In line with its core values of educational development, environmental sustainability, alternative conflict resolution among others, the Boss Friendship Club (BFC), a Non- Governmental Organisation (NGO) in conjunction with World Dynasty Pageant, has initiated the Pan-African Girl Child Education campaign. At the flag off of the campaign in Abuja recently, District Governor of Boss Friendship Club in Nigeria, Dr Edet Ekpenyong, in his welcome address said the club through the campaign aims to support, contribute and sponsor over 10,000 girl children in Nigeria and other African countries, to ensure they achieve their educational pursuits which would enable them build their […]

What a privilege and joy it is to worship the Lord here at Grace church. Patricia and I miss it when we’re not here; there&rsqu

Earlier in the service I read from the first chapter of Romans what is really a very, very shocking portion of Scripture just to remind you that Romans cha

U.S. President-elect Donald Trump has left little question about the sort of economic policies he will pursue when he is sworn in for a second term as president in January. The once-and-future president has promised to extend existing tax cuts and implement new ones; to pursue a deregulation agenda, particularly when it comes to energy production; to reinstate a strong protectionist trade policy, including substantial tariffs on imports; and to undertake a "mass deportation" program that would remove a large number of the millions of undocumented immigrants currently residing in the United States. While there may be little doubt about the kind of policies Trump will implement, the degree to which he will pursue them is an open question. "The problem that all economists are dealing with is they don't know how much of what Trump said on the campaign trail to take seriously," Steven B. Kamin, a senior fellow at the conservative-leaning American Enterprise Institute, told VOA. "They don't know if he's going to do a lot of these things, or if he is, how far he'll take it." When it comes to tariffs, Trump has promised across-the-board 10%-20% levies on all imports, and charges of up to 60% on goods coming from China, which experts warn would be economically ruinous. His rhetoric about fossil fuel extraction suggests he will drive up oil and gas production, even though the U.S. is currently producing more energy than it ever has. On immigration, he and his advisers have vacillated between suggesting that all undocumented people will be forcibly removed and describing a much more targeted operation. Tax policy One thing that appears certain is that Trump will work with Congress — which seems likely to be fully controlled by the Republican Party — to extend the tax cuts that became law as part of the Tax Cuts and Jobs Act, which he signed into law in 2017. Those tax cuts reduced the income taxes paid by many American workers and reduced taxable income by increasing the standard deduction. They also sharply cut the top business income tax bracket from 39% to 21%. Those provisions are all scheduled to expire over the next several years, some as soon as 2025, and Trump has proposed making them permanent. Trump has also floated the idea of other tax cuts, including further reducing the business income tax to a maximum of 15%, and making income from overtime wages, tips and Social Security payments nontaxable, all of which would reduce government revenues. Kamin said the stimulative impact of Trump's proposed additional tax changes would likely not be great, but the impact on the country's debt might be, because they will virtually guarantee additional government borrowing to finance deficit spending. "The real concern for folks that are concerned about the fiscal balance — and I'm one of them — is that by cementing in place large fiscal deficits as far as the eye can see, even in environments of strong economic activity when we should be running surpluses, that leads to increases in the debt," he said. "That, eventually, should lead to crowding out of private investment, rising interest rates, and more worries about the government's sustainability position," Kamin added. "But when the debt will reach a level that will be worrisome in that respect, nobody knows." Cost-cutting In theory, some of the deficit spending made necessary by large tax cuts could be offset by a reduction in government spending, something Trump has also floated on the campaign trail. In particular, the president-elect has proposed creating a Department of Government Efficiency, to be headed by Elon Musk, the billionaire founder of the electric car company Tesla and the rocket builder SpaceX, and the owner of X, the social network formerly known as Twitter. For his part, Musk has mused that it should be possible to slash federal spending by as much as $2 trillion per year, or about 30%. Reductions of that magnitude would require deep cuts to a vast array of programs, including elements of the social safety net such as Social Security and federal health programs like Medicaid. However, it is unclear how Trump would persuade even a Republican Congress to enact such a wide-ranging reduction in government services. Immigration policy If Trump follows through on a policy of mass deportation of undocumented immigrants, it is virtually certain to have a negative impact on economic sectors where they are present as laborers in significant concentrations, especially agriculture and construction, said Marcus Noland, executive vice president and director of studies at the Peterson Institute for International Economics. "If you take lots of people out of the labor force, you reduce the amount of output, because there's less labor available, and you raise prices," Noland told VOA. "These people are not distributed evenly across the United States economy," he said. "They're concentrated in agriculture and construction, so you would disrupt those sectors the most, especially if you combine it with tariffs." Trade policy Trump's tariff proposals, especially if he follows through with his maximalist proposals from the campaign trail, could be significantly damaging. While theoretically meant to stimulate American manufacturing, Noland warned that they could have the opposite effect. "Some modeling that I worked on suggest that those tariff policies, instead of reviving the industrial sector, will actually reduce industrial activity in the United States," he warned. Blanket tariffs on imports, and especially high levies on Chinese goods, would create severe challenges for U.S. manufacturers. "The reason is that you would increase the price of industrial inputs, and so, the United States would become a high-cost place to produce," he said. "Investment would fall — and investment is intensive in industrial materials — so, ironically, it has the opposite effect of what its proponents say."

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

The police Criminal Investigation and Detection Group raided a SIM (Subscriber Identity Module) card scam hub in Pasay last week.

The UN High Commission for Refugees estimates that nearly 50,000 migrants are in Greece, awaiting asylum interviews in which they will make their cases for staying in Europe. While many migrants remain without jobs, some have found work in camps, or have even started their own businesses.

JOHANNESBURG — South Africa's four main political parties began the final weekend of campaigning Saturday before a possibly pivotal election that could bring the country's most important change in three decades. Supporters of the long-governing African National Congress, which has been in the government ever since the end of white minority rule in 1994, gathered at a soccer stadium in Johannesburg to hear party leader and South African President Cyril Ramaphosa speak. The ANC is under unprecedented pressure to keep hold of its parliamentary majority in Africa's most advanced country. Having seen its popularity steadily decline over the last two decades, Wednesday's vote could be a landmark moment when the party once led by Nelson Mandela drops below 50% of the vote for the first time. Several polls have the ANC's support at less than 50%, raising the possibility that it will have to form a national coalition. That would also be a first for South Africa's young democracy, which was only established 30 years ago with the first all-race vote that officially ended the apartheid system of racial segregation. As thousands of supporters in the ANC's black, green and gold colors attended its last major rally before the election, Ramaphosa recognized some of the grievances that have contributed to his party losing support, which include high levels of poverty and unemployment that mainly affect the country's Black majority. “We have a plan to get more South Africans to work," Ramaphosa said. “Throughout this campaign, in the homes of our people, in the workplaces, in the streets of our townships and villages, so many of our people told us of their struggles to find work and provide for their families.” The main opposition Democratic Alliance party had a rally in Cape Town, South Africa's second-biggest city and its stronghold. Party leader John Steenhuisen made a speech while supporters in the DA's blue colors held up blue umbrellas. “Democrats, friends, are you ready for change?” Steenhuisen said. The crowd shouted back “Yes!” "Are you ready to rescue South Africa?" Steenhuisen added. While the ANC's support has shrunk in three successive national elections and appears set to continue dropping, no party has emerged to overtake it — or even challenge it — and it is still widely expected to be the largest party by some way in this election. But losing its majority would be the clearest rejection yet of the famous party that led the anti-apartheid movement and is credited with leading South Africans to freedom. Some ANC supporters at the rally in Johannesburg also expressed their frustration with progress, as South Africa battles poverty, desperately high unemployment, some of the worst levels of inequality in the world, and other problems with corruption, violent crime and the failure of basic government services in some places. “We want to see job opportunities coming and basically general change in every aspect,” ANC supporter Ntombizonke Biyela said. “Since 1994 we have been waiting for ANC, it has been long. We have been voting and voting but we see very little progress as the people, only a special few seem to benefit.” While conceding to some failures, the ANC has maintained that South Africa is a better place than it was during apartheid, when a set of race-based laws oppressed the country's Black majority in favor of a small white minority. The ANC was also widely credited with success in expanding social support and housing and other services for millions of poor South Africans in the decade after apartheid, even if critics say it has lost its way recently. "There are many problems in South Africa, but nobody can deny the changes that have happened since 1994, and that was because of the ANC,” said 42-year-old Eric Phoolo, another supporter of the ruling party. “These other parties don’t have a track record of bringing change to the country." As some voters have turned away from the ANC, it has led to a slow fracturing of South African politics. They have changed allegiances to an array of different opposition parties, some of them new. South Africa has dozens of parties registered to contest next week's election. South Africans vote for parties and not directly for their president in national elections. Parties then get seats in Parliament according to their share of the vote and the lawmakers elect the president — which is why the ANC losing its majority would be so critical to the 71-year-old Ramaphosa's hope of being reelected for a second and final five-year term. If the ANC goes below 50, it would likely need a coalition or agreement with other parties to have the votes in Parliament to keep Ramaphosa, once a protege of Mandela, as president. The far-left Economic Freedom Fighters had their last big pre-election gathering in the northern city of Polokwane, the hometown of fiery leader Julius Malema. The new MK Party of former South African President and former ANC leader Jacob Zuma was also campaigning in a township just outside the east coast city of Durban, although Zuma didn't attend the event. The 82-year-old Zuma rocked South African politics when he announced late last year he was turning his back on the ANC and joining MK, while fiercely criticizing the ANC under Ramaphosa. Zuma has been disqualified from standing as a candidate for Parliament in the election because of a previous criminal conviction.

Just before the teach-in, the school’s Jewish provost called him and asked if he wanted extra security.

MANILA, Philippines — The excess campaign funds of then-president Rodrigo Duterte were used for the reward system of police officers during his administration’s brutal war on drugs.  Duterte himself admitted this to Santa Rosa City Rep. Dan Fernandez during the House of Representatives quad committee during its 11th probe on his controversial anti-drug campaign.  “I still remember that you mentioned na yung pera galing sa donation ng inyong campaign funds will be utilized for the reward system, that’s private money,” Fernandez said.  (I still remember you mentioned that the money from the donation for your campaign funds would be utilized […]...

Keep on reading: Excess campaign funds used for drug war reward system, Duterte admits

The 2001 memorandum of understanding (MoU) between Thailand and Cambodia regarding territory claimed by both sides in the Gulf of Thailand provides a framework for negotiations on two main subjects: maritime demarcation and economic benefits from the development of energy resources, said Foreign Affairs Minister Maris Sangiampongsa.

At least three killed in Israeli strike on Gaza's Nuseirat refugee camp

On November 6, the World Health Organization (WHO) announced that the second round of polio vaccinations in the Gaza Strip has been completed. A total of 556,744 children under ten years of age received the mOPV2 vaccine along with a dose of vitamin A to ensure immunization. However, due to rampant hostilities from the Israeli […]

On the 7th of November 2024, the Gauteng MEC for Finance and Economic Development, Lebogang Maile, delivered a keynote address at Bolt South Africa's Global Safety Campaign launch in Johannesburg. The campaign is aimed at improving safety in the e-hailing industry

Meghan Markle ready to make peace with Kate Middleton, Queen Camilla Meghan Markle has reportedly made a big decision about the years-long royal feud.According to Closer magazine, the Duchess of Sussex may take advantage of Christmas to send a message of "peace and harmony" to Kate Middleton...

High-security card grants access to Queen Camilla and King Charles.Queen Camilla's son, Tom Parker Bowles, has revealed that his mother is likely the "first Queen to have cooked," highlighting her impressive culinary skills. The 49-year-old son of Queen Camilla shared that while his...

Queen Camilla has sparked a surge of support for a cause close to her heart, following in the footsteps of Prince William with a powerful new documentary. Her Majesty The Queen: Behind Closed Doors, which aired on ITV on Monday evening, offered a deeply personal look at her first year as...

Queen Camilla makes first statement after missing key royal eventQueen Camilla marked her comeback to royal duties after she was forced to miss an important event on the royal calendar on doctor’s advice.A week after palace had cancelled her scheduled engagements, Camilla on Tuesday attended...

Queen Camilla issues statement after cancelling another event amid recoveryQueen Camilla returned to her public duties on Tuesday after doctor’s instructed her to cancel scheduled events due to her health condition.A week after Palace issued a statement about her “seasonal chest...

c500 digital cameras owners manual

camera manuals

engineering corporation 199toyota camry repair manual free download

This study outlines actions Cambodia can take to diversify its economy and shows how cutting business costs, tackling human capital deficits, and reducing vulnerability to external shocks can help drive sustainable, inclusive growth.

Eight Australian sea lions were fitted with cameras and trackers to capture unprecedented insights into their behaviour and the marine habitats where they hunt

A camera trap at an Australian nature refuge has captured a boisterous interaction between a northern hairy-nosed wombat and an echidna

Voyager 2 flew by Uranus in 1986, giving us our only up-close look at the planet – but unusual space weather just before the craft arrived has given us a misleading idea about the planet’s magnetic field

Evidence from an archaeological site in Ethiopia suggests ancient humans adapted their diet during a dry spell after the Toba volcano eruption 74,000 years ago

Title: Thousands of COVID Cases Already on College Campuses
Category: Health News
Created: 8/26/2020 12:00:00 AM
Last Editorial Review: 8/26/2020 12:00:00 AM

Title: Maine Summer Camps Identified, Isolated COVID-19 Cases
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/27/2020 12:00:00 AM

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

This single-center, single-arm, phase II trial (ChiCTR2100050057) investigated the ability of ¹⁸F-labeled fibroblast activation protein inhibitor ([¹⁸F]AlF-NOTA-FAPI-04, denoted as ¹⁸F-FAPI) PET/CT to predict the response to neoadjuvant camrelizumab plus chemotherapy (nCC) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). Methods: This study included 32 newly diagnosed LA-ESCC participants who underwent ¹⁸F-FAPI PET/CT at baseline, of whom 23 also underwent scanning after 2 cycles of nCC. The participants underwent surgery after 2 cycles of nCC. Recorded PET parameters included maximum, peak, and mean SUVs and tumor-to-background ratios (TBRs), metabolic tumor volume, and total lesion FAP expression. PET parameters were compared between patient groups with good and poor pathologic responses, and the predictive performance for treatment response was analyzed. Results: The good and poor response groups each included 16 participants (16/32, 50.0%). On ¹⁸F-FAPI PET/CT, the posttreatment SUVs were significantly lower in good responders than in poor responders, whereas the changes in SUVs with treatment were significantly higher (all P < 0.05). SUV_max (area under the curve [AUC], 0.87; P = 0.0026), SUV_peak (AUC, 0.89; P = 0.0017), SUV_mean (AUC, 0.88; P = 0.0021), TBR_max (AUC, 0.86; P = 0.0031), and TBR_mean (AUC, 0.88; P = 0.0021) after nCC were significant predictors of pathologic response to nCC, with sensitivities of 63.64%–81.82% and specificities of 83.33%–100%. Changes in SUV_max (AUC, 0.81; P = 0.0116), SUV_peak (AUC, 0.82; P = 0.0097), SUV_mean (AUC, 0.81; P = 0.0116), and TBR_mean (AUC, 0.74; P = 0.0489) also were significant predictors of the pathologic response to nCC, with sensitivities and specificities in similar ranges. Conclusion: ¹⁸F-FAPI PET/CT parameters after treatment and their changes from baseline can predict the pathologic response to nCC in LA-ESCC participants.

Sleep is a fundamental feature of life for virtually all multicellular animals, but many questions remain about how sleep is regulated and what biological functions it plays. Substantial headway has been made in the study of both circadian rhythms and sleep in the fruit fly Drosophila melanogaster, much of it through studies of individual fly activity using beam break counts from Drosophila activity monitors (DAMs). The number of laboratories worldwide studying sleep in Drosophila has grown from only a few 20 years ago to hundreds today. The utility of these studies is limited by the quality of the metrics that can be extracted from the data. Many software options exist to help analyze DAM data; however, these are often expensive or have significant limitations. Therefore, we describe here a method for analyzing DAM-based data using the sleep and circadian analysis MATLAB program (SCAMP). This user-friendly software has an advantage of combining several analyses of both sleep and circadian rhythms in one package and produces graphical outputs as well as spreadsheets of the outputs for further statistical analysis. The version of SCAMP described here is also the first published software package that can analyze data from multibeam DAM5Ms, enabling determination of positional preference over time.

It will likely release in 2026 and feature Apple Intelligence, according to a reliable analyst.