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The role of single-cell mechanical behaviour and polarity in driving collective cell migration




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Estimating narrow-sense heritability using family data from admixed populations




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Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers




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The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias




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Biomimetic niches reveal the minimal cues to trigger apical lumen formation in single hepatocytes




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Targeting adenosine in SSc




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform




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HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α




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Mechanisms by which angiotensin-receptor blockers increase ACE2 levels




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Antibody-free enzyme-assisted chemical approach for detection of <i>N</i><sup>6</sup>-methyladenosine




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A metabolic labeling method detects m<sup>6</sup>A transcriptome-wide at single base resolution




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Cyanobacterial in vivo solar hydrogen production using a photosystem I–hydrogenase (PsaD-HoxYH) fusion complex




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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons




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Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation




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A single-centre investigator-blinded randomised parallel-group study protocol to investigate the influence of an acclimatisation appointment on children’s behaviour during N<sub>2</sub>O/O<sub>2</sub> sedation as measured by psycho




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Clinical and radiographic evaluation of indirect pulp treatment of young permanent molars using photo-activated oral disinfection versus calcium hydroxide: a randomized controlled pilot trial




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Single-cell RNA counting at allele and isoform resolution using Smart-seq3




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Exposure to direct-to-consumer advertising is associated with overestimation of benefits regarding ultrahypofractionated radiation therapy for prostate cancer




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MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility

npj Microgravity, Published online: 16 March 2020; doi:10.1038/s41526-020-0099-7

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility




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Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




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Simultaneous quantification of protein–DNA interactions and transcriptomes in single cells with scDam&amp;T-seq




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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Dermatophagoides pteronyssinus peptidase 1 (DERP1)

In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma.




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SciBX: Science-Business eXchange




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Acta Pharmacologica Sinica




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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SIN List criticism based on misunderstandings




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Impact of COVID-19 outbreak on spinal pathology: single center first impression




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Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human




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Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis




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Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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Design, implementation, and evaluation of a nurse-led intravitreal injection programme for retinal diseases in Singapore




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Analyses of breakpoint junctions of complex genomic rearrangements comprising multiple consecutive microdeletions by nanopore sequencing




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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Assessing Progress on Nuclear Security Action Plans

Participants at the final Nuclear Security Summit in 2016 agreed on “action plans” for initiatives they would support by five international organizations and groups—the International Atomic Energy Agency, the Global Initiative to Combat Nuclear Terrorism, INTERPOL, the United Nations, and the Global Partnership Against the Spread of Weapons and Materials of Destruction. These institutions were supposed to play key roles in bolstering ongoing nuclear security cooperation after the summit process ended. The action plans were modest documents, largely endorsing activities already underway, and there have been mixed results in implementing them. To date, these organizations have not filled any substantial part of the role once played by the nuclear security summits.




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Closing Critical Gaps that Hinder Homeland Security Technology Innovation

Rapid technological advances are making nonstate actors much more capable than they were even a decade ago. Malicious actors like terrorist groups, criminal organizations, and state proxies are increasingly able to threaten American civilians and their interests around the world. At the same time, we are increasingly vulnerable to the emergence of new disease and natural disasters, as vividly shown by the hurricanes of 2017 (Harvey, Irma, and Maria) and the COVID-19 pandemic.

Effectively countering these threats, including by developing and supporting private sector-generated new technological solutions, is a core government responsibility. DHS is the U.S. government’s primary civilian public safety agency and the main source of government funding for nonmilitary development of public safety technologies. Unfortunately, DHS has a poor record of developing new technological solutions to advance its mission and address emerging threats. This article assesses the current situation, identifies lines of research that are urgently needed, and makes recommendations on how DHS can more effectively partner with industry and how new technologies can be quickly seeded.




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Insight 219: Singapore in the Global Energy Transition

For decades, Singapore has been a premier refinery hub and gatekeeper between Asia and the Middle East, but its position is increasingly threatened as producer countries are shifting into the downstream activities that helped make Singapore the “Houston of Asia”. Oil and petrochemicals drive about one quarter of Singapore’s net exports. Greater competition in the global oil and gas value chain could take a heavy toll on the city-state’s national budget and economic growth prospects.




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Study Group on Energy Innovation and the Transition to a Low-Carbon Economy: Advising Fortune 500 Companies

This study group will explore the role of the private sector in evolving energy systems, and how corporations might change in a climate constrained world. 




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Harvard Business School Professor Rebecca Henderson Outlines Ways Organizations are Changing in Response to the Coronavirus Pandemic and Climate Change in New Edition of "Environmental Insights"

Rebecca Henderson, the John and Natty McArthur University Professor at Harvard University, shared her perspectives on how large organizations are changing in response to the coronavirus pandemic and climate change in the newest episode of "Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program," a podcast produced by the Harvard Environmental Economics Program. Listen to the interview here. Listen to the interview here.




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Transatlantic Dialogue: The Missing Link in Europe’s Post-Covid-19 Green Deal?

This policy brief emphasizes that the European Green Deal's effectiveness in a post Covid-19 world will require the involvement of strategic partners, especially the US. In the context of a potential US withdrawal from the Paris Agreement and the consequential vacuum, it will be even more important to engage the US in implementing the GD. In light of divergence between the US and the EU during past climate negotiations (e.g. Kyoto, Copenhagen, and Paris), we suggest a gradual approach to US engagement with GD initiatives and objectives.




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Hopes and disappointments: regime change and support for democracy after the Arab Uprisings

Analysing two waves of the Arab Barometer surveys and employing an item-response method that offers methodological improvements compared to previous studies, this article finds that support for democracy actually decreased in countries that successfully overthrew their dictators during the Uprisings. 




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Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort




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Hopes and disappointments: regime change and support for democracy after the Arab Uprisings

Analysing two waves of the Arab Barometer surveys and employing an item-response method that offers methodological improvements compared to previous studies, this article finds that support for democracy actually decreased in countries that successfully overthrew their dictators during the Uprisings. 




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Insight 219: Singapore in the Global Energy Transition

For decades, Singapore has been a premier refinery hub and gatekeeper between Asia and the Middle East, but its position is increasingly threatened as producer countries are shifting into the downstream activities that helped make Singapore the “Houston of Asia”. Oil and petrochemicals drive about one quarter of Singapore’s net exports. Greater competition in the global oil and gas value chain could take a heavy toll on the city-state’s national budget and economic growth prospects.