New California Horse Racing Board Rule 1867.1, which becomes effective July 1, prohibits the administration of bisphosphonates to any horse within a facility regulated by the CHRB and also prohibits any horse from entering the grounds that has been administered the drug within six months. This means that any horse administered bisphosphonates since January 1, […]

The post California Prohibits Bisphosphonate Use In Any Horse On CHRB Grounds appeared first on Horse Racing News | Paulick Report.

It's the first Orioles game to be played there under a long-term partnership with the Naval Academy.

Grand Canyon National Park was once again invited to display its contracted MD 900 Explorer helicopter at the recent "Thunder in the Desert" Open House and Air Show at Luke Air Force Base on March 21 and 22 in Glendale, Arizona.  https://www.nps.gov/grca/learn/news/news-2009-04-02-luke.htm

https://www.nps.gov/grca/learn/news/15jun10_news.htm

test https://www.nps.gov/grca/learn/news/grca-archeol-exhibit-open.htm

Grand Canyon National Park recently completed installation of new interpretive and orientation exhibits at the Grand Canyon Visitor Center located near Mather Point on the South Rim. https://www.nps.gov/grca/learn/news/2012-04-23_exhibits.htm

An international team of paleontologists has united to study important fossil footprints recently discovered in a remote location within Grand Canyon National Park, Arizona. A large sandstone boulder contains several exceptionally well-preserved trackways of primitive tetrapods (four-footed animals) which inhabited an ancient desert environment. https://www.nps.gov/grca/learn/news/newly-discovered-fossils.htm

The actor who played ‘Gollum’ in The Lord of the Rings, Andy Serkis, will give a LIVE reading of The Hobbit, from cover to cover, for charity May 8.

The post ‘Gollum’ Actor Andy Serkis Plans a Live Reading of ‘The Hobbit’ –There And Back Again– Friday For Charity appeared first on Good News Network.

Higher global temperatures are changing ecosystems in the Arctic. They are becoming greener as the climate and land become more hospitable to taller vegetation.

Martens are small forest carnivores associated with dense, mature forests.

With the passage of the Multiple Use Sustained Yield Act of 1960, the U.S. Forest Service has managed its 193 million acres of forest and grassland for multiple uses, including timber, watersheds, and wildlife. Using today’s terminology, some of these purposes are considered ecosystem services, which encompass a breadth of benefits provided by forests, including their ability to absorb and store atmospheric carbon, a greenhouse gas linked to climate change.

We describe a food-based system for quantitatively evaluating habitat quality for deer called the Forage Resource Evaluation System for Habitat and provide its rationale and suggestions for use. The system was developed as a tool for wildlife biologists and other natural resource managers and planners interested in evaluating habitat quality and, especially, comparing two or more patches of habitat or the same patch at different seasons or under different conditions. It is based on the quantity (of biomass) and quality (digestible energy and digestible protein) of the habitat's food resources in relation to user-specified metabolic requirements of deer (which differ with species, age, sex, season, and reproductive status). It uses a linear programming algorithm to determine the suitable forage that can sustain deer at the specified requirements.

In forest reserves of the U.S. Pacific Northwest, management objectives include protecting late-seral habitat structure by reducing the threat of large-scale disturbances like wildfire. We simulated how altering within and among-stand structure with silvicultural treatments of differing intensity affected late-seral forest (LSF) structure and fire threat (FT) reduction over 30 years in a 6070-ha reserve. We then evaluated how different financial requirements influenced the treatment mix selected for each decade, the associated effects on FT reduction and LSF structure in the reserve, and treatment costs. Requirements for treatments to earn money (NPV+), break even (NPVO), or to not meet any financial goal at the scale of the entire reserve (landscape) affected the predicted reduction of FT and the total area of LSF structure in different ways. With or without a requirement to break even, treatments accomplished about the same landscape level of FT reduction and LSF structure. Although treatment effects were similar, their associated net revenues ranged from negative $1 million to positive $3000 over 30 years. In contrast, a requirement for landscape treatments to earn money ($0.5 to $1.5 million NPV) over the same period had a negative effect on FT reduction and carried a cost in terms of both FT reduction and LSF structure. Results suggest that the spatial scale at which silvicultural treatments were evaluated was influential because the lowest cost to the reserve objectives was accomplished by a mix of treatments that earned or lost money at the stand level but that collectivel broke even at the landscape scale. Results also indicate that the timeframe over which treatments were evaluated was important because if breaking even was required within each decade instead of cumulatively over all three, the cost in terms of FT reduction and LSF structure was similar to requiring landscape treatments to earn $0.5 million NPV.

Millions of miles of highway crisscross the United States. Highways fragment the landscape, affecting the distribution of animal populations and limiting the ability of individuals to disperse between those populations. Moreover, animal-vehicle collisions are a serious hazard to wildlife, not to mention people.

The Northwest Forest Plan (the Plan) is a large-scale ecosystem management plan for federal land in the Pacific Northwest. Marbled murrelet (Brachyramphus marmoratus) populations and habitat were monitored to evaluate effectiveness of the Plan. The chapters in this volume summarize information on marbled murrelet ecology and present the monitoring results for marbled murrelets over the first 10 years of the Plan, 1994 to 2003.

On October 18, 2006, a workshop was held in Vancouver, WA, with the title "Managing for wildlife habitat in Westside production forests." The purpose of the workshop was to provide prescriptions and guidelines for people who manage Westside forests (those west of the Cascade Mountains' crest) primarily for wood production, but because of mandate or personal preference, want to integrate wildlife values. The audience included over 150 professionals from forest industry, consulting firms, and public and tribal forest and wildlife management agencies. This proceedings includes ten papers based on oral presentations at the workshop plus a synthesis paper summarizing workshop themes, discussions, and related information. Topics include a history of wildlife management research in the Pacific Northwest, elements of habitat and how to manage for them, the challenges of appropriately implementing ecosystem management, and economic implications to private forestland owners.

This publication provides information about prescribed fire effects on habitats and populations of birds of the interior West and a synthesis of existing information on bird responses to fire across North America. Our literature synthesis indicated that aerial, ground, and bark insectivores favored recently burned habitats, whereas foliage gleaners preferred unburned habitats.

We describe a protocol to monitor the effectiveness of the Tongass Land Management Plan (TLMP) management standards for maintaining fish habitat. The protocol uses juvenile coho salmon (Oncorhynchus kisutch) in small tributary streams in forested watersheds. We used a 3-year pilot study to develop detailed methods to estimate juvenile salmonid populations, measure habitat, and quantitatively determine trends in juvenile coho salmon abundance over 10 years. Coho salmon have been shown to be sensitive to habitat alterations, and we use coho salmon parr as the primary indicator in the protocol. A priori criteria for type I and type II error rates, effect size, and sample sizes for the protocol were derived with estimates of variance computed from the 3-year pilot study. The protocol is designed to detect trends in abundance of coho salmon parr, as well as coho salmon fry and Dolly Varden (Salvelinus malma), in small streams managed according to TLMP standards and guidelines and to compare these to trends in unmanaged (old-growth) watersheds. Trends are adjusted to account for statistically significant habitat covariates. This information provides an important element in monitoring land management practices in the Tongass National Forest. The methods we describe may have application to monitoring protocols elsewhere for fish populations and land management practices.

Greenhouse pot studies were conducted to quantify the competitive abilities of three native perennial grass species to inhibit development of Scotch broom (Cytisus scoparius (L.) Link ) seedlings: spike bentgrass (Agrostis exarata Trin. ), blue wildrye (Elymus glaucus Buckley), and western fescue (Festuca occidentalis Hook. ). In single-species stands (1) soil water content decreased with increasing grass density, (2) soil water depletion per plant differed among species as ratios of 2.4:1.3:1 for bentgrass, fescue, and wildrye, respectively, and (3) average percentage of ground cover per plant was ranked by species as bentgrass (14 percent), wildrye (8 percent), broom (8 percent), and fescue (5 percent). Regression models predicted 90, 85, and 72 percent reductions in average biomass per plant of broom when grown with approximately 250 plants/m2 of bentgrass, wildrye, and fescue, respectively. Bentgrass and wildrye were more competitive than fescue because of their early-season depletion of soil water and rapid development of cover.

This report documents the results from the first “5-year” round of understory responses to the Tongass-Wide Young-Growth Studies (TWYGS) treatments, especially in relation to their effects on food resources for black-tailed deer (Odocoileus hemionus sitkensis). Responses of understory vegetation to precommercial silviculture experiments after their first 4 to 8 years posttreatment were analyzed with the Forage Resource Evaluation System for Habitat (FRESH)-Deer model. The studies were conducted in western hemlock (Tsuga heterophylla)-Sitka spruce (Picea sitchensis) young-growth forests in southeast Alaska. All four TWYGS experiments were studied: (I) planting of red alder (Alnus rubra) within 1- to 5-year-old stands; (II) precommercial thinning at narrow and wide spacings (549 and 331 trees per hectare, respectively) in 15- to 25-year-old stands; (III) precommercial thinning at medium spacing (420 trees per hectare) with and without pruning in 25- to 35-yearold stands; and (IV) precommercial thinning at wide spacing (203 trees per hectare) with and without slash treatment versus thinning by girdling in >35-year-old stands. All experiments also included untreated control stands of identical age. FRESHDeer was used to evaluate the implications for deer habitat in terms of forage resources (species-specific biomass, digestible protein, and digestible dry matter) relative to deer metabolic requirements in summer (at two levels of requirements—maintenance only vs. lactation) and in winter (at six levels of snow depth).

Stem decays of living trees, known also as heart rots, are essential elements of wildlife habitat, especially for cavity-nesting birds and mammals. Stem decays are common features of old-growth forests of coastal Alaska, but are generally absent in young, managed forests. We offer several strategies for maintaining or restoring fungal stem decay in these managed forests that can be used to enhance specific types of wildlife habitat.

This report addresses the need for developing consistent regional guidelines for stand-level management that integrates goals and objectives for dry forest restoration and habitat management for the northern spotted owl.

Northwest Forest Plan—the first 20 years (1994-2013): status and trends of northern spotted owl habitats.

This is the second in a series of periodic monitoring reports on northern spotted owl (Strix occidentalis caurina) population and habitat trends on federally administered lands since implementation of the Northwest Forest Plan in 1994. Here we summarize results from a population analysis that included data from longterm demographic studies during 1985–2008. This data was analyzed separately by study area, and also in a meta-analysis across all study areas to assess temporal and spatial patterns in fecundity, apparent survival, recruitment, and annual rates of population change.

The primary objectives of the effectiveness monitoring plan for the marbled murrelet (Brachyramphus marmoratus) include mapping baseline nesting habitat (at the start of the Northwest Forest Plan [the Plan]) and estimating changes in that habitat over time. Using vegetation data derived from satellite imagery, we modeled habitat suitability by using a maximum entropy model. We used Maxent software to compute habitat suitability scores from vegetation and physiographic attributes based on comparisons of conditions at 342 sites that were occupied by marbled murrelets (equal numbers of confirmed nest sites and likely nest sites) and average conditions over all forested lands in which the murrelets occurred. We estimated 3.8 million acres of higher suitability nesting habitat over all lands in the murrelet's range in Washington, Oregon, and California at the start of the Plan (1994/96). Most (89 percent) baseline habitat on federally administered lands occurred within reserved-land allocations. A substantial amount (36 percent) of baseline habitat occurred on nonfederal lands. Over all lands, we observed a net loss of about 7 percent of higher suitability potential nesting habitat from the baseline period to 2006/07. If we focus on losses and ignore gains, we estimate a loss of about 13 percent of the higher suitability habitat present at baseline, over this same period. Fire has been the major cause of loss of nesting habitat on federal lands since the Plan was implemented; timber harvest is the primary cause of loss on nonfederal lands. We also found that murrelet population size is strongly and positively correlated with amount of nesting habitat, suggesting that conservation of remaining nesting habitat and restoration of currently unsuitable habitat is key to murrelet recovery.

Statement Highlights: Improving lifestyle habits – such as attaining and maintaining a healthy body weight and getting regular, moderate physical activity – may be useful additions to physician-guided management of atrial fibrillation (AF), a serious...

Puntos destacados de la investigación: Mientras más joven comience a fumar, es más probable que fume diariamente cuando sea adulto y es menos probable que haya dejado el hábito a los 40 años, según un estudio internacional que incluye a EE. UU. Los ...

Puntos destacados de la investigación: Las personas con mejor salud cardíaca, con hábitos de sueño saludables y que cumplen con AHA Life Simple 7, tienen menos probabilidades de tener un diagnóstico de cardiopatía y menos probabilidades de desarrollar...

Research Highlights: People who had the best heart health, defined as having healthy sleep in addition to meeting the AHA Life Simple 7, were less likely to have a diagnosis of a heart disease and were less likely to develop heart disease in the ...

As the time passes by, the dependency of humans are increasing day by day on the technology and applications to manage their daily chores. But at the same time, the need of changing habits are in high need now a days due to unnatural life and tough...

The post 9 Apps to help you develop Life-changing Habits for the Worth Living Life appeared first on SmashingApps.com.

CEDAR RAPIDS — You weren’t taken out to the ballgame or the crowd. You couldn’t get Cracker Jack, though you could get peanuts. Not to mention hot dogs and bacon cheeseburgers, a...

Isobar’s Rob Larsen suggests that there is often a need to build CSS selectors dynamically when building applications. ”This is typically some existing pattern paired with a loop counter or something pulled from a data attribute,” he writes on his blog. His choice is to create a variable called ”selector” and ”to craft the selector Read the rest...

In the world of smartwatches, the two big contenders are the Apple Watch and the Fitbit Versa. The Smartwatch Showdown infographic from The Watchstrap is very timely with recent news that Google has just acquired Fitbit.

In the world of wearable gadgets, smartwatches are all the rage at the moment. The smartwatch market is growing by the day, and new and improved devices are constantly being released. This means that picking the right smartwatch can be a real head-scratcher. To help you choose the right device for your needs, we’ve compared two of the hottest smartwatches on the market: the Apple Watch Series 4 and Fitbit Versa!

If you want to find out which of these devices came on top in the end, don’t miss the comprehensive infographic below!

First, this is a great use of infographics in content marketing! The Watchstrap is an online retailer of watch bands, and the infographic is a comparison design without being a sales pitch. It draws in traffic by providing valuable information, which build credibility for their brand.

There are a handful of things I didn’t like about the design itself that could be easily improved to make this a better infographic design:

• Too much text. I realize there isn’t much data to work with, but they need to cut down the text in the infographic. Paragraphs of explanation don’t belong in the infographic, they belong on the landing page. The infographic should be short and draw in readers to the website if they want to learn more.

• The scale is wrong in the Size & Design section of the infographic. The dimensions of the Apple Watch are larger, but the graphic illustration on the page is smaller. The illustrations should be visually correct to scale.

• Eliminate any word wrap when possible. There are a number of list points that have one hanging word wrapping to a second line. This could be avoided by shortening the text or just widening the text box. There’s room in the design without wrapping some of these words.

• The URL in the footer should link to the infographic landing page, not the home page of the company site.

• Copyright or Creative Commons license is completely missing.

• Don’t obscure the source by only listing the home page URL. What’s the link to the research data?

Andrew Rickmann posted a photo:

The Rose house with a Sophie Ryder rabbit.

We study the geometry and topology of exotic Springer fibers for orbits corresponding to one-row bipartitions from an explicit, combinatorial point of view. This includes a detailed analysis of the structure of the irreducible components and their intersections as well as the construction of an explicit affine paving. Moreover, we compute the ring structure of cohomology by constructing a CW-complex homotopy equivalent to the exotic Springer fiber. This homotopy equivalent space admits an action of the type C Weyl group inducing Kato's original exotic Springer representation on cohomology. Our results are described in terms of the diagrammatics of the one-boundary Temperley-Lieb algebra (also known as the blob algebra). This provides a first step in generalizing the geometric versions of Khovanov's arc algebra to the exotic setting.

The article is devoted to the expansion of iterated Stratonovich stochastic integrals of arbitrary multiplicity $k$ $(kinmathbb{N})$ based on the generalized iterated Fourier series. The case of Fourier-Legendre series as well as the case of trigonotemric Fourier series are considered in details. The obtained expansion provides a possibility to represent the iterated Stratonovich stochastic integral in the form of iterated series of products of standard Gaussian random variables. Convergence in the mean of degree $2n$ $(nin mathbb{N})$ of the expansion is proved. Some modifications of the mentioned expansion were derived for the case $k=2$. One of them is based of multiple trigonomentric Fourier series converging almost everywhere in the square $[t, T]^2$. The results of the article can be applied to the numerical solution of Ito stochastic differential equations.

Let $f colon X o X$ be a surjective endomorphism of a normal projective surface. When $operatorname{deg} f geq 2$, applying an (iteration of) $f$-equivariant minimal model program (EMMP), we determine the geometric structure of $X$. Using this, we extend the second author's result to singular surfaces to the extent that either $X$ has an $f$-invariant non-constant rational function, or $f$ has infinitely many Zariski-dense forward orbits; this result is also extended to Adelic topology (which is finer than Zariski topology).

Within the field of multilinear algebra, inverses and generalized inverses of tensors based on the Einstein product have been investigated over the past few years. In this paper, we explore the singular value decomposition and full-rank decomposition of arbitrary-order tensors using {it reshape} operation. Applying range and null space of tensors along with the reshape operation; we further study the Moore-Penrose inverse of tensors and their cancellation properties via the Einstein product. Then we discuss weighted Moore-Penrose inverses of arbitrary-order tensors using such product. Following a specific algebraic approach, a few characterizations and representations of these inverses are explored. In addition to this, we obtain a few necessary and sufficient conditions for the reverse-order law to hold for weighted Moore-Penrose inverses of arbitrary-order tensors.

One of the main open problems in the qualitative theory of real planar differential systems is the study of limit cycles. In this article, we present an algorithmic approach for detecting how many limit cycles can bifurcate from the periodic orbits of a given polynomial differential center when it is perturbed inside a class of polynomial differential systems via the averaging method. We propose four symbolic algorithms to implement the averaging method. The first algorithm is based on the change of polar coordinates that allows one to transform a considered differential system to the normal form of averaging. The second algorithm is used to derive the solutions of certain differential systems associated to the unperturbed term of the normal of averaging. The third algorithm exploits the partial Bell polynomials and allows one to compute the integral formula of the averaged functions at any order. The last algorithm is based on the aforementioned algorithms and determines the exact expressions of the averaged functions for the considered differential systems. The implementation of our algorithms is discussed and evaluated using several examples. The experimental results have extended the existing relevant results for certain classes of differential systems.

Bitvector filtering is an important query processing technique that can significantly reduce the cost of execution, especially for complex decision support queries with multiple joins. Despite its wide application, however, its implication to query optimization is not well understood.

In this work, we study how bitvector filters impact query optimization. We show that incorporating bitvector filters into query optimization straightforwardly can increase the plan space complexity by an exponential factor in the number of relations in the query. We analyze the plans with bitvector filters for star and snowflake queries in the plan space of right deep trees without cross products. Surprisingly, with some simplifying assumptions, we prove that, the plan of the minimal cost with bitvector filters can be found from a linear number of plans in the number of relations in the query. This greatly reduces the plan space complexity for such queries from exponential to linear.

Motivated by our analysis, we propose an algorithm that accounts for the impact of bitvector filters in query optimization. Our algorithm optimizes the join order for an arbitrary decision support query by choosing from a linear number of candidate plans in the number of relations in the query. We implement our algorithm in Microsoft SQL Server as a transformation rule. Our evaluation on both industry standard benchmarks and customer workload shows that, compared with the original Microsoft SQL Server, our technique reduces the total CPU execution time by 22%-64% for the workloads, with up to two orders of magnitude reduction in CPU execution time for individual queries.

Celebrities: They're just like us! Along with everyone else, famous people are self-isolating at home, and some of them have taken to social media to alleviate the stress of the outside world. We don't need to tell you that events everywhere are canceled, so a few big-time musicians are putting on personal concerts for their fans and followers, and a lot of them — save for that cringe-inducing, star-studded cover of "Imagine" that was going around yesterday — are actually pretty good.…

The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

The present invention provides compounds of the formula: which are useful as inhibitors of PHD and pharmaceutical compositions thereof.

Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.

The present invention provides 4,6-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.

The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.