Jerad Eickhoff took his latest first step on Sunday morning at Spectrum Field. He threw a bullpen session, his first since sustaining a setback last month following carpal tunnel surgery in October.

Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

Oregon, Ohio State, Georgia and Miami lead the first edition of the 2024-25 College Football Playoff rankings, the selection committee announced.

Tua Tagovailoa and Daniel Jones are among UPI senior sports writer Alex Butler's five must-start fantasy football quarterbacks for Week 10.

Billy Napier will remain in place as head football coach at Florida, despite the Gators producing another lackluster campaign during his third season, athletic director Scott Stricklin announced Thursday.

Mike Gesicki and Jonnu Smith are among UPI senior sports writer Alex Butler's four must-start fantasy football tight ends for Week 10.

Tyrone Tracy Jr. and Najee Harris are among UPI senior sports writer Alex Butler's four must-start fantasy football running backs for Week 10.

Brian Thomas Jr. and Jameson Williams are among UPI senior sports writer Alex Butler's four must-start wide receivers for Week 10 of the fantasy football campaign.

Gerry Faust, who won five Ohio high school football state titles before taking over as coach at Notre Dame in the early 1980s, has died, his family announced. He was 89.

Justin Herbert, Russell Wilson and Quentin Johnston lead UPI senior sports writer Alex Butler's fantasy football waiver wire priority list for Week 11 of the 2024 NFL season.

Mysterious black balls that washed up on Sydney, Australia, beaches were initially suspected to be tar balls but turned out to be miniature "fatbergs" containing human feces.

BOISE, Idaho, Nov. 12, 2024 — Micron Technology, Inc. today announced it has begun qualification of the 6550 ION NVMe SSD with customers. The Micron 6550 ION is the world’s […]

The post Micron’s 6550 ION 60TB SSD Advances High-Capacity Storage for HPC and AI Workloads appeared first on HPCwire.

Slivered onions served on McDonald's Quarter Pounders and other menu items caused a recent E. coli outbreak, the U.S. Centers for Disease Control and Prevention announced Wednesday.

Strict protocols and limited community spread helped a Maine high school stay open for in person instruction when its first coronavirus case turned up.

The shooting death of a 10-year-old spectator at a high school football game exposes a critical vulnerability and crucial responsibility for schools: keeping people safe at events outside school buildings.

The Bulldogs are the first team out of the 12-team playoff after Week 11.

Nothing has changed at the top of the second 2024 College Football Playoff rankings.

The latest update of the College Football Playoff rankings was officially released Tuesday night on ESPN, with the Alabama Crimson Tide seeing some movement as a result of their dominant 42-13 road win over the LSU Tigers on Saturday. In the rankings

The second College Football Playoff rankings were released, with the big questions surrounding who would be No. 3 and where the SEC teams would land.

No. 1 Oregon will travel to Madison this weekend to take on the Wisconsin Badgers at Camp Randall Stadium.

The second College Football Playoff poll of the 2024 season was released Tuesday. Check out the Top 25 and where Tennessee ranks.

After Lane Kiffin's Ole Miss football team beat Georgia, the Rebels moved up in the latest College Football Playoff rankings released Tuesday night.

Texas A&M's Week 11 bye week was (hopefully) successful in terms of fixing the issues that plagued the Aggies, especially the defensive issues that led to 25 missed tackles in the 44-20 loss to South Carolina, which dropped the Aggies to No. 14 in the first Col

Where did Texas A&M land in the latest CFP bracket? Here’s the College Football Playoff picture for the Aggies and their path to the championship.

LSU landed 22nd in the latest College Football Rankings. Here’s a playoff picture for the Tigers. LSU fell seven spots, matching the tumble the Tigers took in the media polls. The fall was expected after Alabama boat raced LSU 42-13 in the Tiger Stadium. For LSU, the ranking…

Where did Georgia land in the latest CFP bracket and rankings? Here’s the College Football Playoff picture for the Bulldogs and path to championship.

Penn State football landed Xth in the second CFP rankings. Here’s the College Football Playoff picture for the Nittany Lions.

The College Football Playoff selection committee released its second top-25 rankings of the season ahead of the first 12-team playoff, and unsurprisingly, the Oregon Ducks are still the No. 1 team. Of course, there are still many game

The second College Football Playoff top 25 rankings and a 12-team bracket projection were released on Tuesday. Tennessee (8-1, 5-1 SEC) is ranked No. 7 after defeating Mississippi State, 33-14, in Week 11. The Vols are also ranked No. 4 in the US LBM…

How did the Miami and Georgia losses impact the CFP rankings in their second release?

Georgia and Miami misery translates into joy for the Texas Longhorns. Thanks to losses by the 'Canes and Bulldogs on Saturday, the Horns move up two spots in the college football playoff ranki

Texas Longhorns fans were very happy after the second edition of the College Football Playoff rankings were released Tuesday.

The College Football Playoff Selection Committee has released its second set of rankings, and Clemson football's moved up to No. 20 following a 24-14 win over Virginia Tech. Starting at No. 23 in last week’s CFP rankings, the Tigers’ latest rise highlights thei

Here's a look at the College Football Playoff bracket and playoff picture after the latest committee rankings were released.

The second College Football Playoff rankings produced some positives and negatives for teams. Here are the winners and losers from Tuesday's reveal:

It's possible there could be an eight-way tie atop the SEC standings at the end of the regular season. Then what will the College Football Playoff committee do?

The second College Football Playoff rankings dropped on Tuesday night with Oregon retaining its status as the No. 1 team in the country ahead of No. 2 Ohio State and No. 3 Texas. College Football Playoff:

Notre Dame football has one remaining game against a CFP-ranked team: Nov. 23 at Yankee Stadium against No. 24 Army (9-0).

Ohio State is No. 2 in the new CFP rankings, joining three other Big Ten teams in the top 5.

The second release of College Football Playoff rankings changes the projected bracket. Here's what it looks like if the season ended today.

While Tuesday is exciting because college hoops fans get to take in the Champions Classic, the College Football Playoff results after this past week were released after the first of two basketball games on ESPN. Ohio State football, as expected, stay

Kansas State football coach Chris Klieman talks about what the Wildcats did during the open week ahead of their home game against Arizona State.

Kansas State football actually benefitted from an open week in the latest College Football Playoff rankings.

Georgia football tumbled nine spots in the College Football Playoff rankings Tuesday and fell out of the 12-team bracket. What committee chair said