By 2030, according to Forbes, millennials will make up 75% of the workforce. Digitally wired since their childhoods, millennials favour work-life integration rather than work-life balance reflecting the way today’s boundaries between professio...

Ghardaia -Une large op�ration de...

What's happened? The High Court has considered multiple warranty claims under an aerospace SPA. The case from earlier this year is interesting due to the range of warranty claims considered and the court’s interpretation of the relevant SPA pr...

Japan will launch its first space operations unit within the Air Self-Defense Force on May 18 to monitor threats to Japanese satellites in outer space, ...

[This Day] The federal government yesterday raised the alarm that many states in the country may soon run out of bed spaces for COVID-19 patients at their isolation centres due to the increasing number of Nigerians testing positive to Coronavirus.

US Space Force chief explains why he didn't want Steve Carell to play him on Netflix film

BEIJING: China’s new prototype spacecraft “successfully landed” on Friday, marking an important step in its ambitions to run a permanent space station and send astronauts to the moon. The spacecraft — which was launched Tuesday — arrived safely at a predetermined...

Microchip’s Low-Power Radiation-Tolerant (RT) PolarFire FPGA Enables High-Bandwidth Space Systems with Lower Total System Cost

Microchip Announces Industry’s First Space-Qualified COTS-Based Radiation-Tolerant Ethernet Transceiver and Embedded Microcontroller

MUMBAI/BANGALORE: Multinational companies are increasingly buying properties to set up their offices instead of leasing offices as they preferred for years, marking a strategic shift that signals the growing importance of the Indian market and the long-term commitment of the global firms. Foreign firms including GlaxoSmithKline Pharma, Sanofi Aventis, Adobe, Honeywell, SanDisk and Amazon have recently bought office space in India. MNCs accounted for 35% of total commercial asset sales in the country in the first three months of 2014, according to a report by real estate services firm Cushman & Wakefield. In 2012, MNCs contributed as much as 60% to the total commercial asset sales, backed by two deals […]

MUNICH, Germany – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, today announced the opening of its first Experience Store in Europe....

A radical new idea erases quantum theory's weird uncertainties – by ripping up all we thought we knew about how the universe works, says physicist Lee Smolin

A bold new perspective suggests space-time isn’t a fundamental entity but emerges from quantum entanglement, says physicist Sean Carroll

Einstein’s framework for the universe, space-time, is at odds with quantum theory. Overcoming this clash and others is vital to unravelling the true nature of the cosmos

One-way corridors, buffer zones around desks, and clear plastic screens to guard against colleagues' coughs and sneezes may become office standards after coronavirus stay-at-home orders are lifted,...

Arizona-based company World View Enterprises says it has taken a major step towards launching commercial balloon flights to the edge of space, with a successful unmanned test flight that reached an altitude of about 23 miles. The company hopes to begin taking tourists to near space in 2016 with advanced technology it says will open up a new view of the Earth. Sharon Reich reports.

An aerial view of crabeater seals in Antarctica, mating damselflies and a twilight rocket launch were among the most lauded entries to the inaugural Nature TTL Photographer of the Year award

The unique metal asteroid Psyche may be a space miner's fantasy – but there are better reasons to want to visit it, says mission leader Lindy Elkins-Tanton

Watch a new series charting our planet from above, read all about the biggest living things, fend off space rocks for fun, plus more picks for your diary

An aerial view of crabeater seals in Antarctica, mating damselflies and a twilight rocket launch were among the most lauded entries to the inaugural Nature TTL Photographer of the Year award

Nicolas Cage grapples with a weird luminous alien presence in the movie Color Out of Space. It's a story that has roots in a late-19th-century obsession with new forms of radiation, says Simon Ings

NASA on Thursday selected space firms SpaceX, Blue Origin and Dynetics to build lunar landing systems that can carry astronauts to the moon by 2024, the White House's accelerated deadline under the space agency's moon-to-Mars campaign. Jillian Kitchener has more.

It might be hard to imagine but space is getting crowded. ‘Space junk’ is becoming a dangerous hazard for orbiting satellites, and now some countries are joining forces to tackle it.

Our images of deep space are spectacular, but don’t reflect what our eyes would see. Here's what their stunning true colours reveal about the cosmos

Weird blasts of radio waves from space called fast radio bursts have been baffling astronomers since they were discovered, but after finding one in our galaxy we may finally know what creates them

SpaceX’s first crewed launch is planned for 27 May and will be run from a mission control with desks set six feet apart to comply with social distancing protocols

From vintage satellites to lunar rovers, space archaeologist Alice Gorman is teasing out a unique history of humanity from the objects we've dispatched from Earth

China just tested its biggest rocket yet, along with a new capsule designed to carry humans to its planned space station, the moon and beyond

Title: Health Tip: Create a Space for Sleep
Category: Health News
Created: 4/30/2008 2:00:00 AM
Last Editorial Review: 4/30/2008 12:00:00 AM

Title: Long Periods in Space Alter Astronauts' Brains
Category: Health News
Created: 4/14/2020 12:00:00 AM
Last Editorial Review: 4/15/2020 12:00:00 AM

Real geography is continuous, but standard models in population genetics are based on discrete, well-mixed populations. As a result, many methods of analyzing genetic data assume that samples are a random draw from a well-mixed population, but are applied to clustered samples from populations that are structured clinally over space. Here, we use simulations of populations living in continuous geography to study the impacts of dispersal and sampling strategy on population genetic summary statistics, demographic inference, and genome-wide association studies (GWAS). We find that most common summary statistics have distributions that differ substantially from those seen in well-mixed populations, especially when Wright’s neighborhood size is < 100 and sampling is spatially clustered. "Stepping-stone" models reproduce some of these effects, but discretizing the landscape introduces artifacts that in some cases are exacerbated at higher resolutions. The combination of low dispersal and clustered sampling causes demographic inference from the site frequency spectrum to infer more turbulent demographic histories, but averaged results across multiple simulations revealed surprisingly little systematic bias. We also show that the combination of spatially autocorrelated environments and limited dispersal causes GWAS to identify spurious signals of genetic association with purely environmentally determined phenotypes, and that this bias is only partially corrected by regressing out principal components of ancestry. Last, we discuss the relevance of our simulation results for inference from genetic variation in real organisms.

The CRISPR/Cas9 nucleases have been widely applied for genome editing in various organisms. Cas9 nucleases complexed with a guide RNA (Cas9–gRNA) find their targets by scanning and interrogating the genomic DNA for sequences complementary to the gRNA. Recognition of the DNA target sequence requires a short protospacer adjacent motif (PAM) located outside this sequence. Given that the efficiency of target location may depend on the strength of interactions that promote target recognition, here we sought to compare affinities of different Cas9 nucleases for their cognate PAM sequences. To this end, we measured affinities of Cas9 nucleases from Streptococcus pyogenes, Staphylococcus aureus, and Francisella novicida complexed with guide RNAs (gRNAs) (SpCas9–gRNA, SaCas9–gRNA, and FnCas9–gRNA, respectively) and of three engineered SpCas9–gRNA variants with altered PAM specificities for short, PAM-containing DNA probes. We used a “beacon” assay that measures the relative affinities of DNA probes by determining their ability to competitively affect the rate of Cas9–gRNA binding to fluorescently labeled target DNA derivatives called “Cas9 beacons.” We observed significant differences in the affinities for cognate PAM sequences among the studied Cas9 enzymes. The relative affinities of SpCas9–gRNA and its engineered variants for canonical and suboptimal PAMs correlated with previous findings on the efficiency of these PAM sequences in genome editing. These findings suggest that high affinity of a Cas9 nuclease for its cognate PAM promotes higher genome-editing efficiency.

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

The low supply of traditional office space expanding in central districts of Ho Chi Minh City (HCMC) has lead to the growth of coworking spaces, or flexible office spaces there.

We're bringing you something new: SpeakerChat. This event is both a way to revisit some great eLearning Guild content from a recorded session while also […]

The post SpeakerChat for 05/15/20: Spaced Learning – Why It’s So Good & How to Get Started appeared first on e-Learning Feeds.

X-37B? Sorry, I thought you said your name was X Æ A-12.

Strange blasts from space called fast radio bursts continue to puzzle astronomers with their odd behaviour, as they seem to come from a variety of galaxies

Huge constellations of satellites like SpaceX’s Starlink could make ground-based astronomy impossible, and we’re running out of time to deal with the problem