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Queen Camilla's son claims she's the 'first queen to ever cook'

High-security card grants access to Queen Camilla and King Charles.Queen Camilla's son, Tom Parker Bowles, has revealed that his mother is likely the "first Queen to have cooked," highlighting her impressive culinary skills. The 49-year-old son of Queen Camilla shared that while his...




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to write everlasting characters english edition

to write everlasting characters english edition




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Leveraging Lessons Learned from India’s Unified Payments Interface for Digital Transformation in Asia and the Pacific

This brief shows how India sparked a digital payments boom and boosted financial inclusion through the introduction of its Unified Payments Interface (UPI) and outlines ways countries in the region can ramp up their own digital transformation.




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Motor made from bacteria parts is one of the smallest ever built

The natural motors that power tail-like appendages in bacteria seem to have a single evolutionary origin, allowing parts from different species to be combined to create a tiny new engine




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We are closer than ever to finally proving the multiverse exists

One hundred years ago, we discovered there were other galaxies beyond our own. Now, we might be on the verge of another discovery: that there are other universes




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How the most precise clock ever could change our view of the cosmos

Forget atomic clocks. Nuclear clocks, which only drop a second every 300 billion years, can test whether nature's fundamental constants are constant after all




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Can we finally reverse balding with these new experimental treatments?

Male pattern baldness could soon be a thing of the past, with new hair loss treatments beginning to show tantalising results




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The free-energy principle: Can one idea explain why everything exists?

What life is and how the mind works fall within the compass of one bold concept. But critics say that by attempting to explain everything, it may end up explaining nothing




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X-ray laser fires most powerful pulse ever recorded

The Linac Coherent Light Source in California fired an X-ray pulse that lasted only a few hundred billionths of a billionth of a second but carried nearly a terawatt of power




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We are closer than ever to finally proving the multiverse exists

One hundred years ago, we discovered there were other galaxies beyond our own. Now, we might be on the verge of another discovery: that there are other universes




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We may finally know what caused the biggest cosmic explosion ever seen

The gamma ray burst known as GRB221009A is the biggest explosion astronomers have ever glimpsed and we might finally know what caused the blast




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How the most precise clock ever could change our view of the cosmos

Forget atomic clocks. Nuclear clocks, which only drop a second every 300 billion years, can test whether nature's fundamental constants are constant after all




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Certain quantum systems may be able to defy entropy's effects forever

A mathematical proof shows that some quantum states can resist nature’s tendency to disorder – but only under very specific conditions




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Tiniest 'ruler' ever measures distances as small as an atom's width

A new technique uses glowing molecules, laser light and microscopes to measure distances as minuscule as 0.1 nanometres – the width of a typical atom




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Heat can flow backwards in a gas so thin its particles never touch

A surprising reversal of our usual understanding of the second law of thermodynamics shows that it may be possible for heat to move in the “wrong” direction, flowing from a cold area to a warm one




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Knots made in a weird quantum fluid can last forever

Shapes created by vortices in water often fall apart, but an odd quantum fluid made from ultracold atoms could support vortex knots that never lose their knottiness




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Jets of liquid bounce off hot surfaces without ever touching them

Droplets of fluid have been known to hover above a hot surface, but a new experiment suggests the same can happen to tiny jets of liquid too




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Ocean thunderstorms generate the most intense lightning ever observed

An analysis of satellite observations has identified some extreme thunderstorms over the Indian Ocean and Gulf of Mexico with lightning flashes so frequent that the sky would appear continuously lit




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Giant magma flow in Iceland was the fastest ever recorded

As a 15-kilometre crack formed ahead of the recent eruptions, magma flowed into it at the highest rate observed anywhere in the world




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How 'river piracy' made Mount Everest grow even taller

Rapid erosion caused by a geological act of “piracy” tens of thousands of years ago may have raised Earth’s crust and elevated Mount Everest by as much as 50 metres




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Chimpanzees will never randomly type the complete works of Shakespeare

The infinite monkey theorem states that illiterate primates could write great literature with enough time, but the amount of time needed is much longer than the lifespan of the universe




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Heat can flow backwards in a gas so thin its particles never touch

A surprising reversal of our usual understanding of the second law of thermodynamics shows that it may be possible for heat to move in the “wrong” direction, flowing from a cold area to a warm one




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Knots made in a weird quantum fluid can last forever

Shapes created by vortices in water often fall apart, but an odd quantum fluid made from ultracold atoms could support vortex knots that never lose their knottiness




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Why do we burn more coal and wood than ever, asks a provocative book

In More and More and More, Jean-Baptiste Fressoz argues that tackling climate change means rethinking our history of energy consumption – and exposing the green transition as a fiction




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Jets of liquid bounce off hot surfaces without ever touching them

Droplets of fluid have been known to hover above a hot surface, but a new experiment suggests the same can happen to tiny jets of liquid too




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PFAS 'Forever Chemicals' Linked With Liver Cancer

Title: PFAS 'Forever Chemicals' Linked With Liver Cancer
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM




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Breakthrough Might Break Down PFAS 'Forever Chemicals'

Title: Breakthrough Might Break Down PFAS 'Forever Chemicals'
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM




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Mechanical Blood Clot 'Retrievers' May Aid Stroke Patients

Title: Mechanical Blood Clot 'Retrievers' May Aid Stroke Patients
Category: Health News
Created: 8/27/2012 10:05:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM




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Should Everyone Over 65 Take a Statin?

Title: Should Everyone Over 65 Take a Statin?
Category: Health News
Created: 8/28/2013 4:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM




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Everest Study Finds High Altitude Affects Blood Pressure

Title: Everest Study Finds High Altitude Affects Blood Pressure
Category: Health News
Created: 8/27/2014 9:35:00 AM
Last Editorial Review: 8/27/2014 12:00:00 AM




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Concussion Recovery Can Reverse After Return to Activity, Study Shows

Title: Concussion Recovery Can Reverse After Return to Activity, Study Shows
Category: Health News
Created: 8/28/2014 9:36:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM




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Health Tip: Recognizing Hay Fever

Title: Health Tip: Recognizing Hay Fever
Category: Health News
Created: 8/28/2014 7:35:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM




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Mouse Study Suggests Stem Cells May Reverse Stroke Damage

Title: Mouse Study Suggests Stem Cells May Reverse Stroke Damage
Category: Health News
Created: 8/22/2016 12:00:00 AM
Last Editorial Review: 8/23/2016 12:00:00 AM




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America's New Dads Are Older Than Ever

Title: America's New Dads Are Older Than Ever
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM




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Every Sudden Infant Death Deserves a Closer Look: Report

Title: Every Sudden Infant Death Deserves a Closer Look: Report
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM




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Many Americans Eyeing CBD, Pot as Pain Relievers Without Knowing Risks

Title: Many Americans Eyeing CBD, Pot as Pain Relievers Without Knowing Risks
Category: Health News
Created: 8/27/2019 12:00:00 AM
Last Editorial Review: 8/28/2019 12:00:00 AM




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AHA News: It's Never Too Late to Reap Health Rewards of Exercise, Strength Training

Title: AHA News: It's Never Too Late to Reap Health Rewards of Exercise, Strength Training
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM




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Flu Shots for Kids Protect Everybody, Study Shows

Title: Flu Shots for Kids Protect Everybody, Study Shows
Category: Health News
Created: 8/21/2020 12:00:00 AM
Last Editorial Review: 8/24/2020 12:00:00 AM




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Just Like COVID, Severe Flu Can Trigger Heart Crises

Title: Just Like COVID, Severe Flu Can Trigger Heart Crises
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM




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One Pandemic Silver Lining: Fewer Severe Asthma Attacks in Kids

Title: One Pandemic Silver Lining: Fewer Severe Asthma Attacks in Kids
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM




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COVID Vaccine Protection Against Severe Disease

Title: COVID Vaccine Protection Against Severe Disease
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM




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Could a Long-Used Cholesterol Drug Fight Severe COVID-19?

Title: Could a Long-Used Cholesterol Drug Fight Severe COVID-19?
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM




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Regular Exercise Can Help Shield You From Severe COVID

Title: Regular Exercise Can Help Shield You From Severe COVID
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM




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AHA News: Newborn Was 'Very Sick Little Boy' Despite Several Normal Prenatal Ultrasounds

Title: AHA News: Newborn Was 'Very Sick Little Boy' Despite Several Normal Prenatal Ultrasounds
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM




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Everyday Activities That Can Cut Your Odds for Dementia

Title: Everyday Activities That Can Cut Your Odds for Dementia
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM




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Does Tinnitus Ever Go Away?

Title: Does Tinnitus Ever Go Away?
Category: Diseases and Conditions
Created: 6/3/2022 12:00:00 AM
Last Editorial Review: 6/3/2022 12:00:00 AM




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High Blood Pressure Doubles Odds That COVID Will Be Severe

Title: High Blood Pressure Doubles Odds That COVID Will Be Severe
Category: Health News
Created: 7/25/2022 12:00:00 AM
Last Editorial Review: 7/25/2022 12:00:00 AM




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Looking for Reliable Hay Fever Advice? It's Probably Not on YouTube

Title: Looking for Reliable Hay Fever Advice? It's Probably Not on YouTube
Category: Health News
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM




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Epidemiology of severe asthma in children: a systematic review and meta-analysis

Background

Severe asthma significantly impacts a minority of children with asthma, leading to frequent symptoms, hospitalisations and potential long-term health consequences. However, accurate global data on severe asthma epidemiology is lacking. This study aims to address this gap, providing data on severe asthma epidemiology, regional differences and associated comorbidities.

Methods

We conducted a rigorous systematic review and meta-analysis following a registered protocol (PROSPERO CRD42023472845). We searched PubMed, Scopus and Web of Science for cohort or cross-sectional studies published since 2003, evaluating severe asthma incidence and prevalence in children. Study quality and risk of bias were assessed using STROBE guidelines.

Results

Nine studies investigating European children with asthma (aged 5–18 years) were included in the meta-analysis. No significant publication bias was found. The overall severe asthma prevalence in children with asthma was 3% (95% CI 1–6; I2=99.9%; p<0.001), with no significant difference between males and females. Prevalence estimates varied significantly depending on the diagnostic criteria used (Global Initiative for Asthma: 6%; European Respiratory Society/American Thoracic Society: 1%; other: 3%). Because none of the examined studies were prospectively designed, incidence rates could not be determined.

Conclusions

This systematic review and meta-analysis provide the first robust assessment of severe asthma prevalence among European children. Our findings underscore the need for comprehensive research to address knowledge gaps in severe asthma, including determining incidence rates, standardising definitions, investigating regional differences and evaluating comorbidities and treatment strategies.




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Be SMART About Asthma Management: Single Maintenance and Reliever Therapy

Single maintenance and reliever therapy (SMART) is an asthma treatment approach that utilizes combined inhaled corticosteroids and long-acting β-agonists for maintenance and quick relief therapy. Despite the evidence for its benefits in asthma treatment and its adoption into American and international asthma guidelines and recommendations, SMART remains a practice of some debate. This article reviews the available evidence for SMART and offers guidance for its integration into comprehensive asthma management. Overall, short-acting β-agonist-only asthma therapy regimens should be avoided, regardless of condition severity (SOR A Recommendation). Family medicine clinicians should start SMART for patients requiring either GINA Step 3 or 4 therapy, especially if they have signs of poor adherence (SOR B Recommendation). Finally, use budesonide-formoterol over other inhaled corticosteroid/long-acting β-agonist combinations when implementing SMART (SOR B Recommendation).