Wolfgang Dahmen, Felix Gruber and Olga Mula
Math. Comp. 89 (2020), 1605-1646.
Abstract, references and article information

Startups moving to the scale-up phase will naturally experience growing pains, here's how to manage your team through that period with as little disruption as possible

dlberek posted a photo:

Liz Vivas
Proc. Amer. Math. Soc. 148 (2020), 2525-2537.
Abstract, references and article information

Premiere US troupe Cirque Mechanics will bring their fun-filled show Pedal Punk to Hong Kong audiences as young as three in December.

Audiences will experience the excitement, artistry and surprises that occur when a wacky bike shop mechanic interacts with cyclists and bikes, ultimately repairing more than broken bicycle parts.

With circus acrobatics, mechanical wonders and a bit of clowning around, the show promises to provide an entertaining acrobatic experience for audiences looking for fun and excitement.

Presented by the Leisure & Cultural Services Department as part of the “Cheers!” Series, the show will be staged at 8pm from December 26 to 28 at Queen Elizabeth Stadium.

Tickets are available at URBTIX. One ticket per person is required regardless of age.

Call 2268 7323 for enquiries.

About 200 archaeological Song-Yuan period finds unearthed at Kai Tak will go on display in an exhibition at the Heritage Discovery Centre from tomorrow until February 26.

Following the closure of Kai Tak Airport in 1998, the planning work for the Kai Tak Development Area created opportunities for archaeological studies around the former Sacred Hill in Kowloon Bay.

An abundance of Song-Yuan period cultural remains were subsequently unearthed, including a huge amount of ceramics produced by various kilns in Zhejiang, Fujian and Jiangxi.

Similar products from the same period were exported widely and could be found in shipwrecks along the maritime ceramics route.

Highlights of the Treasures from the Sacred Hill: Song-Yuan Period Archaeological Discoveries from Kai Tak exhibition include green glazed incense burners with an eight trigrams pattern and a green glazed dish with a moulded double fish pattern produced by Longquan Kiln.

Other highlights include a brown glazed dragon jar with lugs and a green glazed basin with a phoenix pattern produced by Cizao Kiln and a Daguan Tongbao bronze coin.

Ceramics from the same period on loan from the Art Museum of the Chinese University of Hong Kong will also be displayed.

Curated by the Antiquities & Monuments Office, admission to the exhibition is free.

Call 2208 4400 for details.

The Les Arcs Co-Production village, running December 13-16 within the Les Arcs European Film Festival (Dec 13-20), will present 25 projects in development and a further 10 works-in-progress. Several of the projects chosen for this year’s event are Irish films and films with Irish producers’ backing.

The 2020 honours and awards selection and appointment of Justices of the Peace (JPs) exercise will be postponed, as well as the announcement of the list of honours and awards and JP appointments, the Government announced today.

It decided to defer the exercise to accord top priority to the ongoing anti-epidemic work and implementation of measures to retain employment, support businesses and ease people's livelihood in the face of challenges arising from the COVID-19 epidemic.

The Honours List and JP appointments will be announced on October 1 instead of July 1 as in previous years, the Government added.

A group of technologists has led crowdsourcing efforts to create a single repository of information for specialists fighting the Coronavirus outbreak. Techworld speaks with founder Edward Saperia to hear more about how collaboration tools can help the efforts

(Rice University) Rice University researchers have integrated high-efficiency solar cells and electrode catalysts into an efficient, low-cost device that splits water to produce hydrogen fuel.

(University of Jyväskylä - Jyväskylän yliopisto) Researchers at the universities of Jyvaskyla and Xiamen discovered a novel way to make functional macroscopic crystalline materials out of nanometer-size 34-atom silver-gold intermetallic clusters. The cluster material has a highly anisotropic electrical conductivity, being a semiconductor in one direction and an electrical insulator in other directions. The research was published in Nature Communications on May 6, 2020.

VOLUME 285 (2010) PAGES 13742–13747In Fig. 1E, passage 10, the splicing of a non-adjacent lane from the same immunoblot was not marked. This error has now been corrected and does not affect the results or conclusions of this work.jbc;295/16/5533/F1F1F1Figure 1E.

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.