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After this week's near-record heat, California will return to cooler weather in mid-May

A trough off the West Coast is expected to bring a robust cooling trend to California next week.




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Timeline: Cook Islands

A chronology of key events




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Regions and territories: Cook Islands

Key facts, political leaders and notes on the media.




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A hit-and-run scooter crash nearly killed him. Now he’s fighting for the data that could reveal the rider’s identity.

A Chicago cyclist was injured by an electric scooter rider who fled the scene. Now he's gone to court to get the city's scooter companies to turn over personal information about their riders and their history.




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After death of YouTube star, Amazon will push for e-scooter safety warnings in the U.K.

Amazon, the global e-commerce giant, will ask electronic scooter manufacturers to make clear in their online listings that their devices cannot be used on public roads.




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Hyundai’s solution for navigating traffic-clogged cities: Mounting an electric scooter on your car

Hyundai, one of the world’s largest automakers, is exploring adding e-scooters to their vehicles. The company has released an e-scooter prototype that is charged using electricity produced while driving.




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Banking that electric cars can also be cool, Ford introduces an all-electric Mustang

Ford Motor has unveiled the Mustang Mach-E, an all-electric sport utility vehicle that the company claims will have a range of at least 230 miles.




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All the coolest features of every Tesla vehicle ever made or unveiled, ranked (TSLA)

  • Tesla's vehicles are and always have been crammed with great ideas.
  • These range from touchscreen interfaces to innovative battery designs to staggering acceleration.
  • I've driven or experienced every vehicle Tesla has ever sold or intends to sell in the future.
  • Here are all my favorite features, ranked.
  • Visit Business Insider's homepage for more stories.

In about two decades, Tesla has done what everyone in the auto industry thought was impossible: create an all-electric brand that could sell hundreds of thousands of vehicles.

Tesla could have done that in a boring or modest way, developing  the equivalent of an electric VW Beetle.

Instead, Tesla made fantastically compelling cars that are fast, look amazing, and are packed with features.

Here's a rundown of all my favorites, ranked from bottom to top:

FOLLOW US: On Facebook for more car and transportation content!

Tesla has been in business for 17 years. In that period of time, it's consistently captivated the world not just because it makes all-electric cars, but because those cars have always been packed with cool features.



"Easter eggs" — frivolous little extras that Tesla throws in whenever it does software updates. Owners enjoy finding them.



The Model X's falcon-wing doors. Dramatic, slightly impractical, and a nightmare to manufacture. But Tesla has the only SUV on the road with such an exotic feature.



Bioweapon Defense Mode uses a powerful filtration system to render the interior air quality of the Model X or Model S "hospital grade," according to Tesla.



The Model X's 5,000-pound towing capacity. Nobody ever talks about it, but the Model X can tow a goodly amount for an electric SUV. It's very competitive with gas-powered SUVs that tout their capabilities.



The large, central portrait touchscreen on the Model S and Model X. This mega-tablet interface was a revelation when Tesla first introduced it on the Model S in 2012, but it's now emulated throughout the auto industry. It's actually canted slightly toward the driver.



Aero Wheels on the Model 3. The proprietary design is standard on the vehicle, enhancing airflow, reducing drag, and improving range.



Ludicrous Mode. The acceleration feature — which followed Insane Mode, first rolled for the all-wheel-drive Model S — enables Teslas to cover the 0-60 mph sprint at supercar-like velocities.



Frunks! All Teslas currently on sale have front trunks, expanding their cargo capacities. Having no gas engine helps to free up space.



Trunks! Teslas are commendable cargo haulers because they're effectively boxes on top of battery packs, creating ample space for luggage, groceries, of gear.



Quiet. In operation, Teslas are notably quiet and smooth, thanks to the optimization of airflow, solid build quality, and mostly silent electric motors.



The Tesla smartphone app. I've actually tested a number of these from assorted manufacturers, but Tesla's is the only one that's truly useful. For the Model 3, it replaces the traditional key fob.



The glass roof of the Model 3. It creates a stunning silhouette and floods the cabin with natural light.



The space-age operators' platform in the cab of the Tesla Semi. This space — clearly anticipating a time when semi-trucks drive themselves — is the most futuristic thing Tesla has ever designed.



Roadsters in space. CEO Elon Musk's personal Tesla Roadster was launched atop the SpaceX Falcon Heavy rocket in 2017, as a test payload. Piloted by "Starman," it set a new standard for automotive marketing.



Tesla's in-house audio system. Most luxury brands partner with a big-name audio company for premium sound systems, but Tesla developed its own — and it sounds absolutely fantastic.



Charge monitoring and mapping. Charging is among the most important things Tesla has to think about, so the company has made it a priority to track it in the vehicle and via the app, as well as to plot road-trip courses that use GPS navigation to permit island-hopping from charging location to charging location.



Navigate on Autopilot combines Tesla's GPS mapping system with Autopilot's ability to execute lane changes and freeway on- and off-ramping maneuvers.



The new Roadster's staggering performance specs. The all-new machine has a claimed 0-60 mph time of 1.9 seconds, making it the fastest production vehicle in the world.



The Model 3's consolidated vehicle-management system and central landscape touchscreen. Almost every aspect of the Model 3 is controlled here, and the traditional instrument cluster has been moved to the left side of the screen, and streamlined.



The radical design of the Cybertruck. In late 2019, Tesla had fallen into a design rut. The otherworldly, stainless-steel Cybertruck changed all that. Controversial to be sure, but also thrilling.

Read about the Cybertrucks' rad design.



Manufacturing simplicity. Electric cars are less complicated to build than gas-powered ones. Tesla has designed its factory in China to optimize this aspect of production, which could support and enviable profit margin for Tesla in the 20-30% range.



The white interior. It's an extra, but a very popular one. I was initially skeptical, but I'm now a fan. After all, it survived a 700-plus-mile family road trip!

Read about the road trip.



Over-the-air software updates. Just like smartphones, Teslas can be routinely upgraded while sitting in owners' driveways. This means that an older Tesla can acquire new features quite literally overnight.



The Supercharger network. Access to DC fast-charging used to be a lifetime perk for Tesla owners, but Tesla has begun to bill for the service. Still, it enables longer road trips and is completely integrated with each Tesla vehicle's systems.



Tesla's design philosophy. Head designer Franz von Holzhausen and Elon Musk argue that it doesn't cost anymore to make Teslas beautiful. But von Holzhausen has also exercised tasteful restraint, ensuring that Tesla's vehicles have a long market life.

Read about Franz's design influence.



Performance! Tesla vehicles have always combined electric virtuosity with industry-leading performance. Owners can usually expect to be driving one of the fastest cars on the road.



Battery design. Tesla has taken a complicated, multi-cell concept — thousands are wired together in packs — and perfected it, yielding impressive range and performance. The company also manufactures its own packs, in partnership with Panasonic.



The Model 3's minimalist driving experience. With the clean dashboard, you can focus on the road ahead. It's a blissful thing and my top Tesla feature.



The bottom line is that while plenty of other automakers put cool features in their cars, Teslas are crammed with ideas, ideas, and more ideas.






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Quarkus Cookbook

Optimized for Kubernetes, Quarkus is designed to help you create Java applications that are cloud first, container native, and serverless capable. With this cookbook, authors Alex Soto Bueno and Jason Porter from Red Hat provide detailed solutions for installing, interacting with, and using Quarkus in the development and production of microservices. The recipes in this book show mid-level to senior developers familiar with Java enterprise application development how to get started with Quarkus quickly.




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Arduino Cookbook

Want to create devices that interact with the physical world? This cookbook is perfect for anyone who wants to experiment with the popular Arduino microcontroller and programming environment. Updated for Arduino 1.8, the third edition includes more than 200 tips and techniques for building a variety of objects and prototypes such as IoT solutions, environmental monitors, location and position-aware systems, and products that can respond to touch, sound, heat, and light. You don’t need to have mastered Arduino or programming to get started.





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Slow Cooker Taco Soup

This slow cooker taco soup with ground beef is so easy — and SO GOOD! It's perfect for busy weeks with flexible cooking times for any schedule. Serve with tortilla chips, cilantro-lime rice, or cornbread.

Continue reading "Slow Cooker Taco Soup" »





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velocityconf: Free webcast w/ @jon lives http://t.co/TxL60Oagos 'Michelin Starred Cooking with Chef at Etsy' starting NOW. #velocityconf #devops

velocityconf: Free webcast w/ @jon lives http://t.co/TxL60Oagos 'Michelin Starred Cooking with Chef at Etsy' starting NOW. #velocityconf #devops




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Cool Start-up Interview Series – Mondly Languages

We’ve recently had the pleasure to chat with Andrei Nastasie, the affiliate program manager at Mondly Languages, an innovative language learning app that incorporates native language recordings, augmented reality and virtual reality to help people learn new languages. In this interview, he shares how Mondly started out, what it has been up to and what’s next for this creative company.




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AT#238 - Travel to the Cook Islands

The Amateur Traveler talks to Melanie Waldman of TravelsWithTwo.com about a recent trip to the Cook Islands in the Pacific. Think of the Cook Islands as Tahiti without the French language and using the New Zealand dollar to make it more affordable. Melanie tells us about this corner of Polynesia with beautiful resorts that she and her husband visited for their 10th anniversary. They hiked the mountainous spine of Raratongo with Pa who knows all of the plants and their uses and cruised the small outer islands of Aitutaki with a guide named Captain Awesome. They also took an archeology tour, drove the ring roads, shopped in the farmer’s market and just hung out on the beach drinking the cocktails of the moment.




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This solar oven can cook using the power of the sun, and it's on sale

TL;DR: Have a hot meal wherever you go with the Go portable solar oven for $119, a 14% savings as of May 9.


As we look toward upcoming summer festivities, our calendars are looking pretty bleak. Nearly every event has been postponed. Festival season was straight-up canceled. And gatherings in public places are basically extinct. With fewer options on the table, you're probably going to be spending a lot of time enjoying the great outdoors in small groups or on your own as the weather warms up. By then, you'll be sick of staying home, so it's a good thing nature isn't canceled.

As you head outside for your camping, hiking, biking, and beach excursions, you'll probably need a way to cook your own food, especially if restaurants are still closed or operating on abbreviated hours. We've got just thing, and it's on sale: the Go Portable Solar Oven. All you need is a little bit of sun and this lightweight grill can cook just about anything. Read more...

More about Cooking, Camping, Mashable Shopping, Tech, and Consumer Tech




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Synergy in North Africa: Furthering Cooperation

21 January 2020

Discussions of North African integration have evoked ideas of a shared identity and a common destiny in the region. However, recent attempts to build regional blocs in North Africa have been unsuccessful. This paper examines the benefits of a ‘synergistic’ approach to North African cooperation. 

Dr Mohammed Masbah

Associate Fellow, Middle East and North Africa Programme

Mohamed El Dahshan

Associate Fellow, Middle East and North Africa Programme

2020-01-21-Market.jpg

A Tunisian vendor poses as he sells white truffles at a market in the town of Ben Guerdane, 40km west of the Libyan border, in February 2016. Photo: Getty Images.

Summary

  • North African integration is not a new idea. However, countries in the region have so far struggled to form a cohesive bloc with deep political, economic and social ties. Political instability has effectively deprioritized North African integration. A focus on thematic (political, economic and security) ‘synergies’ may provide a better framework for cooperation than seeking opportunities for all-encompassing ‘deep’ and ‘comprehensive’ integration.
  • Governments of North Africa dedicate considerable resources to domestic security. Much of their efforts are conducted at the national-level and directed towards threats from terrorists, insurgents and militias. Improved security cooperation would achieve better outcomes and economies of scale, including efforts to tackle human trafficking.
  • A new generation of jihadis has emerged in North Africa since 2011. Nearly 27 per cent of the 30,000 fighters who travelled to Syria are from the Maghreb. While government counterterrorism operations have been effective, countries have failed to address the root causes of radicalization.
  • Border economies have suffered as a consequence of a security focus on terrorism and smuggling, which has rendered many previously accepted cross-border trade activities illegal. States have struggled to provide alternative livelihoods for those who have lost this source of income. Border forces tend to lack the right combination of capacity, training and equipment to secure borders and often resort to heavy-handed tactics.
  • New thinking is required to develop a more human-centric and proactive approach to migration issues in the region, which continues to witness huge flows of migrants. The migration policy of Morocco, introduced through legislation in 2014, could be a model for North Africa.
  • The countries of North Africa have varying economic profiles, ranging from economically diverse Morocco to oil-and-gas-dependant Libya. However, they all face similar challenges including unemployment (particularly among the young), poor public-service delivery, low FDI levels, an oversized public sector, ineffective tax collection, and high informality.
  • Fostering entrepreneurship and the development of small and medium-sized enterprises (SMEs) are priorities for North African countries, particularly regarding job creation. Regulatory cooperation – such as harmonizing SME definitions, legislation and support institutions – across North Africa is an obvious area where further integration would encourage the development of start-ups and small businesses.
  • With the advent of the fourth industrial revolution, North African governments must address their technological gaps and work to improve public–private cooperation. In some sectors, such as the fintech industry, North African countries can build upon nascent synergies that have developed organically, such as those of start-up incubators and angel investors that work across the region.
  • Renewables, particularly solar energy production, are a promising development for North Africa. While regional initiatives, such as Desertec, have stalled due to political differences between countries, the sector has witnessed exponential growth in Tunisia, Egypt and Morocco, where the involvement of the private sector has proved successful.




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Transatlantic Economic Cooperation and the Global Economy

Members Event

13 February 2015 - 1:00pm to 2:00pm

Chatham House, London

Event participants

Caroline Atkinson, Deputy Assistant to President Obama and Deputy National Security Advisor for International Economics
Chair: Sebastian Mallaby, Paul A. Volcker Senior Fellow in International Economics, The Council on Foreign Relations

The speaker will outline the importance of economic cooperation in the transatlantic relationship and consider recent developments in the global economy.

Members Events Team




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Transatlantic Cooperation to Prevent and Stop Mass Atrocities

Invitation Only Research Event

16 February 2015 - 1:00pm to 5:00pm

Chatham House, London

Event participants

Ambassador Lee Feinstein, Founding Dean, School of Global & International Studies, Indiana University
Xenia Wickett, Project Director, US; Dean, The Queen Elizabeth II Academy, Chatham House
Paul Arkwright, Director, Multilateral Policy, Foreign & Commonwealth Office
Dr Patricia Lewis, Research Director, International Security Programme, Chatham House
Jonathan Prentice, Director, London Office & Senior Adviser for European Advocacy, International Crisis Group
Sir John Holmes, Director, The Ditchley Foundation

The international community is in urgent need of successful, cooperative strategies for both preventing mass atrocities before they begin and stopping those in progress. As recent crises have highlighted, effective international cooperation to save lives and preserve peace and security remains largely aspirational. Participants will discuss current thinking on mass atrocity prevention and intervention, and identify how transatlantic cooperation in this space could be more effective.

Attendance at this event is by invitation only.

Department/project

Richard Gowing

Programme Administrator
+44 (0)20 7389 3270




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The Future of US Global Leadership: Implications for Europe, Canada and Transatlantic Cooperation

10 May 2016

As the United States’ international engagement changes, Canada and Europe should increase coordination with it to prevent power vacuums from emerging.

Xenia Wickett

Former Head, US and the Americas Programme; Former Dean, The Queen Elizabeth II Academy for Leadership in International Affairs

Rory Kinane

Former Manager, US and the Americas Programme

2016-05-06-future-us-global-leadership.jpg

Marine One, carrying US President Barack Obama, departs the White House on 26 August 2014, Washington DC. Photo: Getty Images.

Summary

  • The United States’ transatlantic allies need to appreciate how its global leadership is changing and what this means for their interests, and respond accordingly. Notions of US decline have been overstated, but the country is not going to play the same international role in the future that it has previously.
  • As the United States’ international engagement changes, Canada and Europe should increase coordination with it to prevent power vacuums from emerging. The transatlantic allies should work together to build greater links at all stages of the policy process, from perceptions of threat, prioritization, analysis, threat definition and policy formation to implementation and action.  
  • As the United States’ capabilities adapt to its changed circumstances and role, so too must those of its allies. This adjustment must go far beyond military aspects to enhancing diplomatic, energy, economic, intelligence and other resources.
  • In addition to the challenges around differing interests, priorities and capabilities inherent in any alliance, Europe appears to have lost its confidence. In part this is due to its growing disengagement and introspection. But Europe retains huge potential for influence if it uses its resources effectively. There is much that European states can do, individually and together, to take more control over advancing their strategic interests. Equally, by working together they can do much to nudge the United States in helpful directions to support the mutual interests of all parties.
  • The conversation on reforming global institutions such as the IMF must move beyond the need for change per se towards articulating the actual shape of such changes. Europe and Canada will likely need to push the United States into accepting reform of these institutions to better reflect today’s reality and tomorrow’s challenges. Global institutions need more diversified leaderships if they are to ensure their long-term legitimacy and influence. This will be difficult to push through politically in the United States, but by working with new regional and global powers to propose reforms, Europe and Canada can help find an acceptable solution.
  • The use of ad hoc coalitions does not necessarily damage the efficacy of broader consensus institutions such as NATO. In fact, flexible coalitions may often be desirable when solutions to new challenges need to be developed and agreed quickly.
  • Canada and Europe should consider partnering with other actors besides the United States where necessary. This may be expedient for meeting individual objectives, and would have the secondary benefit of demonstrating to emerging powers that the West does not exclude cooperation with others out of an arbitrary loyalty to the United States.
  • Europe needs to appreciate the potentially dire consequences of failing to adapt to changing US leadership and an increasingly complex world. There is a real chance that the European project could unravel in the next few years due to external and internal pressures. While many European policy-makers display an understanding of these challenges in private, in public there is little appetite for taking the decisions necessary to bring long-term stability to the continent. 

Department/project




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The Hurdles to Developing a COVID-19 Vaccine: Why International Cooperation is Needed

23 April 2020

Professor David Salisbury CB

Associate Fellow, Global Health Programme

Dr Champa Patel

Director, Asia-Pacific Programme
While the world pins its hopes on vaccines to prevent COVID-19, there are scientific, regulatory and market hurdles to overcome. Furthermore, with geopolitical tensions and nationalistic approaches, there is a high risk that the most vulnerable will not get the life-saving interventions they need.

2020-04-23-Covid-Vaccine.jpg

A biologist works on the virus inactivation process in Belo Horizonte, Brazil on 24 March 2020. The Brazilian Ministry of Health convened The Technological Vaccine Center to conduct research on COVID-19 in order to diagnose, test and develop a vaccine. Photo: Getty Images.

On 10 January 2020, Chinese scientists released the sequence of the COVID-19 genome on the internet. This provided the starting gun for scientists around the world to start developing vaccines or therapies. With at least 80 different vaccines in development, many governments are pinning their hopes on a quick solution. However, there are many hurdles to overcome. 

Vaccine development

Firstly, vaccine development is normally a very long process to ensure vaccines are safe and effective before they are used. 

Safety is not a given: a recent dengue vaccine caused heightened disease in vaccinated children when they later were exposed to dengue, while Respiratory Syncytial Virus vaccine caused the same problem. Nor is effectiveness a given. Candidate vaccines that use novel techniques where minute fragments of the viruses’ genetic code are either injected directly into humans or incorporated into a vaccine (as is being pursued, or could be pursued for COVID-19) have higher risks of failure simply because they haven’t worked before. For some vaccines, we know what levels of immunity post-vaccination are likely to be protective. This is not the case for coronavirus. 

Clinical trials will have to be done for efficacy. This is not optional – regulators will need to know extensive testing has taken place before licencing any vaccine. Even if animal tests are done in parallel with early human tests, the remainder of the process is still lengthy. 

There is also great interest in the use of passive immunization, whereby antibodies to SARS-CoV-2 (collected from people who have recovered from infection or laboratory-created) are given to people who are currently ill. Antivirals may prove to be a quicker route than vaccine development, as the testing requirements would be shorter, manufacturing may be easier and only ill people would need to be treated, as opposed to all at-risk individuals being vaccinated.

Vaccine manufacturing

Developers, especially small biotechs, will have to make partnerships with large vaccine manufacturers in order to bring products to market. One notorious bottleneck in vaccine development is getting from proof-of-principle to commercial development: about 95 per cent of vaccines fail at this step. Another bottleneck is at the end of production. The final stages of vaccine production involve detailed testing to ensure that the vaccine meets the necessary criteria and there are always constraints on access to the technologies necessary to finalize the product. Only large vaccine manufacturers have these capacities. There is a graveyard of failed vaccine candidates that have not managed to pass through this development and manufacturing process.

Another consideration is adverse or unintended consequences. Highly specialized scientists may have to defer their work on other new vaccines to work on COVID-19 products and production of existing products may have to be set aside, raising the possibility of shortages of other essential vaccines. 

Cost is another challenge. Vaccines for industrialized markets can be very lucrative for pharmaceutical companies, but many countries have price caps on vaccines. Important lessons have been learned from the 2009 H1N1 flu pandemic when industrialized countries took all the vaccines first. Supplies were made available to lower-income countries at a lower price but this was much later in the evolution of the pandemic. For the recent Ebola outbreaks, vaccines were made available at low or no cost. 

Geopolitics may also play a role. Should countries that manufacture a vaccine share it widely with other countries or prioritize their own populations first? It has been reported that President Trump attempted to purchase CureVac, a German company with a candidate vaccine.  There are certainly precedents for countries prioritizing their own populations. With H1N1 flu in 2009, the Australian Government required a vaccine company to meet the needs of the Australian population first. 

Vaccine distribution

Global leadership and a coordinated and coherent response will be needed to ensure that any vaccine is distributed equitably. There have been recent calls for a G20 on health, but existing global bodies such as the Coalition for Epidemic Preparedness Innovations (CEPI) and GAVI are working on vaccines and worldwide access to them. Any new bodies should seek to boost funding for these entities so they can ensure products reach the most disadvantaged. 

While countries that cannot afford vaccines may be priced out of markets, access for poor, vulnerable or marginalized peoples, whether in developed or developing countries, is of concern. Developing countries are at particular risk from the impacts of COVID-19. People living in conflict-affected and fragile states – whether they are refugees or asylum seekers, internally displaced or stateless, or in detention facilities – are at especially high risk of devastating impacts. 

Mature economies will also face challenges. Equitable access to COVID-19 vaccine will be challenging where inequalities and unequal access to essential services have been compromised within some political systems. 

The need for global leadership 

There is an urgent need for international coordination on COVID-19 vaccines. While the WHO provides technical support and UNICEF acts as a procurement agency, responding to coronavirus needs clarity of global leadership that arches over national interests and is capable of mobilizing resources at a time when economies are facing painful recessions. We see vaccines as a salvation but remain ill-equipped to accelerate their development.

While everyone hopes for rapid availability of safe, effective and affordable vaccines that will be produced in sufficient quantities to meet everyone’s needs, realistically, we face huge hurdles. 




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Webinar: Responding to COVID-19 – International Coordination and Cooperation

Members Event Webinar

1 May 2020 - 1:00pm to 1:45pm

Event participants

Yanzhong Huang, Senior Fellow for Global Health, Council on Foreign Relations

Dr Olive Shisana, President and CEO, Evidence Based Solutions; Special Advisor on Social Policy to President Cyril Ramaphosa 

Rob Yates, Director, Global Health Programme; Executive Director, Centre for Universal Health, Chatham House

Chair: Dr Champa Patel, Director, Asia-Pacific Programme, Chatham House

 

As a body with a relatively small operating budget and no formal mechanisms, or authority, to sanction member states that fail to comply with its guidance, the World Health Organization has been limited in its ability to coordinate a global response to the COVID-19 outbreak. At the same time, the organization is reliant on an international order that the current coronavirus crisis is, arguably, disrupting: as containment measures become more important in stemming the spread of the virus, the temptation to implement protectionist policies is increasing among nations. For example, the UK did not participate in an EU scheme to buy PPE and Germany has accused the US of ‘piracy’ after it reportedly diverted a shipment of masks intended for Berlin. Elsewhere, despite rhetorical commitments from the G7 and G20, a detailed plan for a comprehensive international response has not been forthcoming. 

The panel will discuss issues of coordination and cooperation in the international response to COVID-19. Have global trends prior to the outbreak contributed to the slow and disjointed international response? How has the pandemic exposed fissures in the extent to which nations are willing to cooperate? And what is the capacity of international organizations such as the WHO to coordinate a concerted transnational response and what could the implications be for the future of globalization and the international liberal order?

This event is open to Chatham House Members. Not a member? Find out more.




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Roles of active-site residues in catalysis, substrate binding, cooperativity, and the reaction mechanism of the quinoprotein glycine oxidase [Enzymology]

The quinoprotein glycine oxidase from the marine bacterium Pseudoalteromonas luteoviolacea (PlGoxA) uses a protein-derived cysteine tryptophylquinone (CTQ) cofactor to catalyze conversion of glycine to glyoxylate and ammonia. This homotetrameric enzyme exhibits strong cooperativity toward glycine binding. It is a good model for studying enzyme kinetics and cooperativity, specifically for being able to separate those aspects of protein function through directed mutagenesis. Variant proteins were generated with mutations in four active-site residues, Phe-316, His-583, Tyr-766, and His-767. Structures for glycine-soaked crystals were obtained for each. Different mutations had differential effects on kcat and K0.5 for catalysis, K0.5 for substrate binding, and the Hill coefficients describing the steady-state kinetics or substrate binding. Phe-316 and Tyr-766 variants retained catalytic activity, albeit with altered kinetics and cooperativity. Substitutions of His-583 revealed that it is essential for glycine binding, and the structure of H583C PlGoxA had no active-site glycine present in glycine-soaked crystals. The structure of H767A PlGoxA revealed a previously undetected reaction intermediate, a carbinolamine product-reduced CTQ adduct, and exhibited only negligible activity. The results of these experiments, as well as those with the native enzyme and previous variants, enabled construction of a detailed mechanism for the reductive half-reaction of glycine oxidation. This proposed mechanism includes three discrete reaction intermediates that are covalently bound to CTQ during the reaction, two of which have now been structurally characterized by X-ray crystallography.




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Non-traditional security cooperation between China and south-east Asia: implications for Indo-Pacific geopolitics

8 January 2020 , Volume 96, Number 1

Xue Gong

The ‘free and open Indo-Pacific’ (FOIP) strategy, actively promoted by the United States with support from its allies and partners, is a significant geopolitical response to China's growing power and expanding influence in Asia and beyond. Beijing has adopted various new strategies to cope with the challenges related to FOIP. One of these strategies is to secure a robust relationship with south-east Asia in order to make these regional states either neutral to or less supportive of the Indo-Pacific vision. In addition to economic statecraft and soft power, Beijing believes that it can also tap into the domain of non-traditional security (NTS) to strengthen relations with this region to position itself better in the intensifying regional geopolitical competition. The article addresses the following question: what is the impact of China's NTS cooperation with south-east Asia on Beijing's geopolitical rivalry with other major powers in the Indo-Pacific region? The article argues that China's NTS cooperation with south-east Asian countries may help China maintain its geopolitical standing in the region, but it is unlikely to lead to any dramatic increase of China's strategic influence in the region. This essentially means that Beijing may be able to prevent ASEAN or most ASEAN member states from lending substantive and strong support to the Indo-Pacific construct, but it will not be able to stop ASEAN states from supporting some elements of the FOIP.




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Webinar: Coordinating the Fight Against Financial Crime

Corporate Members Event Webinar

1 July 2020 - 5:00pm to 6:00pm
Add to Calendar

Che Sidanius, Global Head of Regulation & Industry Affairs, Refinitiv

Patricia Sullivan, Global Co-Head, Financial Crime Compliance, Standard Chartered

Dame Sara Thornton, Independent Anti-Slavery Commissioner, UK

Chair: Tom Keatinge, Director, Centre for Financial Crime and Security Studies, RUSI

 

Illicit finance not only threatens financial stability and inclusion but also provides support for terrorism and is a primary incentive for human trafficking, the illegal wildlife trade and narcotics smuggling. Frequently, actors capitalize on loopholes and inefficiencies resulting from the lack of a coordinated response to financial crime and an underpowered global system for tracking illicit financial flows. Enhanced public-private partnerships, in addition to investment in tackling financial crime from governments, international bodies and private industries, are necessary to develop regulatory frameworks, effective responses and valuable coordination between law enforcement, policymakers, regulators and financial institutions. But how should businesses structure their efforts so that their business interests are protected and the work they do is of use to others fighting financial crime?

This webinar will explore solutions to enable public-private partnerships to work together to combat financial crime. What do successful partnerships need from each side to ensure that the work being done is efficient and effective? How can the industry’s internal effectiveness impact the ‘real-world’ victims? And what barriers impede public-private partnerships operating as a force for good? 

This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members and giving circles.

Not a corporate member? Find out more.




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Webinar: Responding to COVID-19 – International Coordination and Cooperation

Members Event Webinar

1 May 2020 - 1:00pm to 1:45pm

Event participants

Yanzhong Huang, Senior Fellow for Global Health, Council on Foreign Relations

Dr Olive Shisana, President and CEO, Evidence Based Solutions; Special Advisor on Social Policy to President Cyril Ramaphosa 

Rob Yates, Director, Global Health Programme; Executive Director, Centre for Universal Health, Chatham House

Chair: Dr Champa Patel, Director, Asia-Pacific Programme, Chatham House

 

As a body with a relatively small operating budget and no formal mechanisms, or authority, to sanction member states that fail to comply with its guidance, the World Health Organization has been limited in its ability to coordinate a global response to the COVID-19 outbreak. At the same time, the organization is reliant on an international order that the current coronavirus crisis is, arguably, disrupting: as containment measures become more important in stemming the spread of the virus, the temptation to implement protectionist policies is increasing among nations. For example, the UK did not participate in an EU scheme to buy PPE and Germany has accused the US of ‘piracy’ after it reportedly diverted a shipment of masks intended for Berlin. Elsewhere, despite rhetorical commitments from the G7 and G20, a detailed plan for a comprehensive international response has not been forthcoming. 

The panel will discuss issues of coordination and cooperation in the international response to COVID-19. Have global trends prior to the outbreak contributed to the slow and disjointed international response? How has the pandemic exposed fissures in the extent to which nations are willing to cooperate? And what is the capacity of international organizations such as the WHO to coordinate a concerted transnational response and what could the implications be for the future of globalization and the international liberal order?

This event is open to Chatham House Members. Not a member? Find out more.




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Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

MS Brown
Jul 1, 1980; 21:505-517
Reviews




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UK–EU Defence and Security Cooperation after Brexit




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Our Shared Humanity: Cool and Reasoned Judgement




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The Hurdles to Developing a COVID-19 Vaccine: Why International Cooperation is Needed

23 April 2020

Professor David Salisbury CB

Associate Fellow, Global Health Programme

Dr Champa Patel

Director, Asia-Pacific Programme
While the world pins its hopes on vaccines to prevent COVID-19, there are scientific, regulatory and market hurdles to overcome. Furthermore, with geopolitical tensions and nationalistic approaches, there is a high risk that the most vulnerable will not get the life-saving interventions they need.

2020-04-23-Covid-Vaccine.jpg

A biologist works on the virus inactivation process in Belo Horizonte, Brazil on 24 March 2020. The Brazilian Ministry of Health convened The Technological Vaccine Center to conduct research on COVID-19 in order to diagnose, test and develop a vaccine. Photo: Getty Images.

On 10 January 2020, Chinese scientists released the sequence of the COVID-19 genome on the internet. This provided the starting gun for scientists around the world to start developing vaccines or therapies. With at least 80 different vaccines in development, many governments are pinning their hopes on a quick solution. However, there are many hurdles to overcome. 

Vaccine development

Firstly, vaccine development is normally a very long process to ensure vaccines are safe and effective before they are used. 

Safety is not a given: a recent dengue vaccine caused heightened disease in vaccinated children when they later were exposed to dengue, while Respiratory Syncytial Virus vaccine caused the same problem. Nor is effectiveness a given. Candidate vaccines that use novel techniques where minute fragments of the viruses’ genetic code are either injected directly into humans or incorporated into a vaccine (as is being pursued, or could be pursued for COVID-19) have higher risks of failure simply because they haven’t worked before. For some vaccines, we know what levels of immunity post-vaccination are likely to be protective. This is not the case for coronavirus. 

Clinical trials will have to be done for efficacy. This is not optional – regulators will need to know extensive testing has taken place before licencing any vaccine. Even if animal tests are done in parallel with early human tests, the remainder of the process is still lengthy. 

There is also great interest in the use of passive immunization, whereby antibodies to SARS-CoV-2 (collected from people who have recovered from infection or laboratory-created) are given to people who are currently ill. Antivirals may prove to be a quicker route than vaccine development, as the testing requirements would be shorter, manufacturing may be easier and only ill people would need to be treated, as opposed to all at-risk individuals being vaccinated.

Vaccine manufacturing

Developers, especially small biotechs, will have to make partnerships with large vaccine manufacturers in order to bring products to market. One notorious bottleneck in vaccine development is getting from proof-of-principle to commercial development: about 95 per cent of vaccines fail at this step. Another bottleneck is at the end of production. The final stages of vaccine production involve detailed testing to ensure that the vaccine meets the necessary criteria and there are always constraints on access to the technologies necessary to finalize the product. Only large vaccine manufacturers have these capacities. There is a graveyard of failed vaccine candidates that have not managed to pass through this development and manufacturing process.

Another consideration is adverse or unintended consequences. Highly specialized scientists may have to defer their work on other new vaccines to work on COVID-19 products and production of existing products may have to be set aside, raising the possibility of shortages of other essential vaccines. 

Cost is another challenge. Vaccines for industrialized markets can be very lucrative for pharmaceutical companies, but many countries have price caps on vaccines. Important lessons have been learned from the 2009 H1N1 flu pandemic when industrialized countries took all the vaccines first. Supplies were made available to lower-income countries at a lower price but this was much later in the evolution of the pandemic. For the recent Ebola outbreaks, vaccines were made available at low or no cost. 

Geopolitics may also play a role. Should countries that manufacture a vaccine share it widely with other countries or prioritize their own populations first? It has been reported that President Trump attempted to purchase CureVac, a German company with a candidate vaccine.  There are certainly precedents for countries prioritizing their own populations. With H1N1 flu in 2009, the Australian Government required a vaccine company to meet the needs of the Australian population first. 

Vaccine distribution

Global leadership and a coordinated and coherent response will be needed to ensure that any vaccine is distributed equitably. There have been recent calls for a G20 on health, but existing global bodies such as the Coalition for Epidemic Preparedness Innovations (CEPI) and GAVI are working on vaccines and worldwide access to them. Any new bodies should seek to boost funding for these entities so they can ensure products reach the most disadvantaged. 

While countries that cannot afford vaccines may be priced out of markets, access for poor, vulnerable or marginalized peoples, whether in developed or developing countries, is of concern. Developing countries are at particular risk from the impacts of COVID-19. People living in conflict-affected and fragile states – whether they are refugees or asylum seekers, internally displaced or stateless, or in detention facilities – are at especially high risk of devastating impacts. 

Mature economies will also face challenges. Equitable access to COVID-19 vaccine will be challenging where inequalities and unequal access to essential services have been compromised within some political systems. 

The need for global leadership 

There is an urgent need for international coordination on COVID-19 vaccines. While the WHO provides technical support and UNICEF acts as a procurement agency, responding to coronavirus needs clarity of global leadership that arches over national interests and is capable of mobilizing resources at a time when economies are facing painful recessions. We see vaccines as a salvation but remain ill-equipped to accelerate their development.

While everyone hopes for rapid availability of safe, effective and affordable vaccines that will be produced in sufficient quantities to meet everyone’s needs, realistically, we face huge hurdles. 




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Non-traditional security cooperation between China and south-east Asia: implications for Indo-Pacific geopolitics

8 January 2020 , Volume 96, Number 1

Xue Gong

The ‘free and open Indo-Pacific’ (FOIP) strategy, actively promoted by the United States with support from its allies and partners, is a significant geopolitical response to China's growing power and expanding influence in Asia and beyond. Beijing has adopted various new strategies to cope with the challenges related to FOIP. One of these strategies is to secure a robust relationship with south-east Asia in order to make these regional states either neutral to or less supportive of the Indo-Pacific vision. In addition to economic statecraft and soft power, Beijing believes that it can also tap into the domain of non-traditional security (NTS) to strengthen relations with this region to position itself better in the intensifying regional geopolitical competition. The article addresses the following question: what is the impact of China's NTS cooperation with south-east Asia on Beijing's geopolitical rivalry with other major powers in the Indo-Pacific region? The article argues that China's NTS cooperation with south-east Asian countries may help China maintain its geopolitical standing in the region, but it is unlikely to lead to any dramatic increase of China's strategic influence in the region. This essentially means that Beijing may be able to prevent ASEAN or most ASEAN member states from lending substantive and strong support to the Indo-Pacific construct, but it will not be able to stop ASEAN states from supporting some elements of the FOIP.




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Bridging an Impossible Gap? Japan-South Korea Cooperation in a Changing Asia

Research Event

10 February 2020 - 12:00pm to 1:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Jennifer Lind, Associate Fellow, US and the Americas Programme and Asia-Pacific Programme, Chatham House
Chair: Tania Branigan, Leader Writer, The Guardian  

China’s growing power and assertiveness in Asia has led the United States and other liberal partners to move toward an Indo-Pacific strategy. While Japan embraces this, South Korea remains noticeably reticent. Moreover, tensions between the two countries have escalated into crisis with the reinvigoration of historical disputes. This roundtable will explore the root causes of current animosity between Seoul and Tokyo, and the potential ways it can be overcome.

This event is co-hosted with Dartmouth College. 

THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED.

Lucy Ridout

Programme Administrator, Asia-Pacific Programme
+44 (0) 207 314 2761




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Network Power in the Asia-Pacific: Making Sense of the New Regionalism and Opportunities for Cooperation

Research Event

7 February 2020 - 9:45am to 5:30pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

The Asia-Pacific region continues to increase in geopolitical and geoeconomic importance. The rise of China and tensions with the US are affecting bilateral relationships and traditional alliances in the region. Whether seen from the perspective of the Quad – Australia, India, Japan and the US – or the Indo-Pacific concept embraced by a wide range of countries but with no shared consensus on scope and objectives or with ASEAN who insists on the importance of its own centrality, the region is redefining and reconceptualising itself.

With a diverse range of initiatives – including the Regional Comprehensive Economic Partnership (RCEP) and Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) – there are a plethora of regional agreements and institutional groupings that add further complexity.

As the Bretton Woods architecture continues to be dominated by Western powers, China is also spearheading parallel governance initiatives such as the Asian Infrastructure Investment Bank (AIIB), the Belt and Road Initiative and the Shanghai Cooperation Organization (SCO) as a means of enhancing its geopolitical and geoeconomic influence.

This one-day conference will focus on how such networks and alliances have been built, and sustained, in the Asia-Pacific region. In order to understand how new regional initiatives might open up opportunities for new forms of international cooperation, the conference will focus on the themes of cyber-technology and innovation, sustainable development and mitigating the impacts of climate change and new infrastructure initiatives. It will assess whether there is a zero-sum conflict between competing networks and agendas or whether a common approach can be developed.

Lucy Ridout

Programme Administrator, Asia-Pacific Programme
+44 (0) 207 314 2761




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Cool Forex Logo Wanted [$25]




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Report of the Fifth Coordination Meeting for Governments and Organizations Implementing or Funding Biosafety Capacity-building Activities.




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Report of the sixth coordination meeting for governments and organizations




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Biosafety Protocol News Issue 8 - Working towards a common goal: Ten years of international cooperation on implementation of the Cartagena Protocol on Biosafety




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Report of the 7th Coordination Meeting for Governments and Organizations Implementing and/or Funding Biosafety Capacity-building Activities




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Report of the eighth Coordination Meeting for Governments and Organizations Implementing and/or Funding Biosafety Capacity-building Activities




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Issue 13 of the Biosafety Protocol News, biosafety newsletter, entitled "Joint Cartagena Protocol on Biosafety/Aarhus Convention Cooperation Public Access to Information and Public Participation" is now available




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CBD News: Statement by the Executive Secretary, Dr. Ahmed Djoghlaf, on the occasion of the Expert Meeting on South-South Cooperation on Biodiversity for Development, Montreal, 6 November 2008.




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CBD News: Report of the Expert Meeting for South-South Cooperation on Biodiversity for Development.




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CBD News: Disaster Reduction and Climate Change Adaptation, statement by the Executive Secretary, Ahmed Djoghlaf, on the occasion of the 5th Annual United Nations Day for South-South Cooperation and the Launch of the Global South-South Development Expo or




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CBD News: Message from Ahmed Djoghlaf, Executive Secretary, on the occasion of the United Nations Day for South-South Cooperation, 19 December 2008.




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CBD News: Statement by Ahmed Djoghlaf Executive Secretary at the Opening Session of the Expert Meeting on Mainstreaming Biodiversity in Development Cooperation, Montreal, 13 May 2009




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CBD News: Statement by Ahmed Djoghlaf, CBD Executive Secretary, at the Closing Session of the Expert Meeting on Mainstreaming Biodiversity in Development Cooperation, Montreal, 15 May 2009.




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CBD Communiqué: Expert Meeting on Mainstreaming Biodiversity in Development Cooperation concludes in Montreal.




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CBD Joint Communiqué: United Nations World Tourism Organization and the Secretariat of the Convention sign Memorandum of Cooperation.




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CBD Communiqué: G-77 Ministers Pay Special Tribute to CBD Secretariat's Leading Role in South-South Cooperation.