The Democratic Party’s defeat has many causes, but its anti-Zionist wing has clearly contributed to its electoral collapse.

With Trump poised to resume his role as a champion of these accords, we have a window of opportunity to take a bold step.

The most solemn and terrifying words ever uttered are those inscribed over the gateway to Hell in Dante’s Inferno: “Abandon all hope, ye who enter here!” Hope is essential for human survival both as individuals and as nations. Surveying the history of the seemingly endless series of wars and counter-wars between Israel and its foes […]

On January 6, 2021, white insurrectionists stormed the U.S. Capitol, proudly displayed the confederate flag, and set up gallows on the Capitol grounds.

TOKYO, Japan — Japan’s Seven & i Holdings 3382.T is considering launching a management buyout that would see the retailer go private in a deal that could be worth up to $58 billion, Bloomberg News reported on Wednesday. The Nikkei newspaper also reported that the owner of the 7-Eleven convenience store chain was looking at […]...

Keep on reading: Japan's 7-Eleven reportedly considering management buyout of up to $58B

Thousands of Serbians demand prime minister's resignation following deadly roof collapse

Trump to appoint hardliners Rubio and Waltz as foreign policy chiefs, reports claim

Church of England head Justin Welby resigns over handling of sex abuse scandal

Meghan Markle ready to make peace with Kate Middleton, Queen Camilla Meghan Markle has reportedly made a big decision about the years-long royal feud.According to Closer magazine, the Duchess of Sussex may take advantage of Christmas to send a message of "peace and harmony" to Kate Middleton...

Princess Kate has found a trusted mentor in the Duchess of Edinburgh, Sophie, 59, as she adjusts to her new role as Princess of Wales. Royal biographer Claudia Joseph revealed that Kate "jumped at the chance" to be mentored by Sophie, describing her as a "tower of strength" and a reliable...

to wire a relay for headlights

to wire a motorcycle headlight

After the release of a shocking video showing Olympic rider Charlotte Dujardin whipping a horse, it is time for equestrians to educate themselves on the science of horse training, says Christa Lesté-Lasserre

Invasive cane toads have decimated native freshwater crocodile populations in northern Australia, as the predators don't know they should avoid the toxic amphibians

Up to 100,000 extraordinary species, from spiders and beetles to salamanders and fish, live in subterranean caves and cracks. They aren’t as safe down there as we thought

Feeding bees edible bits of hydrogel increases their odds of surviving pesticide exposure by 30 per cent

African giant pouched rats proved adept at detecting four commonly trafficked products derived from endangered species including rhino horn and elephant ivory

An army of tadpoles and a stretching lynx are just some of the incredible photos winning accolades at the annual competition

The lifestyle choices you make in middle age play a particularly important role in how your brain ages

Up to 100,000 extraordinary species, from spiders and beetles to salamanders and fish, live in subterranean caves and cracks. They aren’t as safe down there as we thought

Two important barriers to a stable, powerful fusion reaction have been leapt by an experiment in a small tokamak reactor, but we don’t yet know if the technique will work in larger devices

The direction of cause and effect was brought into question for quantum objects more than a decade ago, but new calculations may offer a way to restore it

Earth’s iron-rich inner core may owe some of its surprising softness to the motion of atoms, suggest experiments with iron at high temperature and pressure coupled to AI simulations

Climate change is making extreme cold upwellings more common in certain regions of the world, and these events can be catastrophic for animals such as bull sharks

I have a confession to make. After taking a handful of autonomous taxi rides, I have gone from a hater to a friend of robot cars in just a few weeks, says Annalee Newitz

A young boy who lived towards the end of the last glacial period had dark skin, blue eyes and a congenital heart condition, a study of his genome reveals

Title: Health Tip: Training a Toddler to Use the Toilet
Category: Health News
Created: 8/26/2010 10:10:00 AM
Last Editorial Review: 8/27/2010 12:00:00 AM

Title: Midlife Fitness May Mean Healthier Old Age, Study Finds
Category: Health News
Created: 8/27/2012 6:05:00 PM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Missed Diagnoses in ICU Often Have Deadly Results: Review
Category: Health News
Created: 8/28/2012 2:05:00 PM
Last Editorial Review: 8/29/2012 12:00:00 AM

Title: Parents Deliberately Making Child Ill Can Be Deadly
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: High Cholesterol May Be Particularly Bad for Middle-Aged Men
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM

Title: Middle-Aged Health Behavior a Matter of Degrees
Category: Health News
Created: 8/29/2013 9:35:00 AM
Last Editorial Review: 8/29/2013 12:00:00 AM

Title: Toddlers Can Die From Swallowing Parents' Drug Detox Meds
Category: Health News
Created: 8/29/2013 12:35:00 PM
Last Editorial Review: 8/30/2013 12:00:00 AM

Title: California Trees Harbor Fungus Deadly to People With HIV
Category: Health News
Created: 8/28/2014 9:35:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Could Too Much 'Good' HDL Cholesterol Be Bad for Your Heart?
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/28/2018 12:00:00 AM

Title: Running Red Lights a Deadly Practice That's Becoming More Common
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/29/2019 12:00:00 AM

Title: U.S. Opioid Deaths Take a Small Dip, as Fentanyl Leaves Deadly Mark
Category: Health News
Created: 8/29/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM

Title: What Is More Deadly in the U.S.: Hot Weather or Cold?
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM

Title: Spotting the Signs of Deadly Melanoma Skin Cancers
Category: Health News
Created: 8/22/2021 12:00:00 AM
Last Editorial Review: 8/23/2021 12:00:00 AM

Title: How Can I Help My Toddler With Sleep Problems?
Category: Diseases and Conditions
Created: 6/17/2021 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

Title: Your Salt Shaker May Prove Deadly, Study Finds
Category: Health News
Created: 7/11/2022 12:00:00 AM
Last Editorial Review: 7/12/2022 12:00:00 AM

Influenza A virus (IAV) is one of the leading causes of respiratory infections. The lack of efficient anti-influenza therapeutics requires a better understanding of how IAV interacts with host cells. Alveolar macrophages are tissue-specific macrophages that play a critical role in lung innate immunity and homeostasis, yet their role during influenza infection remains unclear. First, our review highlights an active IAV replication within alveolar macrophages, despite an abortive viral cycle. Such infection leads to persistent alveolar macrophage inflammation and diminished phagocytic function, alongside direct mitochondrial damage and indirect metabolic shifts in the alveolar micro-environment. We also discuss the "macrophage disappearance reaction", which is a drastic reduction of the alveolar macrophage population observed after influenza infection in mice but debated in humans, with unclear underlying mechanisms. Furthermore, we explore the dual nature of alveolar macrophage responses to IAV infection, questioning whether they are deleterious or protective for the host. While IAV may exploit immuno-evasion strategies and induce alveolar macrophage alteration or depletion, this could potentially reduce excessive inflammation and allow for the replacement of more effective cells. Despite these insights, the pathophysiological role of alveolar macrophages during IAV infection in humans remains understudied, urging further exploration to unravel their precise contributions to disease progression and resolution.

Purpose The posterior superior alveolar (PSA) block injection is one of many techniques used to provide profound anesthesia for invasive dental procedures. This technique has a high success rate but is not without complication risks. The purpose of this study was to determine if pulpal anesthesia of the maxillary second molar could be achieved using a reduced needle depth of 10mm or 5mm compared to the traditional needle depth of 16mm.Methods Sixty participants were asked to participate in three sessions. Each session started with a pre neural response test, followed by one randomized needle depth PSA injection, and ending with a post neural response test. The neural response test consisted of two parts, a cold refrigerant and a dental probe, on the buccal and interproximal surface of the maxillary second molar. After receiving a positive neural response, each participant received a posterior superior alveolar block injection using a short (21mm), 27-gauge dental needle with a randomized needle penetration depth of 16mm, 10mm, or 5mm. A post neural response test consisting of the same two parts as the pre-test was conducted on the maxillary second molar to evaluate for profound anesthesia.Results Positive neural responses were obtained from 100% of the participants (n=167) during the pre-tests. Study results demonstrated an 85% success rate at the traditional 16mm needle depth and a 93% and 92% success rates for the reduced needle depths of 10mm and 5mm, respectively. Pulpal anesthesia of the maxillary second molar had been achieved at all three needle depths with no statistically significant difference in the rate of success. Furthermore, there were no adverse events observed.Conclusion The reduced needle depth technique showed promise in achieving desired results of pulpal anesthesia with a reduced risk for complications associated with the PSA block injection. Additional studies are recommended to achieve evidence-based support for this reduced needle depth technique.

ABSTRACTIntroduction:Health risks associated with short interpregnancy intervals, coupled with women’s desires to avoid pregnancy following childbirth, underscore the need for effective postpartum family planning programs. The antenatal period provides an opportunity to intervene; however, evidence is limited on the effectiveness of interventions aimed at reaching women in the antenatal period to increase voluntary postpartum family planning in low- and middle-income countries (LMICs). This systematic review aimed to identify and describe interventions in LMICs that attempted to increase postpartum contraceptive use via contacts with pregnant women in the antenatal period.Methods:Studies published from January 2012 to July 2022 were considered if they were conducted in LMICs, evaluated an intervention delivered during the antenatal period, were designed to affect postpartum contraceptive use, were experimental or quasi-experimental, and were published in French or English. The main outcome of interest was postpartum contraceptive use within 1 year after birth, defined as the use of any method of contraception at the time of data collection. We searched EMBASE, Global Health, and Medline and manually searched the reference lists from studies included in the full-text screening.Results:We double-screened 771 records and included 34 reports on 31 unique interventions in the review. Twenty-three studies were published from 2018 on, with 21 studies conducted in sub-Saharan Africa. Approximately half of the study designs (n=16) were randomized controlled trials, and half (n=15) were quasi-experimental. Interventions were heterogeneous. Among the 24 studies that reported on the main outcome of interest, 18 reported a positive intervention effect, with intervention recipients having greater contraceptive use in the first year postpartum.Conclusion:While the studies in this systematic review were heterogeneous, the findings suggest that interventions that included a multifaceted package of initiatives appeared to be most likely to have a positive effect.

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of CD79B, MyD88, TP53, TBL1XR1, and PIM1 genes, indicating that this lymphoma would be best classified as MCD/C5 DLBCL, an ABC subtype. Despite an initial good clinical response to BTK inhibitor ibrutinib, anti-CD20 antibody rituxan, alkylating agent bendamustine, and hematopoietic stem-cell transplant, the lymphoma relapsed, accompanied by morphologic and molecular evidence of disease progression. Specifically, the recurrent tumor developed loss of TP53 heterozygosity (LOH) and additional chromosomal changes central to ABC DLBCL pathogenesis, such as PRDM1 loss. Acquired resistance to ibrutinib and rituxan was indicated by the emergence of BTK and FOXO1 mutations, respectively, as well as apparent activation of alternative cell-activation pathways, through copy-number alterations (CNAs), detected by high-resolution chromosomal microarrays. In vitro, studies of relapsed lymphoma cells confirmed resistance to standard BTK inhibitors but sensitivity to vecabrutinib, a noncovalent inhibitor active against both wild-type as well as mutated BTK. In summary, we provide in-depth molecular characterization of a de novo leukemic DLBCL and discuss mechanisms that may have contributed to the lymphoma establishment, progression, and development of drug resistance.

It will likely release in 2026 and feature Apple Intelligence, according to a reliable analyst.

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JUDY WOODRUFF: And in the day’s other news: More than 300 people are now confirmed dead after Saturday’s massive truck bombing in Somalia, one of the world’s worst attacks in years.

Nearly 400 more were wounded. The government blamed the al-Qaida-linked Al-Shabaab group. Rescue crews today searched for survivors at the scene of the bombing, a crowded street in the capital, Mogadishu. With dozens still missing, officials say they expect the death toll to rise.

OSMAN LIBAH IBRAHIM, Deputy Minister for Natural Resources, Somalia (through interpreter): More bodies are gradually being found and removed from the rubble. There are other people who are under the rubble. We have heard them as they scream for help. My biggest worry is that even the wounded are succumbing to their injuries.

JUDY WOODRUFF: The attack happened two days after Somalia’s defense minister and army chief resigned for undisclosed reasons.

There’s been yet another shift to the right in European politics; 31-year-old conservative Sebastian Kurz, Austria’s foreign minister, is set to become that country’s next leader. But he’s short of a majority in Parliament and will likely form a coalition with the far-right Freedom Party. It was founded by ex-Nazis in the 1950s.

Kurz has called for the European Union to focus more on internal trade and securing borders. He celebrated in Vienna.

SEBASTIAN KURZ, Austrian People’s Party (through interpreter): I have a big request for you. Use today to celebrate. You all have earned it through hard work and dedication. At the same time, I need to tell you that tomorrow the work starts. We didn’t just run to win the elections. We did so to bring Austria back to the top. We ran in this election to achieve real change.

JUDY WOODRUFF: A final result in the election is likely to be decided on Thursday.

Wildfires that broke out over the weekend in Portugal have killed at least 35 people, including a one-month-old infant. Today, more than 5,300 firefighters with some 1,600 vehicles were battling the fires, some of which officials say were started by arsonists. Wildfires have also left at least four people dead in neighboring Spain.

Army Sergeant Bowe Bergdahl pleaded guilty today to desertion and misbehavior before the enemy. He was captured by the Taliban in 2009, after leaving his post in Afghanistan. It prompted an intense search and a prisoner swap. Bergdahl appeared before a military judge in Fort Bragg, North Carolina, today. The 31-year-old could be sentenced to life in prison. He said his actions were very inexcusable, adding he didn’t — quote — “think there’d be any reason to pull off a crucial mission to look for one guy.”

The truck driver in deadly immigrant smuggling run has pleaded guilty in court. San Antonio police found at least 39 immigrants, 10 of whom died, packed into a sweltering semi-trailer last year and died. The driver, James Matthew Bradley Jr., pleaded to conspiracy and transporting immigrants, resulting in death. He faces now up to life in prison.

A New Jersey man has been convicted of planting two pressure-cooker bombs on New York City streets last year. Ahmed Khan Rahimi faces a maximum sentence of life in prison for charges including using a weapon of mass destruction. One of the bombs exploded in Manhattan’s Chelsea neighborhood, wounding 30. The second didn’t detonate. Officials said Rahimi was inspired by ISIS and al-Qaida.

JOHN MILLER, Deputy Commissioner, NYPD Intelligence & Counterterrorism: Ahmed Khan Rahimi learned a lesson which we keep reminding people of. This is the wrong place to try and carry out an act of terrorism. Witnesses will come forward, evidence will be developed, arrests will be made, prosecutions will be brought forth, and they will be successful.

JUDY WOODRUFF: Prosecutors said Rahimi also planted a pipe bomb in Seaside Heights, New Jersey, but no one was injured.

Colin Kaepernick has filed a grievance against the national football league. The former San Francisco 49ers quarterback says that he remains unsigned due to collusion by team owners over his national anthem protests. Kaepernick sparked a debate when he kneeled during the anthem last year, protesting police mistreatment of African-Americans.

On Wall Street today, the Dow Jones industrial average gained 85 points to close at 22957. The Nasdaq rose 18. And the S&P 500 added four.

It was a milestone day in the world of astronomy. For the first time, researchers say they have detected gravitational waves with a flash of light from the same cosmic event. The dual observation supports Albert Einstein’s general theory of relativity. The ripples in space and the light burst were caused by the collision of two neutron stars. They were first detected in August.

The post News Wrap: Dozens missing after deadly Mogadishu truck bombing appeared first on PBS NewsHour.

A baroque fiddle believed to have been played by Robert Burns will be performed live on stage in the United States for the first time.

Josh demands justice for Jorts. Chris is deployed to the circus wars. And Kelley assures us that Fang sniper is real. We'll see you in 2022. Don't butter your cats!

The post RPG Cast – Episode 612: “He Must Have Put Skill Points Into Broom Handle” appeared first on RPGamer.