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The Muscles and the Flesh, Part 2 A




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The Muscles and the Flesh, Part 2 B




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Singer Avraham Tal releases music video post-ZAKA trauma retreat






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How the NY Public Library acquired a ‘treasure trove’ of Jewish and Yiddish music


Netsky said he thinks the Yiddish theater music in the archive files is particularly valuable because it was maligned by the classical composers as shund (trash) and neglected.




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Meet the medic who understood on Oct. 7 she must do everything to save a child


Dispatch teams gave hotline callers life-saving medical treatment advice over the phone on October 7. One such woman told children where to hide from terrorists.





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Trump names Musk, Ramaswamy to lead newly formed gov't department


Trump said their work would conclude by July 4, 2026, adding that a smaller government would be a "gift" to the country on the 250th anniversary of the signing of the Declaration of Independence.






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Sullivan: World must pressure Hamas to negotiate hostage deal


Sullivan laid the blame squarely on Hamas, clarifying that the issue was that the group simply didn’t want to make a deal under any terms.




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Turkey’s Erdogan calls on Muslim world to boycott, end trade with Israel


Erdogan urged Muslim nations at an Arab League summit in Saudi Arabia to unite against Israel




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Tyrannosaurus Rex of London's Natural History Museum, a model like no other

Tyrannosaurus Rex of London's Natural History Museum, a model like no other




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Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency

Trump says Musk, Ramaswamy will form outside group to advise White House on government efficiency




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Civil society coalition says heads must roll over Terbufos poisoning deaths

Inadequate controls on hazardous chemicals contributed to the death of the six children in Soweto



  • National
  • Child Pesticide Poisoning
  • Corporate Capture Pesticides
  • Highly Hazardous Pesticides
  • news
  • Organophosphate Pesticide Dangers
  • Pesticide ban South Africa
  • Pesticide deaths in South Africa
  • Pesticide Laws South Africa
  • Pesticide Reform South Africa
  • Pesticide safety regulations Agrochemical Poisoning
  • Regulatory failure South Africa
  • South Africa pesticide regulations
  • Soweto pesticide deaths
  • Street Pesticides
  • Terbufos poisoning
  • Toxic Chemicals in Agriculture
  • Toxic pesticide South Africa

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Chloe Fineman says Elon Musk brought her to tears while on 'SNL'

Chloe Fineman named 'SNL' host that made cast cry on the comedy sketch show. Chloe Fineman has recently come out and called the businessman Elon Musk for his time hosting on Saturday Night Live . In a now deleted TikTok video, the American actress claimed that the Tesla CEO made cast...




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Chickens as Well as Cheetahs: Biodiversity Conservation Must Also Include Livestock

As the UN’s COP16 biodiversity conference continues, the temptation is to focus on the wild flora and fauna under threat. But there is another, less obvious yet just as critical biodiversity crisis unfolding around the world that also deserves attention. A quarter of livestock breeds – from chickens, ducks and geese to horses, camels and […]




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UNEP: Nations Must Step Up Adaptation—Starting with Bold Finance Action at COP 29

The United Nations Environment Programme’s (UNEP) 2024 Adaptation Gap Report has warned that adaptation actions are not keeping pace with the surging demands of a warming planet. Released ahead of the COP29 climate conference in Baku, Azerbaijan, the report—titled Come Hell and High Water—projected a bleak future where vulnerable communities bear the brunt of climate-induced hardships.  […]




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Trump 2.0: Elon Musk and anti-‘woke’ Fox News host Pete Hegseth nominated for key posts

U.S. President-elect Donald Trump on Tuesday named Elon Musk to a role aimed at creating a more efficient government, handing even more influence to the world’s richest man who donated millions of dollars to helping Trump get elected. Pete Hegseth, a Fox News commentator and veteran has been picked for the post of secretary of state. […]





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to wire a manual fan switch on a 2000 mustang

to wire a manual fan switch on a 2000 mustang




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New Scientist recommends eight-legged musical instrument Sonic Spider

The books, TV, games and more that New Scientist staff have enjoyed this week




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Dinosaurs may have run like emus by keeping one foot on the ground

It seems to be more energy efficient for emus to keep one foot on the ground when running at a moderate pace, and the same may have been true for dinosaurs




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Epic images show old mines transformed into a library, lab and museum

Amazing images of an open-air library, underground lab and design museum show the reincarnation of dead mines, captured in a new book, 102 Things to Do With a Hole in the Ground




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Long-Term Exercise Can Reduce Vets' Muscle Pain

Title: Long-Term Exercise Can Reduce Vets' Muscle Pain
Category: Health News
Created: 8/26/2010 6:10:00 PM
Last Editorial Review: 8/27/2010 12:00:00 AM




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Mellow Music May Help Stave Off Road Rage

Title: Mellow Music May Help Stave Off Road Rage
Category: Health News
Created: 8/30/2013 9:35:00 AM
Last Editorial Review: 8/30/2013 12:00:00 AM




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Health Tip: Did You Bruise a Muscle?

Title: Health Tip: Did You Bruise a Muscle?
Category: Health News
Created: 8/26/2014 7:35:00 AM
Last Editorial Review: 8/26/2014 12:00:00 AM




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Music Therapy Helps Preemie Babies Thrive

Title: Music Therapy Helps Preemie Babies Thrive
Category: Health News
Created: 8/25/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM




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Federal Prisons Must Now Make Free Tampons, Pads Available

Title: Federal Prisons Must Now Make Free Tampons, Pads Available
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM




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Drug for Spinal Muscular Atrophy May Help Older Children: Study

Title: Drug for Spinal Muscular Atrophy May Help Older Children: Study
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM




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Gene 'Editing' in Dog Study Shows Promise for Kids With Muscular Dystrophy

Title: Gene 'Editing' in Dog Study Shows Promise for Kids With Muscular Dystrophy
Category: Health News
Created: 8/30/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM




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For Muslim Pilgrimage, Climate Change Poses Health Risks

Title: For Muslim Pilgrimage, Climate Change Poses Health Risks
Category: Health News
Created: 8/28/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM




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Hospitals Must Report COVID-19 Data or Be Penalized

Title: Hospitals Must Report COVID-19 Data or Be Penalized
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM




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Pentagon Says Troops Must Start Lining Up Now for COVID Shots

Title: Pentagon Says Troops Must Start Lining Up Now for COVID Shots
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM




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Are Green Mussels Good for You?

Title: Are Green Mussels Good for You?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM




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3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis

Title: 3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM




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Magic Mushroom Hallucinogen May Treat Problem Drinking

Title: Magic Mushroom Hallucinogen May Treat Problem Drinking
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM




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Want to Maintain Muscle? Frequency of Workouts Is Key

Title: Want to Maintain Muscle? Frequency of Workouts Is Key
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM




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'Virtual' Museum Visits Are Good Medicine for Seniors

Title: 'Virtual' Museum Visits Are Good Medicine for Seniors
Category: Health News
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM




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Family Medicine Must Prepare for Artificial Intelligence

Artificial Intelligence (AI) is poised to revolutionize family medicine, offering a transformative approach to achieving the Quintuple Aim. This article examines the imperative for family medicine to adapt to the rapidly evolving field of AI, with an emphasis on its integration in clinical practice. AI's recent advancements have the potential to significantly transform health care. We argue for the proactive engagement of family medicine in directing AI technologies toward enhancing the "Quintuple Aim."

The article highlights potential benefits of AI, such as improved patient outcomes through enhanced diagnostic tools, clinician well-being through reduced administrative burdens, and the promotion of health equity by analyzing diverse data sets. However, we also acknowledge the risks associated with AI, including the potential for automation to diverge from patient-centered care and exacerbate health care disparities. Our recommendations stress the need for family medicine education to incorporate AI literacy, the development of a collaborative for AI integration, and the establishment of guidelines and standards through interdisciplinary cooperation. We conclude that although AI poses challenges, its responsible and ethical implementation can revolutionize family medicine, optimizing patient care and enhancing the role of clinicians in a technology-driven future.




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Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors [Metabolism, Transport, and Pharmacogenetics]

Glioblastoma (GBM) is a disease of the whole brain, with infiltrative tumor cells protected by an intact blood-brain barrier (BBB). GBM has a poor prognosis despite aggressive treatment, in part due to the lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance. Various DDR inhibitors, targeting the key regulators of these pathways such as ataxia telangiectasia mutated and Rad3-related (ATR), are being explored as radio- and chemosensitizers. Elimusertib, a novel ATR kinase inhibitor, can prevent repair of damaged DNA, increasing efficacy of DNA-damaging cytotoxic therapies. Robust synergy was observed in vitro when elimusertib was combined with the DNA-damaging agent temozolomide; however, we did not observe improvement with this combination in in vivo efficacy studies in GBM orthotopic tumor-bearing mice. This in vitro–in vivo disconnect was explored to understand factors influencing central nervous system (CNS) distribution of elimusertib and reasons for lack of efficacy. We observed that elimusertib is rapidly cleared from systemic circulation in mice and would not maintain adequate exposure in the CNS for efficacious combination therapy with temozolomide. CNS distribution of elimusertib is partially limited by P-glycoprotein efflux at the BBB, and high binding to CNS tissues leads to low levels of pharmacologically active (unbound) drug in the brain. Acknowledging the potential for interspecies differences in pharmacokinetics, these data suggest that clinical translation of elimusertib in combination with temozolomide for treatment of GBM may be limited.

SIGNIFICANCE STATEMENT

This study examined the disconnect between the in vitro synergy and in vivo efficacy of elimusertib/temozolomide combination therapy by exploring systemic and central nervous system (CNS) distributional pharmacokinetics. Results indicate that the lack of improvement in in vivo efficacy in glioblastoma (GBM) patient-derived xenograft (PDX) models could be attributed to inadequate exposure of pharmacologically active drug concentrations in the CNS. These observations can guide further exploration of elimusertib for the treatment of GBM or other CNS tumors.




mus

Sarwar: Scottish Government must follow Chancellor and extend rates relief

Ministers must follow the UK Government and extend rates relief for businesses in Scotland, Anas Sarwar has said.




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RPG Cast – Episode 612: “He Must Have Put Skill Points Into Broom Handle”

Josh demands justice for Jorts. Chris is deployed to the circus wars. And Kelley assures us that Fang sniper is real. We'll see you in 2022. Don't butter your cats!

The post RPG Cast – Episode 612: “He Must Have Put Skill Points Into Broom Handle” appeared first on RPGamer.




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Musical chairs on Virgin board

Richard Branson’s Virgin Group has swapped out its envoy on Virgin Australia’s board, putting in Warwick Negus.




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Man accused of killing Muslim teen indicted on capital murder charges

An attendee leaves flowers for Nabra Hassanen, a teenage Muslim girl killed by a bat-wielding motorist near a Virginia mosque, during a vigil in New York City. Photo by Brendan McDermid/Reuters

A grand jury has formally charged a 22-year-old man with capital murder and rape in the death of Nabra Hassanen, who was killed on her walk back to a Virginia mosque.

The Fairfax County Circuit Court indicted Darwin Martinez-Torres of Sterling, Virginia, on Monday on four counts of capital murder for killing Nabra, who was with friends while they had a meal before Ramadan services. Dozens of people had gathered outside the courthouse today, chanting “Justice for Nabra.”

Virginia law has specific conditions for pursuing the death penalty, but the Associated Press reported that the grand jury’s indictment described in graphic detail how Nabra’s killing was grounds for a death penalty against Martinez-Torres. The indictment appears to acknowledge for the first time that the 17-year-old Muslim teen was raped. Under state law, the combination of a rape charge with a premeditated murder charge means the death penalty can be pursued.

Police have said that Martinez-Torres, who is an undocumented immigrant, got into a confrontation on June 18 with a group of teens walking back to the All Dulles Area Muslim Society after grabbing a late meal. He is accused of returning later and beating Nabra with a baseball bat. Police said Nabra’s body was later discovered in a pond. A search warrant affidavit revealed that Martinez-Torres admitted to killing Nabra and had led authorities to where he dumped her body, AP reported.

Nabra’s parents and Muslim advocates have said that Nabra’s death was motivated by hate, but police has said that they will not treat the killing as a hate crime. Instead, police have said it was a road rage incident.

“The reason this guy he hit my daughter is because she’s Muslim,” Nabra’s father Mahmoud Hassanen told WAMU. “Why [didn’t he] hit the boy who bothered him?”

Nabra’s father added that he hoped for the death penalty, while her mother said she wanted Martinez-Torres to serve life in prison.

“I just want people to remember her, and don’t forget her,” Mahmoud told WAMU. “I think nobody can forget her too, for what she did in her life.”

A preliminary hearing for Martinez-Torres reportedly turned emotional on Friday, with Nabra’s parents both shouting at the suspect in court. Nabra’s mother Sawsan Gazzar apparently threw a shoe at Martinez-Torres during the proceedings.

READ MORE: D.C. memorial for slain Muslim teen was set on fire, officials say

The post Man accused of killing Muslim teen indicted on capital murder charges appeared first on PBS NewsHour.




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Elon Musk's Tesla Cybercab is a hollow promise of a robotaxi future

Autonomous taxis are already operating on US streets, while Elon Musk has spent years promising a self-driving car and failing to deliver. The newly announced Tesla Cybercab is unlikely to change that




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Musical AI harmonises with your voice in a transcendent new exhibition

What happens if AI is trained to write choral music by feeding it a specially created vocal dataset? Moving new exhibition The Call tackles some thorny questions about AI and creativity – and stirs the soul with music





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Musk Backs Scott After Calling Thune 'Top Choice of Democrats'

Elon Musk has joined the chorus of conservative and MAGA voices online backing Sen. Rick Scott (R-Fla.) for Senate GOP leader - after calling Sen. John Thune (R-S.D.) the "top choice of Democrats."




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It's PS5's birthday - here's the five best games you must play on Sony's latest console



Just got a PS5 or want to know what to prioritise in your backlog? We've got you covered with the best PlayStation 5 games for your console that you can play right now.




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Trump appoints Musk, Ramaswamy to lead Department of Government Efficiency

President-elect Donald Trump on Tuesday announced that Tesla founder Elon Musk and businessman Vivek Ramaswamy will a new Department of Government Efficiency, a White House office given the task of cutting the federal budget.