Islet transplantation is an emerging therapy for type 1 diabetes (T1D) and hypoglycaemic unawareness. However, a key challenge for islet transplantation is cellular rejection and the requirement for long-term immunosuppression. In this study we established a diabetic-humanized NOD-scidIL2R^null(NSG) mouse model of T cell mediated human islet-allograft rejection and developed a therapeutic regimen of low-dose recombinant human interleukin2(IL-2) combined with low-dose rapamycin to prolong graft survival. NSG-mice that had received renal-subcapsular human islet-allografts and were transfused with 1x10⁷ of human-spleen-mononuclear-cells (hSPMCs), reconstituted human CD45⁺ cells that were predominantly CD3⁺ T cells and rejected their grafts with a median survival time of 27 days. IL-2 alone (0.3x10⁶ IU/m² or 1x10⁶ IU/m²), or rapamycin alone (0.5-1mg/kg) for 3 weeks did not prolong survival. However, the combination of rapamycin with IL-2 for 3 weeks significantly prolonged human islet-allograft survival. Graft survival was associated with expansion of CD4⁺CD25⁺FOXP3⁺ Tregs and enhanced TGF-β production by CD4⁺ T cells. CD8⁺ T cells showed reduced IFN- production and reduced expression of perforin-1. The combination of IL-2 and rapamycin has the potential to inhibit human islet-allograft rejection by expanding CD4⁺FOXP3⁺ Tregs in vivo and supressing effector cell function, and could be the basis of effective tolerance-based regimens.

By the month of May in any given year, the many and varied events and competitions staged by the Jamaica Cultural Development Commission (JCDC) islandwide would have been in high gear. Each year the JCDC rolls out its much-anticipated menu board...

“The United States has launched a stunning attack on Cuba’s medical-aid missions, with the Trump administration pressing countries to reject them during the coronavirus pandemic,” Steve Sweeny reported in the Morning Star, March 26, 2020. Given...

Four companies involved in one of America’s “largest price-fixing cases” are now behind the anti-malaria drug touted by Donald ‘The Great Impeached’ Trump as a snake-oil, cure-all treatment for COVID-19, caused by the novel coronavirus. Several...

BRIDGETOWN, Barbados, CMC – The Barbados-based the Caribbean Disaster Emergency Management Agency (CDEMA) says its executive director, Ronald Jackson, is leaving the post after seven years “of unwavering and exemplary service to the...

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in antitumor immune responses. Noninvasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of ⁸⁹Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging of CD8+ T cells in patients with cancer. Methods: The initial dose escalation phase of this first-in-humans prospective study included 6 patients (melanoma, 1; lung, 4; hepatocellular carcinoma, 1). Patients received approximately 111 MBq (3 mCi) of ⁸⁹Zr-IAB22M2C (at minibody mass doses of 0.2, 0.5, 1.0, 1.5, 5, or 10 mg) as a single dose, followed by PET/CT scans at approximately 1–2, 6–8, 24, 48, and 96–144 h after injection. Biodistribution in normal organs, lymph nodes, and lesions was evaluated. In addition, serum samples were obtained at approximately 5, 30, and 60 min and later at the times of imaging. Patients were monitored for safety during infusion and up to the last imaging time point. Results: ⁸⁹Zr-IAB22M2C infusion was well tolerated, with no immediate or delayed side effects observed after injection. Serum clearance was typically biexponential and dependent on the mass of minibody administered. Areas under the serum time–activity curve, normalized to administered activity, ranged from 1.3 h/L for 0.2 mg to 8.9 h/L for 10 mg. Biodistribution was dependent on the minibody mass administered. The highest uptake was always in spleen, followed by bone marrow. Liver uptake was more pronounced with higher minibody masses. Kidney uptake was typically low. Prominent uptake was seen in multiple normal lymph nodes as early as 2 h after injection, peaking by 24–48 h after injection. Uptake in tumor lesions was seen on imaging as early as 2 h after injection, with most ⁸⁹Zr-IAB22M2C–positive lesions detectable by 24 h. Lesions were visualized early in patients receiving treatment, with SUV ranging from 5.85 to 22.8 in 6 target lesions. Conclusion: ⁸⁹Zr-IAB22M2C imaging is safe and has favorable kinetics for early imaging. Biodistribution suggests successful targeting of CD8+ T-cell–rich tissues. The observed targeting of tumor lesions suggests this may be informative for CD8+ T-cell accumulation within tumors. Further evaluation is under way.

Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childhood. The offspring of mothers with T1D are protected from this process. The aim of this study was to determine whether the protection conferred by maternal T1D is associated with improved neonatal tolerance against (pro)insulin. Consistent with improved neonatal tolerance, the offspring of mothers with T1D had reduced cord blood CD4⁺ T-cell responses to proinsulin and insulin, a reduction in the inflammatory profile of their proinsulin-responsive CD4⁺ T cells, and improved regulation of CD4⁺ T cell responses to proinsulin at 9 months of age, as compared with offspring with a father or sibling with T1D. Maternal T1D was also associated with a modest reduction in CpG methylation of the INS gene in cord blood mononuclear cells from offspring with a susceptible INS genotype. Our findings support the concept that a maternal T1D environment improves neonatal immune tolerance against the autoantigen (pro)insulin.

28 February 2020

The 2021 Code on Dental Procedures and Nomenclature — better known as the CDT Code — could include changes or additions to codes regarding oral/oropharyngeal cancer, caries management by risk assessment, laboratory surface scanning for diagnostic purposes, and counseling for the control and prevention of adverse oral, behavioral, and systemic health effects associated with high-risk substance use.

The Centers for Disease Control and Prevention will provide interim guidance to clinicians regarding the coronavirus outbreak during a webinar at 2 p.m. EST Jan. 31.

In light of the “emerging, rapidly evolving” outbreak of the novel coronavirus 2019-nCoV, the Centers for Disease Control and Prevention is reminding clinicians to use standard precautions consistently and advising they isolate patients who show signs and symptoms of the virus.

The handout covers strategies for helping prevent the transmission of suspected respiratory disease in the dental health care setting and answers frequently asked questions related to the virus, based on guidelines from the Centers for Disease Control and Prevention.

The American Dental Association is urging the Centers for Disease Control and Prevention to provide immediate guidance on the best way to protect dental patients and staff from the transmission of COVID-19 during emergency and urgent care situations.

The American Dental Association is urging the Centers for Disease Control and Prevention to “quickly provide guidance” on how to safely reopen dental practices during the deceleration phase of the COVID-19 outbreak.

The American Dental Association has created a tip sheet with guidance from the National Institute for Occupational Safety and Health group at the Centers for Disease Control and Prevention to help health care professionals avoid buying or using counterfeit N95 respirators, which are often simply referred to as masks.

Infections caused by contaminated food are up 15 percent across the United States, according to preliminary data from the U.S. Centers for Disease Control and Prevention's Foodborne Diseases Active Surveillance Network.

Nearly 5,000 workers in 115 meat processing workers across 19 states have been diagnosed with COVID-19, according to figures released Friday by the U.S. Centers for Disease Control and Prevention.

The CDC estimates that 40 percent of U.S. teens are sexually active -- 42 percent of females and 38 percent of males 15 and 19 years of age -- numbers that have dropped significantly since 1988.

Pediatric vaccination against measles has declined by as much as 60 percent nationally since the start of the COVID-19 outbreak, according to new data released Friday by the Centers for Disease Control and Prevention.

OBJECTIVE

To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.

OBJECTIVE

In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34⁺ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.

Gottingen : Dieterich, 1843.

A private-public partnership is moving forward with efforts to recruit and retain teachers by building housing for educators in rural West Virginia.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

Arizona's Aari McDonald and Pac-12 Networks' Ashley Adamson discuss the guard's decision to return for her senior season in Tucson and how she now has the opportunity to be the face of the league. McDonald, the Pac-12 Defensive Player of the Year, was one of the nation's top scorers in 2019-20, averaging 20.6 points per game.

Huppatz (Family).

Nestin, an intermediate filament protein widely used as a marker of neural progenitors, was recently found to be expressed transiently in developing cortical neurons in culture and in developing mouse cortex. In young cortical cultures, nestin regulates axonal growth cone morphology. In addition, nestin, which is known to bind the neuronal cdk5/p35 kinase, affects responses to axon guidance cues upstream of cdk5, specifically, to Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, and changes in microtubules and actin filaments are well studied. In contrast, the roles of intermediate filament proteins in this process are poorly understood, even in cultured neurons. Here, we investigate the molecular mechanism by which nestin affects growth cone morphology and Sema3a sensitivity. We find that nestin selectively facilitates the phosphorylation of the lissencephaly-linked protein doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected by nestin. We uncover that this substrate selectivity is based on the ability of nestin to interact with DCX, but not with other cdk5 substrates. Nestin thus creates a selective scaffold for DCX with activated cdk5/p35. Last, we use cortical cultures derived from Dcx KO mice to show that the effects of nestin on growth cone morphology and on Sema3a sensitivity are DCX-dependent, thus suggesting a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating the intracellular kinase signaling environment in developing neurons. The sex of animal subjects is unknown.

SIGNIFICANCE STATEMENT Nestin, an intermediate filament protein highly expressed in neural progenitors, was recently identified in developing neurons where it regulates growth cone morphology and responsiveness to the guidance cue Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, but the roles of intermediate filaments in this process are poorly understood. We now report that nestin selectively facilitates phosphorylation of the lissencephaly-linked doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected. This substrate selectivity is based on preferential scaffolding of DCX, cdk5, and p35 by nestin. Additionally, we demonstrate a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating intracellular kinase signaling in developing neurons.

The decision to shelve detailed advice from the nation's top disease control experts for reopening communities during the coronavirus pandemic came from the highest levels of the White House, according to internal government emails obtained by The Associated Press.

Danes haven’t built a “socialist” country. Just one that works.

Washington, D.C. Newsroom, May 7, 2020 / 02:40 pm (CNA).- The governor of Illinois has said he will continue to ban public gatherings of more than 50 people—including religious services—until a vaccine or treatment for coronavirus is available.

The announcement comes as the White House is reported to have shelved guidance from the Centers for Disease Control on gradually reopening sections of the American economy and society.

Illinois governor J.B. Pritzker announced Wednesday that gatherings of more than 50 people in the state would not be allowed until a coronavirus vaccine “or highly effective treatment” is “widely available.”

Public health officials, including Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, have cautioned that a COVID-19 vaccine is at least 12 to 18 months from being developed and made available.

According to Pritzker’s five-part plan for reopening the state, gatherings of ten or fewer people are not even allowed until phase 3, the “recovery” phase that can begin, at earliest, May 29. However, following a lawsuit last week, the governor has allowed citizens to leave their homes for religious services as long as ten or fewer people are gathered for worship.

Previously, religious services of any kind in the state—including drive-in and in-person services—were curtailed during the pandemic, and even other forms of sacramental practice such as drive-in confessions were not allowed.

The Archdiocese of Chicago announced on May 1 that public Masses with 10 or fewer people would resume.

Other dioceses across the United States have already begun rolling back total suspensions on the public celebration of Mass. 

Last week, CNA reported that the White House Domestic Policy Council held a series of conference calls with bishops who had begun the process of reopening churches in line with local public health orders.

During the calls, administration officials expressed their hope to be able to support faith communities with “sensitive and respectful guidance” to help restore public worship “as soon as it is feasible.”

The bishops were told that the Centers for Disease Control hoped that issuing guidance could help inform state and local leaders about the “essential” nature of religious practice, while still allowing for localized responses to the coronavirus and provide “helpful parameters” for state and local governments who are trying to safeguard public health. But, on Thursday, AP reported that the Trump administration had shelved a 17-page report titled “Guidance for Implementing the Opening Up America Again Framework.”

That document included a section on “Interim Guidance for Communities of Faith.”

According to AP, CDC officials expected the guidance to be released at the end of last week but were instead told it “would never see the light of day.” 

Peter Breen, executive director of the Thomas More Society,  told CNA that “policymakers that are making plans based on the development of a vaccine or other cure to this coronavirus are engaging in magical thinking.”

“While there is always a possibility that some miracle cure may emerge, that is entirely uncertain and should not be the basis for setting policy, especially policy in relation to our communities of faith,” Breen stated.

On April 30, the Thomas More Society filed a lawsuit on behalf of The Beloved Church in Lena, Illinois, and by that night, attorney Peter Breen told CNA, a paragraph had been added to an executive order of Pritzker’s allowing for people to leave their home for religious services.

“He [Pritzker] has at least brought churches out of the abyss of ‘non-essential,’ but he has not fully elevated them to the heights of being an ‘essential’ business or operation,” Breen told CNA on Wednesday, noting that businesses deemed “essential” to remain open were not subject to the 10-person rule.

Rome Newsroom, May 8, 2020 / 02:00 pm (CNA).- After the Congregation for the Doctrine of the Faith ruled that the hospitals of the Brothers of Charity in Belgium can no longer be considered as Catholic, the religious order is seeking to prevent the hospital network from using its name, their general superior told CNA. 

Br. René Stockman, general superior of the Congregation of the Brothers of Charity, said he fought to keep the Catholic identity and mission of the hospitals intact. But when the Brothers of Charity Organization, the non-profit group which manages the hospitals, approved pro-euthanasia guidelines 2017, he immediately referred the matter to the Congregation for the Doctrine of the Faith, which issued its decision at the end of March.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

Stockman said he was now working to stop the 15-hospital network run by the Brothers of Charity Organization, the non-profit which brought in the pro-euthanasia policy, from continuing to use the order’s name.

“As a congregation,” Br. Stockman said, “we will clearly ask them not to use the name Brothers of Charity anymore for the psychiatric hospitals,” adding that ”we will do everything to come to clear arrangements without going to legal fight.” 

“We hope that we can make it [work] in that way,” he said, but the non-profit’s board have signalled resistance. 

Raf De Rycke, president of the Brothers of Charity Organization, said on May 5 that he intends to continue using the order’s name, and claimed the hospitals fulfil the same mission, and the same vision as ever, despite bringing in euthanasia.

The Stockman said the order was always adamant that they would never accept the possibility of euthanasia in their hospitals, but only a few brothers remain working in the hospitals, mostly in management roles. The order has asked them to leave their positions, now that they can no longer be considered Catholic. 

But, he said, “there are many doctors who don’t agree with the situation and they made their objection of conscience, but it becomes more difficult for them in an environment where the management is developing clear guidelines on how to perform the process and moving towards euthanasia when a psychiatric patient is asking for it.”

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression. Belgian law prohibits contractual clauses or other provisions prohibiting doctors working in institutions to euthanize patients. A doctor or nurse still has the individual freedom of conscience to refuse to euthanize or participate to euthanasia, but the same freedom is no longer afforded to insitutions. 

Stockman said there was no question of not complying with Rome’s decision, and he hoped it would inspire others to reconsider the gravity of the spread of euthanasia.

“We hope that also others will reflect on it, especially in the field of mental health care. It is the first time that the Holy See through the CDF has given a clear answer on the growing practice of euthanasia in the field of mental health care,” he told CNA.  

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression.

In an official statement published on their website, the Brothers of Charity Organization has accused Stockman of using the issue of euthanasia "within a broader and longer-lasting conflict” between the order and the non-profit on the use of assets. 

The non-profit suggested that Stockman has long wanted to devote more resources to the Brothers’ missions in Africa and Asian, as vocations have dried up in Belgium, where most of the order’s members are over eighty. Meanwhile, in the developing world, the congregation is growing; last year Br. Stockman welcomed 27 new novices in Nairobi.

The Brothers of Charity Organization frames the dispute as one of control over assets, and its statement said they "do not see the need to adapt our operations after this [CDF] letter because we are convinced that we are acting correctly."

The situation is being monitored closely by other Catholic organizations in the country who see it as a possible test case. So far, the bishops have remained circumspect.

In a May 6 statement, the Belgian Episcopal Conference said that "the bishops experience this as an excruciating and complex affair, in which different types of topics and different lines of responsibility meet." 

The conference called for "a prolonged dialogue between all those involved,” while stressing their "utmost appreciation for the commitment of the Brothers of Charity in Belgium and all their employees to the benefit of mentally disabled, sick or injured people."

Calls for dialogue, however, may prove wishful thinking. As part of its review of the situation, the CDF sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor to try to resolve the situation, but, the Congregation said, he was unable to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The conference also said that "based on their pastoral responsibility, the bishops will continue to work for unity and solidarity in the ecclesial community. They maintain their trust and will continue to cooperate with all the health institutions of Christian civil society."

Stockman did not comment on the bishops’ conference statement.

“Of course,” he said, “we feel, as a congregation, alone [in this fight], but [we are proceeding] in line with the doctrine of the Church, with the clear statement made by our general chapter in 2018 and with our charism of charity.” 

Rome Newsroom, May 8, 2020 / 02:00 pm (CNA).- After the Congregation for the Doctrine of the Faith ruled that the hospitals of the Brothers of Charity in Belgium can no longer be considered as Catholic, the religious order is seeking to prevent the hospital network from using its name, their general superior told CNA. 

Br. René Stockman, general superior of the Congregation of the Brothers of Charity, said he fought to keep the Catholic identity and mission of the hospitals intact. But when the Brothers of Charity Organization, the non-profit group which manages the hospitals, approved pro-euthanasia guidelines 2017, he immediately referred the matter to the Congregation for the Doctrine of the Faith, which issued its decision at the end of March.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

Stockman said he was now working to stop the 15-hospital network run by the Brothers of Charity Organization, the non-profit which brought in the pro-euthanasia policy, from continuing to use the order’s name.

“As a congregation,” Br. Stockman said, “we will clearly ask them not to use the name Brothers of Charity anymore for the psychiatric hospitals,” adding that ”we will do everything to come to clear arrangements without going to legal fight.” 

“We hope that we can make it [work] in that way,” he said, but the non-profit’s board have signalled resistance. 

Raf De Rycke, president of the Brothers of Charity Organization, said on May 5 that he intends to continue using the order’s name, and claimed the hospitals fulfil the same mission, and the same vision as ever, despite bringing in euthanasia.

The Stockman said the order was always adamant that they would never accept the possibility of euthanasia in their hospitals, but only a few brothers remain working in the hospitals, mostly in management roles. The order has asked them to leave their positions, now that they can no longer be considered Catholic. 

But, he said, “there are many doctors who don’t agree with the situation and they made their objection of conscience, but it becomes more difficult for them in an environment where the management is developing clear guidelines on how to perform the process and moving towards euthanasia when a psychiatric patient is asking for it.”

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression. Belgian law prohibits contractual clauses or other provisions prohibiting doctors working in institutions to euthanize patients. A doctor or nurse still has the individual freedom of conscience to refuse to euthanize or participate to euthanasia, but the same freedom is no longer afforded to insitutions. 

Stockman said there was no question of not complying with Rome’s decision, and he hoped it would inspire others to reconsider the gravity of the spread of euthanasia.

“We hope that also others will reflect on it, especially in the field of mental health care. It is the first time that the Holy See through the CDF has given a clear answer on the growing practice of euthanasia in the field of mental health care,” he told CNA.  

Belgium has ushered in ever-expanding access to euthanasia in recent years, including for mental health patients, even minors, suffering from conditions like depression.

In an official statement published on their website, the Brothers of Charity Organization has accused Stockman of using the issue of euthanasia "within a broader and longer-lasting conflict” between the order and the non-profit on the use of assets. 

The non-profit suggested that Stockman has long wanted to devote more resources to the Brothers’ missions in Africa and Asian, as vocations have dried up in Belgium, where most of the order’s members are over eighty. Meanwhile, in the developing world, the congregation is growing; last year Br. Stockman welcomed 27 new novices in Nairobi.

The Brothers of Charity Organization frames the dispute as one of control over assets, and its statement said they "do not see the need to adapt our operations after this [CDF] letter because we are convinced that we are acting correctly."

The situation is being monitored closely by other Catholic organizations in the country who see it as a possible test case. So far, the bishops have remained circumspect.

In a May 6 statement, the Belgian Episcopal Conference said that "the bishops experience this as an excruciating and complex affair, in which different types of topics and different lines of responsibility meet." 

The conference called for "a prolonged dialogue between all those involved,” while stressing their "utmost appreciation for the commitment of the Brothers of Charity in Belgium and all their employees to the benefit of mentally disabled, sick or injured people."

Calls for dialogue, however, may prove wishful thinking. As part of its review of the situation, the CDF sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor to try to resolve the situation, but, the Congregation said, he was unable to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The conference also said that "based on their pastoral responsibility, the bishops will continue to work for unity and solidarity in the ecclesial community. They maintain their trust and will continue to cooperate with all the health institutions of Christian civil society."

Stockman did not comment on the bishops’ conference statement.

“Of course,” he said, “we feel, as a congregation, alone [in this fight], but [we are proceeding] in line with the doctrine of the Church, with the clear statement made by our general chapter in 2018 and with our charism of charity.” 

CNA Staff, May 4, 2020 / 12:01 pm (CNA).- The Congregation for the Doctrine of the Faith has ordered 15 psychiatric hospitals in Belgium which belong to the Brothers of Charity to cease identifying as Catholic institutions after they allowed the euthanization of patients in 2017.

The hospitals are managed by a civil non-profit corporation with the same name as the Brothers of Charity religious congregation which owns them.

The CDF decision was communicated in a letter dated March 30, stating that "with deep sadness" the "psychiatric hospitals managed by the Provincialate of the Brothers of Charity association in Belgium will no longer be able to consider themselves Catholic institutions."

In a statement responding to the CDF's decision, the superior general of the Brothers of Charity, Br. René Stockman, said that "with a heavy heart" the religious congregation "must let go of its psychiatric centers in Belgium."

Br. Stockman pointed out that it is "painful" that the psychiatric centers of the Brothers of Charity in Belgium have lost their Catholic status, considering also that the brothers "were among the pioneers in the field of mental health care in Belgium."

At the same time, Stockman said he recognizes that "the congregation [the Brothers of Charity] has no choice but to remain faithful to the charism of charity, which cannot be reconciled with the practice of euthanasia on psychiatric patients."

The decision by the Vatican's doctrinal office ends three years of disputes between the Brothers of Charity and the corporation which manages their hospitals in Belgium.

In 2017, the board decided to allow euthanasia to be carried out in its hospitals in Belgium, where the euthanasia law is among the most broad.

At the time of the decision, the board of the corporation was composed of 15 members, with only three of them religious brothers of the congregation. 

Two of the three religious brothers among the board members, Luc Lemmens, 61, and Veron Raes, 57, supported the euthanasia decision. Their terms on the board ended at the end of September 2018 and were not renewed.

The religious congregation, especially Stockman, protested the decision, reiterating the Brothers of Charity's rejection of euthanasia in their hospitals.

The brothers appealed to the Vatican, which asked the psychiatric hospitals to change their protocol allowing euthanasia as “a medical act” under certain conditions.

The hospital management responded with a long statement in September 2017, in which it contested a lack of dialogue and maintained the hospital was "perfectly consistent" with Christian doctrine.

The CDF's direction that the hospitals must no longer identify as Catholic was communicated in a letter signed by CDF prefect Cardinal Luis Francisco Ladaria Ferrer and secretary Archbishop Giacomo Morandi.

The letter retraced the developments of the story, recalling that the document allowing euthanasia in the brothers' hospitals "refers neither to God, nor to Holy Scripture, nor to the Christian vision of Man."

According to the letter, the CDF had spoken with the Brothers of Charity and had also informed Pope Francis of the gravity of the situation.

Other audiences had also taken place beginning June 2017, including with the Congregation for Institutes of Consecrated Life and Societies of Apostolic Life, the Secretariat of State, the representatives of the Brothers of Charity and the managing corporation, as well as representatives of the Belgian bishops' conference.

The Holy See also sent Bishop Jan Hendriks, auxiliary of Amsterdam, as an apostolic visitor, but he did not register any steps forward nor a desire to find "a viable solution that avoids any form of responsibility of the institution for euthanasia."

The request of the CDF to the Brothers of Charity and to the managing corporation was clear: “affirm in writing and in an unequivocal way their adherence to the principles of the sacredness of human life and the unacceptability of euthanasia, and, as a consequence, the absolute refusal to carry it out in the institutions they depend on."

The corporation "did not give assurance on these points."

The CDF therefore reiterated that "euthanasia remains an inadmissible act, even in extreme cases," and strengthened the statement by citing St. John Paul II's 1995 encyclical Evangelium vitae, and a Jan. 30 speech by Pope Francis to the CDF.

The CDF stressed that "Catholic teaching affirms the sacred value of human life," the "importance of caring for and accompanying the sick and disabled," as well as "the Christian value of suffering, the moral unacceptability of euthanasia" and "the impossibility of introducing this practice in Catholic hospitals, not even in extreme cases, as well as of collaborating in this regard with civil institutions."

The Brothers of Charity is a religious congregation of lay brothers founded in 1807 in Belgium, whose specialization is care for the sick and those with psychiatric diseases.

At the congregation's July 2018 general chapter the group stressed that the Brothers of Charity "believes in sacredness and absolute respect for every human life, from conception to natural death. The general chapter requires that each brother, associate member and others associated with the mission of the congregation adhere to the doctrine of the Catholic Church on ethical issues."

When Berlin Brandenburg Airport is put into operation at the end of October 2020, Schönefeld Airport will become Terminal 5 (T5) of BER. In order to avoid duplicate names of terminal sections, gates and car parks at BER, the building and car park infras...

STYLE AND SUBSTANCE

Celtic Connections

Many US children aged 6 to 24 months who would be classified as low weight-for-age by the Centers for Disease Control and Prevention 2000 reference will be classified as normal weight-for-age by the World Health Organization 2006 standard.

Children who will be reclassified from low to normal weight-for-age using the World Health Organization growth standard are at higher risk of adverse health outcomes than children who are not low weight-for-age by the Centers for Disease Control and Prevention reference. (Read the full article)

Abusive head trauma (AHT) is a rare phenomenon that results in devastating injuries to children. It is necessary to analyze large samples to examine changes in rates over time.

This is the first study to examine rates of AHT at the national, regional, and state level. The results provide a more detailed description of AHT trends than has been previously available. (Read the full article)

The US health care system transition to the ICD-10-CM will occur in October 2015. The logistical and financial impact of the transition for billing codes frequently used by pediatricians has not been studied.

The findings of this study evaluate the government-provided mappings from ICD-9-CM to ICD-10-CM for accuracy and provide the diagnostic codes used by pediatricians, which may be adversely affected by the transition to ICD-10-CM. (Read the full article)

In HIV-infected children, decisions to start antiretroviral therapy must weigh immunologic benefits against potential risks. Current guidelines recommend using CD4 percentage and age when deciding to start treatment. Population-level effects of these factors on immunologic recovery are unknown.

Starting antiretroviral therapy at higher CD4 percentages and younger ages maximizes potential for immunologic recovery. However, not all benefits are sustained, and viral failure may occur. Our results help clinicians better weigh immunologic benefits against viral failure risks. (Read the full article)

The resignation of the former U.S. Department of Education staffer, who has led ASCD since mid-2015, follows a long run of membership declines for the organization.

Lewis Macdonald MSP has been elected as a temporary Deputy Presiding Officer (DPO) of the Scottish Parliament. The election was held as part of the Parliament's response to the coronavirus pandemic.

Lewis Macdonald MSP has today chaired parliamentary proceedings for the first time as Deputy Presiding Officer of the Scottish Parliament.

The terminal sections and car parks at Schönefeld Airport will be given new names at the end of March. When Berlin Brandenburg Airport is put into operation at the end of October 2020, Schönefeld Airport will become Terminal 5 (T5) of BER. In order to a...

The Delaware State Housing Authority (DSHA) today announced that 17 communities and scattered sites will receive funds from the state’s Community Development Block Grant Program (CDBG) and HOME Investment Partnerships Program (HOME). More than $2.85 million will be divided amongst the municipalities of Kent and Sussex Counties for housing rehabilitation, water/sewer hookups, demolition, a planning study, street repair, curb/sidewalk installation, and administration to benefit low- to moderate-income families and individuals.

The highly portable Epson EX3260 delivers solid data-image quality and very good video quality in a projector that's a fine fit for offices and schools.

The Sony MP-CD1 Mobile Projector is a stylish, phone-size mini-projector with a built-in battery. It delivers good overall image quality at a somewhat steep price.

What's thin, light, and bright, with 1080p resolution? Epson's PowerLite 1795F Wireless Full HD 1080p 3LCD Projector, a highly portable model good with data-heavy images and excellent with video, but packing soft audio.