Practical approaches can improve how we promote development research, and increase uptake by policymakers

Next-Generation Miniaturized Rubidium Atomic Clock Improves Performance and adds Features without Increasing Size

Microchip Expands Silicon Carbide (SiC) Family of Power Electronics to Provide System Level Improvements in Efficiency, Size and Reliability

ADB has approved a $177 million loan to India to upgrade 450 kilometers (km) of state highways and major district roads in Maharashtra State.

The Highlands Region Road Improvement Investment Program, a multitranche financing facility (MFF), aimed to ensure the maintenance of the Highlands Core Road Network, comprising 2,500 kilometers (km) of major national and provincial roads. The MFF is funded through three tranches. The first tranche (Project 1) had six components. The physical component was improvements to 211 km of national roads. Two components supported the Department of Works (DOW) and the National Roads Authority (NRA) in project implementation.

ADB joined the governments of Tonga and Australia in an inauguration ceremony today to officially mark the completion of upgrading work of the Mataki’eua water supply system as part of the ADB-supported Nuku’alofa Urban...

ADB, in partnership with the Bill & Melinda Gates Foundation, is providing more sanitary water-tight pit latrines for 330 homes in Mongolia's Arvaikheer city.

ADB today signed a $60 million loan deal (in Chinese Yuan equivalent) with Maxwealth Financial Leasing Co., Ltd. to improve municipal and industrial wastewater treatment capacity and standards in the People’s Republic of China...

This publication provides essential information on the planning, implementation, and management of improved water, sanitation, and hygiene (WASH) in schools, particularly for small and isolated rural settlements in Mongolia.

670,000 households in Indonesia are benefitting from improved access to water and sanitation.

The Health Sector Development Program, supported by the ADF facility and additional ADF grant funding for a total of $20 million, is improving primary health care delivery and information systems in Bhutan.

NEW DELHI: Real estate developers and property consultants today welcomed the RBI decision to cut statutory liquidity ratio (SLR), saying this would enable banks to lend more to industry, including cash-starved realty sector. However, developers demanded easing of interest rates to boost housing sales. RBI today decided to keep the key policy rate unchanged but slashed statutory liquidity ratio (SLR) by 0.5 per cent to unlock about Rs 40,000 crore into the system. “The RBI’s move to cut SLR by 50 basis points to 22 per cent will give banks more headroom to lend and thereby spur lending in future. However, the much anticipated cut in rates would have been […]

Approved project 50333-001 in Bangladesh.

Approved project 50278-002 in Mongolia.

Approved project 52298-001 in India.

Approved project 53097-002 in Papua New Guinea.

Energy security is a nation’s ability to meet the energy needs of its inhabitants uninterruptedly at an affordable price.

This publication provides essential information on the planning, implementation, and management of improved water, sanitation, and hygiene (WASH) in schools, particularly for small and isolated rural settlements in Mongolia.

Energy security is a nation’s ability to meet the energy needs of its inhabitants uninterruptedly at an affordable price.

STAMFORD, CT – HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets,  announced enhancements to its leading-edge Clari-Fi software solution, building on a...

Andrew Wong knew from an early age that running a restaurant required improvisation, having watched his parents steer their London Chinese restaurant through nearly 30 years of good times and bad.

Gymnasts all around the world are making the best of things as they try to keep fit while gyms are closed due to the coronavirus and Italy is no exception.

Olympic medallist Marco Lodadio of Italy transforms his garden swing into the rings gymnastic apparatus.

Always forgetting birthdays? Terrible at staying in touch? New tech promises to turn you into the best buddy ever. We put it to the test

Finland’s two-year test of universal basic income has concluded that it doesn't seem to disincentivise working, and improves recipients’ mental and financial well-being

In a new report, KPMG ranks countries' autonomous vehicle (AV) readiness by analyzing how policymakers perform on four pillars: policy and legislation, technology and innovation, infrastructure, and consumer acceptance. The top rankings? The...

Always forgetting birthdays? Terrible at staying in touch? New tech promises to turn you into the best buddy ever. We put it to the test

Finland’s two-year test of universal basic income has concluded that it doesn't seem to disincentivise working, and improves recipients’ mental and financial well-being

Title: New Drug Fails to Improve Odds for Heart Failure Patients
Category: Health News
Created: 5/2/2007 2:00:00 AM
Last Editorial Review: 5/2/2007 12:00:00 AM

Title: Clot-Preventing Drug Improves Heart Blood Flow After Angioplasty
Category: Health News
Created: 5/4/2007 2:00:00 AM
Last Editorial Review: 5/4/2007 12:00:00 AM

Title: Bioartificial Kidney Cuts Death Risk, Improves Outcomes
Category: Health News
Created: 5/1/2008 2:00:00 AM
Last Editorial Review: 5/1/2008 12:00:00 AM

Title: Home Monitoring Program Improves Outcomes for Heart Patients
Category: Health News
Created: 5/2/2008 2:00:00 AM
Last Editorial Review: 5/2/2008 12:00:00 AM

Title: Antidepressants May Improve Heart Health
Category: Health News
Created: 4/26/2010 12:10:00 PM
Last Editorial Review: 4/27/2010 12:00:00 AM

Title: Adding Surgery to Meds May Improve Life With Parkinson's
Category: Health News
Created: 4/29/2010 8:10:00 AM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Gastric Bypass May Improve Diabetes Quickly
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: How Weight-Loss Surgery Improves Diabetes Control
Category: Health News
Created: 4/30/2013 4:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: U.S. Air Quality Improvements Are Lagging
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

PMC has reorganized its FTP Service site for users interested in accessing the Text Mining Collections, which include the original Open Access (OA) Subset. New top-level FTP directories help users quickly locate the content available for bulk download that best suits their research needs. These directories include:

• oa_package - article packages for individual OA articles
• oa_pdf – individual PDFs for OA articles
• oa_bulk – bulk packages of text from OA articles
• manuscript – author manuscripts collected under a funding agency’s public access policy
• historical_ocr – select OCR texts from the PMC Back Issue Digitization project

To make it easier for users to identify and comply with the different licenses that apply to OA articles, new file lists have been created and the file lists for individual OA articles now include a “license-type” field for each article. Similarly, the bulk packages of OA article text have been divided into two sets. One set comprises articles that may be used for commercial purposes (the Commercial Use Collection); the other contains articles that can be used only for non-commercial purposes. See the Open Access Subset page for details.

To allow regular users to transition to the new arrangement, the previous arrangement of files and directories will be maintained in parallel for at least four weeks (i.e., until the end of August 2016).

There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1–targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration to levels insufficient to inhibit EWS-FLI1. In this study, we perform an siRNA screen of the druggable genome followed by a matrix drug screen to identify mithramycin potentiators and a synergistic "class" effect with cyclin-dependent kinase 9 (CDK9) inhibitors. These CDK9 inhibitors enhanced the mithramycin-mediated suppression of the EWS-FLI1 transcriptional program leading to a shift in the IC₅₀ and striking regressions of Ewing sarcoma xenografts. To determine whether these compounds may also be liver protective, we performed a qPCR screen of all known liver toxicity genes in HepG2 cells to identify mithramycin-driven transcriptional changes that contribute to the liver toxicity. Mithramycin induces expression of the BTG2 gene in HepG2 but not Ewing sarcoma cells, which leads to a liver-specific accumulation of reactive oxygen species (ROS). siRNA silencing of BTG2 rescues the induction of ROS and the cytotoxicity of mithramycin in these cells. Furthermore, CDK9 inhibition blocked the induction of BTG2 to limit cytotoxicity in HepG2, but not Ewing sarcoma cells. These studies provide the basis for a synergistic and less toxic EWS-FLI1–targeted combination therapy for Ewing sarcoma.

To better the health of all North Carolinians, policymakers must come together to improve access to care, expand broadband, and close the coverage gap.

Heat stress (HS) has serious effects on plant development, resulting in heavy agricultural losses. A critical transcription factor network is involved in plant adaptation to high temperature. DEHYDRATION RESPONSIVE ELEMENT-BINDING PROTEIN2A (DREB2A) is a key transcription factor that functions in plant thermotolerance. The DREB2A protein is unstable under normal temperature and is degraded by the 26S proteasome; however, the mechanism by which DREB2A protein stability dramatically increases in response to HS remains poorly understood. In this study, we found that the DREB2A protein of Arabidopsis (Arabidopsis thaliana) is stabilized under high temperature by the posttranslational modification SUMOylation. Biochemical data indicated that DREB2A is SUMOylated at K163, a conserved residue adjacent to the negative regulatory domain during HS. SUMOylation of DREB2A suppresses its interaction with BPM2, a ubiquitin ligase component, consequently increasing DREB2A protein stability under high temperature. In addition, analysis of plant heat tolerance and marker gene expression indicated that DREB2A SUMOylation is essential for its function in the HS response. Collectively, our data reveal a role for SUMOylation in the maintenance of DREB2A stability under high temperature, thus improving our understanding of the regulatory mechanisms underlying HS response in plant cells.