While smoking is inextricably linked to oral/head and neck cancer (HNSCC), only a small fraction of smokers develop HNSCC. Thus, we have sought to identify other factors, which may influence the development of HNSCC in smokers including microbiology. To determine microbial associations with HNSCC among tobacco users, we characterized oral microbiome composition in smokers with and without HNSCC. 16S rRNA MiSeq sequencing was used to examine the oral mucosa microbiome of 27 smokers with (cases) and 24 without HNSCC (controls). In addition, we correlated previously reported levels of DNA damage with the microbiome data. Smokers with HNSCC showed lower microbiome richness compared with controls (q = 0.012). Beta-diversity analyses, assessed as UniFrac (weighted and unweighted) and Bray–Curtis distances, showed significant differences in oral mucosal microbiome signatures between cases and controls (r² = 0.03; P = 0.03) and higher interindividual microbiome heterogeneity in the former (q ≤ 0.01). Higher relative abundance of Stenotrophomonas and Comamonadaceae and predicted bacterial pathways mainly involved in xenobiotic and amine degradation were found in cases compared with controls. The latter, in contrast, exhibited higher abundance of common oral commensals and predicted sugar degradation pathways. Finally, levels of DNA damage in the oral cavity were correlated with the microbiome profiles above. Oral microbiome traits differ in smokers with and without HNSCC, potentially informing the risk of eventual HNSCC and shedding light into possible microbially mediated mechanisms of disease. These findings present data that may be useful in screening efforts for HNSCC among smokers who are unable to quit.

Cruciferous vegetables have been of special interest due to the rich presence of bioactive compounds such as sulforaphane which show promising potential on cancer prevention and therapy as an epigenetic dietary strategy. Abnormal epigenetic alteration as one of the primary contributors to tumor development is closely related to breast cancer initiation and progression. In the present study, we investigated the effect of dietary broccoli sprouts (BSp), a common cruciferous vegetable, on prevention of estrogen receptor (ER)-negative mammary tumors at three different temporal exposure windows using a spontaneous breast cancer mouse model. Our findings indicate that maternal BSp treatment exhibited profound inhibitory and preventive effects on mammary cancer formation in the nontreated mouse offspring. The BSp diet administered to adult mice also showed suppressive effects on mammary cancer but was not as profound as the maternal BSp preventive effects. Moreover, such protective effects were linked with differentially expressed tumor- and epigenetic-related genes, as well as altered global histone acetylation, DNA methylation, and DNA hydroxymethylation levels. We also found that the expression changes of tumor-related genes were associated with the levels of histone methylation of H3K4 and H3K9 in the gene promoter regions. In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNA methyltransferases, and histone deacetylases in ERα-negative breast cancer cell lines. Collectively, these results suggest that maternal exposure to key phytochemicals may contribute to ER-negative mammary tumor prevention in their offspring through epigenetic regulations.

Colorectal cancer is a growing burden in adults less than 50 years old. In 2018, the American Cancer Society published a guideline update recommending a reduction in the colorectal cancer screening start age for average-risk individuals from 50 to 45. Implementing these recommendations would have important implications for public health. However, the approximate number of people impacted by this change, the average-risk population ages 45–49, is not well-described in the literature. Here, we provide methodology to conservatively estimate the average-risk and screening-eligible population in the United States, including those who would be impacted by a lowered colorectal cancer screening start age. Using multiple data sources, we estimated the current average-risk population by subtracting individuals with symptomatic colorectal cancer, with a family history of colorectal cancer, and with inflammatory bowel disease and hereditary nonpolyposis colorectal cancer from the total population. Within this population, we estimated the number of screening-eligible individuals by subtracting those with previous colorectal cancer screening (45- to 49-year-old) or up to date with colorectal cancer screening (50- to 74-year-old). The total average-risk population is estimated between 102.1 and 106.5 million people, of whom 43.4–45.2 million people are eligible for colorectal cancer screening. Lowering the screening age would add roughly 19 million people to the average-risk population and increase the current number of screening-eligible individuals on immediate implementation by over 60% (from 27 to 44 million). Estimating the population size impacted by lowering the recommended colorectal cancer screening start age enables more accurate decision-making for policymakers and epidemiologists focused on cancer prevention.

Ovarian cancer imposes a substantial health and economic burden. We systematically reviewed current health-economic evidence for ovarian cancer early detection or prevention strategies. Accordingly, we searched relevant databases for cost-effectiveness studies evaluating ovarian cancer early detection or prevention strategies. Study characteristics and results including quality-adjusted life years (QALY), and incremental cost-effectiveness ratios (ICER) were summarized in standardized evidence tables. Economic results were transformed into 2017 Euros. The included studies (N = 33) evaluated ovarian cancer screening, risk-reducing interventions in women with heterogeneous cancer risks and genetic testing followed by risk-reducing interventions for mutation carriers. Multimodal screening with a risk-adjusted algorithm in postmenopausal women achieved ICERs of 9,800–81,400 Euros/QALY, depending on assumptions on mortality data extrapolation, costs, test performance, and screening frequency. Cost-effectiveness of risk-reducing surgery in mutation carriers ranged from cost-saving to 59,000 Euros/QALY. Genetic testing plus risk-reducing interventions for mutation carriers ranged from cost-saving to 54,000 Euros/QALY in women at increased mutation risk. Our findings suggest that preventive surgery and genetic testing plus preventive surgery in women at high risk for ovarian cancer can be considered effective and cost-effective. In postmenopausal women from the general population, multimodal screening using a risk-adjusted algorithm may be cost-effective.

Childbirth at any age confers a transient increased risk for breast cancer in the first decade postpartum and this window of adverse effect extends over two decades in women with late-age first childbirth (>35 years of age). Crossover to the protective effect of pregnancy is dependent on age at first pregnancy, with young mothers receiving the most benefit. Furthermore, breast cancer diagnosis during the 5- to 10-year postpartum window associates with high risk for subsequent metastatic disease. Notably, lactation has been shown to be protective against breast cancer incidence overall, with varying degrees of protection by race, multiparity, and lifetime duration of lactation. An effect for lactation on breast cancer outcome after diagnosis has not been described. We discuss the most recent data and mechanistic insights underlying these epidemiologic findings. Postpartum involution of the breast has been identified as a key mediator of the increased risk for metastasis in women diagnosed within 5–10 years of a completed pregnancy. During breast involution, immune avoidance, increased lymphatic network, extracellular matrix remodeling, and increased seeding to the liver and lymph node work as interconnected pathways, leading to the adverse effect of a postpartum diagnosis. We al discuss a novel mechanism underlying the protective effect of breastfeeding. Collectively, these mechanistic insights offer potential therapeutic avenues for the prevention and/or improved treatment of postpartum breast cancer.

SUMMARY:

The cerebral ventricles have been studied since the fourth century BC and were originally thought to harbor the soul and higher executive functions. During the infancy of neuroradiology, alterations to the ventricular shape and position on pneumoencephalography and ventriculography were signs of mass effect or volume loss. However, in the current era of high-resolution cross-sectional imaging, variation in ventricular anatomy is more easily detectable and its clinical significance is still being investigated. Interpreting radiologists must be aware of anatomic variations of the ventricular system to prevent mistaking normal variants for pathology. We will review of the anatomy and development of the lateral ventricles and discuss several ventricular variations.

Real estate insiders and experts said it is essential to develop strict penalties to combat those operating fraudulent property businesses to protect the legitimate rights of consumers and legitimate enterprises.

Government of Central province Khanh Hoa has just asked a property developer to terminate 20 contracts selling apartments to foreigners as the sale was unauthorized.

As they implement stricter measures and distribute millions worth of donations to communities in need.

Hearing the kingdom’s cry for help, these developers are offering their resources to everyone in need.

Business Insider asked real-estate agents across the U.S., and they point out 11 reason that prevent your home from being sold.

Every seller wants his homes to be sold smoothly and quickly with the highest possible price. However, there are still houses which have been listed on the market for months without any potential buyer because the sellers make one, or maybe more, of the following popular mistakes:

The upsurge of land price leads to a real estate bubble, pushing up production costs, creating a virtual tendency and gradually increasing bad debt.

Choosing good location, prestigious investor, reasonable price; considering legal issues and focusing on infrastructure are the secrets for investors to gain high profit from investing in land.

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Live streaming isn’t a trend; it’s fast becoming the dominant form of communication in the connected age. In fact, 78% of online audiences are already […]

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Unlike for previous generations, career development doesn’t only happen in educational institutions. The more we work, the more we realize our passion and discover the […]

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Sony Interactive Entertainment announced Rainbow Six Siege, The Evil Within 2 and Get Even are now available for PlayStation Now subscribers. 

Rainbow Six Siege will only be available to download and stream until Monday, November 2. Downloads for the game are limited to the PlayStation 4 only. 

PlayStation Now features over 800 games on the PlayStation 4, PlayStation 3 and PlayStation 2 available to stream and play on the PlayStation 4 and Windows PC. PS4 subscribers can download and install over 300 games to play locally. 

Here is an overview of the three games:

Rainbow Six Siege

It’s the perfect time to try out the deeply tactical, always tense multiplayer shooter that has become an esports phenomenon in the years since its 2015 debut. Strained matches are built around two competing teams of players using a variety of weapons, gadgets and sound strategies to triumph over the other. While you’ll need to adapt to its uncompromising gameplay, it only makes every well-earned victory all the sweeter. Please note: this is the base edition.

The Evil Within 2

Genre aficionados will have plenty to savour with this horror sequel as you enter the alternate reality town of Union in search of your long thought dead daughter. Sickeningly brilliant creature designs and jump scares await as you explore the town’s expansive areas filled with dangers and secrets. But armed as you are with an arsenal of monster-shredding weaponry, as well as having the option to keep things low-key with a more stealthy approach, you’re ready to take on every abomination that stands between you and your family reunion.

Get Even

Puzzler, shooter, psychological thriller. Developer The Farm 51’s mashup of genres makes for an intriguing first-person adventure. Finding yourself trapped inside an insane asylum with a virtual reality device surgically grafted to your head, you’re forced to track down and ‘enter’ memories to gradually unravel the mystery behind your incarceration. As gripping as any murder mystery and with events shaped by your decisions, Get Even is a must play for those who love stories with plenty of twists.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443391/playstation-now-adds-rainbow-six-siege-the-evil-within-ii-and-get-even/

Microsoft has announced it will share new information on the Xbox Series X every month in 2020 starting with the May 7th episode of Inside Xbox, which will showcase gameplay from third-party partners. Microsoft is calling it "Xbox 20/20." The event starts at 8am PT / 11am ET. 

"These monthly moments will take place throughout the rest of the year and will be a way for us to engage, connect and celebrate with you about what’s in store for the next generation of gaming, including what’s next for Xbox Series X, Xbox Game Studios, Xbox Game Pass and Project xCloud," said Microsoft. "Every month will bring something different. Stay tuned to Xbox Wire for more details."

The company did reveal the July event will be focused on upcoming first-party games from Xbox Game Studios. 

"A number of our studio teams are looking forward to sharing first looks at new gameplay, insights from development teams being optimized for Xbox Series X, and brand-new game announcements," said Microsoft.  "We cannot wait to share this initial look at what some of those teams are working on."

A new teaser video of the May 7 Inside Xbox event has been posted online and the closed captions reveals it is the "New Xbox Sound." It is possible it is the new bootup screen for the Xbox Series X. View the video below:

The Inside Xbox event for May 7 can be watched from multiple streaming sites:

• Facebook
• Mixer
• Twitch
• Twitter
• YouTube (4K stream)

Read more information below:

This is a momentous year for Xbox, with our next-gen console paving the way for all our games and services to come together in even better ways. Here’s what 2020 looks like, just to start:

• Our goal remains to launch Xbox Series X and Halo Infinite this Holiday
• All 15 Xbox Game Studios teams are hard at work on next-generation games for Xbox Series X and Xbox Game Pass
• The best development teams around the world are working hard to have their games ready to play on Xbox Series X this holiday
• For PC players, we plan to support the community by making all our major releases at launch available with Xbox Game Pass for PC, including Halo Infinite, Wasteland 3, Minecraft Dungeons and of course, Microsoft Flight Simulator.
• We have new updates and titles lined up for Xbox Game Pass for console and PC
• We’re expanding Project xCloud into new countries and on new devices—and later this year Project xCloud and Xbox Game Pass will come together, enabling you and your friends to play together in more ways.

It’s a lot – and that’s saying something in 2020, a year which could be summed up as “a lot.” With all this in mind, we set out to create new touchpoints to celebrate gaming and share what’s next with our global community.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443394/xbox-series-x-news-planned-for-every-month-of-2020-starts-with-inside-xbox-gameplay-reveals-on-may-7/

Microsoft earlier announced it will share new information on the Xbox Series X every month in 2020 calling it "Xbox 20/20." The first event will be held on May 7th at 8am PT / 11am ET and will focus on gameplay from third-party partners. 

The event in June has now been revealed it will focus on platform and services, according to Bloomberg.

It is possible the June event will see the unveiling of the long rumored weaker next generation Xbox, codenamed Lockhart, with an expected official name of Xbox Series S. The price and launch date for the Xbox Series X is also possible, as well as information on Game Pass, Xbox Live Gold and Project xCloud. 

The July event will be focused on upcoming first-party games from Xbox Game Studios. 

"These monthly moments will take place throughout the rest of the year and will be a way for us to engage, connect and celebrate with you about what’s in store for the next generation of gaming, including what’s next for Xbox Series X, Xbox Game Studios, Xbox Game Pass and Project xCloud," said Microsoft. "Every month will bring something different. Stay tuned to Xbox Wire for more details."

The Xbox Series X will launch in Holiday 2020.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443395/xbox-series-x-june-event-to-focus-on-platform-and-services/

After lots and lots of #hype in the form of a livestream digital painting reveal that was the precursor to a proper trailer which was also just a precursor to what we were assured would be a first look at actual gameplay, folks were a bit let down by the not very gameplay-looking new video for […]

Never Rarely Sometimes Always – Movie Review Rating: A- (Great) Trailer/Thumbnail Courtesy Universal Pictures Getting pregnant can be a tricky event for any teenager and how they approach this can often depend on their environment. In exploring the topic, director/writer Eliza Hittman has opted for a realistic portrayal. The journey taken by Autumn and her […]

The post Never Rarely Sometimes Always – Movie Review appeared first on The Scene Magazine.

As anticipated due to the COVID-19 pandemic, Windsor’s unemployment rate closed in on historic levels in April as it reached 12.9 per cent of the labour force, according to the latest numbers released Friday by Statistics Canada. There were 21,800 people in the Windsor area recorded as being unemployed in the latest StatsCan survey. But […]

Ironbark is one of 2020’s anticipated movies. Benedict Cumberbatch plays the MI6 handler of a Russian spy who may have helped prevent nuclear war

Weighing around 1270 kilograms, the largest ever firework travelled at more than 480 kilometres and exploded over Steamboat Springs in Colorado

Qubits are often stabilised by being supercooled, which makes quantum computer chips hard to scale up. Now they have been operated at above -272°C for the first time

Black paint usually absorbs heat, but a new two-layer polymer paint reflects infrared light and keeps objects 16°C cooler, which could help make buildings more energy efficient

In a new photography book, the home computer revolution of the 1970s, 1980s and 1990s is told through nostalgic industrial-design images

This unusual contraption recreates the sounds of an old-school mechanical typewriter on a modern keyboard.

But can you still write "BOOBS" on it?

If you think you’ve got something of value to share with the world – or maybe you just want a project to tackle to fill the hours – then we’ll take you through what you need to know.

Last week, former Vice President Joe Biden told the world that he “unequivocally” denied accusations by Tara Reade, a former staffer in his Senate office, that he sexually assaulted her in the early ’90s.

On Friday evening, Reade responded: Prove it.

“Joe Biden should take the polygraph,” Reade told former television anchor Megyn Kelly, in an interview that aired on Kelly’s YouTube channel. “I will take one if Joe Biden takes one, but I’m not a criminal.”

Read more at The Daily Beast.

The Queen gave a 75th anniversary VE Day speech Friday night that doubled as a rallying cry against coronavirus. “Never give up, never despair, that was the message of VE Day,” she told the British people.

Second World War heroes would “recognize and admire,” the sacrifices the British were making today in the fight against coronavirus, the Queen added. It was her second major coronavirus-themed speech to the nation.

“It may seem hard that we cannot mark this special anniversary as we would wish. Instead we remember from our homes and our doorsteps. But our streets are not empty,” the Queen said, “They are filled with the love and the care that we have for each other.”

Read more at The Daily Beast.

On Friday afternoon, I had a fun, wide-ranging conversation with Rosie O’Donnell, the renowned comedian, daytime TV host, philanthropist, and Trump Enemy No. 1.

The occasion for our talk was I Know This Much Is True, an HBO miniseries premiering May 10 which sees the A League of Their Own star flex her dramatic muscles like never before as Lisa Sheffer, a no-nonsense social worker at a mental health facility housing Thomas Birdsey (Mark Ruffalo).

Over the course of our chat—which will run Monday, May 11—we touched on not only the show (she is excellent) but Trump’s years-long vendetta against her, the Tara Reade allegations, and the untimely death of SMILF amid claims of misconduct against creator and star Frankie Shaw.

Read more at The Daily Beast.

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For the past two months, Katie Holliday has been cooped up alone in her Brooklyn apartment thinking longingly about an unlikely erogenous zone: the lower half of a stranger’s face. 

“I remember joking to my friend before all of this started, ‘Imagine if someone’s face becomes their most coveted body part?’” Holliday, who is 31, told The Daily Beast. “‘When someone removes their mask, is it a sign of trust? Is it like letting someone see you naked?’ I was kidding back then, but now it’s reality.”

Holliday doesn’t know exactly when it will be safe to start seeing people like she did before the pandemic began, but she’ll return to a singles scene unlike any other in history. “I’m picturing walking into a bar where everyone’s wearing masks,” she said. “I’ll meet someone whose face is covered. Are they cute or not? I don’t know!” 

Read more at The Daily Beast.

Morningside USA was supposed to be apocalypse-proof. 

A gated, stucco fortress in the southwest corner of Missouri’s Ozark mountains, Morningside is an evangelical Christian community built to rent condos right through the end of the world.

“Where are you going to go when the world's on fire? Where are you going to go? This place is for God's people and this place, we need some farmers to move here,” Morningside’s founder, the disgraced doomsday televangelist Jim Bakker, said in a May 2018 sermon. “Did you know people from the government, from NASA, research from so many of them, they have said in their research, the safest place to live in troubled times is right here?”  

Read more at The Daily Beast.

Two years ago, the voices of survivors of sexual harassment and assault launched an unprecedented movement the world over, using Tarana Burke’s MeToo framework. That one moment was a spark into the unknown, but the movement itself was no happy accident. It was built to fuel a reclamation of power for those who had been silenced for too long, a laborious undertaking by activists, advocates, and organizations including mine—the National Women’s Law Center, which also houses and administers the TIME’S UP Legal Defense Fund.

Since then, the #MeToo movement has enabled considerable progress, including making space for more and more people who have claims of sexual misconduct to come forward. People like Tara Reade.

But despite this dramatic cultural awakening, our institutions and systems are just beginning to stir. The lack of necessary legal and policy changes both in our government and in our workplaces, schools, houses of worship, and otherwise have created a world that very imperfectly serves the needs of survivors. Every domestic worker who is entirely unprotected by our federal and most state civil rights statutes, and every person who is classified as an independent contractor and left out of civil rights protections, have proven that our work must take on the reform and re-envisioning of the very systems that excluded them in the first place. 

Read more at The Daily Beast.

APRIL saw 20.5 million job losses in the United States, the biggest rise in the jobless rate since the Great Depression.

Jurgen Klopp never got to manage Steven Gerrard at Liverpool but the pair still have a strong relationship given their connections to the club.

China has connected the world’s first portable ground station for quantum communication to the Mozi satellite, and has plans to launch another quantum satellite soon

Astrology is bunk, but a new book exploring its ancient history argues that it has crucial lessons for today's data science with its seemingly opaque algorithms

The best picture of the sun is more than five times more detailed than the previous highest-resolution images, revealing weird structures on our star’s surface

Out of 28,000 suggestions, NASA selected the name Perseverance for its Mars 2020 rover, which will search for signs of life on the Red Planet