Dozens of protesters descended on the legislature Saturday afternoon, calling for a quicker reopening of the Alberta economy.

Former captain Paul O'Connell says it will be vital for the British & Irish Lions to pick a leader capable of beating the Springboks at their own game.

Former New Zealand head coach and current England defence chief John Mitchell believes some good may come for rugby union from the coronavirus.

The DML News App offers the best in news reporting.

The post REPORT: Here’s What Comey Told Congress About Whether Flynn Lied To FBI: Transcript appeared first on Dennis Michael Lynch.

As Quebec begins to reopen schools and businesses, Prime Minister Justin Trudeau said he’s ‘worried’ about the province’s deconfinement plans, particularly in Montreal.

The following article, Rep. Ilhan Omar Asks For Contributions To Her Campaign To Help MN Food Bank…Food Bank Director Says Omar Has Nothing To Do With Project: “I have no idea where this money is going”, was first published on 100PercentFedUp.com.

Ilhan Omar is a lot of things. First, and foremost, she’s deceitful. David Steinberg of PJ Media was one of the first investigative journalists to break the story about the anti-Semitic, freshman lawmaker’s marriage to her immigrant brother while she was still married to her first husband, who she has since divorced after having an […]

Continue reading: Rep. Ilhan Omar Asks For Contributions To Her Campaign To Help MN Food Bank…Food Bank Director Says Omar Has Nothing To Do With Project: “I have no idea where this money is going” ...

7 October 2014

6 January 2017 , Volume 93, Number 1

The White House has halted talks with Congress over any further coronavirus stimulus package as it waits for more information about how U.S. state reopenings affect the economy, White House top economic adviser Larry Kudlow told reporters on Friday. The Senate and House of Representatives have already passed four major bills to address the novel coronavirus outbreak, including three aimed at stabilizing the economy as most Americans have sheltered in place and unemployment has soared.

"I think it's always important to think about suicide as individual vulnerabilities and context," Eric Caine said.

The government said it's distributing the promising coronavirus drug, remdesivir, to some hard-hit states. Eventually, all 50 states should get it.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

Drawing on experiences from Asia, Europe, North America, and the Pacific region, this report presents eight strategies that represent best practices developed by immigrant-receiving countries to increase the economic contributions of immigration.

The United States has historically offered unparalleled economic opportunity to successive generations of immigrants and their children, poised to play an increasing role in the U.S. economy. But the lasting impact of job loss and slower growth over the next decade will translate into fewer opportunities for workers—and immigrants may prove the most vulnerable.

Cavalier’s technical director, Rudolph Speid, says the recent positive ranking by CIES (International Centre for Sports Studies) Football Observatory, a research group based in Switzerland, is a reflection of the work the club is doing in trying to...

Recent calls by the Jamaica Manufacturing and Exporters Association, JMEA, for more targeted concessions on raw materials that are processed for re-export sent Jamaica Agricultural Commodities Regulatory Authority, JACRA, back to the drawing board...

Health Minister Dr Christopher Tufton and a 70-member team of healthcare workers are now in Dover, St Mary where they have been conducting house to house visits to test persons for COVID-19.  They have also been providing health...

The National Water Commission (NWC) says a loss in power supply forced the shutdown of the Dinthill facility today, leaving some northern St Catherine communities without water.  The affected communities are: Linstead,...

This edited volume from the World Health Organization (WHO), which includes chapters written by MPI researchers, examines country-level responses to the international movement of health-care workers, both before and after adoption of the WHO’s Global Code of Practice on the International Recruitment of Health Personnel.

This year’s Mother’s Day has undoubtedly been impacted by the COVID-19 virus. Plans to show appreciation to the one you call ‘mama’ have been thwarted due to worldwide quarantine conditions. But while there may not be the usual elaborate dinner at...

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

A webinar on language access contracting for federal, state, and local officials, agency administrators, and community stakeholders concerned with the oversight and implementation of language access provision.

A webinar on language access contracting for federal, state, and local officials, agency administrators, and community stakeholders concerned with the oversight and implementation of language access provision.

A broad consensus exists that the long-term impact of immigration on Americans' average income is small but positive, improving employment, productivity, and income. In the short term, however, immigration may slightly reduce native employment and average income. This report provides an analysis of short- and long-run impacts of immigration over the business cycle.

Briefing and discussion of the release of the latest paper by MPI's Labor Markets Initiative: The Impact of Immigrants in Recession and Economic Expansion.

Briefing and discussion of the release of the latest paper by MPI's Labor Markets Initiative. Speakers are report author Giovanni Peri, UC Davis Professor of Economics; Ross Eisenbrey, Vice President, Economic Policy Institute; and Demetrios G. Papademetriou, MPI President.

In a report by MPI's Labor Markets Initiative, noted economist and Georgetown University Public Policy Institute Professor Harry J. Holzer examines the economic reasoning and research on these questions and looks at the policy options that shape the impact of less-skilled immigration on the economy. The discussion is on what policy reform would best serve native-born American workers, consumers, and employers, as well as the overall U.S. economy.

This volume, which brings together research by leading economists and labor market specialists, examines the role immigrants play in the U.S. workforce, how they fare in good and bad economic times, and the effects they have on native-born workers and the labor sectors in which they are engaged. The book traces the powerful economic forces at play in today’s globalized world and includes policy prescriptions for making the American immigration system more responsive to labor market needs.

At this release event in Washington, DC, co-sponsored by MPI, the Chicago Council on Global Affairs, and ImmigrationWorks USA, the Chicago Council's independent task force on immigration released its report, U.S. Economic Competitiveness at Risk: A Midwest Call to Action on Immigration Reform.

“Badass” new method uses a magnetised protein to activate brain cells rapidly, reversibly, and non-invasively

Researchers in the United States have developed a new method for controlling the brain circuits associated with complex animal behaviours, using genetic engineering to create a magnetised protein that activates specific groups of nerve cells from a distance.

Understanding how the brain generates behaviour is one of the ultimate goals of neuroscience – and one of its most difficult questions. In recent years, researchers have developed a number of methods that enable them to remotely control specified groups of neurons and to probe the workings of neuronal circuits.

Related: Remote control of brain activity with heated nanoparticles

Related: Researchers read and write brain activity with light

State-of-the-art electron microscopy reveals the large-scale organization of the proteins that regulate neurotransmitter release

This spectacular image – which took the best part of a year to create – shows the fine structure of a nerve terminal at high resolution, revealing, for the very first time, an intricate network of fine filaments that controls the movements of synaptic vesicles.

The brain is soft and wet, with the consistency of a lump of jelly. Yet, it is the most complex and highly organized structure that we know of, containing hundreds of billions of neurons and glial cells, and something on the order of one quadrillion synaptic connections, all of which are arranged in a very specific manner.

Related: 3D model of a nerve terminal in atomic detail | Mo Costandi

Related: Blowing up the brain to reveal its finer details

New findings challenge our understanding of how the brain matures

Faces are important to us. From the moment we are are born, we prefer to look at faces than at other, inanimate objects, and, being social animals, we encounter faces every day of our lives. The face is the first thing we look to when identifying other people; faces also convey emotions, informing us of peoples’ mood, and from them we can usually determine a person’s sex and, sometimes, roughly how old they are. Eye movements can also reveal to us something about another person’s intentions.

Related: How your eyes betray your thoughts

Related: Live imaging of synapse density in the human brain

Why did right-winger Yosemite Sam have problem with the leftist Bugs Bunny?

https://diazhub.com/news/boris-johnson-will-tell-public-to-stay-alert-control-the-virus-and-save-lives/

Part of a series exploring recommendations likely to be addressed by the new National Integration Plan, this webinar, with perspectives from MPI, the WE Global Network, and Lutheran Immigrant and Refugee Services, examines the role of economic development initiatives and refugee resettlement programs/infrastructure in immigrant integration. 

This webinar, with perspectives from MPI, the WE Global Network, and Lutheran Immigrant and Refugee Service, examines the role of economic development initiatives and refugee resettlement programs/infrastructure in immigrant integration.

Testimony of Andrew Selee, President of MPI, before the Senate Judiciary Committee's Subcommittee on Border Security and Immigration on December 12, 2018 regarding the intersections of transnational crime, immigration, and border security.

(May 5, 2020) On April 11, 2020, Panama published a law allowing its legislative assembly to conduct virtual sessions in cases of a national emergency or other situations that prevent the assembly from meeting in regular fashion. The original bill of this law explained that, in the context of the COVID-19 pandemic, it became necessary […]

(May 5, 2020) On March 28, 2020, Colombian President Iván Duque Márquez issued Legislative Decree 491/2020, which permits governmental bodies, including the legislature, to conduct business virtually during the COVID-19 pandemic. Article 12 of the decree allows for remote sessions in which members can deliberate by any means (por cualquier medio) and make decisions by […]

(May 7, 2020) On April 30, 2020, Singapore’s minister for health made an amendment to the COVID‑19 (Temporary Measures) (Control Order) Regulations 2020 to extend the expiration date of the COVID-19 control orders under the regulations to June 1, 2020. The Control Order Regulations, which had been originally issued on April 7, 2020, under the authorization […]

The first time Robyn Hedden tried to cross the Nova Scotia-New Brunswick border, she was turned away. The next day, she was waved through without much hassle.