ant A Previously Unknown Dendritic Cell Type Reduces Antitumor Response [Immunology] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 A cluster of dendritic cells (termed mregDCs), observed in humans and mice, restricted antitumor immunity. Full Article
ant New Drug-Discovery Assay Identifies Novel Mutant-EGFR Inhibitors [Drug Discovery] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 The MaMTH-DS assay detected inhibitors of mutant EGFR in non–small cell lung cancer cells. Full Article
ant Microbiome Predicts Blood-Cell Transplant Success [News in Brief] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 A large international study found that the composition of the intestinal microbiome can predict clinical outcomes in patients undergoing allogenic hematopoietic-cell transplant (HCT) for blood cancers. The findings may help assess patients' transplantation-related mortality risk and aid in developing interventions to prevent or mitigate microbiome changes that affect HCT outcomes. Full Article
ant Engagement of T Cell-Expressed PD-L1 Weakens Antitumor Immunity [Immunology] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 T cell–expressed PD-L1 exerts tolerogenic effects on tumor immunity in pancreatic cancer. Full Article
ant Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study [RESEARCH REPORT] By molecularcasestudies.cshlp.org Published On :: 2020-04-01T06:30:17-07:00 Clinical benefit of immune checkpoint blockade in glioblastoma (GBM) is rare, and we hypothesize that tumor clonal evolution and the immune microenvironment are key determinants of response. Here, we present a detailed molecular characterization of the intratumoral and immune heterogeneity in an IDH wild-type, MGMT-negative GBM patient who plausibly benefited from anti-PD-1 therapy with an unusually long 25-mo overall survival time. We leveraged multiplex immunohistochemistry, RNA-seq, and whole-exome data from the primary tumor and three resected regions of recurrent disease to survey regional tumor-immune interactions, genomic instability, mutation burden, and expression profiles. We found significant regional heterogeneity in the neoantigenic and immune landscape, with a differential T-cell signature among recurrent sectors, a uniform loss of focal amplifications in EGFR, and a novel subclonal EGFR mutation. Comparisons with recently reported correlates of checkpoint blockade in GBM and with TCGA-GBM revealed appreciable intratumoral heterogeneity that may have contributed to a differential PD-1 blockade response. Full Article
ant Lipid Trait Variants and the Risk of Non-Hodgkin Lymphoma Subtypes: A Mendelian Randomization Study By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Lipid traits have been inconsistently linked to risk of non-Hodgkin lymphoma (NHL). We examined the association of genetically predicted lipid traits with risk of diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and marginal zone lymphoma (MZL) using Mendelian randomization (MR) analysis. Methods: Genome-wide association study data from the InterLymph Consortium were available for 2,661 DLBCLs, 2,179 CLLs, 2,142 FLs, 824 MZLs, and 6,221 controls. SNPs associated (P < 5 x 10–8) with high-density lipoprotein (HDL, n = 164), low-density lipoprotein (LDL, n = 137), total cholesterol (TC, n = 161), and triglycerides (TG, n = 123) were used as instrumental variables (IV), explaining 14.6%, 27.7%, 16.8%, and 12.8% of phenotypic variation, respectively. Associations between each lipid trait and NHL subtype were calculated using the MR inverse variance–weighted method, estimating odds ratios (OR) per standard deviation and 95% confidence intervals (CI). Results: HDL was positively associated with DLBCL (OR = 1.14; 95% CI, 1.00–1.30) and MZL (OR = 1.09; 95% CI, 1.01–1.18), while TG was inversely associated with MZL risk (OR = 0.90; 95% CI, 0.83–0.99), all at nominal significance (P < 0.05). A positive trend was observed for HDL with FL risk (OR = 1.08; 95% CI, 0.99–1.19; P = 0.087). No associations were noteworthy after adjusting for multiple testing. Conclusions: We did not find evidence of a clear or strong association of these lipid traits with the most common NHL subtypes. While these IVs have been previously linked to other cancers, our findings do not support any causal associations with these NHL subtypes. Impact: Our results suggest that prior reported inverse associations of lipid traits are not likely to be causal and could represent reverse causality or confounding. Full Article
ant Total Antioxidant Capacity and Pancreatic Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Total antioxidant capacity (TAC) reflects an individual's overall antioxidant intake. We sought to clarify whether higher TAC is associated with lower risks of pancreatic cancer incidence and mortality in the U.S. general population. Methods: A total of 96,018 American adults were identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. A ferric-reducing ability of plasma score was used to reflect an individual's TAC intake from diet and/or supplements. Cox regression was used to calculate hazard ratios (HR) for pancreatic cancer incidence, and competing risk regression was used to calculate subdistribution HRs for pancreatic cancer mortality. Restricted cubic spline regression was used to test nonlinearity. Results: A total of 393 pancreatic cancer cases and 353 pancreatic cancer–related deaths were documented. Total (diet + supplements) TAC was found to be inversely associated with pancreatic cancer incidence (HR quartile 4 vs. quartile 1 = 0.53; 95% confidence interval, 0.39–0.72; Ptrend = 0.0002) and mortality (subdistribution HR quartile 4 vs. quartile 1 = 0.52; 95% confidence interval 0.38–0.72; Ptrend = 0.0003) in a nonlinear dose–response manner (all Pnonlinearity < 0.01). Similar results were observed for dietary TAC. No association of supplemental TAC with pancreatic cancer incidence and mortality was found. Conclusions: In the U.S. general population, dietary but not supplemental TAC level is inversely associated with risks of pancreatic cancer incidence and mortality in a nonlinear dose–response pattern. Impact: This is the first prospective study indicating that a diet rich in antioxidants may be beneficial in decreasing pancreatic cancer incidence and mortality. Full Article
ant Sensitive Determination of Infectious Titer of Recombinant Adeno-Associated Viruses (rAAVs) Using TCID50 End-Point Dilution and Quantitative Polymerase Chain Reaction (qPCR) By cshprotocols.cshlp.org Published On :: 2020-05-01T06:29:31-07:00 Adeno-associated virus (AAV) recombinants are currently the vector of choice for many gene therapy applications. As experimental therapies progress to clinical trials, the need to characterize recombinant adeno-associated viruses (rAAVs) accurately and reproducibly increases. Accurate determination of rAAV infectious titer is important for determining the activity of each vector lot and for ensuring lot-to-lot consistency. The following protocol developed in our laboratory uses a 96-well TCID50 format and quantitative polymerase chain reaction (qPCR) detection for the determination of rAAV infectious titer. Full Article
ant Titration of Recombinant Adeno-Associated Virus (rAAV) Genome Copy Number Using Real-Time Quantitative Polymerase Chain Reaction (qPCR) By cshprotocols.cshlp.org Published On :: 2020-05-01T06:29:31-07:00 This protocol is used to determine the concentration of DNase-resistant vector genomes (i.e., packaged in the capsid) in purified recombinant adeno-associated virus (rAAV) preparations. The protocol begins with treatment of the vector stock with DNase I to eliminate unencapsidated AAV DNA or contaminating plasmid DNA. This is followed by a heat treatment to heat-inactivate DNase I, to disrupt the viral capsid, and to release the packaged vector genomes for quantification by real-time polymerase chain reaction (PCR) using a set of standards (linearized plasmid used for vector production) containing known copy numbers. To accomplish high-throughput titration, the primer and probe sets used in real-time PCR are usually designed to target common elements present in most rAAV genomes, such as promoters and poly(A) signals. This strategy significantly reduces the number of PCRs, controls, and turnaround time. Several important controls should be included in the assay as follows: The first two controls should have a known copy number of the rAAV genome plasmid treated or not treated with DNase I. This control tests the effectiveness of DNase treatment. To control for potential cross-contamination between samples during the preparation process, a blank control containing nuclease-free water only should be processed and tested in parallel. A validation vector sample with a known titer should be included in every assay to monitor interassay variability. Finally, for the PCR run, a no-template control (NTC) is included to indicate cross-contamination during PCR setup. Full Article
ant Purification of Recombinant Adeno-Associated Virus 2 (rAAV2) by Heparin Column Affinity Chromatography By cshprotocols.cshlp.org Published On :: 2020-05-01T06:29:31-07:00 This protocol describes a simple single-step column purification (SSCP) of rAAV2 by gravity flow based on its affinity to heparin, without ultracentrifugation. Full Article
ant [PERSPECTIVES] Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives By perspectivesinmedicine.cshlp.org Published On :: 2020-05-01T06:30:15-07:00 Preimplantation genetic testing (PGT) is a reproductive technology that, in the course of in vitro fertilization (IVF), allows prospective parents to select their future offspring based on genetic characteristics. PGT could be seen as an exercise of reproductive liberty, thus potentially raising significant socioethical and legal controversy. In this review, we examine—from a comparative perspective—variations in policy approaches to the regulation of PGT. We draw on a sample of 19 countries (Australia, Austria, Belgium, Brazil, Canada, China, France, Germany, India, Israel, Italy, Japan, Mexico, Netherlands, Singapore, South Korea, Switzerland, United Kingdom, and the United States) to provide a global landscape of the spectrum of policy and legislative approaches (e.g., restrictive to permissive, public vs. private models). We also explore central socioethical and policy issues and contentious applications, including permissibility criteria (e.g., medical necessity), nonmedical sex selection, and reproductive tourism. Finally, we further outline genetic counseling requirements across policy approaches. Full Article
ant Comparison of Enhancement of the Vestibular Perilymph between Variable and Constant Flip Angle-Delayed 3D-FLAIR Sequences in Meniere Disease [HEAD & NECK] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: Endolymphatic hydrops in patients with Menière disease relies on delayed postcontrast 3D-FLAIR sequences. The purpose of this study was to compare the degree of perilymphatic enhancement and the detection rate of endolymphatic hydrops using constant and variable flip angles sequences. MATERIALS AND METHODS: This was a retrospective study performed in 16 patients with Menière disease who underwent 3T MR imaging 4 hours after gadolinium injection using two 3D-FLAIR sequences with a constant flip angle at 140° for the first and a heavily-T2 variable flip angle for the second. The signal intensity ratio was measured using the ROI method. We graded endolymphatic hydrops and evaluated the cochlear blood-labyrinth barrier impairment. RESULTS: Both for symptomatic and asymptomatic ears, the median signal intensity ratio was significantly higher with the constant flip angle than with the heavily-T2 variable flip angle (7.16 versus 1.54 and 7.00 versus 1.45, P < .001). Cochlear blood-labyrinth barrier impairment was observed in 4/18 symptomatic ears with the heavily-T2 variable flip angle versus 8/19 with constant flip angle sequences. With heavily-T2 variable flip angle sequences, endolymphatic hydrops was observed in 7–10/19 symptomatic ears versus 12/19 ears with constant flip angle sequences. We found a significant association between the clinical symptomatology and the presence of endolymphatic hydrops with constant flip angle but not with heavily-T2 variable flip angle sequences. Interreader agreement was always perfect with constant flip angle sequences while it was fair-to-moderate with heavily-T2 variable flip angle sequences. CONCLUSIONS: 3D-FLAIR constant flip angle sequences provide a higher signal intensity ratio and are superior to heavily-T2 variable flip angle sequences in reliably evaluating the cochlear blood-labyrinth barrier impairment and the endolymphatic space. Full Article
ant CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice [INTERVENTIONAL] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error. MATERIALS AND METHODS: Five hundred twenty consecutive patients with a clinical diagnosis of acute ischemic stroke (49.4% men; mean age, 72 years) who underwent CTA to evaluate large-vessel occlusion of the proximal anterior circulation were included. CTA scans were retrospectively reviewed by a consensus panel of 2 neuroradiologists. Logistic regression analysis was performed to investigate the association between several variables and missed large-vessel occlusion at the initial CTA interpretation. RESULTS: The prevalence of large-vessel occlusion was 16% (84/520 patients); 20% (17/84) of large-vessel occlusions were missed at the initial CTA evaluation. In multivariate analysis, non-neuroradiologists were more likely to miss large-vessel occlusion compared with neuroradiologists (OR = 5.62; 95% CI, 1.06–29.85; P = .04), and occlusions of the M2 segment were more likely to be missed compared with occlusions of the distal internal carotid artery and/or M1 segment (OR = 5.69; 95% CI, 1.44–22.57; P = .01). There were no calcified emboli in initially correctly identified large-vessel occlusions. However, calcified emboli were present in 4 of 17 (24%) initially missed or misinterpreted large-vessel occlusions. CONCLUSIONS: Several factors may have an association with missing a large-vessel occlusion on CTA, including the CTA interpreter (non-neuroradiologists versus neuroradiologists), large-vessel occlusion location (M2 segment versus the distal internal carotid artery and/or M1 segment), and large-vessel occlusion caused by calcified emboli. Awareness of these factors may improve the accuracy in interpreting CTA and eventually improve stroke outcome. Full Article
ant Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists [FUNCTIONAL] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: NeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis. MATERIALS AND METHODS: We reviewed 144 adult patients who underwent presurgical evaluation for temporal lobe epilepsy. The reference standard for hippocampal sclerosis was defined by having hippocampal sclerosis on pathology (n = 61) or not having hippocampal sclerosis on pathology (n = 83). Sensitivities, specificities, positive predictive values, and negative predictive values were compared between NeuroQuant analysis and visual MR imaging analysis by using a McNemar paired test of proportions and the Bayes theorem. RESULTS: NeuroQuant analysis had a similar specificity to neuroradiologist visual MR imaging analysis (90.4% versus 91.6%; P = .99) but a lower sensitivity (69.0% versus 93.0%, P < .001). The positive predictive value of NeuroQuant analysis was comparable with visual MR imaging analysis (84.0% versus 89.1%), whereas the negative predictive value was not comparable (79.8% versus 95.0%). CONCLUSIONS: Visual MR imaging analysis by a neuroradiologist with expertise in epilepsy had a higher sensitivity than did NeuroQuant analysis, likely due to the inability of NeuroQuant to evaluate changes in hippocampal T2 signal or architecture. Given that there was no significant difference in specificity between NeuroQuant analysis and visual MR imaging analysis, NeuroQuant can be a valuable tool when the results are positive, particularly in centers that lack neuroradiologists with expertise in epilepsy, to help identify and refer candidates for temporal lobe epilepsy resection. In contrast, a negative test could justify a case referral for further evaluation to ensure that false-negatives are detected. Full Article
ant The Antonia By batdongsan.com.vn Published On :: Tue, 04 Feb 2020 11:33:04 GMT The Antonia là dự án căn hộ được chủ đầu tư Phú Mỹ Hưng định vị là dòng sản phẩm cao cấp, hội tụ đầy đủ các hạng mục tiện ích dịch vụ đẳng cấp - mang đến những cảm xúc trọn vẹn tại không gian sống đậm chất nghỉ dưỡng 5 sao hàng đầu cho cộng đồng các cư dân ưu tú. Full Article
ant De 1st Quantum By batdongsan.com.vn Published On :: Mon, 17 Feb 2020 17:23:29 GMT De 1ST Quantum là dự án căn hộ cao cấp được triển khai với quy mô gồm 14 tầng với tổng số 119 căn hộ tiêu chuẩn 5* - lần đầu tiên có mặt tại cố đô Huế. Full Article
ant Shantira An Bang- Hoi An for ren By batdongsan.com.vn Published On :: Tue, 24 Dec 2019 08:56:53 GMT Comfortable, modern and luxurious living space right at Shantira Hoi An Living room: - Comfortable, modern and luxurious design - Get in the sun and wind and natural light - 5 star imported furniture Kitchen: Designed with comfort so that the family can cook their own favourite f... Full Article
ant DO YOU WANT TO OWN AN APARTMENT IN THE HEART OF QUY NHON CITY? By batdongsan.com.vn Published On :: Thu, 16 Apr 2020 16:14:00 GMT DO YOU WANT TO OWN AN APARTMENT IN THE HEART OF QUY NHON CITY? - Unique and prime location, at 1 Nguyen Tat Thanh, the arterial road of Quy Nhon city, 4 facades 3 frontal face sea. - The project belongs to the segment of luxury apartments, 5-star utilities, strategic location in ... Full Article
ant Cho thuê sân thượng lắp đặt anten - trạm phát sóng BTS, cột viễn thông By batdongsan.com.vn Published On :: Wed, 06 May 2020 11:22:10 GMT Nhà mới xây 5 tấm ngay mặt tiền đường rộng 10m có sân thượng rộng khoảng 100m2, thuận tiện lắp đặt anten, trạm thu phát sóng BTS, cột viễn thông, hợp đồng lâu dài. Giá thỏa thuận.Cách Hà Huy Giáp 300m. Cách Tô Ngọc Vân 250m. Cách Ngã 4 Ga 1km. Cách Quốc Lộ 1A 300m.LH: 0919 939 70... Full Article
ant Cho thuê mặt bằng sân thượng đặt anten, trạm thu phát sóng By batdongsan.com.vn Published On :: Thu, 07 May 2020 15:06:56 GMT Tôi có tòa nhà cao 5 tầng, có sân thượng rộng thoáng, cần cho thuê để đặt anten, trụ sóng điện thoại trên cao, khu vực rộng thoáng. Vị trí: Ngay TTTM Giga Mall, ngã tư Bình Triệu.... Full Article
ant 6 important questions to ask yourself before buying a home By batdongsan.com.vn Published On :: 12:02 29/11/2018 In order to find the right accommodation, asking questions and answering them are essential. According to BankBazaar, you definitely need to answer the following 6 important questions before buying a home. Full Article
ant 4 Important Terms in House Purchase & Sale Agreement By batdongsan.com.vn Published On :: 16:14 11/10/2019 [Having appointment with real estate experts #3] “Innominate Terms are considered the most important ones in a house purchase & sale agreement. It is recommended that homebuyers, especially first-time buyers, should choose reputable developers.” Full Article
ant Shantira Beach Resort & Spa Hội An By batdongsan.com.vn Published On :: Thu, 12 Dec 2019 15:09:58 GMT Shantira Hội An Resort & Spa là khu nghỉ dưỡng được đầu tư bởi Công ty TNHH Du lịch VinaCapital Hội An với quy mô 8.6ha tại Điện Bàn, Quảng Nam. Full Article
ant Cantavil Long Hải Resort By batdongsan.com.vn Published On :: Mon, 24 Feb 2020 18:06:27 GMT Cantavil Long Hải Resort là dự án khu nghỉ dưỡng do Daewon Thủ Đức làm chủ đầu tư. Với mong muốn kiến tạo nên một Santorini đậm chất Địa Trung Hải tại miền biển Long Hải Full Article
ant Landlord/Tenant Relationship By batdongsan.com.vn Published On :: 16:41 11/10/2013 The relationship between a landlord and his tenant is often fraught with tension. Just ask the average unhappy tenant and he will most likely tell you that his landlord’s sole ambition is to rip him off and make his life as difficult as possible. An unhappy landlord on the other hand, tends to view the situation somewhat differently and feels that no matter how much he does for his tenant, there are always problems, and always reasons to delay paying the rent. Full Article
ant Be a wise tenant By batdongsan.com.vn Published On :: 17:12 11/10/2013 Know your rights when you rent a house or apartment Full Article
ant Tips for tenants By batdongsan.com.vn Published On :: 10:58 15/11/2013 Thinking about renting a property? Here are a few handy tips from us Full Article
ant Renter's Guide: Ten Tips for Tenants By batdongsan.com.vn Published On :: 13:45 15/11/2013 Tip 1: Bring your paperwork. The best way to win over a prospective landlord is to be prepared. To get a competitive edge over other applicants, bring the following when you meet the landlord: a completed rental application; written references from landlords, employers, and colleagues; and a current copy of your credit report. Full Article
ant 6 Tips to Turn Bad Tenants into Great Tenants By batdongsan.com.vn Published On :: 16:55 12/09/2014 If you are involved in real estate investing, you’re bound to run into a bad tenant or two. Sometimes you think you rent out your property to the right people, but once they’ve moved in, it seems like you’re dealing with entirely new ones. Full Article
ant How to Screen Potential Tenants – Questions, Credit & Background Check By batdongsan.com.vn Published On :: 09:28 27/09/2014 With a good tenant, you can sleep easy at night as a landlord knowing the rent will get paid and the property will stay relatively undamaged. With a bad tenant, on the other hand, you’re left to wonder about the state of your investment while fielding calls from angry neighbors. Full Article
ant 5 Important Buy-to-Let Tips By batdongsan.com.vn Published On :: 16:56 10/03/2015 If you are currently searching for a perfect buy to let investment property anywhere in the world, the experts at British listed real estate and lettings agency Belvoir have revealed five things to consider before you put pen to paper and sign on the dotted line. Full Article
ant Five important rules of land investment By batdongsan.com.vn Published On :: 09:33 30/11/2018 Land price "fevers" help many investors make a lot of money. However, many people still wonder whether they should invest in land at this time or not? According to experts, investing in land is quite safe, but in order to get profit, you should be alert and follow the basic rules. Full Article
ant Narad Jayanti 2020 Date: नारद जयंती आज, जानें मुहूर्त, पूजा विधि और जन्म कथा By www.amarujala.com Published On :: Fri, 08 May 2020 12:08:00 +0530 Narad Jayanti 2020 Date: नारद जयंती 'देवऋषि नारद मुनि' के जन्म दिवस के रूप में वैशाख कृष्ण प्रतिपदा के दिन मनाई जाती है। इस साल यह तिथि 8 मई तो पड़ रही है। इसलिए नारद जयंती 8 मई मनाई जाएगी। Full Article
ant Narsingh Jayanti 2020: नरसिंह जयंती आज, जानें मुहूर्त, पूजा विधि और पौराणिक कथा By www.amarujala.com Published On :: Wed, 06 May 2020 05:06:20 +0530 Narsingh Jayanti 2020: नरसिंह जयंती भगवान नरसिंह जी का जन्मोत्सव है। हिन्दू पंचांग के अनुसार, भगवान नरसिंह जी का अवतरण वैशाख शुक्ल पक्ष की चतुर्दशी तिथि के दिन हुआ था। इस वर्ष यह तिथि 6 मई को पड़ रही है। इसलिए नरसिंह जयंती 6 मई को मनाई जाएगी। Full Article
ant Narasimha Jayanti 2020: जानिए पूजा विधि और भगवान विष्णु के नरसिंह अवतार के पीछे की कथा By www.amarujala.com Published On :: Wed, 06 May 2020 12:46:59 +0530 भगवान विष्णु ने नरसिंह का अवतार लेकर हिरण्कश्यपु का वध करके अपने प्रिय भक्त प्रह्रलाद की जान बचाई थी। भगवान विष्णु ने पृथ्वी पर कई अलग-अलग अवतार लेकर अपने भक्तों को मुसीबतों से बचाया है। Full Article
ant Narsingh jayanti 2020: एक क्लिक में पढ़ें श्री नृसिंह चालीसा By www.amarujala.com Published On :: Tue, 05 May 2020 03:56:08 +0530 मास वैशाख कृतिका युत, हरण मही को भार। शुक्ल चतुर्दशी सोम दिन, लियो नरसिंह अवतार।। Full Article
ant Narsingh Jayanti 2020: इस स्तुति को करने से होते हैं भगवान नृसिंह प्रसन्न By www.amarujala.com Published On :: Wed, 06 May 2020 05:21:16 +0530 उदयरवि सहस्रद्योतितं रूक्षवीक्षं प्रळय जलधिनादं कल्पकृद्वह्नि वक्त्रम् | सुरपतिरिपु वक्षश्छेद रक्तोक्षिताङ्गं प्रणतभयहरं तं नारसिंहं नमामि || Full Article
ant Shani Jayanti 2020: शनि ने दिया राजा दशरथ को वरदान, जो आएगा आपके काम By www.amarujala.com Published On :: Wed, 06 May 2020 05:17:59 +0530 शनि स्तुति की रचना के पीछे सुंदर घटना छिपी हुई है। शनिदेव की इन सभी स्थितियों एवं दशाओं से बचने के लिए प्राणी यदि स्वयं दशरथ जी द्वारा की गयी शनिस्तुति का पाठ करे Full Article
ant Narsingh Jayanti 2020: इन मंत्रों के जप से मिलता है भगवान नृसिंह का आशीर्वाद, दूर होते हैं दुख-दर्द By www.amarujala.com Published On :: Wed, 06 May 2020 05:21:10 +0530 भक्त प्रह्राद की रक्षा के लिए भगवान विष्णु ने नरसिंह अवतार लिया था। नरसिंह जयंती के दिन भगवान नरसिंह की उपासना करने से सभी संकटों से मुक्ति मिलती है। Full Article
ant Narad Jayanti 2020: धरती के पहले पत्रकार हैं देवर्षि नारद, जानिए उनके बारे में महत्वपूर्ण बातें By www.amarujala.com Published On :: Fri, 08 May 2020 12:07:43 +0530 Narad Jayanti 2020: नारद जयंती 8 मई को है। नारद जयंती प्रति वर्ष ज्येष्ठ कृष्ण पक्ष की द्वितीया तिथि को मनाई जाती है। हिन्दू धार्मिक आस्था के अनुसार, देवर्षि नारद का महत्वपूर्ण स्थान है। Full Article
ant Shani Jayanti 2020: क्यों शनि को अपना पुत्र नहीं मानते हैं सूर्य देव? By www.amarujala.com Published On :: Sat, 09 May 2020 12:09:56 +0530 Shani Jayanti 2020 Date: शनि जयंती 22 मई को है। हिन्दू पंचांग के अनुसार, शनि जयंती प्रति वर्ष ज्येष्ठ माह की अमावस्या को मनाई जाती है। Full Article
ant What is Employee Development, and Why is it Important? By feedproxy.google.com Published On :: Sat, 09 May 2020 15:16:03 +0000 Unlike for previous generations, career development doesn’t only happen in educational institutions. The more we work, the more we realize our passion and discover the […] The post What is Employee Development, and Why is it Important? appeared first on e-Learning Feeds. Full Article eLearning Companies Employee Development And Retention
ant More than 900 COVID-19 cases at Cargill plant, but governments allow it to reopen By feedproxy.google.com Published On :: Thu, 07 May 2020 18:05:13 +0000 Karl NerenbergCargill Incorporated is the largest privately held company in the United States, and that means it is essentially a family business. You cannot buy Cargill shares on the Toronto, New York or any other stock exchange. The descendants of William Cargill, who founded the company in 1865 as a grain storage operation, own 90 per cent of the company. But if it is a family business, Cargill is no mom-and-pop operation. The company has grown over the past century and a half into a multi-tentacled corporate behemoth, involved in everything from grain to livestock to potash to steel to transport to financial services. In 2018, Cargill and its various subsidiaries reported revenues of over $110 billion. Cargill has operations on five continents, in more than 70 countries, including Canada, and the company's meat-packing plant in High River, Alberta is a tiny piece of that worldwide empire. In this country, however, the High River plant has an extremely high profile. It is one of the epicentres of COVID-19 in Canada -- in all of North America, in fact -- with over 900 reported cases out of 2,000 employees. That's almost half the workforce. Two people have died in connection with the Cargill outbreak -- one, a plant worker originally from Vietnam; the other, an infected plant worker's father, who had been visiting from the Philippines. Cargill initially resisted pleas from workers and their union to close the plant, but finally relented, in late April. After only two weeks, it hastily reopened, on Monday, May 4, giving the largely immigrant workforce the Hobson's choice of either going back to a potentially fatal workplace or losing their jobs. Neither the workers, nor their union think the plant has become safe. The union, the United Food and Commercial Workers (UFCW), has gone to court to force a shutdown, until Cargill can absolutely guarantee safe and healthy conditions for all employees. The UFCW does not think the notoriously low-paid plant workers should have to risk their lives to fatten the balance sheet of a U.S.-based transnational corporation that ranks number 15 on the Fortune 500. Kenney and Trump on the same wavelength Alberta Premier Jason Kenney has a different view from that of the union and the workers it represents. The premier, and former Harper Conservative government cabinet minister, appropriates a concept meant to describe access to necessary basic foodstuffs we all need for sustenance – food security – and applies it to the much different situation of the High River plant. The Cargill workers have to do their part, the Alberta premier argues, to ensure food security for Canadians. The truth is that Canada's food security does not depend on meat from Cargill or any other commercial operation. If our local butcher runs out of hamburger for the barbecue, we all have other nutritious options. There are, for instance, the protein-packed pulses -- chickpeas, lentils and the like -- that farmers in Saskatchewan grow in great quantity. In the U.S., as in Canada, COVID-19 has been particularly hard on the meat-packing industry, forcing more than 20 plant closures, and causing meat shortages on grocery shelves. Some fast food chains have even had to take hamburgers off the menu. Corporate executives in the meat industry told U.S. President Trump that they were reluctant to reopen their U.S.-based plants for fear of lawsuits. The U.S. is a far more litigious country than Canada. The president's response was to give the corporations cover, by invoking the U.S. Defense Protection Act (DPA). In effect, the president is forcing the corporations to reopen their plants. The purpose of the DPA is to allow a president to harness the resources of private industry to serve public needs in time of war or national emergency. Many have urged Trump to invoke the act to assure production of personal protective equipment for front-line workers during the pandemic, but he has refused. Now, Trump is using the extraordinary powers of the DPA to force workers back to dangerous plants, while shielding their bosses from responsibility. As for the High River Cargill plant workers, they fall under provincial labour jurisdiction. And the Alberta premier has already indicated he will not lift a finger to protect them. But there might be a way that federal authorities could step in. Jagmeet Singh urges Trudeau government to act In Canada, it is the federal government that has authority over food safety, and NDP Leader Jagmeet Singh believes the Trudeau team should assertively use that power to protect the Cargill workers. Singh put the question to Deputy Prime Minister Chrystia Freeland during the House of Commons' weekly face-to-face session on Wednesday, May 6. "Food safety and worker safety cannot be divorced," Singh told the House. "Will the government ensure that the Cargill workers are in safe work conditions?" Freeland, in a manner all-too-typical of Liberal politicians, dissimulated, offering sympathy but no action. "The member opposite is quite right that where the federal government has particular authority in food processing is to guarantee the safety of the foods processed there for Canadians to eat," she said, and then expressed some vague sentiments of concern. "When it comes to Cargill and food processing, I agree with the member opposite that it's something we all need to be particularly concerned about, and we have been." The NDP leader was not satisfied. "Will the government commit to using the authority that it has under food safety to ensure that workers are also safe, because there's no way that food can truly be safe if workers are in dangerous conditions and if workers are contracting COVID-19?" Singh asked, adding: "If workers are dying, the food can't be safe." Freeland would not budge. The Trudeau government wants to get credit for caring, without pushing the envelope in dealing with the most prickly and confrontational provincial government in the country, Alberta's. "I think we all understand there is a very clear difference between the duty to inspect food which is produced and to ensure that that food is safe for Canadians, and even more sacred duty to ensure that workers are working in safe conditions," Freeland answered. "We take both of those extremely seriously and we are aware what falls specifically in our jurisdictions. Having said that, we care very much about all Canadian workers." Freeland's assertion that responsibility for the safety of a product that consumers eat does not include making sure a processing plant is not an active breeder of a deadly virus reflects a narrow and limited understanding of the federal role. There is no evidence of food borne transmission of COVID-19, or of food packaging carrying the virus, according to authorities in both the U.S. and Canada. But experts have not always got it right about COVID-19 since the outbreak at the beginning of this year. At this stage, all we know for sure is that there remain many unanswered questions about it. 'The worst company in the world' What is not in doubt is the kind of company we're dealing with. Not too long ago the U.S. environmental organization Mighty Earth undertook a study of the social and environmental impact of Cargill's operations and issued a report they called "The Worst Company in the World." The report opens by stating "when it comes to addressing the most important problems facing our world, including the destruction of the natural environment, the pollution of our air and water, the warming of the globe, the displacement of Indigenous peoples, child labor, and global poverty, Cargill is not only consistently in last place, but is driving these problems at a scale that dwarfs their closest competitors." The report details how Cargill has become more powerful than governments and has betrayed repeated promises to adhere to high environmental standards. "Nowhere is Cargill's pattern of deception and destruction more apparent than in its participation in the destruction of the lungs of the planet, the world's forests. Despite repeated and highly publicized promises to the contrary, Cargill has continued to bulldoze ancient ecosystems, sometimes within the bounds of lax laws -- and, too often, outside those bounds as well." With the advent to power of virulently anti-environmental Trump in the U.S. and Jair Bolsonaro in Brazil, there is now virtually no limit, Mighty Earth says, to Cargill's capacity to ravage rainforests, savannahs and other vital habitats. Mighty Earth cites many examples. One of those is that of "the Gran Chaco, a 110-million-hectare ecosystem spanning Argentina, Bolivia, and Paraguay." This ecosystem "is one of the largest remaining continuous tracts of native vegetation in South America, second in size only to the Amazon rainforest. These forests are home to vibrant communities of Indigenous Peoples … who have depended on and coexisted with the Chaco forest for millennia." Cargill, the report tells us, is now actively endangering both the people and other inhabitants of the Gran Chaco to produce a cash crop -- soy -- that feeds the animals which become Big Macs and Whoppers. "Once the impenetrable stronghold of creatures like the screaming hairy armadillo, the jaguar, and the giant anteater, Cargill has infiltrated the Gran Chaco, bulldozing and burning to make way for vast fields of genetically modified soy." Mighty Earth also documents Cargill's use of violence to subdue Indigenous peoples, its exploitative labour practices, including child labour, and its predatory practices that have driven competitors out of certain businesses. This is the company that Jason Kenney says must be allowed to operate, uninhibited by health concerns, to assure our food security. If you believe that, you might also believe that injecting bleach into your veins can cure COVID-19, or that, as many opinion leaders in the U.S. say, it is necessary to accept that thousands must die in the interests of what they call the economy. The owners of Cargill are not personally offering to sacrifice their lives. They are offering their employees' lives instead. Karl Nerenberg has been a journalist and filmmaker for more than 25 years. He is rabble's politics reporter. Image: Alberta Newsroom/Flickr Full Article
ant More than 900 COVID-19 cases at Cargill plant, but governments allow it to reopen By feedproxy.google.com Published On :: Thu, 07 May 2020 18:22:02 +0000 May 7, 2020More than 900 COVID-19 cases at Cargill plant, but governments allow it to reopenNeither the workers, nor their union think the plant has become safe. The UFCW is taking legal action to force a shutdown, until Cargill can absolutely guarantee safe conditions for all employees. Full Article
ant Xbox Game Pass Adds DayZ, Final Fantasy IX And More in May By feedproxy.google.com Published On :: Wed, 06 May 2020 18:15:51 GMT Microsoft has announced many new titles coming to Xbox Game Pass for console and Windows PC in May. The list of games includes DayZ, Final Fantasy IX, and Fractured Minds, Endless Legend and the previously announced Red Dead Redemption 2 for console and Halo 2: Anniversary for Halo: The Master Chief Collection for PC. Here is the list of games coming soon to Xbox Game Pass for Console: DayZ (ID@Xbox) – May 7An unforgiving, authentic, open world game where each one of 60 players on a server follows a single goal: Survive as long as they can, by any means necessary. There are no superficial tips, waypoints, or help given to you. Every decision matters with no saves and no extra lives where mistakes can be lethal. Your choices and decisions will create a gameplay experience that’s completely unique. Red Dead Redemption 2 – May 7America, 1899. Arthur Morgan and the Van der Linde gang are outlaws on the run. With federal agents and the best bounty hunters in the nation massing on their heels, the gang must rob, steal, and fight their way across the rugged heartland of America to survive. As deepening internal divisions threaten to tear the gang apart, Arthur must make a choice between his own ideals and loyalty to the gang who raised him. Includes access to Red Dead Online (Xbox Live Gold required). Final Fantasy IX – May 14Zidane and the Tantalus Theater Troupe have kidnapped Princess Garnet, the heir of Alexandria. To their surprise, however, the princess herself yearned to escape the castle. Through a series of unusual circumstances, she and her personal guard, Steiner, fall in with Zidane and set out on an incredible journey in this classic entry in the heralded Final Fantasy series. Fractured Minds (ID@Xbox) – May 19Fractured Minds is an immersive artistic short game, exploring anxiety and mental health issues. Embark on a journey through the human psyche to experience the everyday challenges associated with these conditions. Here is the list of games coming soon to Xbox Game Pass for PC: Endless LegendJump in to this 4X strategy game as you lead one of eight unique civilizations, each with their own unique gameplay and story. Food must be grown, industries built, science and magic advanced, and wealth collected. Your planet holds a history of unexplained apocalypse, and the winter you just survived was the worst on record. You have a city, a loyal populace, and a few troops; your power and magic should be sufficient to keep them alive. But beyond that, nothing is certain… Where will you go, what will you find, and how will you react? Final Fantasy IXZidane and the Tantalus Theater Troupe have a plan to kidnap Princess Garnet, the heir of Alexandria. To their surprise, the princess herself beats them to the punch and orchestrates her own escape with their unwitting help, granting her the freedom she yearned for beyond the castle walls. Through a series of unusual circumstances, she and her personal guard, Steiner, fall in with Zidane and his crew, and set out on an incredible journey in this classic Final Fantasy adventure. Halo Master Chief Collection: Halo 2Halo 2: Anniversary comes to PC as the next installment in Halo: The Master Chief Collection. Following the destruction of the first Halo ring, Master Chief returns to Earth to prevent the Covenant invasion, leading to a battle with long-hidden secrets that will dramatically alter the course of the Human-Covenant Conflict forever. A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.Full Article - https://www.vgchartz.com/article/443405/xbox-game-pass-adds-dayz-final-fantasy-ix-and-more-in-may/ Full Article Analysis Charts Industry
ant Final Fantasy VII Remake Tops the US PlayStation Store Downloads in April 2020 By feedproxy.google.com Published On :: Thu, 07 May 2020 17:54:35 GMT Sony has released the US PlayStation Store downloads charts for March 2020. Final Fantasy VII Remake topped the PS4 charts, Beat Saber topped the PlayStation VR charts, and Call of Duty: Warzone topped the Free-to-Play Games chart. Fortnite – The Iris Pack topped the DLC and Expansions chart. Here is the complete list of charts: PS4 Games 1 Final Fantasy VII Remake 2 Call of Duty: Modern Warfare 3 NBA 2K20 4 Grand Theft Auto V 5 Call of Duty: Modern Warfare 2 Campaign Remastered 6 Resident Evil 3 7 Minecraft 8 EA Sports FIFA 20 9 Monopoly Plus 10 Marvel’s Spider-Man 11 Madden NFL 20 12 Tom Clancy’s Rainbow Six Siege 13 Uno 14 Predator: Hunting Grounds 15 MLB The Show 20 16 Red Dead Redemption 2 17 Need for Speed Heat 18 Rocket League 19 God of War 20 Kingdom Hearts III PS VR Games 1 Beat Saber 2 Creed Rise to Glory 3 Job Simulator 4 Rick and Morty: Virtual Rick-ality 5 Arizona Sunshine 6 Superhot VR 7 Vacation Simulator 8 Drunkn Bar Fight 9 Astro Bot Rescue Mission 10 The Room VR: A Dark Matter Free-to-Play Games 1 Call of Duty: Warzone 2 Fortnite 3 Apex Legends 4 Destiny 2 5 Brawlhalla 6 Dauntless 7 3on3 FreeStyle 8 Warframe 9 Paladins 10 Warface DLC and Expansions 1 Fortnite – The Iris Pack 2 GTA Online: Criminal Enterprise Starter Pack 3 Fortnite – Bassassin Challenge Pack 4 Marvel’s Spider-Man: The City That Never Sleeps 5 Mortal Kombat 11 Kombat Pack 6 Call of Duty: Modern Warfare – Atlanta FaZe Pack 7 Need for Speed Heat – McLaren F1 Black Market Delivery 8 Call of Duty Black Ops III: Zombies Chronicles 9 Dragon Ball Z: Kakarot Season Pass 10 Mortal Kombat 11 – Shao Kahn A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.Full Article - https://www.vgchartz.com/article/443430/final-fantasy-vii-remake-tops-the-us-playstation-store-downloads-in-april-2020/ Full Article Analysis Charts Industry
ant GTAV Tops the EU PlayStation Store Downloads in April 2020, Final Fantasy VII Remake Debuts in 4th By feedproxy.google.com Published On :: Thu, 07 May 2020 17:58:58 GMT Sony has released the Europe PlayStation Store downloads charts for April 2020. Grand Theft Auto V topped the PS4 charts, Blood and Truth topped the PlayStation VR charts, and Call of Duty: Warzone topped the Free-to-Play Games chart. Fortnite – The Iris Pack topped the DLC and Expansions chart. Final Fantasy VII Remake debuted in fourth on the PS4 charts. Resident Evil 3 debuted in 10th place. Here is the complete list of charts: PlayStation 4 Grand Theft Auto V (3) EA SPORTS FIFA 20 (2) Call of Duty: Modern Warfare (1) FINAL FANTASY VII REMAKE (New) NBA 2K20 (RE) Call of Duty: Modern Warfare 2 Campaign Remastered (20) EA SPORTS UFC 3 (RE) Minecraft (5) Marvel’s Spider-Man (RE) RESIDENT EVIL 3 (New) MONOPOLY PLUS (RE) Rocket League (11) Assassin’s Creed Odyssey (10) Days Gone (RE) TOM CLANCY’S RAINBOW SIX | SIEGE (RE) Red Dead Redemption 2 (19) The Crew 2 (13) Tom Clancy’s The Division 2 (RE) eFootball PES 2020 (RE) Need for Speed Heat (RE) PlayStation VR Blood and Truth (5) Beat Saber (1) Creed: Rise to Glory (9) Job Simulator (2) RICK AND MORTY: VIRTUAL RICK-ALITY (RE) ASTRO BOT Rescue Mission (RE) Until Dawn: Rush of Blood (RE) BOXVR (RE) Farpoint (RE) SUPERHOT VR (4) DLC Fortnite – The Iris Pack (1) Fortnite – Bassassin Challenge Pack (3) GTA Online: Criminal Enterprise Starter Pack (5) Marvel’s Spider-Man: The City That Never Sleeps – Season Pass (RE) Assassin’s Creed Odyssey – Season pass (RE) Fortnite: Save the World – Standard Founder’s Pack (10) The Division 2 – Warlords of New York – Expansion (2) Need for Speed Heat – McLaren F1 Black Market Delivery (6) Modern Warfare – Atlanta FaZe Pack (New) Assassin’s Creed Origins – The Hidden Ones (RE) Free-to-Play Call of Duty: Warzone (1) Fortnite (2) Apex Legends (3) Brawlhalla (5) DON’T EVEN THINK (New) eFootball PES 2020 LITE (4) Destiny 2 (New) WORLD OF WARSHIPS: LEGENDS (7) DRAGON BALL XENOVERSE 2 Lite Version (6) Paladins (9) A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.Full Article - https://www.vgchartz.com/article/443431/gtav-tops-the-eu-playstation-store-downloads-in-april-2020-final-fantasy-vii-remake-debuts-in-4th/ Full Article Analysis Charts Industry
ant Don't miss: Emotional veg, antique innovations and spooky maths By www.newscientist.com Published On :: Wed, 12 Feb 2020 18:00:00 +0000 This week, hide behind the sofa from mind-altering plants, listen and learn from technologies past and find out how the world is underpinned by numbers Full Article
ant Politicians are mulling a global tax rate to tame the tech giants By www.newscientist.com Published On :: Thu, 27 Feb 2020 12:19:17 +0000 Tech firms are making record profits but paying little tax. Now global leaders are discussing ways to make them pay their fair share Full Article
ant Surprise contender Honeywell enters the quantum computing race By www.newscientist.com Published On :: Tue, 03 Mar 2020 12:00:17 +0000 Honeywell, the same company that might make your humidifier or home security system, is unveiling a powerful quantum computer that will be available to the public Full Article
