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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Transcription factors in ferroptotic cell death




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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Strain creates a trion factory




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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Acta Pharmacologica Sinica




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Microbiota and colorectal cancer: colibactin makes its mark




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Listening to the sound of a bacterium




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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Impact of COVID-19 outbreak on spinal pathology: single center first impression




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A standardized patient-centered characterization of the phenotypic spectrum of <i>PCDH19</i> girls clustering epilepsy




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Activation and targeting of ATG8 protein lipidation




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Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea




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Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis




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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment




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Alemtuzumab plus CHOP versus CHOP in elderly patients with peripheral T-cell lymphoma: the DSHNHL2006-1B/ACT-2 trial




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Fixed orthodontic appliances: a practical guide




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NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




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Mining bacteria for biosensors




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Impact of the COVID-19 lockdown on basic science research in ophthalmology: the experience of a highly specialized research facility in France




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Julius Weitzdörfer: Managing the Impact of Nuclear Disasters

Julius Weitzdörfer’s earliest childhood memories are the major global events of 1986—the Space Shuttle Challenger explosion and the Chernobyl disaster. Looking back, he realizes that these events must have contributed to shaping his later research interests in managing technological risks. 




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The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




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Carbon Taxes vs. Cap and Trade: Theory and Practice

How do the two major approaches to carbon pricing compare on relevant dimensions, including efficiency, cost-effectiveness, and distributional equity? This paper addresses this question by drawing on theories of policy instrument choice pertaining to the attributes — or merits — of the instruments.




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Factoring Pandemic Risks into Financial Modelling

Today’s economic crisis leaves us with an unsettling and perplexing regret. Why weren’t financial portfolios already adjusted for risks that stem from health events such as pandemics? After all, financial portfolios are adjusted for liquidity risks, market risks, credit risks, and even operational and political risks.




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The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




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The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




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Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers




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Enhancer–promoter interactions and transcription




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Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors




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Controversial practice of rewarding for publications in national journals

Nazarovets, Serhii Controversial practice of rewarding for publications in national journals., 2020 [Preprint]




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Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el

Casero-Ripollés, Andreu Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el brote. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]




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Carbon Taxes vs. Cap and Trade: Theory and Practice

How do the two major approaches to carbon pricing compare on relevant dimensions, including efficiency, cost-effectiveness, and distributional equity? This paper addresses this question by drawing on theories of policy instrument choice pertaining to the attributes — or merits — of the instruments.




act

Factoring Pandemic Risks into Financial Modelling

Today’s economic crisis leaves us with an unsettling and perplexing regret. Why weren’t financial portfolios already adjusted for risks that stem from health events such as pandemics? After all, financial portfolios are adjusted for liquidity risks, market risks, credit risks, and even operational and political risks.




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The Global Pandemic Has Spawned New Forms of Activism — and They're Flourishing

The authors have identified nearly 100 distinct methods of nonviolent action that include physical, virtual and hybrid actions.




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Assessing Progress on Nuclear Security Action Plans

Participants at the final Nuclear Security Summit in 2016 agreed on “action plans” for initiatives they would support by five international organizations and groups—the International Atomic Energy Agency, the Global Initiative to Combat Nuclear Terrorism, INTERPOL, the United Nations, and the Global Partnership Against the Spread of Weapons and Materials of Destruction. These institutions were supposed to play key roles in bolstering ongoing nuclear security cooperation after the summit process ended. The action plans were modest documents, largely endorsing activities already underway, and there have been mixed results in implementing them. To date, these organizations have not filled any substantial part of the role once played by the nuclear security summits.




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Washington Should Take Action on AI or Stay Out of the Way

Federal and local regulations are part of the solution to tough issues related to Artificial Intelligence, writes K. Gretchen Greene, but no regulatory approach on its own can fully answer these questions today. "Finding answers will require significant investments in research and development, collaboration, negotiation, and experimentation, deep and careful thought across many fields and leadership at all levels, across and between governments. The U.S. federal government is well positioned to lead, but if it won't, it should at least stay out of the way."




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How to Avoid a Pandemic Patriot Act

The last time the United States faced a big, hard-to-track threat, we ended up with the Patriot Act and a mass-surveillance program that still rankles. This time, how do we use technology to combat the novel coronavirus without creating elements of a police state?




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Why Matter Matters: How Technology Characteristics Shape the Strategic Framing of Technologies

The authors investigate how the executives of the two largest research institutes for photovoltaic technologies — the National Renewable Energy Laboratory (NREL) in Golden, USA and the Fraunhofer Institute for Solar Energy Systems (Fraunhofer ISE) in Freiburg, Germany — have made use of public framing to secure funding and shape the technological development of solar photovoltaic (PV) technologies. The article shows that the executives used four framing dimensions (potential, prospect, performance, and progress) and three framing tactics (conclusion, conditioning, and concession), and that the choice of dimensions and tactics is tightly coupled to the characteristics of the specific technologies pursued by the research institutes.