ind Former Flyer Mark Howe knows NHL is trying to stay 'open-minded' about 2019-20 season By sports.yahoo.com Published On :: Sat, 09 May 2020 02:08:08 GMT Former Flyer and current Red Wings scout Mark Howe said the "open-minded" NHL is determined to finish the 2019-20 season. By Joe Fordyce Full Article article News
ind Introduction to Mindfulness & Manifestation Zine By search.wellcomelibrary.org Published On :: 2017 Full Article
ind Human : a dialogue between body and mind. By search.wellcomelibrary.org Published On :: [London] : [publisher not identified], [2019] Full Article
ind A survey of alcohol and drug abuse programs in the railroad industry / [Lyman C. Hitchcock, Mark S. Sanders ; Naval Weapons Support Center]. By search.wellcomelibrary.org Published On :: Washington, D.C. : Department of Transportation, Federal Railroad Administration, 1976. Full Article
ind The wilderness of mind : sacred plants in cross-cultural perspective / Marlene Dobkin De Rios. By search.wellcomelibrary.org Published On :: Beverly Hills : Sage Publications, 1976. Full Article
ind On polyhedral estimation of signals via indirect observations By projecteuclid.org Published On :: Tue, 05 May 2020 22:00 EDT Anatoli Juditsky, Arkadi Nemirovski. Source: Electronic Journal of Statistics, Volume 14, Number 1, 458--502.Abstract: We consider the problem of recovering linear image of unknown signal belonging to a given convex compact signal set from noisy observation of another linear image of the signal. We develop a simple generic efficiently computable non linear in observations “polyhedral” estimate along with computation-friendly techniques for its design and risk analysis. We demonstrate that under favorable circumstances the resulting estimate is provably near-optimal in the minimax sense, the “favorable circumstances” being less restrictive than the weakest known so far assumptions ensuring near-optimality of estimates which are linear in observations. Full Article
ind Parseval inequalities and lower bounds for variance-based sensitivity indices By projecteuclid.org Published On :: Tue, 05 May 2020 22:00 EDT Olivier Roustant, Fabrice Gamboa, Bertrand Iooss. Source: Electronic Journal of Statistics, Volume 14, Number 1, 386--412.Abstract: The so-called polynomial chaos expansion is widely used in computer experiments. For example, it is a powerful tool to estimate Sobol’ sensitivity indices. In this paper, we consider generalized chaos expansions built on general tensor Hilbert basis. In this frame, we revisit the computation of the Sobol’ indices with Parseval equalities and give general lower bounds for these indices obtained by truncation. The case of the eigenfunctions system associated with a Poincaré differential operator leads to lower bounds involving the derivatives of the analyzed function and provides an efficient tool for variable screening. These lower bounds are put in action both on toy and real life models demonstrating their accuracy. Full Article
ind Non-parametric adaptive estimation of order 1 Sobol indices in stochastic models, with an application to Epidemiology By projecteuclid.org Published On :: Wed, 22 Apr 2020 04:02 EDT Gwenaëlle Castellan, Anthony Cousien, Viet Chi Tran. Source: Electronic Journal of Statistics, Volume 14, Number 1, 50--81.Abstract: Global sensitivity analysis is a set of methods aiming at quantifying the contribution of an uncertain input parameter of the model (or combination of parameters) on the variability of the response. We consider here the estimation of the Sobol indices of order 1 which are commonly-used indicators based on a decomposition of the output’s variance. In a deterministic framework, when the same inputs always give the same outputs, these indices are usually estimated by replicated simulations of the model. In a stochastic framework, when the response given a set of input parameters is not unique due to randomness in the model, metamodels are often used to approximate the mean and dispersion of the response by deterministic functions. We propose a new non-parametric estimator without the need of defining a metamodel to estimate the Sobol indices of order 1. The estimator is based on warped wavelets and is adaptive in the regularity of the model. The convergence of the mean square error to zero, when the number of simulations of the model tend to infinity, is computed and an elbow effect is shown, depending on the regularity of the model. Applications in Epidemiology are carried to illustrate the use of non-parametric estimators. Full Article
ind Noise Accumulation in High Dimensional Classification and Total Signal Index By Published On :: 2020 Great attention has been paid to Big Data in recent years. Such data hold promise for scientific discoveries but also pose challenges to analyses. One potential challenge is noise accumulation. In this paper, we explore noise accumulation in high dimensional two-group classification. First, we revisit a previous assessment of noise accumulation with principal component analyses, which yields a different threshold for discriminative ability than originally identified. Then we extend our scope to its impact on classifiers developed with three common machine learning approaches---random forest, support vector machine, and boosted classification trees. We simulate four scenarios with differing amounts of signal strength to evaluate each method. After determining noise accumulation may affect the performance of these classifiers, we assess factors that impact it. We conduct simulations by varying sample size, signal strength, signal strength proportional to the number predictors, and signal magnitude with random forest classifiers. These simulations suggest that noise accumulation affects the discriminative ability of high-dimensional classifiers developed using common machine learning methods, which can be modified by sample size, signal strength, and signal magnitude. We developed the measure total signal index (TSI) to track the trends of total signal and noise accumulation. Full Article
ind Robust Asynchronous Stochastic Gradient-Push: Asymptotically Optimal and Network-Independent Performance for Strongly Convex Functions By Published On :: 2020 We consider the standard model of distributed optimization of a sum of functions $F(mathbf z) = sum_{i=1}^n f_i(mathbf z)$, where node $i$ in a network holds the function $f_i(mathbf z)$. We allow for a harsh network model characterized by asynchronous updates, message delays, unpredictable message losses, and directed communication among nodes. In this setting, we analyze a modification of the Gradient-Push method for distributed optimization, assuming that (i) node $i$ is capable of generating gradients of its function $f_i(mathbf z)$ corrupted by zero-mean bounded-support additive noise at each step, (ii) $F(mathbf z)$ is strongly convex, and (iii) each $f_i(mathbf z)$ has Lipschitz gradients. We show that our proposed method asymptotically performs as well as the best bounds on centralized gradient descent that takes steps in the direction of the sum of the noisy gradients of all the functions $f_1(mathbf z), ldots, f_n(mathbf z)$ at each step. Full Article
ind Bayesian inference on power Lindley distribution based on different loss functions By projecteuclid.org Published On :: Mon, 26 Aug 2019 04:00 EDT Abbas Pak, M. E. Ghitany, Mohammad Reza Mahmoudi. Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 894--914.Abstract: This paper focuses on Bayesian estimation of the parameters and reliability function of the power Lindley distribution by using various symmetric and asymmetric loss functions. Assuming suitable priors on the parameters, Bayes estimates are derived by using squared error, linear exponential (linex) and general entropy loss functions. Since, under these loss functions, Bayes estimates of the parameters do not have closed forms we use lindley’s approximation technique to calculate the Bayes estimates. Moreover, we obtain the Bayes estimates of the parameters using a Markov Chain Monte Carlo (MCMC) method. Simulation studies are conducted in order to evaluate the performances of the proposed estimators under the considered loss functions. Finally, analysis of a real data set is presented for illustrative purposes. Full Article
ind Bayesian approach for the zero-modified Poisson–Lindley regression model By projecteuclid.org Published On :: Mon, 26 Aug 2019 04:00 EDT Wesley Bertoli, Katiane S. Conceição, Marinho G. Andrade, Francisco Louzada. Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 826--860.Abstract: The primary goal of this paper is to introduce the zero-modified Poisson–Lindley regression model as an alternative to model overdispersed count data exhibiting inflation or deflation of zeros in the presence of covariates. The zero-modification is incorporated by considering that a zero-truncated process produces positive observations and consequently, the proposed model can be fitted without any previous information about the zero-modification present in a given dataset. A fully Bayesian approach based on the g-prior method has been considered for inference concerns. An intensive Monte Carlo simulation study has been conducted to evaluate the performance of the developed methodology and the maximum likelihood estimators. The proposed model was considered for the analysis of a real dataset on the number of bids received by $126$ U.S. firms between 1978–1985, and the impact of choosing different prior distributions for the regression coefficients has been studied. A sensitivity analysis to detect influential points has been performed based on the Kullback–Leibler divergence. A general comparison with some well-known regression models for discrete data has been presented. Full Article
ind Simple tail index estimation for dependent and heterogeneous data with missing values By projecteuclid.org Published On :: Mon, 14 Jan 2019 04:01 EST Ivana Ilić, Vladica M. Veličković. Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 1, 192--203.Abstract: Financial returns are known to be nonnormal and tend to have fat-tailed distribution. Also, the dependence of large values in a stochastic process is an important topic in risk, insurance and finance. In the presence of missing values, we deal with the asymptotic properties of a simple “median” estimator of the tail index based on random variables with the heavy-tailed distribution function and certain dependence among the extremes. Weak consistency and asymptotic normality of the proposed estimator are established. The estimator is a special case of a well-known estimator defined in Bacro and Brito [ Statistics & Decisions 3 (1993) 133–143]. The advantage of the estimator is its robustness against deviations and compared to Hill’s, it is less affected by the fluctuations related to the maximum of the sample or by the presence of outliers. Several examples are analyzed in order to support the proofs. Full Article
ind Nights below Foord Street : literature and popular culture in postindustrial Nova Scotia By dal.novanet.ca Published On :: Fri, 1 May 2020 19:34:09 -0300 Author: Thompson, Peter, 1981- author.Callnumber: PS 8131 N6 T56 2019ISBN: 0773559345 Full Article
ind Reclaiming indigenous governance : reflections and insights from Australia, Canada, New Zealand, and the United States By dal.novanet.ca Published On :: Fri, 1 May 2020 19:34:09 -0300 Callnumber: K 3247 R43 2019ISBN: 9780816539970 (paperback) Full Article
ind Semi-parametric estimation for conditional independence multivariate finite mixture models By projecteuclid.org Published On :: Fri, 06 Feb 2015 08:39 EST Didier Chauveau, David R. Hunter, Michael Levine. Source: Statistics Surveys, Volume 9, 1--31.Abstract: The conditional independence assumption for nonparametric multivariate finite mixture models, a weaker form of the well-known conditional independence assumption for random effects models for longitudinal data, is the subject of an increasing number of theoretical and algorithmic developments in the statistical literature. After presenting a survey of this literature, including an in-depth discussion of the all-important identifiability results, this article describes and extends an algorithm for estimation of the parameters in these models. The algorithm works for any number of components in three or more dimensions. It possesses a descent property and can be easily adapted to situations where the data are grouped in blocks of conditionally independent variables. We discuss how to adapt this algorithm to various location-scale models that link component densities, and we even adapt it to a particular class of univariate mixture problems in which the components are assumed symmetric. We give a bandwidth selection procedure for our algorithm. Finally, we demonstrate the effectiveness of our algorithm using a simulation study and two psychometric datasets. Full Article
ind Short-term forecasts of COVID-19 spread across Indian states until 1 May 2020. (arXiv:2004.13538v2 [q-bio.PE] UPDATED) By arxiv.org Published On :: The very first case of corona-virus illness was recorded on 30 January 2020, in India and the number of infected cases, including the death toll, continues to rise. In this paper, we present short-term forecasts of COVID-19 for 28 Indian states and five union territories using real-time data from 30 January to 21 April 2020. Applying Holt's second-order exponential smoothing method and autoregressive integrated moving average (ARIMA) model, we generate 10-day ahead forecasts of the likely number of infected cases and deaths in India for 22 April to 1 May 2020. Our results show that the number of cumulative cases in India will rise to 36335.63 [PI 95% (30884.56, 42918.87)], concurrently the number of deaths may increase to 1099.38 [PI 95% (959.77, 1553.76)] by 1 May 2020. Further, we have divided the country into severity zones based on the cumulative cases. According to this analysis, Maharashtra is likely to be the most affected states with around 9787.24 [PI 95% (6949.81, 13757.06)] cumulative cases by 1 May 2020. However, Kerala and Karnataka are likely to shift from the red zone (i.e. highly affected) to the lesser affected region. On the other hand, Gujarat and Madhya Pradesh will move to the red zone. These results mark the states where lockdown by 3 May 2020, can be loosened. Full Article
ind Strong Converse for Testing Against Independence over a Noisy channel. (arXiv:2004.00775v2 [cs.IT] UPDATED) By arxiv.org Published On :: A distributed binary hypothesis testing (HT) problem over a noisy (discrete and memoryless) channel studied previously by the authors is investigated from the perspective of the strong converse property. It was shown by Ahlswede and Csisz'{a}r that a strong converse holds in the above setting when the channel is rate-limited and noiseless. Motivated by this observation, we show that the strong converse continues to hold in the noisy channel setting for a special case of HT known as testing against independence (TAI), under the assumption that the channel transition matrix has non-zero elements. The proof utilizes the blowing up lemma and the recent change of measure technique of Tyagi and Watanabe as the key tools. Full Article
ind Sequential Aggregation of Probabilistic Forecasts -- Applicaton to Wind Speed Ensemble Forecasts. (arXiv:2005.03540v1 [stat.AP]) By arxiv.org Published On :: In the field of numerical weather prediction (NWP), the probabilistic distribution of the future state of the atmosphere is sampled with Monte-Carlo-like simulations, called ensembles. These ensembles have deficiencies (such as conditional biases) that can be corrected thanks to statistical post-processing methods. Several ensembles exist and may be corrected with different statistiscal methods. A further step is to combine these raw or post-processed ensembles. The theory of prediction with expert advice allows us to build combination algorithms with theoretical guarantees on the forecast performance. This article adapts this theory to the case of probabilistic forecasts issued as step-wise cumulative distribution functions (CDF). The theory is applied to wind speed forecasting, by combining several raw or post-processed ensembles, considered as CDFs. The second goal of this study is to explore the use of two forecast performance criteria: the Continous ranked probability score (CRPS) and the Jolliffe-Primo test. Comparing the results obtained with both criteria leads to reconsidering the usual way to build skillful probabilistic forecasts, based on the minimization of the CRPS. Minimizing the CRPS does not necessarily produce reliable forecasts according to the Jolliffe-Primo test. The Jolliffe-Primo test generally selects reliable forecasts, but could lead to issuing suboptimal forecasts in terms of CRPS. It is proposed to use both criterion to achieve reliable and skillful probabilistic forecasts. Full Article
ind The archaeology of monastic healing: spirit, mind and body By blog.wellcomelibrary.org Published On :: Fri, 17 Nov 2017 10:06:12 +0000 The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 21 November. Speaker: Professor Roberta Gilchrist (University of Reading), ‘The archaeology of monastic healing: spirit, mind and body’ This paper highlights the potential of archaeology to… Continue reading Full Article Early Medicine Events and Visits archaeology Early Health and Well-being Early Medicine and Religion hospitals
ind The interaction of food industry and environment By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9780128175156 (electronic bk.) Full Article
ind Ecology, conservation, and restoration of Chilika Lagoon, India By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9783030334246 (electronic bk.) Full Article
ind Commercial status of plant breeding in India By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Author: Tiwari, Aparna, author.Callnumber: OnlineISBN: 9789811519062 Full Article
ind Aquatic biopolymers : understanding their industrial significance and environmental implications By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Author: Olatunji, Ololade.Callnumber: OnlineISBN: 9783030347093 (electronic bk.) Full Article
ind Agri-food industry strategies for healthy diets and sustainability : new challenges in nutrition and public health By dal.novanet.ca Published On :: Fri, 1 May 2020 19:44:43 -0300 Callnumber: OnlineISBN: 9780128172261 Full Article
ind Markov equivalence of marginalized local independence graphs By projecteuclid.org Published On :: Mon, 17 Feb 2020 04:02 EST Søren Wengel Mogensen, Niels Richard Hansen. Source: The Annals of Statistics, Volume 48, Number 1, 539--559.Abstract: Symmetric independence relations are often studied using graphical representations. Ancestral graphs or acyclic directed mixed graphs with $m$-separation provide classes of symmetric graphical independence models that are closed under marginalization. Asymmetric independence relations appear naturally for multivariate stochastic processes, for instance, in terms of local independence. However, no class of graphs representing such asymmetric independence relations, which is also closed under marginalization, has been developed. We develop the theory of directed mixed graphs with $mu $-separation and show that this provides a graphical independence model class which is closed under marginalization and which generalizes previously considered graphical representations of local independence. Several graphs may encode the same set of independence relations and this means that in many cases only an equivalence class of graphs can be identified from observational data. For statistical applications, it is therefore pivotal to characterize graphs that induce the same independence relations. Our main result is that for directed mixed graphs with $mu $-separation each equivalence class contains a maximal element which can be constructed from the independence relations alone. Moreover, we introduce the directed mixed equivalence graph as the maximal graph with dashed and solid edges. This graph encodes all information about the edges that is identifiable from the independence relations, and furthermore it can be computed efficiently from the maximal graph. Full Article
ind Testing for independence of large dimensional vectors By projecteuclid.org Published On :: Fri, 02 Aug 2019 22:04 EDT Taras Bodnar, Holger Dette, Nestor Parolya. Source: The Annals of Statistics, Volume 47, Number 5, 2977--3008.Abstract: In this paper, new tests for the independence of two high-dimensional vectors are investigated. We consider the case where the dimension of the vectors increases with the sample size and propose multivariate analysis of variance-type statistics for the hypothesis of a block diagonal covariance matrix. The asymptotic properties of the new test statistics are investigated under the null hypothesis and the alternative hypothesis using random matrix theory. For this purpose, we study the weak convergence of linear spectral statistics of central and (conditionally) noncentral Fisher matrices. In particular, a central limit theorem for linear spectral statistics of large dimensional (conditionally) noncentral Fisher matrices is derived which is then used to analyse the power of the tests under the alternative. The theoretical results are illustrated by means of a simulation study where we also compare the new tests with several alternative, in particular with the commonly used corrected likelihood ratio test. It is demonstrated that the latter test does not keep its nominal level, if the dimension of one sub-vector is relatively small compared to the dimension of the other sub-vector. On the other hand, the tests proposed in this paper provide a reasonable approximation of the nominal level in such situations. Moreover, we observe that one of the proposed tests is most powerful under a variety of correlation scenarios. Full Article
ind Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors By projecteuclid.org Published On :: Wed, 15 Apr 2020 22:05 EDT Joseph Antonelli, Maitreyi Mazumdar, David Bellinger, David Christiani, Robert Wright, Brent Coull. Source: The Annals of Applied Statistics, Volume 14, Number 1, 257--275.Abstract: Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently protective of human health. The quantification of the effects of exposure to an environmental mixture poses several statistical challenges. It is often the case that exposure to multiple pollutants interact with each other to affect an outcome. Further, the exposure-response relationship between an outcome and some exposures, such as some metals, can exhibit complex, nonlinear forms, since some exposures can be beneficial and detrimental at different ranges of exposure. To estimate the health effects of complex mixtures, we propose a flexible Bayesian approach that allows exposures to interact with each other and have nonlinear relationships with the outcome. We induce sparsity using multivariate spike and slab priors to determine which exposures are associated with the outcome and which exposures interact with each other. The proposed approach is interpretable, as we can use the posterior probabilities of inclusion into the model to identify pollutants that interact with each other. We utilize our approach to study the impact of exposure to metals on child neurodevelopment in Bangladesh and find a nonlinear, interactive relationship between arsenic and manganese. Full Article
ind Bayesian indicator variable selection to incorporate hierarchical overlapping group structure in multi-omics applications By projecteuclid.org Published On :: Wed, 27 Nov 2019 22:01 EST Li Zhu, Zhiguang Huo, Tianzhou Ma, Steffi Oesterreich, George C. Tseng. Source: The Annals of Applied Statistics, Volume 13, Number 4, 2611--2636.Abstract: Variable selection is a pervasive problem in modern high-dimensional data analysis where the number of features often exceeds the sample size (a.k.a. small-n-large-p problem). Incorporation of group structure knowledge to improve variable selection has been widely studied. Here, we consider prior knowledge of a hierarchical overlapping group structure to improve variable selection in regression setting. In genomics applications, for instance, a biological pathway contains tens to hundreds of genes and a gene can be mapped to multiple experimentally measured features (such as its mRNA expression, copy number variation and methylation levels of possibly multiple sites). In addition to the hierarchical structure, the groups at the same level may overlap (e.g., two pathways can share common genes). Incorporating such hierarchical overlapping groups in traditional penalized regression setting remains a difficult optimization problem. Alternatively, we propose a Bayesian indicator model that can elegantly serve the purpose. We evaluate the model in simulations and two breast cancer examples, and demonstrate its superior performance over existing models. The result not only enhances prediction accuracy but also improves variable selection and model interpretation that lead to deeper biological insight of the disease. Full Article
ind Spatio-temporal short-term wind forecast: A calibrated regime-switching method By projecteuclid.org Published On :: Wed, 16 Oct 2019 22:03 EDT Ahmed Aziz Ezzat, Mikyoung Jun, Yu Ding. Source: The Annals of Applied Statistics, Volume 13, Number 3, 1484--1510.Abstract: Accurate short-term forecasts are indispensable for the integration of wind energy in power grids. On a wind farm, local wind conditions exhibit sizeable variations at a fine temporal resolution. Existing statistical models may capture the in-sample variations in wind behavior, but are often shortsighted to those occurring in the near future, that is, in the forecast horizon. The calibrated regime-switching method proposed in this paper introduces an action of regime dependent calibration on the predictand (here the wind speed variable), which helps correct the bias resulting from out-of-sample variations in wind behavior. This is achieved by modeling the calibration as a function of two elements: the wind regime at the time of the forecast (and the calibration is therefore regime dependent), and the runlength, which is the time elapsed since the last observed regime change. In addition to regime-switching dynamics, the proposed model also accounts for other features of wind fields: spatio-temporal dependencies, transport effect of wind and nonstationarity. Using one year of turbine-specific wind data, we show that the calibrated regime-switching method can offer a wide margin of improvement over existing forecasting methods in terms of both wind speed and power. Full Article
ind Efficient estimation in single index models through smoothing splines By projecteuclid.org Published On :: Fri, 31 Jan 2020 04:06 EST Arun K. Kuchibhotla, Rohit K. Patra. Source: Bernoulli, Volume 26, Number 2, 1587--1618.Abstract: We consider estimation and inference in a single index regression model with an unknown but smooth link function. In contrast to the standard approach of using kernels or regression splines, we use smoothing splines to estimate the smooth link function. We develop a method to compute the penalized least squares estimators (PLSEs) of the parametric and the nonparametric components given independent and identically distributed (i.i.d.) data. We prove the consistency and find the rates of convergence of the estimators. We establish asymptotic normality under mild assumption and prove asymptotic efficiency of the parametric component under homoscedastic errors. A finite sample simulation corroborates our asymptotic theory. We also analyze a car mileage data set and a Ozone concentration data set. The identifiability and existence of the PLSEs are also investigated. Full Article
ind SPDEs with fractional noise in space: Continuity in law with respect to the Hurst index By projecteuclid.org Published On :: Tue, 26 Nov 2019 04:00 EST Luca M. Giordano, Maria Jolis, Lluís Quer-Sardanyons. Source: Bernoulli, Volume 26, Number 1, 352--386.Abstract: In this article, we consider the quasi-linear stochastic wave and heat equations on the real line and with an additive Gaussian noise which is white in time and behaves in space like a fractional Brownian motion with Hurst index $Hin (0,1)$. The drift term is assumed to be globally Lipschitz. We prove that the solution of each of the above equations is continuous in terms of the index $H$, with respect to the convergence in law in the space of continuous functions. Full Article
ind Letter from J. H Bannatyne to Other Windsor Berry Esq. relating to the Myall Creek Massacre, 17 December 1838 By feedproxy.google.com Published On :: 21/04/2015 12:00:00 AM Full Article
ind Federal watchdog finds 'reasonable grounds to believe' vaccine doctor's ouster was retaliation, lawyers say By news.yahoo.com Published On :: Fri, 08 May 2020 16:37:13 -0400 The Office of Special Counsel is recommending that ousted vaccine official Dr. Rick Bright be reinstated while it investigates his case, his lawyers announced Friday.Bright while leading coronavirus vaccine development was recently removed from his position as the director of the Department of Health and Human Services' Biomedical Advanced Research and Development Authority, and he alleges it was because he insisted congressional funding not go toward "drugs, vaccines, and other technologies that lack scientific merit" and limited the "broad use" of hydroxychloroquine after it was touted by President Trump. In a whistleblower complaint, he alleged "cronyism" at HHS. He has also alleged he was "pressured to ignore or dismiss expert scientific recommendations and instead to award lucrative contracts based on political connections."On Friday, Bright's lawyers said that the Office of Special Counsel has determined there are "reasonable grounds to believe" his firing was retaliation, The New York Times reports. The federal watchdog also recommended he be reinstated for 45 days to give the office "sufficient time to complete its investigation of Bright's allegations," CNN reports. The decision on whether to do so falls on Secretary of Health and Human Services Alex Azar, and Office of Special Counsel recommendations are "not binding," the Times notes. More stories from theweek.com Outed CIA agent Valerie Plame is running for Congress, and her launch video looks like a spy movie trailer 7 scathing cartoons about America's rush to reopen Trump says he couldn't have exposed WWII vets to COVID-19 because the wind was blowing the wrong way Full Article
ind Train kills 15 migrant workers walking home in India By news.yahoo.com Published On :: Fri, 08 May 2020 00:56:54 -0400 A train in India on Friday plowed through a group of migrant workers who fell asleep on the tracks after walking back home from a coronavirus lockdown, killing 15, the Railways Ministry said. Early this week the government started running trains to carry stranded workers to their home states. Full Article
ind India uses drones to disinfect virus hotspot as cases surge By news.yahoo.com Published On :: Sat, 09 May 2020 11:19:33 -0400 Indian authorities used drones and fire engines to disinfect the pandemic-hit city of Ahmedabad on Saturday, as virus cases surged and police clashed with migrant workers protesting against a reinforced lockdown. The western city of 5.5 million people in Prime Minister Narendra Modi's home state has become a major concern for authorities as they battle an uptick in coronavirus deaths and cases across India. Full Article
ind Nearly one-third of Americans believe a coronavirus vaccine exists and is being withheld, survey finds By news.yahoo.com Published On :: Fri, 08 May 2020 16:49:35 -0400 The Democracy Fund + UCLA Nationscape Project found some misinformation about the coronavirus is more widespread that you might think. Full Article
ind Probability Based Independence Sampler for Bayesian Quantitative Learning in Graphical Log-Linear Marginal Models By projecteuclid.org Published On :: Tue, 11 Jun 2019 04:00 EDT Ioannis Ntzoufras, Claudia Tarantola, Monia Lupparelli. Source: Bayesian Analysis, Volume 14, Number 3, 797--823.Abstract: We introduce a novel Bayesian approach for quantitative learning for graphical log-linear marginal models. These models belong to curved exponential families that are difficult to handle from a Bayesian perspective. The likelihood cannot be analytically expressed as a function of the marginal log-linear interactions, but only in terms of cell counts or probabilities. Posterior distributions cannot be directly obtained, and Markov Chain Monte Carlo (MCMC) methods are needed. Finally, a well-defined model requires parameter values that lead to compatible marginal probabilities. Hence, any MCMC should account for this important restriction. We construct a fully automatic and efficient MCMC strategy for quantitative learning for such models that handles these problems. While the prior is expressed in terms of the marginal log-linear interactions, we build an MCMC algorithm that employs a proposal on the probability parameter space. The corresponding proposal on the marginal log-linear interactions is obtained via parameter transformation. We exploit a conditional conjugate setup to build an efficient proposal on probability parameters. The proposed methodology is illustrated by a simulation study and a real dataset. Full Article
ind Sequential Monte Carlo Samplers with Independent Markov Chain Monte Carlo Proposals By projecteuclid.org Published On :: Tue, 11 Jun 2019 04:00 EDT L. F. South, A. N. Pettitt, C. C. Drovandi. Source: Bayesian Analysis, Volume 14, Number 3, 773--796.Abstract: Sequential Monte Carlo (SMC) methods for sampling from the posterior of static Bayesian models are flexible, parallelisable and capable of handling complex targets. However, it is common practice to adopt a Markov chain Monte Carlo (MCMC) kernel with a multivariate normal random walk (RW) proposal in the move step, which can be both inefficient and detrimental for exploring challenging posterior distributions. We develop new SMC methods with independent proposals which allow recycling of all candidates generated in the SMC process and are embarrassingly parallelisable. A novel evidence estimator that is easily computed from the output of our independent SMC is proposed. Our independent proposals are constructed via flexible copula-type models calibrated with the population of SMC particles. We demonstrate through several examples that more precise estimates of posterior expectations and the marginal likelihood can be obtained using fewer likelihood evaluations than the more standard RW approach. Full Article
ind Maximum Independent Component Analysis with Application to EEG Data By projecteuclid.org Published On :: Tue, 03 Mar 2020 04:00 EST Ruosi Guo, Chunming Zhang, Zhengjun Zhang. Source: Statistical Science, Volume 35, Number 1, 145--157.Abstract: In many scientific disciplines, finding hidden influential factors behind observational data is essential but challenging. The majority of existing approaches, such as the independent component analysis (${mathrm{ICA}}$), rely on linear transformation, that is, true signals are linear combinations of hidden components. Motivated from analyzing nonlinear temporal signals in neuroscience, genetics, and finance, this paper proposes the “maximum independent component analysis” (${mathrm{MaxICA}}$), based on max-linear combinations of components. In contrast to existing methods, ${mathrm{MaxICA}}$ benefits from focusing on significant major components while filtering out ignorable components. A major tool for parameter learning of ${mathrm{MaxICA}}$ is an augmented genetic algorithm, consisting of three schemes for the elite weighted sum selection, randomly combined crossover, and dynamic mutation. Extensive empirical evaluations demonstrate the effectiveness of ${mathrm{MaxICA}}$ in either extracting max-linearly combined essential sources in many applications or supplying a better approximation for nonlinearly combined source signals, such as $mathrm{EEG}$ recordings analyzed in this paper. Full Article
ind Models as Approximations—Rejoinder By projecteuclid.org Published On :: Wed, 08 Jan 2020 04:00 EST Andreas Buja, Arun Kumar Kuchibhotla, Richard Berk, Edward George, Eric Tchetgen Tchetgen, Linda Zhao. Source: Statistical Science, Volume 34, Number 4, 606--620.Abstract: We respond to the discussants of our articles emphasizing the importance of inference under misspecification in the context of the reproducibility/replicability crisis. Along the way, we discuss the roles of diagnostics and model building in regression as well as connections between our well-specification framework and semiparametric theory. Full Article
ind Rejoinder: Bayes, Oracle Bayes, and Empirical Bayes By projecteuclid.org Published On :: Thu, 18 Jul 2019 22:01 EDT Bradley Efron. Source: Statistical Science, Volume 34, Number 2, 234--235. Full Article
ind Rejoinder: Response to Discussions and a Look Ahead By projecteuclid.org Published On :: Fri, 12 Apr 2019 04:00 EDT Vincent Dorie, Jennifer Hill, Uri Shalit, Marc Scott, Dan Cervone. Source: Statistical Science, Volume 34, Number 1, 94--99.Abstract: Response to discussion of Dorie (2017), in which the authors of that piece express their gratitude to the discussants, rebut some specific criticisms, and argue that the limitations of the 2016 Atlantic Causal Inference Competition represent an exciting opportunity for future competitions in a similar mold. Full Article
ind The Joyful Reduction of Uncertainty: Music Perception as a Window to Predictive Neuronal Processing By www.jneurosci.org Published On :: 2020-04-01T09:30:19-07:00 Full Article
ind Dopamine D1 and D2 Receptor Family Contributions to Modafinil-Induced Wakefulness By www.jneurosci.org Published On :: 2009-03-04 Jared W. YoungMar 4, 2009; 29:2663-2665Journal Club Full Article
ind Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization By www.jneurosci.org Published On :: 2017-05-24 Catherine MankiwMay 24, 2017; 37:5221-5231Development Plasticity Repair Full Article
ind Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging By www.jneurosci.org Published On :: 2012-10-03 Jasper AkerboomOct 3, 2012; 32:13819-13840Cellular Full Article
ind Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP By www.jneurosci.org Published On :: 2003-06-01 Steven PoserJun 1, 2003; 23:4420-4427Cellular Full Article
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