Yichong Wu, Tiejun Li, Xiaoping Liu, Luonan Chen.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1269--1301.

Abstract:
Detecting the change of biological interaction networks is of great importance in biological and medical research. We proposed a simple loss function, named as CrossFDTL, to identify the network change or differential network by estimating the difference between two precision matrices under Gaussian assumption. The CrossFDTL is a natural fusion of the D-trace loss for the considered two networks by imposing the $ell _{1}$ penalty to the differential matrix to ensure sparsity. The key point of our method is to utilize the cross variables, which correspond to the sum and difference of two precision matrices instead of using their original forms. Moreover, we developed an efficient minimization algorithm for the proposed loss function and further rigorously proved its convergence. Numerical results showed that our method outperforms the existing methods in both accuracy and convergence speed for the simulated and real data.

Fabien Panloup, Samy Tindel, Maylis Varvenne.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1075--1136.

Abstract:
In this paper we consider the drift estimation problem for a general differential equation driven by an additive multidimensional fractional Brownian motion, under ergodic assumptions on the drift coefficient. Our estimation procedure is based on the identification of the invariant measure, and we provide consistency results as well as some information about the convergence rate. We also give some examples of coefficients for which the identifiability assumption for the invariant measure is satisfied.

The Neyman-Pearson (NP) paradigm in binary classification seeks classifiers that achieve a minimal type II error while enforcing the prioritized type I error controlled under some user-specified level $alpha$. This paradigm serves naturally in applications such as severe disease diagnosis and spam detection, where people have clear priorities among the two error types. Recently, Tong, Feng, and Li (2018) proposed a nonparametric umbrella algorithm that adapts all scoring-type classification methods (e.g., logistic regression, support vector machines, random forest) to respect the given type I error (i.e., conditional probability of classifying a class $0$ observation as class $1$ under the 0-1 coding) upper bound $alpha$ with high probability, without specific distributional assumptions on the features and the responses. Universal the umbrella algorithm is, it demands an explicit minimum sample size requirement on class $0$, which is often the more scarce class, such as in rare disease diagnosis applications. In this work, we employ the parametric linear discriminant analysis (LDA) model and propose a new parametric thresholding algorithm, which does not need the minimum sample size requirements on class $0$ observations and thus is suitable for small sample applications such as rare disease diagnosis. Leveraging both the existing nonparametric and the newly proposed parametric thresholding rules, we propose four LDA-based NP classifiers, for both low- and high-dimensional settings. On the theoretical front, we prove NP oracle inequalities for one proposed classifier, where the rate for excess type II error benefits from the explicit parametric model assumption. Furthermore, as NP classifiers involve a sample splitting step of class $0$ observations, we construct a new adaptive sample splitting scheme that can be applied universally to NP classifiers, and this adaptive strategy reduces the type II error of these classifiers. The proposed NP classifiers are implemented in the R package nproc.

One of the common tasks in unsupervised learning is dimensionality reduction, where the goal is to find meaningful low-dimensional structures hidden in high-dimensional data. Sometimes referred to as manifold learning, this problem is closely related to the problem of localization, which aims at embedding a weighted graph into a low-dimensional Euclidean space. Several methods have been proposed for localization, and also manifold learning. Nonetheless, the robustness property of most of them is little understood. In this paper, we obtain perturbation bounds for classical scaling and trilateration, which are then applied to derive performance bounds for Isomap, Landmark Isomap, and Maximum Variance Unfolding. A new perturbation bound for procrustes analysis plays a key role.

A common divide-and-conquer approach for Bayesian computation with big data is to partition the data, perform local inference for each piece separately, and combine the results to obtain a global posterior approximation. While being conceptually and computationally appealing, this method involves the problematic need to also split the prior for the local inferences; these weakened priors may not provide enough regularization for each separate computation, thus eliminating one of the key advantages of Bayesian methods. To resolve this dilemma while still retaining the generalizability of the underlying local inference method, we apply the idea of expectation propagation (EP) as a framework for distributed Bayesian inference. The central idea is to iteratively update approximations to the local likelihoods given the state of the other approximations and the prior. The present paper has two roles: we review the steps that are needed to keep EP algorithms numerically stable, and we suggest a general approach, inspired by EP, for approaching data partitioning problems in a way that achieves the computational benefits of parallelism while allowing each local update to make use of relevant information from the other sites. In addition, we demonstrate how the method can be applied in a hierarchical context to make use of partitioning of both data and parameters. The paper describes a general algorithmic framework, rather than a specific algorithm, and presents an example implementation for it.

Graph learning from data is a canonical problem that has received substantial attention in the literature. Learning a structured graph is essential for interpretability and identification of the relationships among data. In general, learning a graph with a specific structure is an NP-hard combinatorial problem and thus designing a general tractable algorithm is challenging. Some useful structured graphs include connected, sparse, multi-component, bipartite, and regular graphs. In this paper, we introduce a unified framework for structured graph learning that combines Gaussian graphical model and spectral graph theory. We propose to convert combinatorial structural constraints into spectral constraints on graph matrices and develop an optimization framework based on block majorization-minimization to solve structured graph learning problem. The proposed algorithms are provably convergent and practically amenable for a number of graph based applications such as data clustering. Extensive numerical experiments with both synthetic and real data sets illustrate the effectiveness of the proposed algorithms. An open source R package containing the code for all the experiments is available at https://CRAN.R-project.org/package=spectralGraphTopology.

We study the identity testing problem in the context of spin systems or undirected graphical models, where it takes the following form: given the parameter specification of the model $M$ and a sampling oracle for the distribution $mu_{M^*}$ of an unknown model $M^*$, can we efficiently determine if the two models $M$ and $M^*$ are the same? We consider identity testing for both soft-constraint and hard-constraint systems. In particular, we prove hardness results in two prototypical cases, the Ising model and proper colorings, and explore whether identity testing is any easier than structure learning. For the ferromagnetic (attractive) Ising model, Daskalakis et al. (2018) presented a polynomial-time algorithm for identity testing. We prove hardness results in the antiferromagnetic (repulsive) setting in the same regime of parameters where structure learning is known to require a super-polynomial number of samples. Specifically, for $n$-vertex graphs of maximum degree $d$, we prove that if $|eta| d = omega(log{n})$ (where $eta$ is the inverse temperature parameter), then there is no polynomial running time identity testing algorithm unless $RP=NP$. In the hard-constraint setting, we present hardness results for identity testing for proper colorings. Our results are based on the presumed hardness of #BIS, the problem of (approximately) counting independent sets in bipartite graphs.

Great attention has been paid to Big Data in recent years. Such data hold promise for scientific discoveries but also pose challenges to analyses. One potential challenge is noise accumulation. In this paper, we explore noise accumulation in high dimensional two-group classification. First, we revisit a previous assessment of noise accumulation with principal component analyses, which yields a different threshold for discriminative ability than originally identified. Then we extend our scope to its impact on classifiers developed with three common machine learning approaches---random forest, support vector machine, and boosted classification trees. We simulate four scenarios with differing amounts of signal strength to evaluate each method. After determining noise accumulation may affect the performance of these classifiers, we assess factors that impact it. We conduct simulations by varying sample size, signal strength, signal strength proportional to the number predictors, and signal magnitude with random forest classifiers. These simulations suggest that noise accumulation affects the discriminative ability of high-dimensional classifiers developed using common machine learning methods, which can be modified by sample size, signal strength, and signal magnitude. We developed the measure total signal index (TSI) to track the trends of total signal and noise accumulation.

High dimensional data often contain multiple facets, and several clustering patterns can co-exist under different variable subspaces, also known as the views. While multi-view clustering algorithms were proposed, the uncertainty quantification remains difficult --- a particular challenge is in the high complexity of estimating the cluster assignment probability under each view, and sharing information among views. In this article, we propose an approximate Bayes approach --- treating the similarity matrices generated over the views as rough first-stage estimates for the co-assignment probabilities; in its Kullback-Leibler neighborhood, we obtain a refined low-rank matrix, formed by the pairwise product of simplex coordinates. Interestingly, each simplex coordinate directly encodes the cluster assignment uncertainty. For multi-view clustering, we let each view draw a parameterization from a few candidates, leading to dimension reduction. With high model flexibility, the estimation can be efficiently carried out as a continuous optimization problem, hence enjoys gradient-based computation. The theory establishes the connection of this model to a random partition distribution under multiple views. Compared to single-view clustering approaches, substantially more interpretable results are obtained when clustering brains from a human traumatic brain injury study, using high-dimensional gene expression data.

The success of Deep Learning and its potential use in many safety-critical applicationshas motivated research on formal verification of Neural Network (NN) models. In thiscontext, verification involves proving or disproving that an NN model satisfies certaininput-output properties. Despite the reputation of learned NN models as black boxes,and the theoretical hardness of proving useful properties about them, researchers havebeen successful in verifying some classes of models by exploiting their piecewise linearstructure and taking insights from formal methods such as Satisifiability Modulo Theory.However, these methods are still far from scaling to realistic neural networks. To facilitateprogress on this crucial area, we exploit the Mixed Integer Linear Programming (MIP) formulation of verification to propose a family of algorithms based on Branch-and-Bound (BaB). We show that our family contains previous verification methods as special cases.With the help of the BaB framework, we make three key contributions. Firstly, we identifynew methods that combine the strengths of multiple existing approaches, accomplishingsignificant performance improvements over previous state of the art. Secondly, we introducean effective branching strategy on ReLU non-linearities. This branching strategy allows usto efficiently and successfully deal with high input dimensional problems with convolutionalnetwork architecture, on which previous methods fail frequently. Finally, we proposecomprehensive test data sets and benchmarks which includes a collection of previouslyreleased testcases. We use the data sets to conduct a thorough experimental comparison ofexisting and new algorithms and to provide an inclusive analysis of the factors impactingthe hardness of verification problems.

pyts is an open-source Python package for time series classification. This versatile toolbox provides implementations of many algorithms published in the literature, preprocessing functionalities, and data set loading utilities. pyts relies on the standard scientific Python packages numpy, scipy, scikit-learn, joblib, and numba, and is distributed under the BSD-3-Clause license. Documentation contains installation instructions, a detailed user guide, a full API description, and concrete self-contained examples.

Derivatives play an important role in bandwidth selection methods (e.g., plug-ins), data analysis and bias-corrected confidence intervals. Therefore, obtaining accurate derivative information is crucial. Although many derivative estimation methods exist, the majority require a fixed design assumption. In this paper, we propose an effective and fully data-driven framework to estimate the first and second order derivative in random design. We establish the asymptotic properties of the proposed derivative estimator, and also propose a fast selection method for the tuning parameters. The performance and flexibility of the method is illustrated via an extensive simulation study.

Anomaly detection is not an easy problem since distribution of anomalous samples is unknown a priori. We explore a novel method that gives a trade-off possibility between one-class and two-class approaches, and leads to a better performance on anomaly detection problems with small or non-representative anomalous samples. The method is evaluated using several data sets and compared to a set of conventional one-class and two-class approaches.

This paper considers a new identifiability condition for additive noise models (ANMs) in which each variable is determined by an arbitrary Borel measurable function of its parents plus an independent error. It has been shown that ANMs are fully recoverable under some identifiability conditions, such as when all error variances are equal. However, this identifiable condition could be restrictive, and hence, this paper focuses on a relaxed identifiability condition that involves not only error variances, but also the influence of parents. This new class of identifiable ANMs does not put any constraints on the form of dependencies, or distributions of errors, and allows different error variances. It further provides a statistically consistent and computationally feasible structure learning algorithm for the identifiable ANMs based on the new identifiability condition. The proposed algorithm assumes that all relevant variables are observed, while it does not assume faithfulness or a sparse graph. Demonstrated through extensive simulated and real multivariate data is that the proposed algorithm successfully recovers directed acyclic graphs.

Abbas Pak, M. E. Ghitany, Mohammad Reza Mahmoudi.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 894--914.

Abstract:
This paper focuses on Bayesian estimation of the parameters and reliability function of the power Lindley distribution by using various symmetric and asymmetric loss functions. Assuming suitable priors on the parameters, Bayes estimates are derived by using squared error, linear exponential (linex) and general entropy loss functions. Since, under these loss functions, Bayes estimates of the parameters do not have closed forms we use lindley’s approximation technique to calculate the Bayes estimates. Moreover, we obtain the Bayes estimates of the parameters using a Markov Chain Monte Carlo (MCMC) method. Simulation studies are conducted in order to evaluate the performances of the proposed estimators under the considered loss functions. Finally, analysis of a real data set is presented for illustrative purposes.

Wesley Bertoli, Katiane S. Conceição, Marinho G. Andrade, Francisco Louzada.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 826--860.

Abstract:
The primary goal of this paper is to introduce the zero-modified Poisson–Lindley regression model as an alternative to model overdispersed count data exhibiting inflation or deflation of zeros in the presence of covariates. The zero-modification is incorporated by considering that a zero-truncated process produces positive observations and consequently, the proposed model can be fitted without any previous information about the zero-modification present in a given dataset. A fully Bayesian approach based on the g-prior method has been considered for inference concerns. An intensive Monte Carlo simulation study has been conducted to evaluate the performance of the developed methodology and the maximum likelihood estimators. The proposed model was considered for the analysis of a real dataset on the number of bids received by $126$ U.S. firms between 1978–1985, and the impact of choosing different prior distributions for the regression coefficients has been studied. A sensitivity analysis to detect influential points has been performed based on the Kullback–Leibler divergence. A general comparison with some well-known regression models for discrete data has been presented.

Dani Gamerman.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 686--705.

Abstract:
Point processes are one of the most commonly encountered observation processes in Spatial Statistics. Model-based inference for them depends on the likelihood function. In the most standard setting of Poisson processes, the likelihood depends on the intensity function, and can not be computed analytically. A number of approximating techniques have been proposed to handle this difficulty. In this paper, we review recent work on exact solutions that solve this problem without resorting to approximations. The presentation concentrates more heavily on discrete time but also considers continuous time. The solutions are based on model specifications that impose smoothness constraints on the intensity function. We also review approaches to include a regression component and different ways to accommodate it while accounting for additional heterogeneity. Applications are provided to illustrate the results. Finally, we discuss possible extensions to account for discontinuities and/or jumps in the intensity function.

Christian Rau.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 549--557.

Abstract:
We revisit a shape inversion formula derived by Panaretos in the context of a particle density estimation problem with unknown rotation of the particle. A distribution is presented which imitates, or “fakes”, the uniformity or Haar distribution that is part of that formula.

Christian Olivera, Ciprian Tudor.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 520--531.

Abstract:
Via a special transform and by using the techniques of the Malliavin calculus, we analyze the density of the solution to a stochastic differential equation with unbounded drift.

Rodrigo Citton P. dos Reis, Enrico A. Colosimo, Gustavo L. Gilardoni.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 374--396.

Abstract:
In the data analysis from multiple repairable systems, it is usual to observe both different truncation times and heterogeneity among the systems. Among other reasons, the latter is caused by different manufacturing lines and maintenance teams of the systems. In this paper, a hierarchical model is proposed for the statistical analysis of multiple repairable systems under different truncation times. A reparameterization of the power law process is proposed in order to obtain a quasi-conjugate bayesian analysis. An empirical Bayes approach is used to estimate model hyperparameters. The uncertainty in the estimate of these quantities are corrected by using a parametric bootstrap approach. The results are illustrated in a real data set of failure times of power transformers from an electric company in Brazil.

Khamis K. Said, Wei Ning, Yubin Tian.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 280--300.

Abstract:
In this paper, we study the change point problem for the skew normal distribution model from the view of model selection problem. The detection procedure based on the modified information criterion (MIC) for change problem is proposed. Such a procedure has advantage in detecting the changes in early and late stage of a data comparing to the one based on the traditional Schwarz information criterion which is well known as Bayesian information criterion (BIC) by considering the complexity of the models. Due to the difficulty in deriving the analytic asymptotic distribution of the test statistic based on the MIC procedure, the bootstrap simulation is provided to obtain the critical values at the different significance levels. Simulations are conducted to illustrate the comparisons of performance between MIC, BIC and likelihood ratio test (LRT). Such an approach is applied on two stock market data sets to indicate the detection procedure.

Pierre Lafaye de Micheaux, Benoît Liquet, Matthew Sutton.

Source: Statistics Surveys, Volume 13, 119--149.

Abstract:
Partial Least Squares (PLS) methods have been heavily exploited to analyse the association between two blocks of data. These powerful approaches can be applied to data sets where the number of variables is greater than the number of observations and in the presence of high collinearity between variables. Different sparse versions of PLS have been developed to integrate multiple data sets while simultaneously selecting the contributing variables. Sparse modeling is a key factor in obtaining better estimators and identifying associations between multiple data sets. The cornerstone of the sparse PLS methods is the link between the singular value decomposition (SVD) of a matrix (constructed from deflated versions of the original data) and least squares minimization in linear regression. We review four popular PLS methods for two blocks of data. A unified algorithm is proposed to perform all four types of PLS including their regularised versions. We present various approaches to decrease the computation time and show how the whole procedure can be scalable to big data sets. The bigsgPLS R package implements our unified algorithm and is available at https://github.com/matt-sutton/bigsgPLS .

Norbert Hirschauer, Sven Grüner, Oliver Mußhoff, Claudia Becker.

Source: Statistics Surveys, Volume 12, 136--172.

Abstract:
Data on how many scientific findings are reproducible are generally bleak and a wealth of papers have warned against misuses of the $p$-value and resulting false findings in recent years. This paper discusses the question of what we can(not) learn from the $p$-value, which is still widely considered as the gold standard of statistical validity. We aim to provide a non-technical and easily accessible resource for statistical practitioners who wish to spot and avoid misinterpretations and misuses of statistical significance tests. For this purpose, we first classify and describe the most widely discussed (“classical”) pitfalls of significance testing, and review published work on these misuses with a focus on regression-based “confirmatory” study. This includes a description of the single-study bias and a simulation-based illustration of how proper meta-analysis compares to misleading significance counts (“vote counting”). Going beyond the classical pitfalls, we also use simulation to provide intuition that relying on the statistical estimate “$p$-value” as a measure of evidence without considering its sample-to-sample variability falls short of the mark even within an otherwise appropriate interpretation. We conclude with a discussion of the exigencies of informed approaches to statistical inference and corresponding institutional reforms.

Clément Marteau, Theofanis Sapatinas.

Source: Statistics Surveys, Volume 9, 253--297.

Abstract:
We are concerned with minimax signal detection. In this setting, we discuss non-asymptotic and asymptotic approaches through a unified treatment. In particular, we consider a Gaussian sequence model that contains classical models as special cases, such as, direct, well-posed inverse and ill-posed inverse problems. Working with certain ellipsoids in the space of squared-summable sequences of real numbers, with a ball of positive radius removed, we compare the construction of lower and upper bounds for the minimax separation radius (non-asymptotic approach) and the minimax separation rate (asymptotic approach) that have been proposed in the literature. Some additional contributions, bringing to light links between non-asymptotic and asymptotic approaches to minimax signal, are also presented. An example of a mildly ill-posed inverse problem is used for illustrative purposes. In particular, it is shown that tools used to derive ‘asymptotic’ results can be exploited to draw ‘non-asymptotic’ conclusions, and vice-versa. In order to enhance our understanding of these two minimax signal detection paradigms, we bring into light hitherto unknown similarities and links between non-asymptotic and asymptotic approaches.

A. Philip Dawid, Vanessa Didelez

Source: Statist. Surv., Volume 4, 184--231.

Abstract:
We consider the problem of learning about and comparing the consequences of dynamic treatment strategies on the basis of observational data. We formulate this within a probabilistic decision-theoretic framework. Our approach is compared with related work by Robins and others: in particular, we show how Robins’s ‘ G -computation’ algorithm arises naturally from this decision-theoretic perspective. Careful attention is paid to the mathematical and substantive conditions required to justify the use of this formula. These conditions revolve around a property we term stability , which relates the probabilistic behaviours of observational and interventional regimes. We show how an assumption of ‘sequential randomization’ (or ‘no unmeasured confounders’), or an alternative assumption of ‘sequential irrelevance’, can be used to infer stability. Probabilistic influence diagrams are used to simplify manipulations, and their power and limitations are discussed. We compare our approach with alternative formulations based on causal DAGs or potential response models. We aim to show that formulating the problem of assessing dynamic treatment strategies as a problem of decision analysis brings clarity, simplicity and generality.

References:
Arjas, E. and Parner, J. (2004). Causal reasoning from longitudinal data. Scandinavian Journal of Statistics 31 171–187.

Arjas, E. and Saarela, O. (2010). Optimal dynamic regimes: Presenting a case for predictive inference. The International Journal of Biostatistics 6. http://tinyurl.com/33dfssf

Cowell, R. G., Dawid, A. P., Lauritzen, S. L. and Spiegelhalter, D. J. (1999). Probabilistic Networks and Expert Systems. Springer, New York.

Dawid, A. P. (1979). Conditional independence in statistical theory (with Discussion). Journal of the Royal Statistical Society, Series B 41 1–31.

Dawid, A. P. (1992). Applications of a general propagation algorithm for probabilistic expert systems. Statistics and Computing 2 25–36.

Dawid, A. P. (1998). Conditional independence. In Encyclopedia of Statistical Science ({U}pdate Volume 2) ( S. Kotz, C. B. Read and D. L. Banks, eds.) 146–155. Wiley-Interscience, New York.

Dawid, A. P. (2000). Causal inference without counterfactuals (with Discussion). Journal of the American Statistical Association 95 407–448.

Dawid, A. P. (2001). Separoids: A mathematical framework for conditional independence and irrelevance. Annals of Mathematics and Artificial Intelligence 32 335–372.

Dawid, A. P. (2002). Influence diagrams for causal modelling and inference. International Statistical Review 70 161–189. Corrigenda, ibid ., 437.

Dawid, A. P. (2003). Causal inference using influence diagrams: The problem of partial compliance (with Discussion). In Highly Structured Stochastic Systems ( P. J. Green, N. L. Hjort and S. Richardson, eds.) 45–81. Oxford University Press.

Dawid, A. P. (2010). Beware of the DAG! In Proceedings of the NIPS 2008 Workshop on Causality. Journal of Machine Learning Research Workshop and Conference Proceedings ( D. Janzing, I. Guyon and B. Schölkopf, eds.) 6 59–86. http://tinyurl.com/33va7tm

Dawid, A. P. and Didelez, V. (2008). Identifying optimal sequential decisions. In Proceedings of the Twenty-Fourth Annual Conference on Uncertainty in Artificial Intelligence (UAI-08) ( D. McAllester and A. Nicholson, eds.). 113-120. AUAI Press, Corvallis, Oregon. http://tinyurl.com/3899qpp

Dechter, R. (2003). Constraint Processing. Morgan Kaufmann Publishers.

Didelez, V., Dawid, A. P. and Geneletti, S. G. (2006). Direct and indirect effects of sequential treatments. In Proceedings of the Twenty-Second Annual Conference on Uncertainty in Artificial Intelligence (UAI-06) ( R. Dechter and T. Richardson, eds.). 138-146. AUAI Press, Arlington, Virginia. http://tinyurl.com/32w3f4e

Didelez, V., Kreiner, S. and Keiding, N. (2010). Graphical models for inference under outcome dependent sampling. Statistical Science (to appear).

Didelez, V. and Sheehan, N. S. (2007). Mendelian randomisation: Why epidemiology needs a formal language for causality. In Causality and Probability in the Sciences, ( F. Russo and J. Williamson, eds.). Texts in Philosophy Series 5 263–292. College Publications, London.

Eichler, M. and Didelez, V. (2010). Granger-causality and the effect of interventions in time series. Lifetime Data Analysis 16 3–32.

Ferguson, T. S. (1967). Mathematical Statistics: A Decision Theoretic Approach. Academic Press, New York, London.

Geneletti, S. G. (2007). Identifying direct and indirect effects in a non–counterfactual framework. Journal of the Royal Statistical Society: Series B 69 199–215.

Geneletti, S. G. and Dawid, A. P. (2010). Defining and identifying the effect of treatment on the treated. In Causality in the Sciences ( P. M. Illari, F. Russo and J. Williamson, eds.) Oxford University Press (to appear).

Gill, R. D. and Robins, J. M. (2001). Causal inference for complex longitudinal data: The continuous case. Annals of Statistics 29 1785–1811.

Guo, H. and Dawid, A. P. (2010). Sufficient covariates and linear propensity analysis. In Proceedings of the Thirteenth International Workshop on Artificial Intelligence and Statistics, (AISTATS) 2010, Chia Laguna, Sardinia, Italy, May 13-15, 2010. Journal of Machine Learning Research Workshop and Conference Proceedings ( Y. W. Teh and D. M. Titterington, eds.) 9 281–288. http://tinyurl.com/33lmuj7

Henderson, R., Ansel, P. and Alshibani, D. (2010). Regret-regression for optimal dynamic treatment regimes. Biometrics (to appear). doi:10.1111/j.1541-0420.2009.01368.x

Hernán, M. A. and Taubman, S. L. (2008). Does obesity shorten life? The importance of well defined interventions to answer causal questions. International Journal of Obesity 32 S8–S14.

Holland, P. W. (1986). Statistics and causal inference (with Discussion). Journal of the American Statistical Association 81 945–970.

Huang, Y. and Valtorta, M. (2006). Identifiability in causal Bayesian networks: A sound and complete algorithm. In AAAI’06: Proceedings of the 21st National Conference on Artificial Intelligence 1149–1154. AAAI Press.

Kang, J. D. Y. and Schafer, J. L. (2007). Demystifying double robustness: A comparison of alternative strategies for estimating a population mean from incomplete data. Statistical Science 22 523–539.

Lauritzen, S. L., Dawid, A. P., Larsen, B. N. and Leimer, H. G. (1990). Independence properties of directed Markov fields. Networks 20 491–505.

Lok, J., Gill, R., van der Vaart, A. and Robins, J. (2004). Estimating the causal effect of a time-varying treatment on time-to-event using structural nested failure time models. Statistica Neerlandica 58 271–295.

Moodie, E. M., Richardson, T. S. and Stephens, D. A. (2007). Demystifying optimal dynamic treatment regimes. Biometrics 63 447–455.

Murphy, S. A. (2003). Optimal dynamic treatment regimes (with Discussion). Journal of the Royal Statistical Society, Series B 65 331-366.

Oliver, R. M. and Smith, J. Q., eds. (1990). Influence Diagrams, Belief Nets and Decision Analysis. John Wiley and Sons, Chichester, United Kingdom.

Pearl, J. (1995). Causal diagrams for empirical research (with Discussion). Biometrika 82 669-710.

Pearl, J. (2009). Causality: Models, Reasoning and Inference, Second ed. Cambridge University Press, Cambridge.

Pearl, J. and Paz, A. (1987). Graphoids: A graph-based logic for reasoning about relevance relations. In Advances in Artificial Intelligence ( D. Hogg and L. Steels, eds.) II 357–363. North-Holland, Amsterdam.

Pearl, J. and Robins, J. (1995). Probabilistic evaluation of sequential plans from causal models with hidden variables. In Proceedings of the 11th Conference on Uncertainty in Artificial Intelligence ( P. Besnard and S. Hanks, eds.) 444–453. Morgan Kaufmann Publishers, San Francisco.

Raiffa, H. (1968). Decision Analysis. Addison-Wesley, Reading, Massachusetts.

Robins, J. M. (1986). A new approach to causal inference in mortality studies with sustained exposure periods—Application to control of the healthy worker survivor effect. Mathematical Modelling 7 1393–1512.

Robins, J. M. (1987). Addendum to “A new approach to causal inference in mortality studies with sustained exposure periods—Application to control of the healthy worker survivor effect”. Computers & Mathematics with Applications 14 923–945.

Robins, J. M. (1989). The analysis of randomized and nonrandomized AIDS treatment trials using a new approach to causal inference in longitudinal studies. In Health Service Research Methodology: A Focus on AIDS ( L. Sechrest, H. Freeman and A. Mulley, eds.) 113–159. NCSHR, U.S. Public Health Service.

Robins, J. M. (1992). Estimation of the time-dependent accelerated failure time model in the presence of confounding factors. Biometrika 79 321–324.

Robins, J. M. (1997). Causal inference from complex longitudinal data. In Latent Variable Modeling and Applications to Causality, ( M. Berkane, ed.). Lecture Notes in Statistics 120 69–117. Springer-Verlag, New York.

Robins, J. M. (1998). Structural nested failure time models. In Survival Analysis, ( P. K. Andersen and N. Keiding, eds.). Encyclopedia of Biostatistics 6 4372–4389. John Wiley and Sons, Chichester, UK.

Robins, J. M. (2000). Robust estimation in sequentially ignorable missing data and causal inference models. In Proceedings of the American Statistical Association Section on Bayesian Statistical Science 1999 6–10.

Robins, J. M. (2004). Optimal structural nested models for optimal sequential decisions. In Proceedings of the Second Seattle Symposium on Biostatistics ( D. Y. Lin and P. Heagerty, eds.) 189–326. Springer, New York.

Robins, J. M., Greenland, S. and Hu, F. C. (1999). Estimation of the causal effect of a time-varying exposure on the marginal mean of a repeated binary outcome. Journal of the American Statistical Association 94 687–700.

Robins, J. M., Hernán, M. A. and Brumback, B. (2000). Marginal structural models and causal inference in epidemiology. Epidemiology 11 550–560.

Robins, J. M. and Wasserman, L. A. (1997). Estimation of effects of sequential treatments by reparameterizing directed acyclic graphs. In Proceedings of the 13th Annual Conference on Uncertainty in Artificial Intelligence ( D. Geiger and P. Shenoy, eds.) 409-420. Morgan Kaufmann Publishers, San Francisco. http://tinyurl.com/33ghsas

Rosthøj, S., Fullwood, C., Henderson, R. and Stewart, S. (2006). Estimation of optimal dynamic anticoagulation regimes from observational data: A regret-based approach. Statistics in Medicine 25 4197–4215.

Shpitser, I. and Pearl, J. (2006a). Identification of conditional interventional distributions. In Proceedings of the 22nd Annual Conference on Uncertainty in Artificial Intelligence (UAI-06) ( R. Dechter and T. Richardson, eds.). 437–444. AUAI Press, Corvallis, Oregon. http://tinyurl.com/2um8w47

Shpitser, I. and Pearl, J. (2006b). Identification of joint interventional distributions in recursive semi-Markovian causal models. In Proceedings of the Twenty-First National Conference on Artificial Intelligence 1219–1226. AAAI Press, Menlo Park, California.

Spirtes, P., Glymour, C. and Scheines, R. (2000). Causation, Prediction and Search, Second ed. Springer-Verlag, New York.

Sterne, J. A. C., May, M., Costagliola, D., de Wolf, F., Phillips, A. N., Harris, R., Funk, M. J., Geskus, R. B., Gill, J., Dabis, F., Miro, J. M., Justice, A. C., Ledergerber, B., Fatkenheuer, G., Hogg, R. S., D’Arminio-Monforte, A., Saag, M., Smith, C., Staszewski, S., Egger, M., Cole, S. R. and When To Start Consortium (2009). Timing of initiation of antiretroviral therapy in AIDS-Free HIV-1-infected patients: A collaborative analysis of 18 HIV cohort studies. Lancet 373 1352–1363.

Taubman, S. L., Robins, J. M., Mittleman, M. A. and Hernán, M. A. (2009). Intervening on risk factors for coronary heart disease: An application of the parametric g-formula. International Journal of Epidemiology 38 1599–1611.

Tian, J. (2008). Identifying dynamic sequential plans. In Proceedings of the Twenty-Fourth Annual Conference on Uncertainty in Artificial Intelligence (UAI-08) ( D. McAllester and A. Nicholson, eds.). 554–561. AUAI Press, Corvallis, Oregon. http://tinyurl.com/36ufx2h

Verma, T. and Pearl, J. (1990). Causal networks: Semantics and expressiveness. In Uncertainty in Artificial Intelligence 4 ( R. D. Shachter, T. S. Levitt, L. N. Kanal and J. F. Lemmer, eds.) 69–76. North-Holland, Amsterdam.

Arctic sea ice extent (SIE) in September 2019 ranked second-to-lowest in history and is trending downward. The understanding of how internal variability amplifies the effects of external $ ext{CO}_2$ forcing is still limited. We propose the VARCTIC, which is a Vector Autoregression (VAR) designed to capture and extrapolate Arctic feedback loops. VARs are dynamic simultaneous systems of equations, routinely estimated to predict and understand the interactions of multiple macroeconomic time series. Hence, the VARCTIC is a parsimonious compromise between fullblown climate models and purely statistical approaches that usually offer little explanation of the underlying mechanism. Our "business as usual" completely unconditional forecast has SIE hitting 0 in September by the 2060s. Impulse response functions reveal that anthropogenic $ ext{CO}_2$ emission shocks have a permanent effect on SIE - a property shared by no other shock. Further, we find Albedo- and Thickness-based feedbacks to be the main amplification channels through which $ ext{CO}_2$ anomalies impact SIE in the short/medium run. Conditional forecast analyses reveal that the future path of SIE crucially depends on the evolution of $ ext{CO}_2$ emissions, with outcomes ranging from recovering SIE to it reaching 0 in the 2050s. Finally, Albedo and Thickness feedbacks are shown to play an important role in accelerating the speed at which predicted SIE is heading towards 0.

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distributions. We exemplify this use case by using single-sensor accelerometer data from healthy subjects performing activities of daily living - ADLs (source dataset), to extract features relevant to multi-sensor accelerometer gait data (target dataset) for Parkinson's disease classification. We train the pre-trained model using the source dataset and use it as a feature extractor. We show that the features extracted for the target dataset can be used to train an effective classification model. Our pre-trained source model consists of a convolutional autoencoder, and the target classification model is a simple multi-layer perceptron model. We explore two different pre-trained source models, trained using different activity groups, and analyze the influence the choice of pre-trained model has over the task of Parkinson's disease classification.

Beginning from a basic neural-network architecture, we test the potential benefits offered by a range of advanced techniques for machine learning, in particular deep learning, in the context of a typical classification problem encountered in the domain of high-energy physics, using a well-studied dataset: the 2014 Higgs ML Kaggle dataset. The advantages are evaluated in terms of both performance metrics and the time required to train and apply the resulting models. Techniques examined include domain-specific data-augmentation, learning rate and momentum scheduling, (advanced) ensembling in both model-space and weight-space, and alternative architectures and connection methods.

Following the investigation, we arrive at a model which achieves equal performance to the winning solution of the original Kaggle challenge, whilst being significantly quicker to train and apply, and being suitable for use with both GPU and CPU hardware setups. These reductions in timing and hardware requirements potentially allow the use of more powerful algorithms in HEP analyses, where models must be retrained frequently, sometimes at short notice, by small groups of researchers with limited hardware resources. Additionally, a new wrapper library for PyTorch called LUMINis presented, which incorporates all of the techniques studied.

A deep neural network has relieved the burden of feature engineering by human experts, but comparable efforts are instead required to determine an effective architecture. On the other hands, as the size of a network has over-grown, a lot of resources are also invested to reduce its size. These problems can be addressed by sparsification of an over-complete model, which removes redundant parameters or connections by pruning them away after training or encouraging them to become zero during training. In general, however, these approaches are not fully differentiable and interrupt an end-to-end training process with the stochastic gradient descent in that they require either a parameter selection or a soft-thresholding step. In this paper, we propose a fully differentiable sparsification method for deep neural networks, which allows parameters to be exactly zero during training, and thus can learn the sparsified structure and the weights of networks simultaneously using the stochastic gradient descent. We apply the proposed method to various popular models in order to show its effectiveness.

A major difficulty of solving continuous POMDPs is to infer the multi-modal distribution of the unobserved true states and to make the planning algorithm dependent on the perceived uncertainty. We cast POMDP filtering and planning problems as two closely related Sequential Monte Carlo (SMC) processes, one over the real states and the other over the future optimal trajectories, and combine the merits of these two parts in a new model named the DualSMC network. In particular, we first introduce an adversarial particle filter that leverages the adversarial relationship between its internal components. Based on the filtering results, we then propose a planning algorithm that extends the previous SMC planning approach [Piche et al., 2018] to continuous POMDPs with an uncertainty-dependent policy. Crucially, not only can DualSMC handle complex observations such as image input but also it remains highly interpretable. It is shown to be effective in three continuous POMDP domains: the floor positioning domain, the 3D light-dark navigation domain, and a modified Reacher domain.

Boosting is one of the most successful ideas in machine learning. The most well-accepted explanations for the low generalization error of boosting algorithms such as AdaBoost stem from margin theory. The study of margins in the context of boosting algorithms was initiated by Schapire, Freund, Bartlett and Lee (1998) and has inspired numerous boosting algorithms and generalization bounds. To date, the strongest known generalization (upper bound) is the $k$th margin bound of Gao and Zhou (2013). Despite the numerous generalization upper bounds that have been proved over the last two decades, nothing is known about the tightness of these bounds. In this paper, we give the first margin-based lower bounds on the generalization error of boosted classifiers. Our lower bounds nearly match the $k$th margin bound and thus almost settle the generalization performance of boosted classifiers in terms of margins.

We study the problem of parameter estimation for a non-ergodic Gaussian Vasicek-type model defined as $dX_t=(mu+ heta X_t)dt+dG_t, tgeq0$ with unknown parameters $ heta>0$ and $muinR$, where $G$ is a Gaussian process. We provide least square-type estimators $widetilde{ heta}_T$ and $widetilde{mu}_T$ respectively for the drift parameters $ heta$ and $mu$ based on continuous-time observations ${X_t, tin[0,T]}$ as $T ightarrowinfty$.

Our aim is to derive some sufficient conditions on the driving Gaussian process $G$ in order to ensure that $widetilde{ heta}_T$ and $widetilde{mu}_T$ are strongly consistent, the limit distribution of $widetilde{ heta}_T$ is a Cauchy-type distribution and $widetilde{mu}_T$ is asymptotically normal. We apply our result to fractional Vasicek, subfractional Vasicek and bifractional Vasicek processes. In addition, this work extends the result of cite{EEO} studied in the case where $mu=0$.

We study the interplay of two important issues on Bayesian model selection (BMS): censoring and model misspecification. We consider additive accelerated failure time (AAFT), Cox proportional hazards and probit models, and a more general concave log-likelihood structure. A fundamental question is what solution can one hope BMS to provide, when (inevitably) models are misspecified. We show that asymptotically BMS keeps any covariate with predictive power for either the outcome or censoring times, and discards other covariates. Misspecification refers to assuming the wrong model or functional effect on the response, including using a finite basis for a truly non-parametric effect, or omitting truly relevant covariates. We argue for using simple models that are computationally practical yet attain good power to detect potentially complex effects, despite misspecification. Misspecification and censoring both have an asymptotically negligible effect on (suitably-defined) false positives, but their impact on power is exponential. We portray these issues via simple descriptions of early/late censoring and the drop in predictive accuracy due to misspecification. From a methods point of view, we consider local priors and a novel structure that combines local and non-local priors to enforce sparsity. We develop algorithms to capitalize on the AAFT tractability, approximations to AAFT and probit likelihoods giving significant computational gains, a simple augmented Gibbs sampler to hierarchically explore linear and non-linear effects, and an implementation in the R package mombf. We illustrate the proposed methods and others based on likelihood penalties via extensive simulations under misspecification and censoring. We present two applications concerning the effect of gene expression on colon and breast cancer.

Given a multivariate data set, sparse principal component analysis (SPCA) aims to extract several linear combinations of the variables that together explain the variance in the data as much as possible, while controlling the number of nonzero loadings in these combinations. In this paper we consider 8 different optimization formulations for computing a single sparse loading vector; these are obtained by combining the following factors: we employ two norms for measuring variance (L2, L1) and two sparsity-inducing norms (L0, L1), which are used in two different ways (constraint, penalty). Three of our formulations, notably the one with L0 constraint and L1 variance, have not been considered in the literature. We give a unifying reformulation which we propose to solve via a natural alternating maximization (AM) method. We show the the AM method is nontrivially equivalent to GPower (Journ'{e}e et al; JMLR 11:517--553, 2010) for all our formulations. Besides this, we provide 24 efficient parallel SPCA implementations: 3 codes (multi-core, GPU and cluster) for each of the 8 problems. Parallelism in the methods is aimed at i) speeding up computations (our GPU code can be 100 times faster than an efficient serial code written in C++), ii) obtaining solutions explaining more variance and iii) dealing with big data problems (our cluster code is able to solve a 357 GB problem in about a minute).

We present LCE, a Local Cascade Ensemble for traditional (tabular) multivariate data classification, and its extension LCEM for Multivariate Time Series (MTS) classification. LCE is a new hybrid ensemble method that combines an explicit boosting-bagging approach to handle the usual bias-variance tradeoff faced by machine learning models and an implicit divide-and-conquer approach to individualize classifier errors on different parts of the training data. Our evaluation firstly shows that the hybrid ensemble method LCE outperforms the state-of-the-art classifiers on the UCI datasets and that LCEM outperforms the state-of-the-art MTS classifiers on the UEA datasets. Furthermore, LCEM provides explainability by design and manifests robust performance when faced with challenges arising from continuous data collection (different MTS length, missing data and noise).

We introduce an optimized physics-informed neural network (PINN) trained to solve the problem of identifying and characterizing a surface breaking crack in a metal plate. PINNs are neural networks that can combine data and physics in the learning process by adding the residuals of a system of Partial Differential Equations to the loss function. Our PINN is supervised with realistic ultrasonic surface acoustic wave data acquired at a frequency of 5 MHz. The ultrasonic surface wave data is represented as a surface deformation on the top surface of a metal plate, measured by using the method of laser vibrometry. The PINN is physically informed by the acoustic wave equation and its convergence is sped up using adaptive activation functions. The adaptive activation function uses a scalable hyperparameter in the activation function, which is optimized to achieve best performance of the network as it changes dynamically the topology of the loss function involved in the optimization process. The usage of adaptive activation function significantly improves the convergence, notably observed in the current study. We use PINNs to estimate the speed of sound of the metal plate, which we do with an error of 1\%, and then, by allowing the speed of sound to be space dependent, we identify and characterize the crack as the positions where the speed of sound has decreased. Our study also shows the effect of sub-sampling of the data on the sensitivity of sound speed estimates. More broadly, the resulting model shows a promising deep neural network model for ill-posed inverse problems.

Simplicity is the ultimate sophistication. Differentiable Architecture Search (DARTS) has now become one of the mainstream paradigms of neural architecture search. However, it largely suffers from several disturbing factors of optimization process whose results are unstable to reproduce. FairDARTS points out that skip connections natively have an unfair advantage in exclusive competition which primarily leads to dramatic performance collapse. While FairDARTS turns the unfair competition into a collaborative one, we instead impede such unfair advantage by injecting unbiased random noise into skip operations' output. In effect, the optimizer should perceive this difficulty at each training step and refrain from overshooting on skip connections, but in a long run it still converges to the right solution area since no bias is added to the gradient. We name this novel approach as NoisyDARTS. Our experiments on CIFAR-10 and ImageNet attest that it can effectively break the skip connection's unfair advantage and yield better performance. It generates a series of models that achieve state-of-the-art results on both datasets.

We propose a new semiparametric approach for modelling nonlinear univariate diffusions, where the observed process is a nonparametric transformation of an underlying parametric diffusion (UPD). This modelling strategy yields a general class of semiparametric Markov diffusion models with parametric dynamic copulas and nonparametric marginal distributions. We provide primitive conditions for the identification of the UPD parameters together with the unknown transformations from discrete samples. Likelihood-based estimators of both parametric and nonparametric components are developed and we analyze the asymptotic properties of these. Kernel-based drift and diffusion estimators are also proposed and shown to be normally distributed in large samples. A simulation study investigates the finite sample performance of our estimators in the context of modelling US short-term interest rates. We also present a simple application of the proposed method for modelling the CBOE volatility index data.

The ability of intelligent agents to learn and remember multiple tasks sequentially is crucial to achieving artificial general intelligence. Many continual learning (CL) methods have been proposed to overcome catastrophic forgetting. Catastrophic forgetting notoriously impedes the sequential learning of neural networks as the data of previous tasks are unavailable. In this paper we focus on class incremental learning, a challenging CL scenario, in which classes of each task are disjoint and task identity is unknown during test. For this scenario, generative replay is an effective strategy which generates and replays pseudo data for previous tasks to alleviate catastrophic forgetting. However, it is not trivial to learn a generative model continually for relatively complex data. Based on recently proposed orthogonal weight modification (OWM) algorithm which can keep previously learned input-output mappings invariant approximately when learning new tasks, we propose to directly generate and replay feature. Empirical results on image and text datasets show our method can improve OWM consistently by a significant margin while conventional generative replay always results in a negative effect. Our method also beats a state-of-the-art generative replay method and is competitive with a strong baseline based on real data storage.

Recent advancements in diagnostic learning and development of gesture-based human machine interfaces have driven surface electromyography (sEMG) towards significant importance. Analysis of hand gestures requires an accurate assessment of sEMG signals. The proposed work presents a novel sequential master-slave architecture consisting of deep neural networks (DNNs) for classification of signs from the Indian sign language using signals recorded from multiple sEMG channels. The performance of the master-slave network is augmented by leveraging additional synthetic feature data generated by long short term memory networks. Performance of the proposed network is compared to that of a conventional DNN prior to and after the addition of synthetic data. Up to 14% improvement is observed in the conventional DNN and up to 9% improvement in master-slave network on addition of synthetic data with an average accuracy value of 93.5% asserting the suitability of the proposed approach.

Uplift modeling is a predictive modeling technique that estimates the user-level incremental effect of a treatment using machine learning models. It is often used for targeting promotions and advertisements, as well as for the personalization of product offerings. In these applications, there are often hundreds of features available to build such models. Keeping all the features in a model can be costly and inefficient. Feature selection is an essential step in the modeling process for multiple reasons: improving the estimation accuracy by eliminating irrelevant features, accelerating model training and prediction speed, reducing the monitoring and maintenance workload for feature data pipeline, and providing better model interpretation and diagnostics capability. However, feature selection methods for uplift modeling have been rarely discussed in the literature. Although there are various feature selection methods for standard machine learning models, we will demonstrate that those methods are sub-optimal for solving the feature selection problem for uplift modeling. To address this problem, we introduce a set of feature selection methods designed specifically for uplift modeling, including both filter methods and embedded methods. To evaluate the effectiveness of the proposed feature selection methods, we use different uplift models and measure the accuracy of each model with a different number of selected features. We use both synthetic and real data to conduct these experiments. We also implemented the proposed filter methods in an open source Python package (CausalML).

Restricted Boltzmann Machine (RBM) is an energy based, undirected graphical model. It is commonly used for unsupervised and supervised machine learning. Typically, RBM is trained using contrastive divergence (CD). However, training with CD is slow and does not estimate exact gradient of log-likelihood cost function. In this work, the model expectation of gradient learning for RBM has been calculated using a quantum annealer (D-Wave 2000Q), which is much faster than Markov chain Monte Carlo (MCMC) used in CD. Training and classification results are compared with CD. The classification accuracy results indicate similar performance of both methods. Image reconstruction as well as log-likelihood calculations are used to compare the performance of quantum and classical algorithms for RBM training. It is shown that the samples obtained from quantum annealer can be used to train a RBM on a 64-bit `bars and stripes' data set with classification performance similar to a RBM trained with CD. Though training based on CD showed improved learning performance, training using a quantum annealer eliminates computationally expensive MCMC steps of CD.

An accurate and prompt diagnosis of pediatric pneumonia is imperative for successful treatment intervention. One approach to diagnose pneumonia cases is using radiographic data. In this article, we propose a novel parsimonious scalar-on-image classification model adopting the ideas of functional data analysis. Our main idea is to treat images as functional measurements and exploit underlying covariance structures to select basis functions; these bases are then used in approximating both image profiles and corresponding regression coefficient. We re-express the regression model into a standard generalized linear model where the functional principal component scores are treated as covariates. We apply the method to (1) classify pneumonia against healthy and viral against bacterial pneumonia patients, and (2) test the null effect about the association between images and responses. Extensive simulation studies show excellent numerical performance in terms of classification, hypothesis testing, and efficient computation.

Reducing domain divergence is a key step in transfer learning problems. Existing works focus on the minimization of global domain divergence. However, two domains may consist of several shared subdomains, and differ from each other in each subdomain. In this paper, we take the local divergence of subdomains into account in transfer. Specifically, we propose to use low-dimensional manifold to represent subdomain, and align the local data distribution discrepancy in each manifold across domains. A Manifold Maximum Mean Discrepancy (M3D) is developed to measure the local distribution discrepancy in each manifold. We then propose a general framework, called Transfer with Manifolds Discrepancy Alignment (TMDA), to couple the discovery of data manifolds with the minimization of M3D. We instantiate TMDA in the subspace learning case considering both the linear and nonlinear mappings. We also instantiate TMDA in the deep learning framework. Extensive experimental studies demonstrate that TMDA is a promising method for various transfer learning tasks.

Hyperbolic balance laws with uncertain (random) parameters and inputs are ubiquitous in science and engineering. Quantification of uncertainty in predictions derived from such laws, and reduction of predictive uncertainty via data assimilation, remain an open challenge. That is due to nonlinearity of governing equations, whose solutions are highly non-Gaussian and often discontinuous. To ameliorate these issues in a computationally efficient way, we use the method of distributions, which here takes the form of a deterministic equation for spatiotemporal evolution of the cumulative distribution function (CDF) of the random system state, as a means of forward uncertainty propagation. Uncertainty reduction is achieved by recasting the standard loss function, i.e., discrepancy between observations and model predictions, in distributional terms. This step exploits the equivalence between minimization of the square error discrepancy and the Kullback-Leibler divergence. The loss function is regularized by adding a Lagrangian constraint enforcing fulfillment of the CDF equation. Minimization is performed sequentially, progressively updating the parameters of the CDF equation as more measurements are assimilated.

Manifold optimization appears in a wide variety of computational problems in the applied sciences. In recent statistical methodologies such as sufficient dimension reduction and regression envelopes, estimation relies on the optimization of likelihood functions over spaces of matrices such as the Stiefel or Grassmann manifolds. Recently, Huang, Absil, Gallivan, and Hand (2016) have introduced the library ROPTLIB, which provides a framework and state of the art algorithms to optimize real-valued objective functions over commonly used matrix-valued Riemannian manifolds. This article presents ManifoldOptim, an R package that wraps the C++ library ROPTLIB. ManifoldOptim enables users to access functionality in ROPTLIB through R so that optimization problems can easily be constructed, solved, and integrated into larger R codes. Computationally intensive problems can be programmed with Rcpp and RcppArmadillo, and otherwise accessed through R. We illustrate the practical use of ManifoldOptim through several motivating examples involving dimension reduction and envelope methods in regression.