged for Overweight Americans With Heart Risks

Title: Diet, Exercise Counseling Urged for Overweight Americans With Heart Risks
Category: Health News
Created: 8/26/2014 9:35:00 AM
Last Editorial Review: 8/26/2014 12:00:00 AM




sel

'Goth' Teens Report More Depression, Self-Harm

Title: 'Goth' Teens Report More Depression, Self-Harm
Category: Health News
Created: 8/27/2015 12:00:00 AM
Last Editorial Review: 8/28/2015 12:00:00 AM




sel

Restless Legs Syndrome Might Raise Risk of Suicide, Self-Harm

Title: Restless Legs Syndrome Might Raise Risk of Suicide, Self-Harm
Category: Health News
Created: 8/23/2019 12:00:00 AM
Last Editorial Review: 8/26/2019 12:00:00 AM




sel

Posting All Those Selfies Online Could Backfire, Study Finds

Title: Posting All Those Selfies Online Could Backfire, Study Finds
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM




sel

Feel Guilty About 'Useless' Leisure Time? Your Mental Health Might Suffer

Title: Feel Guilty About 'Useless' Leisure Time? Your Mental Health Might Suffer
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM




sel

Poor Sleep Can Make Folks Selfish, Study Finds

Title: Poor Sleep Can Make Folks Selfish, Study Finds
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




sel

Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease

Title: Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM




sel

Are Green Mussels Good for You?

Title: Are Green Mussels Good for You?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM




sel

Self-Employed Women Are Often Healthier: Study

Title: Self-Employed Women Are Often Healthier: Study
Category: Health News
Created: 8/8/2022 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM




sel

Molecular Mechanisms for the Selective Transport of Dichlorofluorescein by Human Organic Anion Transporting Polypeptide 1B1 [Articles]

Human organic anion transporting polypeptide (OATP) 1B1 and 1B3 are two highly homologous liver-specific uptake transporters. However, 2’,7’-dichlorofluorescein (DCF) is preferably transported by OATP1B1. In the present study, the molecular mechanisms for the selective transport of DCF by OATP1B1 were investigated by constructing and characterizing an array of OATP1B1/1B3 chimeras and site-directed mutagenesis. Our results show that transmembrane domain (TM) 10 is crucial for the surface expression and function of OATP1B1, in which Q541 and L545 play the most important roles in DCF transport. Replacement of TM10 in OATP1B1 with its OATP1B3 counterpart led to OATP1B1’s complete intracellular retention. Q541 and L545 may interact with DCF directly via hydrogen bonding and hydrophobic interactions. The decrease of DCF uptake by Q541A and L545S was due to their reduced binding affinity for DCF as compared with OATP1B1. In addition, Q541 and L545 are also crucial for the transport of estradiol-17β-glucuronide (E17βG) but not for the transport of estrone-3-sulfate (E3S), indicating different interaction modes between DCF/E17βG and E3S in OATP1B1. Taken together, Q541 and L545 in TM10 are critical for OATP1B1-mediated DCF uptake, but their effect is substrate-dependent.

SIGNIFICANCE STATEMENT

The key TMs and amino acid residues for the selective transport of DCF by OATP1B1 were identified. TM10 is crucial for the surface expression and function of OATP1B1. Within TM10, Q541 and L545 played the most significant roles and affected the function of OATP1B1 in a substrate-dependent manner. This information is crucial for a better understanding of the mechanism of the multispecificity of OATP1B1 and as a consequence the mechanism of OATP1B1-mediated drug–drug interactions.




sel

Comparison of the CYP3A Selective Inhibitors CYP3cide, Clobetasol, and Azamulin for Their Potential to Distinguish CYP3A7 Activity in the Presence of CYP3A4/5 [Articles]

The CYP3A7 enzyme accounts for ~50% of the total cytochrome P450 (P450) content in fetal and neonatal livers and is the predominant P450 involved in neonatal xenobiotic metabolism. Additionally, it is a key player in healthy birth outcomes through the oxidation of dehydroepiandrosterone (DHEA) and DHEA-sulfate. The amount of the other hepatic CYP3A isoforms, CYP3A4 and CYP3A5, expressed in neonates is low but highly variable, and therefore the activity of individual CYP3A isoforms is difficult to differentiate due to their functional similarities. Consequently, a better understanding of the contribution of CYP3A7 to drug metabolism is essential to identify the risk that drugs may pose to neonates and developing infants. To distinguish CYP3A7 activity from CYP3A4/5, we sought to further characterize the selectivity of the specific CYP3A inhibitors CYP3cide, clobetasol, and azamulin. We used three substrate probes, dibenzylfluorescein, luciferin-PPXE, and midazolam, to determine the IC50 and metabolism-dependent inhibition (MDI) properties of the CYP3A inhibitors. Probe selection had a significant effect on the IC50 values and P450 inactivation across all inhibitory compounds and enzymes. CYP3cide and azamulin were both identified as MDIs and were most specific for CYP3A4. Contrary to previous reports, we found that clobetasol propionate (CP) was not an MDI of CYP3A5 but was more selective for CYP3A5 over CYP3A4/7. We further investigated CYP3cide and CP’s ability to differentiate CYP3A7 activity in an equal mixture of recombinant CYP3A4, CYP3A5, and CYP3A7, and our results provide confidence of CYP3cide’s and CP’s ability to distinguish CYP3A7 activity in the presence of the other CYP3A isoforms.

SIGNIFICANCE STATEMENT

These findings provide valuable insight regarding in vitro testing conditions to investigate the metabolism of new drug candidates and help determine drug safety in neonates. The results presented here also clearly demonstrate the effect that probe selection may have on CYP3A cytochrome P450 inhibition studies.