Hannah Grotzinger
May 29, 2024; 44:e1856232024-e1856232024
BehavioralSystemsCognitive

Elle M. Murata
Sep 18, 2024; 44:e0573242024-e0573242024
BehavioralSystemsCognitive

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

Watch how the artist directs his team so when a photograph is taken, Bolin is completely camouflaged by his surroundings

Credit: Leftwich Lab

A new exhibition at the Smithsonian's National Museum of Natural History combines satellite observations and historical data to offer a "larger-than-life look" at our planet's climate today

The banana duct-taped to a wall was created to be a "reflection on what we value." An upcoming auction may deliver an answer

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Food is a focal point for understanding broader environmental problems. In this podcast, we learn how food buyers are influenced in surprising ways.

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Interim PC Leader Glen Savoie urged members to find a common purpose rather than blame former leader Blaine Higgs.

Max Topolnisky, a 100-year-old Second World War veteran, was out selling poppies for the Lockerby Legion in Sudbury, Ont., two days before he died, on Nov. 1, 2024.

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Pennsylvania College of Technology’s Diesel Performance Club has captured another first place in drag race competition. The club's 1959 B-61 Mack drag truck, known as “Accelerated Learning,” won top honors in the “Big Rig Auto” bracket at the October Truck Fest at Island Dragway in Great Meadows, New Jersey. That victory qualified the truck for the “King of the Island” bracket race, where it finished in second place.

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