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velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ

velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ




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AT#505 - Travel to Mozambique

Hear about travel to Mozambique as the Amateur Traveler talks to Simon Lewis from TarvelConceptSolution.com about this long thin country in Southeastern Africa.




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Zinc promotes liquid-liquid phase separation of tau protein [Protein Structure and Folding]

Tau is a microtubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies. Recent reports indicate that, in the presence of crowding agents, tau can undergo liquid–liquid phase separation (LLPS), forming highly dynamic liquid droplets. Here, using recombinantly expressed proteins, turbidimetry, fluorescence microscopy imaging, and fluorescence recovery after photobleaching (FRAP) assays, we show that the divalent transition metal zinc strongly promotes this process, shifting the equilibrium phase boundary to lower protein or crowding agent concentrations. We observed no tau LLPS-promoting effect for any other divalent transition metal ions tested, including Mn2+, Fe2+, Co2+, Ni2+, and Cu2+. We also demonstrate that multiple zinc-binding sites on tau are involved in the LLPS-promoting effect and provide insights into the mechanism of this process. Zinc concentration is highly elevated in AD brains, and this metal ion is believed to be an important player in the pathogenesis of this disease. Thus, the present findings bring a new dimension to understanding the relationship between zinc homeostasis and the pathogenic process in AD and related neurodegenerative disorders.




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The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation [DNA and Chromosomes]

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We report here that the histone H4 basic patch regulates H2Bub1. Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H42RA) exhibited a significant loss of global H2Bub1. H42RA mutant yeast strains also displayed chemotoxin sensitivities similar to, but less severe than, strains containing a complete loss of H2Bub1. We found that the H4 basic patch regulates H2Bub1 levels independently of interactions with chromatin remodelers and separately from its regulation of H3K79 methylation. To measure H2B ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool, the light-inducible nuclear exporter, to control the subcellular location of the H2Bub1 E3 ligase, Bre1. The ability of Bre1 to ubiquitylate H2B was unaffected in the H42RA mutant. In contrast, H2Bub1 deubiquitination by SAGA-associated Ubp8, but not by Ubp10, increased in the H42RA mutant. Consistent with a function for the H4 basic patch in regulating SAGA deubiquitinase activity, we also detected increased SAGA-mediated histone acetylation in H4 basic patch mutants. Our findings uncover that the H4 basic patch has a regulatory function in SAGA-mediated histone modifications.




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Cohomologie ????-adique de la tour de Drinfeld: le cas de la dimension 1

Pierre Colmez, Gabriel Dospinescu and Wiesława Nizioł
J. Amer. Math. Soc. 33 (2019), 311-362.
Abstract, references and article information




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In Vivo Identification of Human Small Ubiquitin-like Modifier Polymerization Sites by High Accuracy Mass Spectrometry and an in Vitro to in Vivo Strategy

Ivan Matic
Jan 1, 2008; 7:132-144
Research




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Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

Tamar Geiger
Mar 1, 2012; 11:M111.014050-M111.014050
Special Issue: Prospects in Space and Time




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A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Sebastian A. Wagner
Oct 1, 2011; 10:M111.013284-M111.013284
Research




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A Tandem Affinity Tag for Two-step Purification under Fully Denaturing Conditions: Application in Ubiquitin Profiling and Protein Complex Identification Combined with in vivoCross-Linking

Christian Tagwerker
Apr 1, 2006; 5:737-748
Research




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Building LGBTIQ+ Inclusivity in the Armed Forces, 20 Years After the Ban Was Lifted

16 January 2020

Will Davies

Army Chief of General Staff Research Fellow, International Security Programme
Change was slow to come but progress has since been swift. Not only can a continuing focus on inclusivity benefit service people and the organization, it is also an essential element of a values-based foreign policy.

2020-01-16-Westminster.jpg

Crew members from HMS Westminster march through Admiralty Arch as they exercise their freedom of the city in August 2019 in London. Photo: Getty Images.

The new UK government will conduct a review of foreign, security and defence policy in 2020. If the UK decides to use values as a framework for foreign policy this needs to be reflected in its armed forces. One area where this is essential is continuing to deepen inclusivity for LGBTIQ+ personnel, building on the progress made since the ban on their service was lifted in 2000.

I witnessed the ban first-hand as a young officer in the British Army in 1998. As the duty officer I visited soldiers being held in the regimental detention cells to check all was well. One day a corporal, who I knew, was there awaiting discharge from the army having been convicted of being gay. On the one hand, here was service law in action, which was officially protecting the army’s operational effectiveness and an authority not to be questioned at my level. On the other, here was an excellent soldier in a state of turmoil and public humiliation. How extreme this seems now.

On 12 January 2000 Tony Blair’s Labour government announced an immediate lifting of the ban for lesbian, gay and bisexual personnel (LGB) and introduced a new code of conduct for personal relationships. (LGB is the term used by the armed forces to describe those personnel who had been banned prior to 2000.) This followed a landmark ruling in a case taken to the European Court of Human Rights in 1999 by four LGB ex-service personnel – supported by Stonewall – who had been dismissed from service for their sexuality.

Up to that point the Ministry of Defence's long-held position had been that LGB personnel had a negative impact on the morale and cohesion of a unit and damaged operational effectiveness. Service personnel were automatically dismissed if it was discovered they were LGB, even though homosexuality had been decriminalized in the UK by 1967.

Proof that the armed forces had been lagging behind the rest of society was confirmed by the positive response to the change among service personnel, despite a handful of vocal political and military leaders who foresaw negative impacts. The noteworthy service of LGBTIQ+ people in Iraq and Afghanistan only served to debunk any residual myths.

Twenty years on, considerable progress has been made and my memories from 1998 now seem alien. This is a story to celebrate – however in the quest for greater inclusivity there is always room for improvement.

Defence Minister Johnny Mercer last week apologized following recent calls from campaign group Liberty for a fuller apology. In December 2019, the Ministry of Defence announced it was putting in place a scheme to return medals stripped from veterans upon their discharge.

The armed forces today have a range of inclusivity measures to improve workplace culture including assessments of workplace climate and diversity networks supported by champions drawn from senior leadership.

But assessing the actual lived experience for LGBTIQ+ people is challenging due to its subjectivity. This has not been helped by low participation in the 2015 initiative to encourage people to declare confidentially their sexual orientation, designed to facilitate more focused and relevant policies. As of 1 October 2019, only 20.3 per cent of regular service people had declared a sexual orientation.

A measure of positive progress is the annual Stonewall Workplace Equality Index, the definitive benchmarking tool for employers to measure their progress on LGBTIQ+ inclusion in the workplace; 2015 marked the first year in which all three services were placed in the top 100 employers in the UK and in 2019 the Royal Navy, British Army and Royal Air Force were placed 15th=, 51st= and 68th respectively.

Nevertheless, LGBTIQ+ service people and those in other protected groups still face challenges. The 2019 Ministry of Defence review of inappropriate behaviour in the armed forces, the Wigston Report, concluded there is an unacceptable level of sexual harassment, bullying and discrimination. It found that 26-36% of LGBTIQ+ service people have experienced negative comments or conduct at work because of their sexual orientation.

The Secretary of State for Defence accepted the report’s 36 recommendations on culture, incident reporting, training and a more effective complaints system. Pivotal to successful implementation will be a coherent strategy driven by fully engaged leaders.

Society is also expecting ever higher standards, particularly in public bodies. The armed forces emphasise their values and standards, including ‘respect for others’, as defining organisational characteristics; individuals are expected to live by them. Only in a genuinely inclusive environment can an individual thrive and operate confidently within a team.

The armed forces also recognize as a priority the need to connect to and reflect society more closely in order to attract and retain talent from across all of society. The armed forces’ active participation in UK Pride is helping to break down barriers in this area.

In a post-Brexit world, the UK’s values, support for human rights and reputation for fairness are distinctive strengths that can have an impact on the world stage and offer a framework for future policy. The armed forces must continue to push and promote greater inclusivity in support. When operating overseas with less liberal regimes, this will be sensitive and require careful handling; however it will be an overt manifestation of a broader policy and a way to communicate strong and consistent values over time.

The armed forces were damagingly behind the times 20 years ago. But good progress has been made since. Inclusion initiatives must continue to be pushed to bring benefits to the individual and the organization as well as demonstrate a values-based foreign policy.




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Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein

DL Brasaemle
Nov 1, 1997; 38:2249-2263
Articles




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20 Years On: Removal of the Ban on LGBTIQ+ Personnel Serving in the UK Armed Forces





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Visão embaçada e distorcida nem sempre é miopia: fique atento aos sinais do ceratocone

Aos primeiros sinais de visão embaçada, as hipóteses mais frequentes sempre são miopia, astigmatismo, hipermetropia. Mas esses sintomas podem indicar outra doença ocular chamada ceratocone - uma deformidade progressiva da córnea, que assume o formato...

The post Visão embaçada e distorcida nem sempre é miopia: fique atento aos sinais do ceratocone appeared first on Saúde Próspera.



  • Dicas de Saúde

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CBD Communiqé: Training Workshop for Government Officials in the Use of the Biosafety Clearing-House Successfully Concluded.




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CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif, à l'occasion de la Conférence de haut niveau sur « L'Union Européenne et l'Outre-Mer : Stratégies face au changement climatique et 




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CBD News: Discours de M. Ahmed Djoghlaf, Secretaire executif de la Convention sur la diversite biologique, à l'occasion de la Journee biodiversite & entreprises de l'European Platform for Biodiversity Research Strategy, Paris, France, le




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CBD News: Déclaration de M. Ahmed Djoghlaf, Secretaire executif de la Convention sur la diversite biologique, à la série de conférences: Intégrer la biodiversité dans les stratégies d'entreprise, Montréal, Qu




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CBD Communiqué: Biodiversity elevated to the Top of the G8 environmental Dialogue.




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CBD Communiqué: Visit to the Secretariat by Norwegian Delegation.




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CBD Communiqué: Expert Meeting on Mainstreaming Biodiversity in Development Cooperation concludes in Montreal.




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CBD Communiqué: Executive Secretary discusses Preparations for the Tenth Meeting of the Conference of the Parties with all Japanese Stakeholders.




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CBD Communiqué: Global Private Donor Forum on Biodiversity established in Berlin.




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CBD Communiqué: The GEF Joins Forces with the Convention for the Celebration of the United Nations International Year on Biodiversity




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CBD Communiqué: Convention on Biological Diversity Supports Green Economy Initiative

Montreal, 26 June 2009 - More than 21 United Nations agencies, including the Secretariat of the Convention on Biological Diversity, have backed the call for a world-wide transition to a low carbon, resource-efficient Green Economy able to deliver multiple economic, social and environmental opportunities in the 21st century, including halting the degradation of multi-trillion dollar ecosystem services and the underlying biodiversity.




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CBD Communiqué: Visit of the representative of the incoming President of the Nagoya Biodiversity Summit

The Secretariat of the Convention on Biological Diversity had the privilege to welcome on 9-10 July 2010 Mr. Masayoshi Mizuno, Director of the Global Environment Division of Japan's Ministry of Foreign Affairs.




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CBD Communiqué: Biodiversity Challenges and Reponses on the Agenda of the G8 Summit of L'Aquila, Italy.




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CBD Communiqué: Enhancing Montreal support to the activities of the Secretariat of the Convention on Biological Diversity.




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CBD Communiqué: South-South-Exchange Meeting on the Conservation and Sustainable Use of Forest Biodiversity.




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CBD News: Déclaration de M. Ahmed Djoghlaf, secrétaire exécutif de la Convention sur la diversité biologique, sur le thème de l'environnement, la paix et la sécurité mondiale, Alger, Algérie, Juillet, 2009.




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CBD Communiqué: Iraq becomes the 192nd Party to the Convention on Biological Diversity.




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CBD Communiqué: CBD Secretariat and the UNEP World Conservation Monitoring Centre strengthen links for the preparation of the 2010 Nagoya Biodiversity Summit.




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CBD Joint Communiqué: United Nations World Tourism Organization and the Secretariat of the Convention sign Memorandum of Cooperation.




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CBD Communiqué: International Year of Biodiversity Logo unveiled in Strömstad, Sweden.




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CBD Communiqué: Brainstorming session on Business and Biodiversity.




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CBD Communiqué: G-77 Ministers Pay Special Tribute to CBD Secretariat's Leading Role in South-South Cooperation.




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CBD News: Déclaration de M. Ahmed Djoghlaf, Secrétaire exécutif de la Convention sur la diversite biologique, à l'occasion du devoilement du logotype de l'Annee internationale de la biodiversite, 5 Octobre 2009, Nairobi, Kenya.




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CBD Communiqué: COP 10 and 2010 IYB Logos Launched in Tokyo




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CBD Communiqué: Somalia to Become the 193rd Party to the Convention on Biological Diversity.




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CBD Communique: Japan hosts International Multi-stakeholder Dialogue for COP 10




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CBD Communiqué: Liaison Group on Bushmeat concludes in Buenos Aires with Recommendations to the World Forestry Congress.




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CBD Communiqué: The Group of 77 Initiates the Preparation of a Multi-Year Plan of Action for South-South Cooperation on Biodiversity for Development.




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CBD Communiqué: India Offers to Host the Eleventh Meeting of the Conference of the Parties to the Convention on Biological Diversity in 2012




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CBD Communiqué: Aichi/Nagoya International E-Conference on the Post 2010 Biodiversity Target (ANIEC 2010).




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CBD Communiqué: Establishment of a Vibrant Partnership between the Secretariat of the Convention on Biological Diversity and the Civil Society of its Host Country: Signature of an MOU with the Canadian Environmental Network




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CBD Communiqué: 2010 International Year of Biodiversity Website launched in Montreal.




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CBD Communiqué: CBD Secretariat and the Institute of Energy and Environment of La Francophonie join Forces to Raise Awareness in French-Speaking Countries.




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CBD Communiqué: Enhancing Preparations for the Aichi-Nagoya Biodiversity Summit




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CBD Communiqué: Engaging Business in the Battle for Life on Earth.




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CBD Communiqué: Young Talent Recognised in Global Photography Competition.