rd

Liquid bird feeder

A liquid hummingbird feeder is provided with a liquid container having a sealable top opening and a bottom opening, a liquid tray adapted to immerse the bottom opening in liquid, and a valve mechanism adapted to close the bottom opening to enable the liquid container to be filled through the sealable top opening.




rd

Birdfeeder and seed dispenser therefor

A birdseed dispenser and birdfeeder incorporating the same are provided. The dispenser has a base assembly mounted to a first opening formed in the sidewall of the birdseed reservoir, including a front plate having a second opening formed therein, a flange extending around the second opening and projecting away from the front plate, and an end wall supported by the flange such that the flange and end wall together define a chamber. The dispenser also includes an apertured piece received in the chamber having a first seed aperture of a first configuration and a second seed aperture of a different configuration. The apertured piece is moveable between a first orientation, which places the first seed aperture in a seed accessible state permitting birds access to the seed, and a second orientation to place the second seed aperture in the seed accessible state.




rd

Tube bird feeder

A tube bird feeder comprising a seed tube having a side wall and at least one feed opening in the side wall, a top ring mounted on a top marginal edge of the seed tube, a cover removably engaged with the top ring, at least one perch mounted on the seed tube proximate the feed opening, and a base member removably secured to the seed tube adjacent the bottom marginal edge, the base portion having a protrusion engaging with an aperture in the seed tube proximate the bottom marginal edge.




rd

PULSE AMPLITUDE MODULATION (PAM) DATA COMMUNICATION WITH FORWARD ERROR CORRECTION

The present invention is directed to data communication system and methods. More specifically, embodiments of the present invention provide an apparatus that receives data from multiple lanes, which are then synchronized for transcoding and encoding. A pseudo random bit sequence checker may be coupled to each of the plurality of lanes, which is configured to a first clock signal A. Additionally, an apparatus may include a plurality of skew compensator modules. Each of the skew compensator modules may be coupled to at least one of the plurality of lanes. The skew-compensator modules are configured to synchronize data from the plurality of lanes. The apparatus additionally includes a plurality of de-skew FIFO modules. Each of the de-skew compensator modules may be coupled to at least one of the plurality of skew compensator modules.




rd

MOTION COMPENSATION AND MOTION ESTIMATION LEVERAGING A CONTINUOUS COORDINATE SYSTEM

Computer processor hardware receives settings information for a first image. The first image includes a set of multiple display elements. The computer processor hardware receives motion compensation information for a given display element in a second image to be created based at least in part on the first image. The motion compensation information indicates a coordinate location within a particular display element in the first image to which the given display element pertains. The computer processor hardware utilizes the coordinate location as a basis from which to select a grouping of multiple display elements in the first image. The computer processor hardware then generates a setting for the given display element in the second image based on settings of the multiple display elements in the grouping.




rd

MICRO SCALE ELECTRO HYRDODYNAMIC (EHD) MODULAR CARTRIDE PUMP

An electro hydrodynamic pump apparatus includes a cartridge body member including an interior cavity portion and openings on either end of the cartridge body member; a first electrode member disposed within the interior cavity portion of the cartridge body member, the first electrode member including a conductive bar member with a plurality of spaced apart elements extending therefrom; a second electrode member disposed within the interior cavity portion of the cartridge body member, the second electrode member including a conductive bar with a plurality of spaced apart element extending therefrom; and wherein the elements of the first electrode member are configure to be interspersed with the elements of the second electrode member when the first electrode member and the second electrode member are disposed within the interior cavity portion of the cartridge body member.




rd

Automatically removing waste material using a strip die when cutting a sheet of material according to a predetermined pattern

A strip die is prepared with cutouts according to a pre-determined pattern, e.g., on a cutting table and positioned on a stripping station that has a removal tool to remove waste material. After a sheet of material is cut on the same or another cutting table, the sheet is positioned in the stripping station over the female strip die. The removal tool moves to programmed positions in the stripping station and removes pieces of waste material. The final stripped cut sheet is the brought to the out-stack.




rd

System and process for improving paper and paper board

The invention relates to a process for making paper or paper board comprising forming a cellulosic suspension, flocculating the suspension, draining the suspension on a device to form a sheet and then drying the sheet, wherein the suspension is flocculated using a formation improving 3-component flocculation system comprising a) a linear cationic or ampoteric co-polymer of: i) acrylamide, and ii) a substance with formula (I) with a halide as counter-ion; b) at least one water soluble component chosen from the group of anionic polyacrylamide, non-ionic polyacrylamide and polyethyleneoxide; and c) inorganic microparticles, whereby the flocculation system does not contain a wafer-dispersible or branched anionic organic polymer. The invention also relates to use of the flocculation/retention system in the manufacture of paper or paper board, and to paper and paper board thus produced.




rd

Process for manufacturing paper and board having improved retention and drainage properties

A method for manufacturing a sheet of paper and/or board having improved retention and drainage properties is provided, according to which, before the formation of the sheet and/or board, at least two retention aids are added to the fibrous suspension. These two retention aids are a main retention aid corresponding to a (co)polymer having a cationic charge density above 2 meq/g, obtained by the Hofmann degradation reaction, and a secondary retention aid corresponding to a water-soluble or water-swellable polymer having an anionic charge density above 0.1 meq/g. The main retention aid is introduced into the fibrous suspension in a proportion of 100 to 800 g/t of dry pulp, and the secondary retention aid is introduced into the fibrous suspension in a proportion of 50 to 800 g/t of dry pulp and has an intrinsic viscosity IV above 3 dl/g.




rd

Rubber compositions for bead apex, sidewall packing, base tread, breaker cushion, steel cord topping, strip adjacent to steel cords, tie gum, and sidewall, and pneumatic tires

The present invention provides a rubber composition that improves in terms of the fuel economy of a rubber composition containing an isoprene-based rubber and also offers favorable durability and favorable processability or adhesion to steel cords, and a pneumatic tire formed from the rubber composition. The present invention relates to a rubber composition for a bead apex, sidewall packing, base tread, or breaker cushion, including: a specific rubber component; a specific amount of a specific carbon black; a specific amount of sulfur; and a specific amount of a compound represented by formula (I) below. The present invention also relates to a rubber composition for a steel cord topping, strip adjacent to steel cords, or tie gum, including: a specific rubber component; a specific amount of a specific carbon black; a specific amount of an organic acid cobalt salt; and a specific amount of a compound represented by the formula (I).




rd

Tire having a double cord stitch knit fabric in sidewall area

A tire containing a pair of beads, at least one carcass ply extending from one bead to the other bead forming a pair of sidewall areas of the tire and a tread area of the tire, and at least one layer of a knit fabric in the sidewall area of the tire, where the knit fabric has a warp and weft direction and is a double cord stitch knit fabric. A method of making the fabric and tire are also disclosed.




rd

Rubber-steel hybrid cord and pneumatic radial tire (using the same)

A rubber-steel hybrid cord of the present invention is characteristically formed by twisting a plurality of sheath filaments or sheath strands around a core in which a periphery of and space surrounded by one or a plurality of core filaments or a core strand are coated or filled with a filler rubber (A) containing an adhesion promoter, thereby forming a multilayer-twist steel cord or a multi-twist steel cord, and coating an outer surface of the multilayer-twist steel cord or the multi-twist steel cord with a coating rubber (C). Further, an amount of an adhesion promoter contained in the coating rubber (C) is equal to or more than an amount of the adhesion promoter contained in the filler rubber (A).




rd

ASSOCIATED INFORMATION GENERATION DEVICE, ASSOCIATED INFORMATION GENERATION METHOD, AND RECORDING MEDIUM STORING ASSOCIATED INFORMATION GENERATION PROGRAM

Provided is an associated information generation device and the like that facilitated estimates relating to a project. The associated information generation device (101) has an associated information generation unit (102) that on the basis of project information including a task identifier is associated with a change causes are associate with the proportion at which the change causes occur identifies the change cause associated with a specific task identifier contained in project information, identifies the proportion associated with the identified change cause, and generates associated information in which the identified proportion and the identified task identifier are associated.




rd

CONTINUOUS KEYBOARD RECOGNITION

Methods, systems, and apparatus for receiving data indicating a location of a particular touchpoint representing a latest received touchpoint in a sequence of received touchpoints; identifying candidate characters associated with the particular touchpoint; generating, for each of the candidate characters, a confidence score; identifying different candidate sequences of characters each including for each received touchpoint, one candidate character associated with a location of the received touchpoint, and one of the candidate characters associated with the particular touchpoint; for each different candidate sequence of characters, determining a language model score and generating a transcription score based at least on the confidence score for one or more of the candidate characters in the candidate sequence of characters and the language model score for the candidate sequence of characters; selecting, and providing for output, a representative sequence of characters from among the candidate sequences of characters based at least on the transcription scores.




rd

SYSTEMS AND METHODS FOR ASYMMETRICAL FORMATTING OF WORD SPACES ACCORDING TO THE UNCERTAINTY BETWEEN WORDS

Asymmetrical formatting of word spaces according to the uncertainty between words includes an initial filtering process and subsequent text formatting process. An equivocation filter generates a mapping of keys and values (output) from a corpus or word sequence frequency data (input). Text formatting process for asymmetrically adjusts the width of spaces adjacent to keys using the values. The filtering process, which generates a mapping of keys and values can be performed once to analyze a corpus and once generated, the key-value mapping can be used multiple times by a subsequent text processing process.




rd

SYMBOLIC REFERENTIAL THIRD-PARTY NOTIFICATION

User input including a social network notification symbol followed by a social network tag is detected in association with a social network user interface. The social network tag includes a text keyword that identifies a social network topic within the social network. A referential third-party social network user notification subset within the social network is defined as a subset of social network users within the social network that follow the social network topic. A referential third-party social network notification is published to the defined referential third-party social network user notification subset within the social network. The referential third-party social network notification includes the detected user input that includes the social network notification symbol followed by the social network tag.




rd

RDX ENHANCEMENT OF SYSTEM AND METHOD FOR IMPLEMENTING REUSABLE DATA MARKUP LANGUAGE (RDL)

Methods and systems in accordance with the present invention allow users to efficiently manipulate, analyze, and transmit eXtensible Business Reporting Language (“XBRL”) reports. They allow users to automatically build financial reports that are acceptable to governing agencies such as the IRS. In one embodiment, the reports are developed by a parser that transforms text documents into software elements containing a format with a hierarchal relationship between the software elements, and an editor that develops reports by referencing the software elements transformed from the text documents. Methods and systems in accordance with the present invention also enable reports to be automatically scheduled by gathering desired information from an accounting system, formatting the information into an XBRL document, and transmitting it to an end source. Furthermore, systems and methods in accordance with the present invention allow a user to translate an XBRL document into RDL format and use the RDL system to manipulate and analyze it.




rd

Integrated door operator hardware

Disclosed in one aspect is the fixed door pull handle assembly that includes an elongated door pull handle with two or more support standoffs projecting away from the elongated door pull handle and securing the elongated door pull handle to the doorframe or to the body of the door. One of the support standoffs is user rotatable, and rotatably engages a door latch assembly within the door. In another aspect, the support standoff is not user rotatable. Instead, a center-pivoting handle is mounted in-line with one of the support standoffs and rotatably engages the door latch assembly within the door. The center-pivoting handle is recessed within the elongated handle.




rd

Guarded surgical knife handle

A guarded surgical knife handle includes a handle portion with a blade holder, a chamber within the handle portion, and a slot. The guarded surgical knife handle also includes a guard having an open distal end slidably mounted within the handle portion that can slide longitudinally between an unguarded position and a guarded position. The guard is sized to surround the blade in the guarded position. The guarded surgical knife handle also includes a latch that latches the guard when the guard is slid into the guarded position and a first button that disengages the latch. The guarded surgical knife handle includes a bias member that forces the guard in a proximal direction to an unguarded position when the latch is disengaged along with a second button extending through the slot used to slide the guard in a distal direction into the guarded position.




rd

Pair of garden scissors with an adjustable cutting

A pair of garden scissors with an adjustable cutting angle is provided with first and second scissor members. A positioning protrusion of the first scissor member cooperates with a positioning end of the angle-restricting member of the second scissor member to restrict the maximum cutting angle of the first scissor member, and an adjust member is able to adjust the cutting angle by adjusting the position of the angle-restricting member, so that the cutting angle can be freely adjusted within the movement range of the angle-restricting member.




rd

Hand cutter with blade guard

A hand cutter with a retractable blade guard providing an unimpaired view of the blade, when it is placed on the object. The blade guard is unlocked and retracted by a trigger mechanism, which is activated by closing the hand around the cutter handle. The blade guard remains in the retracted position until the trigger is released or a relocking mechanism is activated by putting the blade to use by cutting the object.




rd

Pump having stepper motor and overdrive control

Apparatus and method for supplying lubricant to a plurality of lubrication sites. Embodiments include a pump with venting and non-venting piston return, a pump with stirrer and direct feed mechanism, a pump with CAN system and self-diagnostics, a pump with heated housing and reservoir and a pump with stepper motor and overdrive control.




rd

Customization of inner sole board

An inner sole board having varying regions of flexibility is provided for use in an article of footwear. The inner sole board may include different materials along its length at different locations that vary its flexibility. An inner sole board is manufactured in an injection molding process requiring only one mold. The process includes a first step of providing a mold, a second step of providing an injection molding assembly, a third step of preparing an injection molding assembly and mold, a fourth step of injecting material into the mold, and a fifth step of establishing the dimensions of a first portion. During the injection molding process, the flow rate of at least one material may be controlled by a nozzle gate to control the shape and size of the flex zone it creates. In this manner, the inner sole board may be customized for a specific sport or individual.




rd

HARDWARE ACCELERATED COMMUNICATIONS OVER A CHIP-TO-CHIP INTERFACE

A device and method for communicating, via a memory-mapped communication path, between a host processor and a cellular-communication modem are disclosed. The method includes providing logical channels over the memory-mapped communication path and transporting data organized according to one or more cellular communication protocols over at least one of the logical channels. In addition, the method includes acknowledging when data transfer occurs between the host processor and the cellular-communication modem, issuing commands between the host processor and the cellular-communication modem, and communicating and managing a power state via one or more of the logical channels.




rd

Motor-driven unit for clearing mines from and securing a hazardous route

The present disclosure relates to a motor-driven unit for clearing mines from and securing a hazardous route. According to the present method, system and device, a marker apparatus for a secured route is a liquid material for marking on the ground, and comprising dispensing members for providing one axial marking and two side markings on either side of said axial marking, respectively, for said route.




rd

Hand operated rifle cartridge loading press affording a repeatable degree of crimping

A hand operated press for reloading metal rifle cartridges including indicating means for providing for an operator of the press discrete indications of the different forces that can be manually applied through the drive mechanism during use of the press to crimp the second end of a cartridge against a bullet in the cartridge to allow the operator to use one of those indications to manually apply the same force to form essentially the same degree of crimp of the second ends of identical cartridges against identical bullets in the cartridges.




rd

Method for case hardening a component by means of oil jets and device for carrying out said method

A method for treating a component comprising a metallic or ceramic material with a crystalline, semi-crystalline or amorphous structure. According to the method, to case-harden the component, at least part of the surface of the component is exposed to an oil jet, while the temperature of the oil and/or the component is regulated. Also disclosed is a device for carrying out the method.




rd

Steel for induction hardening, roughly shaped material for induction hardening, producing method thereof, and induction hardening steel part

A steel for an induction hardening including, by mass %, C: more than 0.75% to 1.20%, Si: 0.002 to 3.00%, Mn: 0.20 to 2.00%, S: 0.002 to 0.100%, Al: more than 0.050% to 3.00%, P: limited to 0.050% or less, N: limited to 0.0200% or less, O: limited to: 0.0030% or less, and the balance composing of iron and unavoidable impurities, wherein an Al content and a N content satisfy, by mass %, Al−(27/14)×N>0.050%.




rd

Wallet card retrieval slip

A wallet card retrieval slip that includes a sleeve having a transparent top sheet and a transparent bottom sheet conjoined at a back edge and a second edge, the sleeve having a vertical pull tab disposed on a first edge proximal the back edge and a horizontal pull tab disposed on a front edge proximal the second edge, wherein a card is removably insertable into the sleeve and easily retrieved from a wallet pocket by means of the vertical and horizontal pull tabs. An alternative embodiment has the vertical pull tab centrally disposed on the first edge to enable a staggered arrangement of vertical pull tabs on a plurality of sleeves when used with a plurality of cards in adjacent pockets in a wallet.




rd

Interactive board cover

An improved interactive learning board cover is provided. The improved interactive learning board cover may provide protection to the learning board, whereby the cover may stretch over the entire surface of a whiteboard and may be secured at each of the four corners of the board with a sewn pocket thereby allowing securement of the board without the need for additional handles, straps and/or padding.




rd

Swing tag card holder

An assembly for holding a transaction card, such as a gift card, upon a panel that pivots to be received within a pouch, pocket or sleeve to hold and retain the card during transport and storage.




rd

Motion greeting cards

The present invention and related disclosure describes greeting cards with moving elements or devices which are operable to create motion in connection with some portion of the greeting card. The greeting card may include a multi-panel greeting card body or a three-dimensional foam greeting card body. At least one movable object is contained upon or within the greeting card body. A sound module having at least one pre-recorded digital audio file saved therein and a motor module are contained and concealed within the greeting card body. One or more switches may be used to activate the sound and motor modules, causing the pre-recorded audio file to play and causing movement of the movable or mobile object.




rd

Display card holder assembly

A display card holder for use on support surfaces, such as golf carts includes a display card retaining sleeve and a sleeve holder. The sleeve holder includes an entrance slot having inwardly extending retention ridges which deform and thereby reduce vibration of the retaining sleeve. The sleeve holder may further include a mechanical locking mechanism for securing the sleeve in the sleeve holder.




rd

Gift card carriers

The invention pertains to improved gift card carriers. More particularly, a first aspect pertains to a gift card carrier that also operates as a greeting card. In a first folded configuration, the gift card carrier presents the gift card for purchase. In a second folded configuration, the gift card carrier acts like a greeting card that encloses the gift card, and possibly supplies a greeting or message. A second aspect pertains to a gift card carrier with a depression for receiving a gift card therein. The depression may make the gift card appear as if its flush mounted within a panel of the gift card carrier. A third aspect pertains to a gift card carrier with an image of hardware device that includes a display, and a gift card that includes an image associated with the hardware device. The gift card is positioned over the display region of the hardware device image making it appear as if the gift card is the display, and the image thereon is being displayed.




rd

Sliding panel gift card holder

A sliding panel gift card holder includes a panel mounted within a sleeve, pouch or bag, the panel being hingedly connected to a draw flap and then to a cover flap. Upon opening the cover flap, the draw flap draws the panel out of the sleeve to reveal a gift card secured upon the panel, thereby presenting the gift card to a recipient.




rd

Pop-up greeting cards with confetti

An interactive electronic greeting card with pop up feature includes a three-sided pocket or cavity which houses various electronic and mechanical components and a pop up element. In a first position, the pop up element is substantially contained within the greeting card pocket or cavity. When the push button is depressed, the pop up element is ejected or “pops up” out of the greeting card pocket or cavity, revealing a greeting or other printed indicia. The push button also initiates playback of a pre-loaded digital audio file, which may be a spoken message, a sound, a song, music or other such audio recording.




rd

Shadow box trading card

A trading card (10) comprises a first substrate (14A), a second substrate (14B) and a spacer (16A). The first substrate (14A) includes a first card image (18). The second substrate (14B) includes a second card image (20). The second substrate (14B) is spaced apart from the first substrate (14A). The spacer (16A) is positioned substantially between the first substrate (14A) and the second substrate (14B) to maintain the first card image (18) spaced apart from the second card image (20). The trading card (10) can further comprise a third substrate (14C) and a second spacer (16B). The third substrate (14C) includes a third card image (22). The third substrate (14C) is spaced apart from the first substrate (14A) and the second substrate (14B). The second spacer (16B) is positioned substantially between the second substrate (14B) and the third substrate (14C) to maintain the second card image (20) spaced apart from the third card image (22). The first card image (18), the second card image (20) and the third card image (22) can cooperate to form a full card image (12).




rd

Popup displays for financial transaction cards

Foldable financial transaction card displays that include at least one popup member, methods of making such displays, and methods of promoting such displays. Some of the displays include folding members that are unitary with the popup members.




rd

Body comprising hard face structure and method for making same

A body, such as a pick tool for cutting coal, includes a steel substrate and a hard face structure fused to the steel substrate. The hard face structure includes at least 1 weight percent Si, at least 5 weight percent Cr and at least 40 weight percent W. Substantially the balance of the hard face structure includes carbon and an iron group metal M selected from Fe, Co, Ni and alloy combinations of these elements. The hard face structure includes a plurality of elongate or platelike micro-structures having a mean length of at least 1 micron, a plurality of nano-particles having a mean size of less than 200 nanometers, and a binder material.




rd

Methods, wires, and apparatus for slicing hard materials

Methods, wires, and apparatus for use in cutting (e.g., slicing) hard, brittle materials is provided. The wire can be a super-abrasive wire that includes a wire core and super-abrasive particles bonded to the wire core via a metal bonding layer. This wire, or another type of wire, can be used to slice workpieces useful for producing wafers. The workpieces can be aligned within a holder to produce wafers using the device and methods presently provided. The holder rotates about its central axis, which translates to workpieces moving in orbit around this axis. A single abrasive wire, or multiple turns of wire stretched tightly between wire guides, is then contacted with the rotating holder to slice the workpieces.




rd

Methods, wires, and apparatus for slicing hard materials

Methods, wires, and apparatus for use in cutting (e.g., slicing) hard, brittle materials is provided. The wire can be a super-abrasive wire that includes a wire core and super-abrasive particles bonded to the wire core via a metal bonding layer. This wire, or another type of wire, can be used to slice workpieces useful for producing wafers. The workpieces can be aligned within a holder to produce wafers using the device and methods presently provided. The holder rotates about its central axis, which translates to workpieces moving in orbit around this axis. A single abrasive wire, or multiple turns of wire stretched tightly between wire guides, is then contacted with the rotating holder to slice the workpieces.




rd

Device for adjusting the blade guard holder of a wall saw

A device (20) for adjusting the blade guard holder (17) arranged on the saw arm (3) of a wall saw (1), having a coupling element (25) is provided, whereby a first end of the coupling element (25) is joined to the blade guard holder (17), and, in a locked state, a second end is joined to the saw arm (3).




rd

Hydraulically-actuated, horizontal flush-cut radial concrete saw and trip hazard removal method

A concrete saw is disclosed having a rigid metal frame, a hydraulic drive system, a water-cooled hub, and an axially rotatable trigger assembly comprising a 12 volt switch. The saw may include a hydraulic pump operable to supply pressurized hydraulic fluid to the drive system. In some embodiments, the saw may includes a flow sharing valve fluidly coupled to the hydraulic drive system to distribute the pressurized hydraulic fluid from the a hydraulic pump in a portable power pack. A method of removing trip hazards with the saw is also disclosed.




rd

Ductile mode machining methods for hard and brittle components of plasma processing apparatuses

A method of ductile mode machining a component of a plasma processing apparatus wherein the component is made of nonmetallic hard and brittle material wherein the method comprises single point turning the component with a diamond cutting tool causing a portion of the nonmetallic hard and brittle material to undergo a high pressure phase transformation to form a ductile phase portion of the hard and brittle material during chip formation wherein a turned surface is formed from a phase changed material and the turned surface is a grooved textured surface of phase changed material.




rd

Systems and methods for producing a hardwearing alloy material

Described herein are systems and methods for producing a hardwearing or wear-resistant material. In one aspect, a first group of materials comprising zirconium dioxide (ZrO2), aluminum oxide (Al2O3), and one or both of calcium oxide (CaO) and yttrium oxide (Y2O3) may be mixed, heated, and cooled to yield a first mixture. The first mixture may be used to generate granules that may then be mixed with a second group of materials comprising iron, nickel, manganese, titanium, carbon, chromium, and optionally, a paraffin, to yield a second mixture. The second mixture may then be compressed, cast, cooled, and heat treated to yield the hardwearing or wear-resistant material.




rd

Device and method to simulate cooking stuffing in a bird

The present invention provides a device and method for simulating cooking stuffing in a bird, such as a turkey. Stuffing prepared with the device and method of the invention has both the appearance and taste of cooked-in-the-bird stuffing. In addition, the device and method of the invention allows the user to prepare simulated cooked-in-the-bird stuffing at any time, in any quantity and in less time compared to the several hours usually needed to cook stuffing in a bird. The invention, therefore, provides all the benefits of cooked-in-the-bird stuffing without the safety concerns of bacterial contamination when cooked in a bird.




rd

CARDIOTONIC STEROID ANTAGONISTS AND RELATED METHODS

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.




rd

USE OF miR-199a-5p, TARGETS AND/OR INHIBITORS THEREOF FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF FIBROPROLIFERATIVE DISORDERS

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.




rd

METHODS AND COMPOSITIONS FOR RISK PREDICTION, DIAGNOSIS, PROGNOSIS, AND TREATMENT OF PULMONARY DISORDERS

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.




rd

DD1ALPHA RECEPTOR AND USES THEREOF IN IMMUNE DISORDERS

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.