Lab Chip, 2020, 20,1410-1417
DOI: 10.1039/C9LC01256G, Paper

Rodi Abdalkader, Ken-ichiro Kamei
Human corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.
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Lab Chip, 2020, 20,1449-1460
DOI: 10.1039/C9LC01220F, Paper

Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. Robitzki
We developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.
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Lab Chip, 2020, 20,1513-1520
DOI: 10.1039/C9LC01261C, Paper

Yuan Yuan, Julie Brouchon, J. Mauricio Calvo-Calle, Jing Xia, Li Sun, Xu Zhang, Kiera L. Clayton, Fangfu Ye, David A. Weitz, John A. Heyman
In-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.
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Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
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Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper

Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper

Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper

Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO₃ wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper

Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper

W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01064E, Paper

Seungbeom Noh, Hanseup Kim
This paper reports in-air monitoring of in vitro monolayer cells under air-exposure utilizing electrochemical impedance spectroscopy (EIS).
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper

Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication

Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper

Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper

Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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Lab Chip, 2020, 20,1639-1647
DOI: 10.1039/D0LC00045K, Paper

Nicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier Theodoly
Permeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.
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Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper

Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper

Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper

Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper

Open Access

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Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC00999J, Paper

Open Access

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A. Link, T. Franke
Novel microfluidic platform to determine the viscoelastic fingerprint of a red blood cell population using surface acoustic waves.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00096E, Paper

Hanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David Issadore
Liquid biopsy (LB) technologies continue to improve in sensitivity, specificity, and multiplexing and can measure an ever growing library of disease biomarkers. However, clinical interpretation of the increasingly large sets...
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DOI: 10.1021/acs.jcim.9b01103

DOI: 10.1021/acs.jcim.9b01107

DOI: 10.1021/acs.jcim.9b01099

DOI: 10.1021/acs.jcim.0c00123

DOI: 10.1021/acs.jcim.9b01178

DOI: 10.1021/acs.jcim.9b01111

DOI: 10.1021/acs.jcim.9b01110

DOI: 10.1021/acs.jcim.9b01167