To make the world safer against future infectious disease threats, national health systems should be strengthened, the World Health Organization’s emergency and outbreak response activities should be consolidated and bolstered, and research and development should be enhanced, says a new Policy Forum article that appears in the May 19 edition of PLOS Medicine.

The U.S. Agency for International Development should speed its transformation into a global leader and catalyst in applying science, technology and innovation to the challenges facing developing countries, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. Global Change Research Program (USGCRP) has made significant accomplishments to advance the science of global environmental change and improve the understanding of its impact on society through activities such as developing Earth-observing systems, improving Earth-system modeling capabilities, and advancing understanding of carbon-cycle processes, says a new report from the National Academies of Sciences, Engineering, and Medicine.

At the Science20 Dialogue Forum held today at the German National Academy of Sciences Leopoldina, a statement on improving global health was handed to German Chancellor Angela Merkel by representatives of the G20 science academies.

A new report from the National Academies of Sciences, Engineering, and Medicine identifies global health priorities in light of current and emerging challenges and makes 14 recommendations for the U.S. government and other stakeholders to address these challenges, while maintaining U.S. status as a world leader in global health.

NASA’s large strategic missions like the Hubble Space Telescope, the Curiosity rover on Mars, and the Terra Earth observation satellite are essential to maintaining the United States’ global leadership in space exploration and should continue to be a primary component of a balanced space science program that includes large, medium, and smaller missions, says a new report by the National Academies of Sciences, Engineering, and Medicine.

The U.S. National Academy of Sciences and U.S. National Academy of Medicine joined the science academies of South Africa, Brazil, and Germany today in issuing a statement calling for urgent worldwide action to reduce air pollution.

International thought leaders will join the next generation of engineers in London from Sept. 16 to 18 for the Global Grand Challenges Summit 2019. The summit aims to help inspire and equip future engineering leaders to address the rapidly evolving challenges of an unpredictable world.

I got the word this week from The Crest of Westwood that they'll be streaming coverage of the Golden Globes at The Crest on Sunday.

It's free and open to the public; doors open at 4:30 and the event starts at 5pm.

The Crest's Virginia Chavez writes, "We're encouraging formal attire, but it's not required for entrance."

But Off-Ramp says, "Phooey! Dress up. It's what classy people do." Like this stunning couple:

(Anne Knudsen/LA Public Library Herald-Examiner collection)

The caption of this 1985 photo reads, "David Hasselhoff in a burgundy-and-black striped tuxedo kept pace with wife Catherine Hickland's high fashion style: Ellene Warren's silk shoulder-beaded jacket, silk jacquard pants and matching evening bra. Hasselhoff and Hickland attended the Emmy Awards at the Pasadena Civic Auditorium.

There's such a thing as an "evening bra?" I don't think so.

The Crest - 1262 Westwood Blvd. LA, CA 90024 - (323) 553 - 3500

This content is from Southern California Public Radio. View the original story at SCPR.org.

A new study has investigated the impacts of human activity on Antarctic Marine and Coastal. Alongside local effects of fishing, pollution and invasive alien species, global climate change is causing sea temperature rises and ocean acidification. Action is therefore needed at all levels to address these impacts.

If we can’t secure the supply chain, eventually everything else will break

The post What happens when the global supply chain breaks? appeared first on WeLiveSecurity

While in France, a citizen of Brazil who resides in California books a bungee jump in New Zealand. Is it a leap of faith into the unknown, for both the operator and the thrill-seeker?

The post Is “global privacy” an oxymoron? appeared first on WeLiveSecurity

Source: Streetwise Reports   05/04/2020

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS^® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

Disclosure:
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( Companies Mentioned: STML:NASDAQ, )

Global air quality will significantly deteriorate by 2050 unless further steps are taken to cut current emissions from human activities, according to recent research. Most people around the world will be affected by worsening air quality with hotspots of particularly poor air occurring in China, northern India and the Middle East.

A recent study has revealed how water use has changed across the world over the last 60 years. Growing populations and economic development, particularly in newly-emerging countries, have increased water demand, but technological developments have led to water efficiencies and savings, which moderate these demands.

Groundwater is the earth’s largest freshwater resource and is vital for irrigation and global food production. In dry periods farmers pump groundwater to water crops, this is already happening at an unsustainable level in many places — exceeding the rate at which rain and rivers can refill the groundwater stores. This study seeks to identify where groundwater pumping is affecting stream flows and estimates where and when environmentally critical stream flows — required to maintain healthy ecosystems — can no longer be sustained.

A map of science could assist research planning strategies by helping to identify emerging topics. The map — which is based on links to almost 20 million scientific articles that have been published over the past 16 years — clusters and links scientific disciplines by citation-based relationships and serves as a highly detailed and scalable infographic. The authors hope it will be used by research planners to help distinguish — and potentially forecast — the research areas in science which have longevity, and also those which are innovative.

Alien plant invasions can have significant environmental, ecosystem and economic implications. Since ornamental horticulture is the primary pathway for invasive alien plant introductions, it is a suitable focus for prevention policies. A recent review of published evidence has examined the effectiveness of four major instruments: pre-border import restrictions, post-border sales bans, industry codes of conduct, and consumer education. The study highlights that, while each instrument has the potential to contribute to a reduction in plant invasion risk, none is sufficient to achieve this goal alone. The researchers, therefore, describe how the four instruments can be integrated along the ornamental horticulture industry supply chain to reduce risk more effectively, and outlines the role that government, industry and other stakeholders must play to achieve this goal.

Under pressure from rising food prices, many nations have begun to acquire large tracts of agricultural land in foreign countries, a practice known as ‘land grabbing’. New research has now quantified current levels of land grabbing and demonstrated that it is accompanied by concerning levels of ‘water grabbing’ which could affect water supply in the ‘grabbed’ countries.

A new global study is the first to quantify the potential of water management strategies to increase crop production. It indicates that a combination of harvesting run-off water and reducing evaporation from soil could increase global crop production by 20 per cent.

Reindeer herding has a long history in the Arctic, but climate change and industrial activity are bringing this important economic and cultural tradition to breaking point. In a unique initiative, reindeer herders across the Arctic are leading an international team of scientists in using modern technology to adapt to global change and empower indigenous communities.

A global cropland percentage map and a global field size map have been created for the first time to guide scientists and policymakers interested in global agricultural modelling and assessment. Both maps are for the baseline year 2005 and combined multiple data sets from global, regional and national levels to achieve a high level of accuracy and 1 km2 resolution.

Crop rotation is gaining increasing research- and policy attention as an environmentally friendly way to manage weeds. In such rotations, crops are introduced that release chemicals into the environment known to inhibit weed germination or growth (so-called allelopathic crops). Previous studies have identified Cynara cardunculus L., a perennial thistle, including varieties of globe artichoke and cardoon, as a potential allelopathic candidate. This study conducted field experiments using three botanical varieties of C. cardunculus to evaluate their effect on weeds within an ecosystem. The results confirm that C. cardunculus has an allelopathic effect in monoculture, reducing the amount of weed seeds present in soil. This paves the way for its inclusion in crop rotation as part of eco-friendly, sustainable weed-management strategies.

The worldwide decline of pollinators could increase cases of vitamin and micronutrient deficiencies in humans, new research suggests. For instance, pollination is needed for the crops that produce half of all plant-derived vitamin A across much of south-east Asia. Furthermore, areas which depend most on pollination for micronutrient supply tend to be poorer and already at higher risk of deficiencies.

The current economic and environmental crisis tells us that the time is ripe for governments around the world to implement a new kind of economy, which is resilient, sustainable, operates within the limits of our planet's resources and creates a fairer society. This thematic issue covers research which can help policy makers develop this Global Green Economy.

Researchers have developed a new energy map that traces the flow of global energy from the fuel sources to the final services provided. The study provides new insight into the potential of energy efficiency measures by focusing on technologies rather than economic sectors.

Biomass is increasingly used to make biofuels and generate electricity and is seen as a valuable source of renewable energy. A recent study has assessed the key factors relating to the sustainability of bioenergy production and suggests global biomass could potentially meet up to one third of the projected global energy demand in 2050.

Dire messages about the impact of global warming may increase scepticism because they contradict a commonly held belief that the world is a just and orderly place. This is the conclusion of new psychological research which investigated the reaction of individuals to messages about global warming.

There are no technical or economic barriers to providing all of the world’s energy from renewable sources, according to a recent study. With a concerted effort, including reduced demand and international cooperation, the researchers suggest that the world could be entirely reliant on renewable energy for electric power, transportation and heating/cooling by 2050.

Reindeer herding has a long history in the Arctic, but climate change and industrial activity are bringing this important economic and cultural tradition to breaking point. In a unique initiative, reindeer herders across the Arctic are leading an international team of scientists in using modern technology to adapt to global change and empower indigenous communities.

Some scientists have suggested that, when all potential inefficiencies are accounted for, local food distribution systems may be less sustainable than globalised systems. However, new research examining the behaviour of participants in local food networks in France suggests that they can be as energy efficient as globalised systems.

Research from the US helps paint a clearer picture of the extent of global sea level rise, by considering new satellite data on the Earth’s gravity. Its findings support reports of accelerating ice melt and suggest that most of the change in sea levels is caused by receding polar ice sheets and mountain glaciers.

Crop pests and pathogens are moving into new habitats, towards the North and South Poles, as global warming progresses, new research suggests. Observation records from around the world show that many crop pests, including insect and bacterial pests, are moving towards the poles at an average rate of 2.7 km per year.

New areas of land suitable for agriculture will open up under climate change’s effects, new research predicts, particularly in far northern regions of the world. However, the overall quality of land for farming will decline and many regions, including Europe, could lose large areas of suitable land.

A number of studies have shown that the public misunderstand global warming. Taking a fresh approach, this study investigated the willingness of the public to take part in activities that mitigate climate change. An international survey of 24 countries revealed that this is strongly related to personal experiences with global warming. The authors say linking actions to benefits could encourage climate change mitigation behaviour.

Driven by trade, the spread of alien species is increasing worldwide. This study combined 60 years of trade data with that on biodiversity and climate to model the spread of plant species across 147 countries. The model predicts significant increases in plant invasions in the next 20 years, especially for emerging economies. The authors say trade legislation must consider biological invasion and focus on regions at high risk.

Researchers have proposed a global roadmap for decarbonisation over the coming decades. The roadmap is based on the idea of a simple heuristic, described by the researchers as ‘carbon law’, of halving carbon dioxide (CO2) emissions every decade from 2020 to 2050. The researchers say that, if combined with the development of new technologies and efforts to reduce CO2 emissions from land use, this target could lead to a carbon-neutral global economy by 2050.

A recent international analysis of waste electrical and electronic equipment (WEEE) management has indicated that current practices will not be able to deal with future increases in WEEE. It calls for rapid, co-ordinated and bold responses that are both technical and non-technical to deal with this ever-increasing global issue.

IT company Cognizant announced it will acquire Collaborative Solutions, a privately-held global consultancy specialising in Workday enterprise cloud applications for finance and HR.

In a freewheeling discussion with ETCIO, Miao Song, Global CIO & Global VP of MARS group emphasized this different Covid-19 challenge which is new for CIOs to tackle and difficult too.

Global demand for copper could increase by up to 341% by 2050, and energy use is likely to increase with it — rising to a possible 2.4% of global energy demand in 2050, according to new research. Policy actions to avoid such drastic changes could include improving copper recycling and using renewable technologies.

In a freewheeling discussion with ETCIO, Miao Song, Global CIO & Global VP of MARS group emphasized this different Covid-19 challenge which is new for CIOs to tackle and difficult too.

Our global customers are looking at the cloud to more effectively meet their toughest business challenges. Yet something is stopping them from making the most of what cloud can deliver

At BT Global Services connections are our business. We are trusted by thousands of enterprises around the world, combining our global strength in networks, IT and innovation with local presence, expertise and delivery. Watch this video to find out how we can help you connect for a better future.

You need to make sure that when a customer calls, they get a response first time, every time. If you fail, your customer might soon become somebody else’s. Inbound Contact global can help