Beijing has kicked off a campaign to help graduates entering the labour market as the country faces growing pressure to reboot the sagging economy and tackle unemployment.Ten initiatives were announced to find jobs for this year’s 8.74 million new graduates in an online launch on Wednesday by officials from the labour, education, human resources, and industry and information technology ministries.The “100-day” campaign – highlighting the urgency for young people to find work – includes more…

The night of March 6, 2020, started much like every other night for boxing camp owner Pitak Kaewprapol – with a visit to a fight.Pitak and thousands of other Muay Thai fans had packed the New Lumpinee Boxing Stadium in Bangkok to watch an evening of kick-boxing, ignoring a government order just three days earlier requiring large gatherings to be cancelled or postponed.Like many others among the crowd of fans, tourists, celebrities, trainers and promoters who packed the 5,000-capacity stadium,…

Another major aid group is warning Kenya not to close the world's largest refugee camp, saying the move is pressuring tens of thousands of Somali refugees to return to their deeply unstable country.

A mobile clinic which was donated by First Lady Margaret Kenyatta remains unused causing much frustration.

President Donald Trump needled his Democratic rival Joe Biden Friday for limiting his campaign appearances to virtual events from the basement of his home in Delaware.

At Camp No 5, in Cox's Bazar, there are about 632,000 displaced people still living in terrible conditions. But an international humanitarian effort is helping people in the community in southern Bangladesh live a better life. 

Life returned to normal Saturday in the Rashidiyeh Palestinian refugee camp, south of Tyre, after a night of clashes that left one person dead and five others injured.

A site designed to help voters who want to stop Brexit has come under fire for its recommendations, but the group behind it say it is backed by statistics

At Unseen Amsterdam, striking images of a melting glacier are stirring visitors to action

College sports will not resume until all students are back on campus, NCAA president Mark Emmert said Friday.

Refugees at the Zaatari camp in Jordan have designed a robot prototype made from LEGOs, which automatically dispenses sanitizer to avoid contact with the bottle and help prevent the spread of the coronavirus.

Refugees at the Zaatari camp in Jordan have designed a robot prototype made from LEGOs, which automatically dispenses sanitizer to avoid contact with the bottle and help prevent the spread of the coronavirus.

College sports will not resume until all students are back on campus, NCAA president Mark Emmert said Friday.

Coronavirus quarantine has supermodel Naomi Campbell reinventing herself as a talk show host with the new series "No Filter with Naomi."

Title: Summer Camp Prep for Kids With Allergies, Asthma
Category: Health News
Created: 4/29/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: Pick Summer Camps Carefully When Your Kid Has Allergies, Asthma
Category: Health News
Created: 2/29/2020 12:00:00 AM
Last Editorial Review: 3/2/2020 12:00:00 AM

ABSTRACT

Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts may be involved in host eusociality. Yet our knowledge of social ant-symbiont dynamics has remained rudimentary. Through 16S rRNA gene deep sequencing of the carpenter ant Camponotus japonicus symbiont community across various castes, we here report caste-dependent diversity of commensal gut microbiota and lineage divergence of "Candidatus Blochmannia," an obligate endosymbiont. While most prevalent gut-associated bacterial populations are found across all castes (Alphaproteobacteria, Gammaproteobacteria, Bacteroidetes, and Cyanobacteria), we also discovered uncultured populations that are found only in males (belonging to Corynebacteriales, Alkanindiges, and Burkholderia). Most of those populations are not detected in laboratory-maintained queens and workers, suggesting that they are facultative gut symbionts introduced via environmental acquisition. Further inspection of "Ca. Blochmannia" endosymbionts reveals that two populations are dominant in all individuals across all castes but that males preferentially contain two different sublineages that are diversified from others. Clearly, each caste has distinct symbiont communities, suggesting an overlooked biological aspect of host-symbiont interaction in social insects.

IMPORTANCE Social animals, such as primates and some insects, have been shown to exchange symbiotic microbes among individuals through sharing diet or habitats, resulting in increased consistency of microbiota among social partners. The ant is a representative of social insects exhibiting various castes within a colony; queens, males, and nonreproductive females (so-called workers) show distinct morphologies, physiologies, and behaviors but tightly interact with each other in the nest. However, how this social context affects their gut microbiota has remained unclear. In this study, we deeply sequenced the gut symbiont community across various castes of the carpenter ant Camponotus japonicus. We report caste-dependent diversity of commensal gut microbial community and lineage divergence of the mutualistic endosymbiont "Candidatus Blochmannia." This report sheds light on the hidden diversity in microbial populations and community structure associated with guts of males in social ants.

ABSTRACT

Protein homeostasis is critical for proliferation and viability of all organisms. For Candida albicans, protein homeostasis also modulates the transition between yeast and filamentous forms, which is critical for virulence. A key regulator of morphogenesis is the molecular chaperone Hsp90, which mediates proteostasis under physiological and stress conditions. Hsp90 regulates morphogenesis by repressing cyclic AMP-protein kinase A (cAMP-PKA) signaling, such that inhibition of Hsp90 causes filamentation in the absence of an inducing cue. We explored the effect of perturbation of another facet of protein homeostasis and discovered that morphogenesis is also regulated by the proteasome, a large 33-subunit protein complex consisting of a 20S catalytic core and two 19S regulatory particles, which controls degradation of intracellular proteins. We identified a conserved role of the proteasome in morphogenesis as pharmacological inhibition of the proteasome induced filamentation of C. albicans and the related species Candida dubliniensis, Candida tropicalis, Candida krusei, and Candida parapsilosis. For C. albicans, genetic depletion of any of 29 subunits of the 19S or 20S particle induced filamentation. Filaments induced by inhibition of either the proteasome or Hsp90 have shared structural characteristics, such as aberrant nuclear content, and shared genetic dependencies, such as intact cAMP-PKA signaling. Consistent with a functional connection between these facets of protein homeostasis that modulate morphogenesis, we observed that proteasome inhibition results in an accumulation of ubiquitinated proteins that overwhelm Hsp90 function, relieving Hsp90-mediated repression of morphogenesis. Together, our findings provide a mechanism whereby interconnected facets of proteostasis regulate C. albicans morphogenesis.

IMPORTANCE Fungi cause life-threatening infections and pose a serious threat to human health as there are very few effective antifungal drugs. Candida albicans is a major human fungal pathogen and cause of morbidity and mortality in immunocompromised individuals. A key trait that enables C. albicans virulence is its ability to transition between yeast and filamentous forms. Understanding the mechanisms regulating this virulence trait can facilitate the development of much-needed, novel therapeutic strategies. A key regulator of morphogenesis is the molecular chaperone Hsp90, which is crucial for proteostasis. Here, we expanded our understanding of how proteostasis regulates fungal morphogenesis and identified the proteasome as a repressor of filamentation in C. albicans and related species. Our work suggests that proteasome inhibition overwhelms Hsp90 function, thereby inducing morphogenesis. This work provides a foundation for understanding the role of the proteasome in fungal virulence and offers potential for targeting the proteasome to disarm fungal pathogens.

BACKGROUND AND PURPOSE:

NeuroQuant is an FDA-approved software that performs automated MR imaging quantitative volumetric analysis. This study aimed to compare the accuracy of NeuroQuant analysis with visual MR imaging analysis by neuroradiologists with expertise in epilepsy in identifying hippocampal sclerosis.

College sports will not resume until all students are back on campus, NCAA president Mark Emmert said Friday.

President Donald Trump’s re-election campaign launched a massive, multi-million dollar ad blitz against presumptive Democratic presidential nominee Joe Biden on Thursday, its biggest onslaught against Biden since the coronavirus pandemic hit the United States.

The Trump campaign released a new ad in Spanish targeting Democrats for their response to the allegations Tara Reade made against presumptive Democratic nominee Joe Biden.

After teasing it for seven months, President Donald Trump’s re-election campaign finally launched a new phone application to rally supporters on Thursday that has been re-imagined for the virtual political age.

Joe Biden's campaign has signed a joint fundraising agreement with the DNC that will help Democrats close the gap with President Donald Trump's massive war chest.

The unified anti-Trump effort has already spent millions on attacking the Trump administration's handling of the virus, or praising former Vice President Joe Biden on the issue.

President Trump new coronavirus TV ad hits critics like Joe Biden and Nancy Pelosi, argues America writing the 'the greatest comeback story'

Unite the Country, a super PAC supporting Joe Biden, and the Trump campaign both launched $10 million ad campaigns this week.

President Trump's reelection campaign trashed Facebook's new oversight board in a statement alleging anti-Trump bias by the social media platform.

Earlier this week, Facebook revealed the first 20 members of its new oversight board, which has responsibility for content enforcement and governance on its platforms. The board includes Pamela Karlan, ...

Rep. Justin Amash believes his White House bid is bad for both President Trump and his Democratic challenger, the Michigan Libertarian indicated in a recent interview.

Mr. Amash, a former Republican who left the GOP last year, told Time that he expects his presence in the presidential race will not ...

College sports will not resume until all students are back on campus, NCAA president Mark Emmert said Friday.

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The heir to the throne, 71, spent seven days self isolating at his Scottish home Birkhall, when he was told he had contracted the disease late last month.

"Our premise has always been to change an industry which is traditionally quite bad, and become sustainable"

The Bishop of London tells April Roach there has never been a greater need for people to come together to help feed hungry Londoners You can donate here virginmoneygiving.com/fund/FoodforLondonNOW

The NHS is launching a campaign encouraging ill people to seek urgent care during the coronavirus outbreak after A&E visits dropped by 50 per cent this month.

Deaf campaigners have begun legal proceedings against the Government over the lack of sign language interpreters during the daily coronavirus briefings.

Captain Tom Moore has now raised a staggering £30m for the NHS in its battle against coronavirus as he celebrates his 100th birthday.

A key figure of Columbia Road flower market and a campaigning businessman dubbed "Mr Highbury" are among the latest victims whose deaths show how coronavirus is tearing through London's communities.

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Police have dropped an investigation into two prominent Brexit campaigners accused of breaching spending rules during the referendum campaign. In 2018 the Electoral commission said that Alan Halsall, of Vote Leave, and Darren Grimes, founder of pro-Brexit youth group BeLeave, failed to declare a payment related to the campaign. The watchdog said that BeLeave "spent more than £675,000 with (Canadian data firm) Aggregate IQ under a common plan with Vote Leave". This spending took Vote Leave over its £7 million legal spending limit by almost £500,000. Vote Leave paid a £61,000 fine, but denied wrongdoing, while Mr Grimes won an appeal against his £20,000 fine in July. The Commission also referred the pair to the Metropolitan Police but on Friday it was revealed that the investigations had now been dropped. A spokesman for the Leave campaigners said: "The Metropolitan Police has written to Vote Leave board member Alan Halsall and BeLeave founder Darren Grimes to confirm that it will not be acting on allegations made against them by the Electoral Commission and various Remain campaigners. "This marks the end of a two-year ordeal for both individuals." Mr Grimes, 26, said the development called into question whether the Electoral Commission was "fit for purpose". He had insisted since the allegations were first made that he was "completely innocent" of making false declarations in relation to the £680,000 donation. In a statement, Mr Grimes, a former fashion student originally from County Durham, said: "The Metropolitan Police has found, after investigation and consultation with the Crown Prosecution Service, that there is no case to be answered. "Once again the Electoral Commission has been found to be part of the mob, a quango out of control that isn't policing elections so much as punishing Leavers who have the temerity to win them. "My ordeal at the hands of the kangaroo court that is the Electoral Commission is now over, but questions must now be asked of whether that body is fit for purpose." Mr Halsall, the responsible person for Vote Leave, said he was "delighted to have been exonerated" and thanked the police for their "professional" investigation. "I was very disappointed that my colleagues at Vote Leave and myself were never given the opportunity of making our case in person to the Electoral Commission before being fined and reported to the police," he added. "It seems a rather unusual way of conducting an inquiry into such matters that only the so-called whistleblowers who made these allegations are interviewed by the regulator." A spokesman for the Met said an investigation into the Electoral Commission's allegations against Vote Leave and BeLeave, submitted on July 17 2018, was handed over in October to the Crown Prosecution Service (CPS). "On Tuesday, March 3 preliminary advice was received from the CPS," said the force spokesman. "This advice has now been duly considered and no further action will be taken."

Katrina vanden Heuvel

The post The Pandemic Has Made the Poor People’s Campaign Virtual—and Vital appeared first on The Nation.