Evdokia Menelaou
Aug 8, 2012; 32:10925-10939
BehavioralSystemsCognitive

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

FAO Director-General José Graziano da Silva today called on countries to put nutrition high on their national and international agendas, and to take a lead role in the upcoming Second [...]

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections

The sprawling estate, which is the largest privately owned home in the country, will open its doors in November after a month-long closure

After a year of negotiations, the postal union has given Canada Post a 72-hour strike notice. At a solidarity rally in St. John's last week, local president Craig Dyer says a strike could mean parcels — including Christmas presents — won't make it to rural communities.

Public Schools Branch director Tracy Beaulieu speaks with CBC News: Compass host Steve Bruce about the money for schools in the new capital budget the province presented last week, and about the work that lies ahead.

On Tuesday, officers were checking on the well-being of a tenant in an apartment on Woolwich Street near Speedvale Avenue when they found the man's body. He was pronounced dead on scene. Police believe he died on or about Oct. 21.

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

Taylor Swift's Eras Tour, which began March 17, 2023, arrives in Toronto for six shows beginning Thursday and will end in early December after three Vancouver performances. With opening night upon us, here's a look at all the hoopla in Toronto.

Rachel Homan and John Morris join That Curling Show fresh off the news they have been chosen to represent Canada in mixed doubles curling at the Beijing Olympics.

Intuitive Software Fosters Rapid Engagement with Engineering Challenges

Students in 500 second level schools across the country will learn fundamental engineering and design skills with easy-to-learn 3D CAD software

OM Hungary team members put on a special Christmas programme a local refugee camp.

OM Hungary’s Christmas puppet ministry is currently underway, with performances in the city of Érd and the surrounding area.

Visiting an elderly home, a ‘Love Moldova’ outreach team experiences how God touches lives and has arranged even the staff’s working hours.

God turns a frustrating situation into one of hope when a lost OM team meets a girl who asks for prayer.

The Creative Arts team perform their Christmas show for school children all over Ireland in the course of three weeks.

An OM short-term team worships God and engages in conversations about God in the public square of a city with an Arab majority in Israel.

God answers the prayers of OM Guatemala and a partnering church with a Christmas celebration for children and families with OM’s Project Rescue.

In December, OM Pakistan hosted a Christmas event for many affected by the bombings in September.

OM Hong Kong hosts a Christmas party on 23 December 2011 for Pakistani women and children.

Many teachers who will be leading classes remotely are building colorful virtual environments for their students featuring avatar versions of themselves. Some districts are even mandating trainings on how to create them.

In Japan, the birth and life of Jesus Christ is hardly known. For this reason, Christmas is a wonderful opportunity to point people to Him.

Stefano Terlizzi joined the Ken and Mary Alice Lindquist Department of Nuclear Engineering as the John and Jean M. Brennan Clean Energy Early Career Professor on July 22. In this Q&A, Terlizzi talks about his research background and interests, why he chose Penn State and more.

Longtime School of Music faculty member Daryl Durran and his wife, Lois Durran, a violinist, have made an estate commitment of $750,000 to establish the Daryl and Lois Durran Endowment for the School of Music, which will provide scholarship support to undergraduate and graduate students in the school. Daryl Durran, professor emeritus of pedagogy and performance in bassoon, retired in 2022 after 39 years on the faculty.

Lindsay Mitchell, a Penn State World Campus graduate who earned a bachelor's degree in accounting in May, is one of Pennsylvania’s newest auditors after securing a position through an intern-to-hire program. World Campus offers the undergraduate accounting program in partnership with the Penn State Harrisburg School of Business Administration.

Ron Gebhardtsbauer and Greg Wright hope their $1 million estate commitment will help Penn State attract the type of high-achieving student for whom a scholarship offer can be the deciding factor between attending Penn State or another institution.

The latest investment insights and market developments.

The latest investment insights and market developments.

The latest investment insights and market developments.

The latest investment insights and market developments.

Active-duty service members and veterans experiencing PTSD have additional opportunities for treatment to support them, along with their partners, after the Department of Defense awarded a $3 million grant to Steffany Fredman, associate professor of human development and family studies, and colleagues in the STRONG STAR Consortium.

OM Albania partners in the Emmanuel Centre ministry to Roma street kids and their mothers during the holiday season.

Despite being rebuked by Congress in its bid to do so last year, the U.S. Department of Education says it will use Education Innovation and Research funds for teacher professional development vouchers.

Army veteran Eddie Brown never thought he’d earn a college degree. Years after leaving the Army, he graduated from Penn State World Campus, earning a bachelor of arts in labor and human resources.

Donald Trump has announced that Elon Musk and Vivek Ramaswamy, a former presidential candidate and ally of Trump, will lead a new Department of Government Efficiency.

The Penn State Berks theatre department will present “8 at Eight” — a collection of eight light-hearted, eight-minute plays at 8 p.m. Nov. 13-16 in the Perkins Student Center Auditorium.

Growthpoint Properties will spend R200 million to convert its 35 000 square metre Riverwoods office park into a resort with luxury apartments.

After handing over almost 3 000 apartments to their owners, residential estates developer, Balwin's revenues surpassed R3 billion for the first time in the company's 26-year history.

It took less than a week for one of Citigroup's recommended Trump trades to sink under water.

The Government Employees' Pension Fund delivered a return of 4.9% on investments for its members in the year to end-March.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.