rd

Method and system for reducing forward link transmission power

This specification describes a method and corresponding system for reducing aggregate forward link transmission power. In one arrangement, a RAN may reduce the aggregate transmission power level in a coverage area by (i) determining which WCDs in the coverage area have a communication error rate that is at least a threshold level of communication error rate, and in response to the determining, (ii) reducing the forward link transmission power level of the determined WCDs. In another arrangement, the RAN may reduce the aggregate transmission power level in a coverage area by reducing the forward link transmission power of WCDs in the coverage area that have (i) a forward link transmission power level that is at least a threshold level of forward link transmission power and (ii) a communication error rate that is at least a threshold level of communication error rate.




rd

Method for continuous, frame-specific click-stream recording

A method for tracking a user's movements between network addresses can include, subsequent to a request for a (current) network address from a user, receiving the network address and an identifier for a region associated with the network address. The method can also include locating a record that contains the identifier for the region and a time that immediately precedes the request for the network address from the user. The record may further contain a prior network address. The method can further include generating an entry for a table that includes the identifier for the region, the current network address, and the prior network address. A server computer or a client computer can generate the entry. Improved accountability and improved user profile accuracy can be obtained with the method. A data processing system readable medium can comprise code that includes instructions for carrying out the method.




rd

Virtual local area network (vlan) coordinator providing access to vlans

A virtual computer system includes virtualization software, and one or more physical network interfaces for connecting to one or more computer networks. The virtualization software supports one or more virtual machines (VMs), and exports one or more virtual network interfaces to the VM(s) to enable the VM(s) to access the computer network(s) through the physical network interface(s). The virtualization software modifies and filters network data frames from the VM(s) and from the physical network interface(s) to restrict one or more VMs to one or more virtual local area networks (VLANs) that are implemented within a VLAN topology. Restricting a VM to a VLAN limits the broadcast domain to which the VM belongs, which may reduce security risks facing the VM. Implementing the VLAN functionality within the virtualization software provides the functionality to every VM in the computer system, without requiring every VM to provide the functionality.




rd

Information processing apparatus, computer-readable recording medium, and control method

An abnormality detection unit provided in at least one node among a plurality of nodes included in an information processing apparatus detects abnormality in a data transmission path of data transmission using a shared memory area sharable in a single node and other node, which is included in the storage unit provided in the single node or other nodes. An error information generation unit provided in the single node generates error information, based on the abnormality detected by the abnormality detection unit, and generates an interrupt with respect to a processor within a self node. The processor provided in the single node performs recovery processing, based on the error information according to the interrupt.




rd

Coordinated multipoint transmission and reception (CoMP)

A communications method implemented in a transmission point (TP) used in a coordinated multipoint transmission and reception (CoMP) system is disclosed. The communications method comprises transmitting, to a user equipment (UE), attributers for up to four indicators indicating at least physical downlink shared channel (PDSCH) resource element (RE) mapping, and transmitting, to the UE, one of the four indicators, each of which is conveyed in 2 bits, wherein the four indicators comprises ‘00’, ‘01’, ‘10’, and ‘11’ corresponding to a first set, a second set, a third set, and a fourth set of parameters, respectively. Other methods, apparatuses, and systems are also disclosed.




rd

Method and apparatus for measurement for inter-cell interference coordination in radio communication system

A wireless communication system and, more specifically, a measurement method and apparatus for inter-cell interference coordination in a wireless communication system are disclosed. Herein, a method for supporting measurement of a User Equipment (UE) by a first base station in a wireless communication system includes the steps of acquiring information of downlink subframe configuration of a second base station, determining measurement objects of downlink resource of the first base station based on the downlink subframe configuration of the second base station; transmitting information of the measurement objects to the UE, and receiving measurement result for the measurement objects from the UE.




rd

Treadle-drive eccentric wheel transmission wheel series with periodically varied speed ratio and having inward packing auxiliary wheel

In the present invention, one or both of an active wheel or a passive wheel is composed of an eccentric transmission wheel and is combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle, and random inward packing is performed to the transmission belt (100) of the engage end of the eccentric passive wheel (413) during the transmission for stabling the operation.




rd

Nonhuman mammal whose mtDNA is from a nonhuman mammal resistant to a selected disease or disorder and whose nDNA is from a nonhuman donor mammal more susceptible to the selected disease or disorder

Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.




rd

Method for making circuit board

A method for making a circuit board includes separating a plurality of versatile circuit boards from a collective board by cutting a connecting portion of the collective board, the plurality of versatile circuit boards being connected each other via the connecting portion, and cutting a part of a wiring formed on each of the plurality of versatile circuit boards to produce the circuit board. The cutting of the part of the wiring is conducted within the separating of the plurality of versatile circuit boards.




rd

Optical transceiver having an extra area in circuit board for mounting electronic circuits

An optical transceiver of one embodiment includes a transmitter optical subassembly to transmit an optical signal, a receiver optical subassembly to receive an optical signal, a mother board, a daughter board, and a housing. The mother board mounts electronic circuits that electrically communicate with the optical transmitter optical subassembly and the receiver optical subassembly. The daughter board mounts other electronic circuits that electrically communicate with the optical transmitter optical subassembly and the receiver optical subassembly. The daughter board has an extra area mounting a portion of the other electronic circuits. The housing defines a space for installing the optical transmitter optical subassembly, the receiver optical subassembly, the mother board, and the daughter board. The extra area is disposed outside the space.




rd

Super-hard cutter inserts and tools

A cutter insert assembly for a drill bit for boring into the earth, comprising a super-hard structure clampable to a support body by means of a clamp mechanism; the clamp mechanism comprising opposed or opposable compression members connected or connectable by a tension member capable of sustaining a clamping force between the compression members when the cutter insert assembly is in a clamped condition, in which condition the compression members exert opposing compressive forces on the super-hard structure and the support body, operable to clamp the super-hard structure to the support body, and in which condition the cutter insert assembly is self-supporting and capable of being mounted onto a drill bit body.




rd

Device for recording biometric data

The invention refers to a device for recording biometric data, such as lines of finger or hand. A rest is provided on the device for the hand and finger, respectively, as well as an illuminating unit. According to the invention an illuminating unit and/or rest is provided that can traverse and be positioned.




rd

Three-dimensional coordinate scanner and method of operation

A noncontact optical three-dimensional measuring device that includes a projector, a first camera, and a second camera; a processor electrically coupled to the projector, the first camera and the second camera; and computer readable media which, when executed by the processor, causes the first digital signal to be collected at a first time and the second digital signal to be collected at a second time different than the first time and determines three-dimensional coordinates of a first point on the surface based at least in part on the first digital signal and the first distance and determines three-dimensional coordinates of a second point on the surface based at least in part on the second digital signal and the second distance.




rd

Printed circuit board

A power source circuit includes a switching circuit 4 that converts a direct current voltage obtained by converting an alternating voltage from an alternating power source input through a pair of power supply lines 2 and 3 into a predetermined direct current voltage by a switching operation. A fuse 5 is provided on one power supply line 2. A series circuit 9 including a first line bypass capacitor 7 and a resistor element 8 is connected between one power supply line 2 and a ground 6. A second line bypass capacitor 10 is connected between the other power supply line 3 and the ground 6. Imbalance of the circuit by an excess current protection element is prevented to reduce common mode noise.




rd

Low forward voltage rectifier using capacitive current splitting

A Low Forward Voltage Rectifier (LFVR) circuit includes a bipolar transistor, a parallel diode, and a capacitive current splitting network. The LFVR circuit, when it is performing a rectifying function, conducts the forward current from a first node to a second node provided that the voltage from the first node to the second node is adequately positive. The capacitive current splitting network causes a portion of the forward current to be a base current of the bipolar transistor, thereby biasing the transistor so that the forward current experiences a low forward voltage drop across the transistor. The LFVR circuit sees use in as a rectifier in many different types of switching power converters, including in flyback, Cuk, SEPIC, boost, buck-boost, PFC, half-bridge resonant, and full-bridge resonant converters. Due to the low forward voltage drop across the LFVR, converter efficiency is improved.




rd

Glass for magnetic recording medium substrate and usage thereof

An aspect of the present invention relates to glass for a magnetic recording medium substrate, which includes essential components in the form of SiO2, Li2O, Na2O, and one or more alkaline earth metal oxides selected from the group consisting of MgO, CaO, SrO, and BaO, wherein a molar ratio of a content of MgO to a combined content of MgO, CaO, SrO, and BaO (MgO/(MgO+CaO+SrO+BaO)) is equal to or greater than 0.80, and which has a Young's modulus of equal to or greater than 80 GPa, and a glass transition temperature of equal to or greater than 620° C.




rd

Interfering near field transducer having a wide metal bar feature for energy assisted magnetic recording

An apparatus for energy assisted magnetic recording of a storage disk include a plurality of dielectric waveguide cores configured to direct received incident light energy to a target, and a near field transducer (NFT) configured to focus light energy received from the plurality of waveguide cores and to transmit the focused light energy onto the storage disk surface to generate a heating spot on the storage disk. The NFT includes a plurality of propagating surface plasmon polariton (PSPP) elements that are energized by the light energy from the waveguide cores. Each of the PSPP elements has a plasmonic metal bar disposed above a single waveguide core in a longitudinal alignment. Each metal bar has a width at least twice the width of the heating spot generated on the storage disk.




rd

Thermally assisted magnetic recording medium and magnetic recording and reproducing apparatus

A thermally assisted magnetic recording medium (1) includes a substrate (101), an underlayer (3) that is formed above the substrate (101), and a magnetic layer (107) that is formed on the underlayer (3) and contains an alloy having an L10 structure as a main component. The underlayer (3) is formed by continuously laminating a first underlayer (104) having a BCC structure with a lattice constant that is 0.302 to 0.332 nm, a second underlayer (105) that has a NaCl structure including C, and a third underlayer (106) that is composed of MgO.




rd

Optical recording and reading method, optical recording and reading apparatus, optical recording medium, and method for producing an optical recording medium

An optical recording medium includes a recording and reading layer that is previously staked or formed afterword and has no concavo-convex pattern for tracking control, and a servo layer in which a concavo-convex pattern or a groove for tracking control is formed. Information can be recorded in the recording and reading layer while tracking is performed using the servo layer.




rd

Optical recording medium

The present technology relates to an optical recording medium for realizing an optical recording medium capable of high-capacity recording. A groove and a land are formed, the groove being concave and the land being convex when seen from a side of a laser light incident surface, both of the groove and the land being recording tracks where recording or reproduction of information is performed. According to this recording layer, a pitch between the groove and the land that are adjacent recording tracks is within a range of 250 nm to 200 nm. Moreover, recording or reproduction of information is performed with respect to the recording tracks by irradiation of laser light whose wavelength is 400 nm to 415 nm by an optical system whose NA is 0.85±0.1.




rd

Thermally-assisted magnetic recording head having a plasmon generator

A return path section includes first and second yoke portions and first, second and third columnar portions. The first and second yoke portions and the first columnar portion are located on the same side in the direction of travel of the recording medium relative to a wave guide core. The second and third columnar portions are located on opposite sides of a plasmon generator and connected to a shield. The first yoke portion connects a main pole to the first columnar portion. The second yoke portion connects the first columnar portion to the second and third columnar portions. A coil is wound around the first columnar portion.




rd

Magnetic recording head and disk device including the same

A recording head for recording information on a rotating recording medium of a storage device includes a main magnetic pole which generates a recording magnetic field in a direction perpendicular to a recording medium facing surface of the magnetic recording head, and a light generating element which is provided on a leading side of the main magnetic pole, and generates light for heating the recording layer of the recording medium. The main magnetic pole includes an end surface facing the light generating element that is inclined with respect to the direction perpendicular to the recording medium facing surface toward the light generating element.




rd

Heat-dissipating stepped slider for a heat-assisted magnetic recording head

In a heat-assisted magnetic recording (HAMR) hard disk drive, a heat-dissipating head slider assembly is described in which the slider is stepped on the disk-opposing side and a HAMR laser module is mounted on the lower surface to assist with dissipation of heat from the laser. The lower surface is a surface of the main body of the slider and is composed primarily of a first material, and the slider may include a heat-dissipating plate that forms the higher stepped surface, where the plate is composed of a second material that has a higher thermal conductivity than the first material, such as silicon.




rd

Optical information recording and reproducing method and device

Disclosed is an optical information recording and reproducing device capable of recording an interference fringe pattern as a hologram in an optical information recording medium, the interference fringe pattern being formed by a signal beam superimposed with signal information and a reference beam, and also capable of reproducing the signal information from the optical information recording medium, the device having a light source unit to emit light, a light splitting unit to split the light into the reference beam and the signal beam, a spatial light modulation unit to superimpose the signal information on the signal light, and a light detection unit to detect an image reproduced by the reference beam, wherein information about defects on the spatial light modulation unit is recorded in the optical information recording medium.




rd

Heat assisted magnetic recording device with pre-heated write element

An apparatus includes a write element configured to apply a magnetic field to write data on a portion of a heat-assisted magnetic recording media in response to an energizing current. An energy source is configured to heat the portion of the media being magnetized by the write element. A preheat energizing current is applied to the write element during an interval before writing the data to the portion of the media. The preheat energizing current does not cause data to be written to the media and brings at least one of the write element and driver circuitry into thermal equilibrium prior to writing the data on the portion.




rd

Multilayer optical recording medium, drive device, reproducing and recording apparatus, and inspection method for multilayer optical recording medium

According to one embodiment, a multilayer optical recording medium including a substrate, a guide layer group that is provided on the substrate and has guide layers in which positional information in a radial direction is recorded, and a recording layer group that is provided on the substrate and has recording layers in which information can be recorded. In the recording layer group, positional information of the recording layers associated with the positional information recorded in the guide layers and control information of the optical device where reflected light volumes of the laser beams on the guide layers and the recording layers become maximum at the positions in the radial direction are recorded at the positions in the radial direction of the recording layers.




rd

Optical disc with pre-recorded and recordable regions and method of forming the disc

An optical disc having a region with pre-recorded data and a recordable region, a method of fabricating the disc, a stamper for forming a disc master, and a recording device for use with the disc are disclosed. Data recorded in the recordable region may be used for activation of the disc, providing unique identification or enhancing program content on the disc.




rd

Self-controlled laser pulsing for thermally assisted recording

A method of storing data includes providing a write signal for a write head of a hard disk drive, generating a transition pulse signal derived from the write signal using a transition pulse generator, and generating a logic signal to drive a thermal source associated with the write head of the hard disk drive. The logic signal includes the logical summation of a cyclical base pulse signal and the transition pulse signal.




rd

Thermally conductive features for a heat-assisted magnetic recording head

In a heat-assisted magnetic recording hard disk drive, one or more thermally conductive features are incorporated to assist with dissipation of heat from a laser module that comprises a laser and a submount. The submount may be coupled to the slider with solder covering a wider adhesive area for enhanced conduction of heat away from the laser module and to the slider, one or both of the submount and the laser may include a surface coating that increases the thermal radiation of the corresponding component, and/or one or both of the submount and the laser may include fins configured to transfer heat from the corresponding component. Further, a HAMR HGA may be configured such that the submount is coupled directly to the suspension flexure using a thermally conductive material, for conduction of heat away from the laser module and to the flexure.




rd

Optical recording method, optical recording medium, optical recording medium recording apparatus, optical recording apparatus, optical disk, and optical disk recording/reproducing apparatus

A mark having a length nT (n being an integer equal to or greater than 3 and T being a clock period) is formed by modulating irradiation laser power with three values of recording power Pw, erase power Pe, and bias power Pb (Pw>Pe>Pb). Constant strength periods (At) of the recording power Pw are set as AtT, A1T, . . . , and AmT and constant strength periods (B) of the bias power Pb are set as BtT, B1T, . . . , BmT, and CT (C=−1 to 3). The application of laser is divided into pulses in order of AtT, BtT, A1T, B1T, . . . , AmT, BmT, and CT (m=(n−k)/2, k=3 (if n is an odd number), or k=4 (if n is an even number)). (Here, the constant strength period of the recording power Pw for n=3, n=4, n≧5 (odd number), and n≧6 (even number) is set as At3, At4, Atod, and Atev, the constant strength period of the bias power Pb for n=3, n=4, n≧5 (odd number), and n≧6 (even number) is set as Bt3, Bt4, Btod, and Btev, and then, At3+Bt3=Atod+Btod=Am+Bm=2T and At4+Bt4=Atev+Btev=3T).




rd

Optical information recording device and method

In an optical information recording device and optical information recording method for angularly multiplexing and recording data on pages on the same recording region on a hologram disk, data on each page is sequentially generated by sequentially dividing input data in predetermined units, the pages to be recorded on the same recording region are divided into page groups so that pages to be recorded adjacently by the angular multiplexing may not belong to the same group, each page group is individually subjected to inter-page coding processing for computing an error-correcting code and adding the computed error-correcting code, and data on the pages subjected to the inter-page coding processing is angularly multiplexed and recorded on the hologram disk.




rd

Optical disc with pre-recorded and recordable regions and method of forming the disc

An optical disc having a region with pre-recorded data and a recordable region, a method of fabricating the disc, a stamper for forming a disc master, and a recording device for use with the disc are disclosed. Data recorded in the recordable region may be used for activation of the disc, providing unique identification or enhancing program content on the disc.




rd

Method and apparatus for laser control during recording

The invention relates to recording on a medium, and in particular, to laser control during recording data on an optical medium. A laser control method for dynamically adjusting laser power during recording data onto an optical disc comprises: recording normal data onto the optical disc according to an initial laser power; stopping recording when a trigger is generated; reading back the recorded normal data and generating a first recording quality index; recording a test pattern at a test pattern starting point according to a selected laser power; reading back the test pattern and generating a second recording quality index; and determining an adaptive laser power to continually record the normal data according to the first recording quality index and the second recording quality index.




rd

Information storage medium, reproducing method, and recording method

A machine readable information storage medium, a reproducing method and apparatus which reproduces data from the storage medium, and a recording method and apparatus for recording data on the storage medium. The information storage medium includes a control area which stores within a data structure information usable by the recording or reproducing apparatus to record or reproduce the data on or from the storage medium. The information stored within the data structure includes a version corresponding to a specification.




rd

Method for restoring activity to a spent hydroprocessing catalyst, a spent hydroprocessing catalyst having restored catalytic activity, and a hyrdoprocessing process

A regenerated spent hydroprocessing catalyst treated with a chelating agent and having incorporated therein a polar additive.




rd

Cardanol derivatives in polyester toner resins

The present disclosure provides a polyester toner resin comprising a polyhydroxylated cardanol derivative, that may be used in manufacturing an emulsion aggregation (EA) toner for imaging devices.




rd

Clean generation of a fluoroaryl grignard reagent

Fluoroaryl Grignard reagents are produced from a hydrocarbyl Grignard reagent and fluoroaromatic compounds via separate additions of different fluoroaromatic compounds, such that the conversion of hydrocarbyl Grignard reagent to the desired fluoroaryl Grignard reagent is essentially complete, and thus the reaction product is free or essentially free of agents that may negatively affect subsequent reactions. The fluoroaryl Grignard reagents may be further reacted with boron trihalides in order to obtain tris(fluoroaryl)boranes or tetrakis(fluoroaryl)borates.




rd

Method and device for actuating a key of a keyboard with a tracer finger of a robot

There is provided a method for actuating a first key of a keyboard with a tracer finger of a robot. An exemplary method comprises acquiring parameters of the keyboard and determining a position of the first key as a function of the acquired parameters using a model of the keyboard. The exemplary method also comprises guiding the tracer finger of the robot to the determined position of the first key. The exemplary method additionally comprises actuating the first key with the tracer finger of the robot.




rd

Azo compound, ink composition, recording method and colored material

A coloring matter which exhibits excellent (ozone) gas resistance, high print density, low color rendering properties, low color saturation, and high-quality black hue when is recorded on a paper only for inkjet exclusive use, i.e., an azo compound represented by formula (1), a tautomer of the azo compound, or a salt of the azo compound or the tautomer; and an ink composition containing the coloring matter, particularly a black ink composition for inkjet recording applications.




rd

Tricarbonyl complexes with tridentate chelators for myocardium imaging

Chelators of the formulae (I), (II) and (III) and tricarbonyl complexes of radioisotopes of Tc and Re bound to them, for use in myocardial imaging.




rd

Series reminders and series recording from an interactive television program guide

An interactive television program guide system with program series reminder and recording capabilities is provided. The system allows a user to set a reminder or schedule a recording for a single episode or for each episode of a program series. In addition, other options may be provided that allow the user to determine, for example, whether to schedule reminders/recordings for episodes on all channels on which the program airs or only on a selected channels, whether to schedule reminders/recordings for all episodes including reruns or only new episodes, whether to schedule reminders/recordings for network or syndicated episodes, and whether to schedule reminders/recordings for episodes on all days or only on selected days of the week. Before the scheduled broadcast time of each episode of each selected program series, the system sends a reminder message to the user that reminds the user of the program episode or sends a record command to a videocassette recorder to initiate recording of the episode. The system allows a user to view a list of all currently requested program reminders and scheduled program recordings. The user may update, change, or cancel any entry in either list or the system may automatically update the lists to match new broadcast schedule information. If the user sets a reminder or schedules a recording that conflicts with an existing reminder or recording, the system may inform the user of the conflict and allow the user to resolve the conflict or the system may resolve the conflict.




rd

Systems and methods for prioritization of data for intelligent discard in a communication network

Systems and methods for optimizing system performance of capacity and spectrum constrained, multiple-access communication systems by selectively discarding packets are provided. The systems and methods provided herein can drive changes in the communication system using control responses. One such control responses includes the optimal discard (also referred to herein as “intelligent discard”) of network packets under capacity constrained conditions. Some embodiments inspect a video stream to determine priorities for various elements of the video stream. The elements may be discarding using the priorities. In various embodiments, the elements include frames, slices, macroblocks, and data partitions.




rd

Method and apparatus for extracting advertisement keywords in association with situations of video scenes

A method and apparatus for extracting advertisement keywords in association with situations of scenes of video include: establishing a knowledge database including a classification hierarchy for classifying situations of scenes of video and an advertisement keyword list, segmenting a video script corresponding to a received video in units of scenes, and determining a situation corresponding to each scene with reference to the knowledge database, and extracting an advertisement keyword corresponding to the situation of a scene of the received video with reference to the knowledge database.




rd

Thumbnail generation and presentation for recorded TV programs

Thumbnail images representative of recorded TV programs are generated and presented to aid a user in browsing the recorded TV programs. In one implementation, a temporary thumbnail image is generated when a TV program first starts recording. The temporary thumbnail is used to populate any user interface (UI) screens that reference the recoded TV program. Once the TV program has reached a threshold amount of recording (e.g., a prescribed duration of recording, or completion of the recording), a permanent thumbnail image is generated and associated with the TV program. The permanent thumbnail is then presented in any subsequent UI screens, replacing the temporary thumbnail. In another implementation, display of the thumbnail images in the UI screens may be further controlled by setting preferences, such as parental controls.




rd

Magnetic recording medium and magnetic recording and reproducing apparatus

A perpendicular magnetic recording medium of the present invention comprises a non-magnetic substrate, and at least a backing layer, an under layer, an intermediate layer and a perpendicular magnetic recording layer, which are sequentially laminated on the non-magnetic substrate, wherein the backing layer is formed of a soft magnetic film having an amorphous structure, the under layer contains a NiW alloy containing any one or both of Co and Fe, the W content of the NiW alloy is within a range from 3 to 10 atom %, the total of the Co and Fe contents of the NiW alloy is 5 atom % or more and less than 40 atom %, the saturation magnetic flux density Bs of the NiW alloy is 280 emu/cm3 or more, the thickness of the under layer is within a range from 2 to 20 nm, and the intermediate layer contains Ru or a Ru alloy.




rd

Perpendicular magnetic recording disk with multiple magnetic layers and intermediate dual nucleation films for control of grain size

A perpendicular magnetic recording disk has a graded-anisotropy recording layer (RL) formed of at least two ferromagnetically exchange coupled CoPtCr-oxide magnetic layers (MAG1 and MAG2) with two nucleation films (NF1 and NF2) between the magnetic layers. NF1 is a metal film, preferably Ru or a Ru-based alloy like RuCr, sputter deposited on MAG1 at low pressure to a thickness between about 0.1-1.5 nm. NF2 is a metal oxide film, preferably an oxide of Ta, sputter deposited on NF1 at high pressure to a thickness between about 0.2-1.0 nm. MAG2 is sputter deposited over NF2. NF1 and NF2 provide a significant reduction in average grain size in the RL from a graded-anisotropy RL without nucleation films between MAG1 and MAG2, while also assuring that MAG1 and MAG2 are strongly exchange coupled.




rd

Methods for inhibiting lymphotoxin-β receptor signaling in TH1 cell-associated disorders

This invention relates to compositions and methods comprising “lymphotoxin-β-receptor blocking agents”, which block lymphotoxin-β receptor signalling. Lymphotoxin-β receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This invention relates to soluble forms of the lymphotoxin-β receptor extracellular domain that act as lymphotoxin-β receptor blocking agents. This invention also relates to the use of antibodies directed against either the lymphotoxin-β receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-β receptor blocking agents. A novel screening method for selecting soluble receptors, antibodies and other agents that block LT-β receptor signalling is provided.




rd

Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders

Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.




rd

Cardioprotective effects of GHRH agonists

Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 μg/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression. The receptor for GHRH was detectable on myocytes supporting direct activation of cardiac signal transduction. Collectively, these findings demonstrate that within the heart GHRH-agonists can activate cardiac repair following MI, suggesting the existence of a potential signaling pathway based on GHRH in the heart. The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications.




rd

Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.