Investors sent record inflows to high-yield corporate bonds and broke a six-week losing streak for investment-grade debt in the week that ended Wednesday as market volatility from the coronavirus...

Boris Johnson has become the new prime minister of the UK after winning the Conservative party leadership campaign. Here's what Johnson has said and done about climate change

Music has always been an important part of human culture, dating all the way back to ancient civilizations. Archeologists have unearthed harps in Egypt and primitive trumpets in Rome, as well as Grecian vases and tablets illustrating the presence of...

One of the world’s largest and most prestigious design competitions, the iF World Design Awards have been recognizing excellence in design for the past 65 years. HARMAN has often been among the companies selected by the competition’s panel of design...

Russell Howard, Nish Kumar, Jon Richardson and others help 'landlady' Kiri Pritchard-Mclean host 'The Big Comedy Quiz at The Covid Arms' and break a Guinness World Record.

Russell Howard, Nish Kumar, Jon Richardson and others help 'landlady' Kiri Pritchard-Mclean host 'The Big Comedy Quiz at The Covid Arms' and break a Guinness World Record.

Central Japan Railways says its magnetically levitating train has broken its previous world speed record in a test-run at a special track West of Tokyo. Rob Muir reports.

Title: Record Number of Americans Got Flu Shots, CDC Says
Category: Health News
Created: 4/29/2010 4:10:00 PM
Last Editorial Review: 4/30/2010 12:00:00 AM

Title: Teen Birth Rate at Record Low in U.S.
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM

The invertebrate trace fossils Selenichnites rossendalensis and Crescentichnus tesiltus are recorded and described from the Middle Jurassic Gristhorpe Member of the Cloughton Formation of the Cleveland Basin. This is the first record of these ichnospecies from the basin and now completes the occurrence of these and other traces assumed to have been made by limulids from all three non-marine formations of the Ravenscar Group.

Recent earthquakes involving complex multi-fault rupture have increased our appreciation of the variety of rupture geometries and fault interactions that occur within the short duration of coseismic slip. Geometrical complexities are intrinsically linked with spatially heterogeneous slip and stress drop distributions, and hence need incorporating into seismic hazard analysis. Studies of exhumed ancient fault zones facilitate investigation of rupture processes in the context of lithology and structure at seismogenic depths. In the Gairloch Shear Zone, NW Scotland, foliated amphibolites host pseudotachylytes that record rupture geometries of ancient low-magnitude (≤M_W 3) seismicity. Pseudotachylyte faults are commonly foliation parallel, indicating exploitation of foliation planes as weak interfaces for seismic rupture. Discordance and complexity are introduced by fault segmentation, stepovers, branching and brecciated dilational volumes. Pseudotachylyte geometries indicate that slip nucleation initiated simultaneously across several parallel foliation planes with millimetre and centimetre separations, leading to progressive interaction and ultimately linkage of adjacent segments and branches within a single earthquake. Interacting with this structural control, a lithological influence of abundant low disequilibrium melting-point amphibole facilitated coseismic melting, with relatively high coseismic melt pressure encouraging transient dilational sites. These faults elucidate controls and processes that may upscale to large active fault zones hosting major earthquake activity.

Supplementary material: Supplementary Figures 1 and 2, unannotated versions of field photographs displayed in Figures 4a and 5 respectively, are available at https://doi.org/10.6084/m9.figshare.c.4573256

Thematic collection: This article is part of the SJG Collection on Early-Career Research available at: https://www.lyellcollection.org/cc/SJG-early-career-research

Transcription factors (TFs) enact precise regulation of gene expression through site-specific, genome-wide binding. Common methods for TF-occupancy profiling, such as chromatin immunoprecipitation, are limited by requirement of TF-specific antibodies and provide only end-point snapshots of TF binding. Alternatively, TF-tagging techniques, in which a TF is fused to a DNA-modifying enzyme...

ABSTRACTBackground:A home-based record (HBR) is a health document kept by the patient or their caregivers, rather than by the health care facility. HBRs are used in 163 countries, but they have not been implemented universally or consistently. Effective implementation maximizes both health impacts and cost-effectiveness. We sought to examine this research-to-practice gap and delineate the facilitators and barriers to the effective implementation and use of maternal and child health HBRs especially in low- and middle-income countries (LMICs).Methods:Using a framework analysis approach, we created a framework of implementation categories in advance using subject expert inputs. We collected information through 2 streams. First, we screened 69 gray literature documents, of which 18 were included for analysis. Second, we conducted semi-structured interviews with 12 key informants, each of whom had extensive experience with HBR implementation. We abstracted the relevant data from the documents and interviews into an analytic matrix. The matrix was based on the initial framework and adjusted according to emergent categories from the data.Results:We identified 8 contributors to successful HBR implementation. These include establishing high-level support from the government and ensuring clear communication between all ministries and nongovernmental organizations involved. Choice of appropriate contents within the record was noted as important for alignment with the health system and for end user acceptance, as were the design, its physical durability, and timely redesigns. Logistical considerations, such as covering costs sustainably and arranging printing and distribution, could be potential bottlenecks. Finally, end users' engagement with HBRs depended on how the record was initially introduced to them and how its importance was reinforced over time by those in leadership positions.Conclusions:This framework analysis is the first study to take a more comprehensive and broad approach to the HBR implementation process in LMICs. The findings provide guidance for policy makers, donors, and health care practitioners regarding best implementation practice and effective HBR use, as well as where further research is required.

BackgroundAwareness of the importance of shared decision making (SDM) is widespread; however, little research has focused on discussions surrounding investigations, despite increasing laboratory testing in primary care.AimTo explore the discussion of blood tests in routine primary care consultations.Design and settingA secondary analysis of 50 video-recorded routine primary care consultations, linked surveys, and records data (all from the One in a Million [OiaM] archive). The consultations were taken by 22 GPs across 12 practices.MethodA coding scheme was developed, using qualitative content analysis, to explore discussion of blood tests in transcripts of recorded consultations. Codes focused on instigating testing, the extent of SDM, and how results were explained. Survey data were used to compare patients’ pre-visit expectations with consultation content. Medical records were reviewed to compare tests discussed with those ordered.ResultsIn 36 out of 50 consultations that discussed ordering blood tests, 11 patients (31%) hinted that they wanted a blood test; however, none asked explicitly. Only four patients (11%) were offered alternative options. In 29 cases (81%) the GP gave some explanation of the indication, but only in six cases (17%) were the limitations of testing explained. Only 10 out of 31 patients (32%) were informed about all blood tests ordered. Of the 23 out of 50 consultations in which results were conveyed, the GP gave no explanation of the results in six cases (26%). Thirteen patients (57%) were only informed of an assessment of the results (for example, ‘normal’), rather than the actual results.ConclusionA lack of information dissemination and SDM exists around ordering tests and conveying results. Promoting SDM could reduce unnecessary testing and improve patient-centred care.

Background:

Unnecessary antibiotic use in the community in Canada is not well defined. Our objective was to quantify unnecessary antibiotic prescribing in a Canadian primary care setting.

As a very ugly standoff develops between legacy cinemas and legacy studios, Disney appears to be playing its cards close to its chest.

Harrell had been working as an executive producer on a TV miniseries about Uptown Records with BET.

Some fans think the new album art was released in anticipation of a rumored platinum edition of Glory.

Laser pointer attacks on aircraft have become increasingly rare over the years in Saskatchewan, as figures from Transport Canada show.

Russia proceeded with Victory Day celebrations despite a rapidly deteriorating situation in the face of the pandemic.

Seed firms report huge rise in sales with people worldwide turning to gardening as hobby

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While the world may feel rather grey at times right now, lockdown has at least enabled some people to go green and inject colour into their gardens.

Britain is blooming – in one sense at least – with a record demand for seeds, and delphiniums, hollyhocks and hydrangeas are having their moment in the sun.

Warming springs can cause plants to bloom earlier, alter hibernation times and locations for migrating animals, and increase insect populations

Across the south-eastern US, trees are unfurling their clouds of leaves after winter. Yet this picturesque and usually welcome development is this year cause for consternation.

New data from the USA National Phenology Network (USA-NPN) shows that in parts of North Carolina, South Carolina and northern Florida, spring has arrived more than three weeks earlier than average, and earlier than at any point in the last 39 years it has been tracked.

A new study of ancient climate has a dire warning about today's dry conditions

The geologic record is exactly that: a record. The strata of rock tell scientists about past environments, much like pages in an encyclopedia. Except this reference book has more pages missing than it has remaining. So geologists are tasked not only with understanding what is there, but also with figuring out what's not, and where it went.

A new method for reliably identifying the presence of beer or other malted foodstuffs in archaeological finds is described in a new study.

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An international team of scientists said two massive stars could have merged before exploding to create the "the most light we have ever seen emitted by a supernova".

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2019 was the hottest year on record for Europe as global warming trends continue, major analysis has shown.

Knife crime was committed in London at a rate more than double the national average last year as offences in the capital involving bladed weapons reached record levels.

America's economic crisis deepened today as new figures revealed 26 million people have now claimed unemployment benefits since the country started going into lockdown.

Record-breaking daredevil pensioner Jack Reynolds has died aged 108, his family have said.

The chief medical officer for England has said the country is not "consistently" past the peak of coronavirus deaths.

Brits have been basking under blue skies during what will likely be the sunniest April on record, the Met Office has said.

Spending on home deliveries of food and drink by "vulnerable" elderly shoppers almost doubled this month as overall grocery sales surged by more than £500 million.

The death toll linked to coronavirus in England is around 40 per cent higher than previously reported, new figures show.

The rising number of Covid-19-related deaths in care homes pushed the overall death toll in England and Wales to the highest level since comparable figures began in 1993, new figures show.

A cuckoo named Carlton II has smashed the record books by flying more than 4,000 miles in just seven days on his annual migration to the UK from Africa.

The number of vehicles on roads during the coronavirus pandemic has hit its highest level since the lockdown began.

The number of speeding drivers caught by traffic police has risen by nearly eight-fold compared with last year, the Met revealed today.