y Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Glucosamine is a widely used supplement typically taken for osteoarthritis and joint pain. Emerging evidence suggests potential links of glucosamine with glucose metabolism, inflammation, and cardiometabolic risk. We prospectively analyzed the association of habitual glucosamine use with risk of type 2 diabetes (T2D) and assessed whether genetic susceptibility and inflammation status might modify the association. RESEARCH DESIGN AND METHODS This study analyzed 404,508 participants from the UK Biobank who were free of diabetes, cancer, or cardiovascular disease at baseline and completed the questionnaire on supplement use. Cox proportional hazards models were used to evaluate the association between habitual use of glucosamine and risk of incident T2D. RESULTS During a median of 8.1 years of follow-up, 7,228 incident cases of T2D were documented. Glucosamine use was associated with a significantly lower risk of T2D (hazard ratio 0.83, 95% CI 0.78–0.89) after adjustment for age, sex, BMI, race, center, Townsend deprivation index, lifestyle factors, history of disease, and other supplement use. This inverse association was more pronounced in participants with a higher blood level of baseline C-reactive protein than in those with a lower level of this inflammation marker (P-interaction = 0.02). A genetic risk score for T2D did not modify this association (P-interaction = 0.99). CONCLUSIONS Our findings indicate that glucosamine use is associated with a lower risk of incident T2D. Full Article
y Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Reparixin is an inhibitor of CXCR1/2 chemokine receptor shown to be an effective anti-inflammatory adjuvant in a pilot clinical trial in allotransplant recipients. RESEARCH DESIGN AND METHODS A phase 3, multicenter, randomized, double-blind, parallel-assignment study (NCT01817959) was conducted in recipients of islet allotransplants randomized (2:1) to reparixin or placebo in addition to immunosuppression. Primary outcome was the area under the curve (AUC) for C-peptide during the mixed-meal tolerance test at day 75 ± 5 after the first and day 365 ± 14 after the last transplant. Secondary end points included insulin independence and standard measures of glycemic control. RESULTS The intention-to-treat analysis did not show a significant difference in C-peptide AUC at both day 75 (27 on reparixin vs. 18 on placebo, P = 0.99) and day 365 (24 on reparixin vs. 15 on placebo, P = 0.71). There was no statistically significant difference between treatment groups at any time point for any secondary variable. Analysis of patient subsets showed a trend for a higher percentage of subjects retaining insulin independence for 1 year after a single islet infusion in patients receiving reparixin as compared with patients receiving placebo (26.7% vs. 0%, P = 0.09) when antithymocyte globulin was used as induction immunosuppression. CONCLUSIONS In this first double-blind randomized trial, islet transplantation data obtained with reparixin do not support a role of CXCR1/2 inhibition in preventing islet inflammation-mediated damage. Full Article
y The Dysfunction of Functions in Abstract Algebra By blogs.ams.org Published On :: Thu, 21 Nov 2019 12:00:56 +0000 Kathleen Melhuish & Kristen Lew Texas State University “[Functions] are completely different, which is what makes this course so challenging.” – Abstract Algebra Student Functions are hard for students, even students in abstract algebra courses. Even if students have seen … Continue reading → Full Article testing
y Help! I need to teach my course online and I’ve never done this before By blogs.ams.org Published On :: Mon, 16 Mar 2020 16:05:52 +0000 By: Yvonne Lai, University of Nebraska-Lincoln Ray Levy, Mathematical Association of America This is cross-posted in MathValues and Abbe Herzig has written a companion post. Additional resources and future meetings are also available here: https://tinyurl.com/OnlineTalkshop. In times of crisis we … Continue reading → Full Article Faculty Experiences Online Education
y Soccer: Germany's Bundesliga approved to return in mid-May By www.upi.com Published On :: Wed, 06 May 2020 12:13:09 -0400 The Bundesliga -- Germany's top soccer league -- will be allowed to resume in May after German Chancellor Angela Merkel lifted some lockdown restrictions in the country on Wednesday amid the coronavirus pandemic. Full Article
y Dallas Cowboys sign former first-round pick Cameron Erving By www.upi.com Published On :: Wed, 06 May 2020 19:14:49 -0400 The Dallas Cowboys agreed to terms with free-agent offensive lineman Cameron Erving, the team announced Wednesday. Full Article
y Cleveland Cavaliers planning to reopen training facility Friday By www.upi.com Published On :: Wed, 06 May 2020 21:52:33 -0400 The Cleveland Cavaliers are planning to reopen their training facility for limited individual workouts amid the coronavirus pandemic. Full Article
y NFL lays out protocols for reopening of team facilities By www.upi.com Published On :: Wed, 06 May 2020 23:33:40 -0400 The NFL outlined protocols Wednesday for the gradual reopening of team facilities amid the coronavirus pandemic. Full Article
y Ex-MLB players in spotlight as world turns to Asia for baseball By www.upi.com Published On :: Thu, 07 May 2020 03:00:08 -0400 Playing in Taiwan once was a last option Justin Nicolino had to continue a professional baseball career. Now the former Miami Marlins pitcher is one of many ex-MLB players who provide entertainment for U.S. sports fans. Full Article
y New Cowboys QB Andy Dalton believes he's 'a starter' By www.upi.com Published On :: Thu, 07 May 2020 07:24:11 -0400 Dalton signed with the Cowboys on Monday after he was released May 30. Dak Prescott has started every game for the Cowboys since 2016. Full Article
y Kentucky Wildcats land star Wake Forest transfer Olivier Sarr By www.upi.com Published On :: Thu, 07 May 2020 09:07:19 -0400 The University of Kentucky has landed a commitment from former Wake Forest big man Olivier Sarr, one of the top transfers ahead of the 2020 season. Full Article
y Soccer: Bundesliga return includes Dortmund on May 16, Bayern Munich, May 17 By www.upi.com Published On :: Thu, 07 May 2020 11:22:58 -0400 The German Bundesliga released its full soccer schedule Thursday after German officials announced that the league is allowed to resume games after they were suspended due to the coronavirus pandemic. Full Article
y Michigan coach Jim Harbaugh proposes major changes to NFL Draft eligibility rules By www.upi.com Published On :: Thu, 07 May 2020 19:41:19 -0400 Michigan coach Jim Harbaugh is urging the NFL and NCAA to amend their rules and provide flexibility to college football players who consider making the jump to the next level. Full Article
y Former Denver Broncos QB Joe Flacco underwent neck surgery By www.upi.com Published On :: Thu, 07 May 2020 22:48:53 -0400 Former Denver Broncos quarterback Joe Flacco, who remains a free agent, could miss the start of the 2020 season after he underwent neck surgery. Full Article
y Peyton Manning trash talks Tom Brady before May 24 golf match By www.upi.com Published On :: Fri, 08 May 2020 07:59:36 -0400 Former star quarterback Peyton Manning delivered some trash talk to Tampa Bay Buccaneers star Tom Brady while they promoted their May 24 charity golf match. Full Article
y Bryce Harper calls MLB 'dumb' to keep stars out of Olympics By www.upi.com Published On :: Fri, 08 May 2020 08:21:27 -0400 Philadelphia Phillies star Bryce Harper thinks Major League Baseball is "dumb" for its policy that makes the Olympics off-limits for baseball's best players. Full Article
y Giannis Antetokounmpo sorry for hacked tweets about Kobe Bryant, LeBron James By www.upi.com Published On :: Fri, 08 May 2020 09:08:44 -0400 Milwaukee Bucks star Giannis Antetokounmpo has apologized after he said someone hacked his Twitter account to send inappropriate tweets about several athletes, including LeBron James, Stephen Curry and Kobe Bryant. Full Article
y Japan offers weekend's only top-level event as horse racing struggles to resume By www.upi.com Published On :: Fri, 08 May 2020 11:10:39 -0400 Coronavirus brings worldwide horse racing almost to a halt, with only one Grade 1 event on the weekend schedule, but rays of hope exist. Full Article
y New Orleans Saints release Pro Bowl OL Larry Warford By www.upi.com Published On :: Fri, 08 May 2020 18:46:39 -0400 The New Orleans Saints released Pro Bowl offensive lineman Larry Warford after three seasons, the team announced Friday. Full Article
y Diabetes in the Emergency Department: Acute Care of Diabetes Patients By clinical.diabetesjournals.org Published On :: 2011-04-01 Candace D. McNaughtonApr 1, 2011; 29:51-59Feature Articles Full Article
y Case Study: Seizures and Hypoglycemia By clinical.diabetesjournals.org Published On :: 2012-01-01 Michael R. BrennanJan 1, 2012; 30:23-24Case Studies Full Article
y Case Study: Type 1 and Type 2, Too? By clinical.diabetesjournals.org Published On :: 2003-07-01 Heidi L. GassnerJul 1, 2003; 21:Case Studies Full Article
y How Foods Affect Blood Glucose: Glycemic Impact By clinical.diabetesjournals.org Published On :: 2011-10-01 Oct 1, 2011; 29:161-161Patient Information Full Article
y Elevated Liver Function Tests in Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2005-07-01 Elizabeth H. HarrisJul 1, 2005; 23:115-119Feature Articles Full Article
y Case Study: A 43-Year-Old Man With Perineal Pain and Swelling By clinical.diabetesjournals.org Published On :: 2001-10-01 David J. MeierOct 1, 2001; 19:Case Studies Full Article
y Glucose, Advanced Glycation End Products, and Diabetes Complications: What Is New and What Works By clinical.diabetesjournals.org Published On :: 2003-10-01 Melpomeni PeppaOct 1, 2003; 21:Council's Voice Full Article
y Case Study: Renal Disease in Type 1 Diabetes By clinical.diabetesjournals.org Published On :: 2001-04-01 William H. HermanApr 1, 2001; 19:Case Studies Full Article
y What Did the Doctor Say? By clinical.diabetesjournals.org Published On :: 2010-09-01 Sep 1, 2010; 28:176-176Patient Information Full Article
y Insulin Therapy: A Personal Approach By clinical.diabetesjournals.org Published On :: 2015-07-01 Mayer B. DavidsonJul 1, 2015; 33:123-135Feature Articles Full Article
y Injecting Insulin: Taking shots safely, correctly, and with little or no pain By clinical.diabetesjournals.org Published On :: 2013-01-01 Jan 1, 2013; 31:46-46Patient Information Full Article
y The Weighty Issue of Low-Carb Diets, or Is the Carbohydrate the Enemy? By clinical.diabetesjournals.org Published On :: 2004-10-01 Jennifer B. MarksOct 1, 2004; 22:155-156Editorials Full Article
y Type 2 Diabetes in Children and Young Adults: A "New Epidemic" By clinical.diabetesjournals.org Published On :: 2002-10-01 Francine Ratner KaufmanOct 1, 2002; 20:President's Pen Full Article
y Medical Nutrition Therapy: A Key to Diabetes Management and Prevention By clinical.diabetesjournals.org Published On :: 2010-12-01 Sara F. MorrisDec 1, 2010; 28:12-18Feature Articles Full Article
y Treatment of Onychomycosis in Diabetic Patients By clinical.diabetesjournals.org Published On :: 2006-10-01 Jason A. WinstonOct 1, 2006; 24:160-166Feature Articles Full Article
y A 52-Year-Old Woman With Hypertension and Diabetes Who Presents With Chest Pain By clinical.diabetesjournals.org Published On :: 2007-07-01 George D. HarrisJul 1, 2007; 25:115-118Case Studies Full Article
y Hypoglycemia in Type 1 and Type 2 Diabetes: Physiology, Pathophysiology, and Management By clinical.diabetesjournals.org Published On :: 2006-07-01 Vanessa J. BriscoeJul 1, 2006; 24:115-121Feature Articles Full Article
y Diabetes Management Issues for Patients With Chronic Kidney Disease By clinical.diabetesjournals.org Published On :: 2007-07-01 Kerri L. CavanaughJul 1, 2007; 25:90-97Feature Articles Full Article
y The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally By clinical.diabetesjournals.org Published On :: 2019-07-01 Renza ScibiliaJul 1, 2019; 37:302-303Book Reviews Full Article
y Management of Diabetic Peripheral Neuropathy By clinical.diabetesjournals.org Published On :: 2005-01-01 Andrew J.M. BoultonJan 1, 2005; 23:9-15Feature Articles Full Article
y Case Study: Postsexual Penile Ulcer as a Symptom of Diabetes By clinical.diabetesjournals.org Published On :: 2005-10-01 Nehman LauderOct 1, 2005; 23:191-192Case Studies Full Article
y A Review of the Pathophysiology, Classification, and Treatment of Foot Ulcers in Diabetic Patients By clinical.diabetesjournals.org Published On :: 2009-03-01 Warren ClaytonMar 1, 2009; 27:52-58Features Full Article
y Case Study: New-Onset Diabetes: How to Tell the Difference Between Type 1 and Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2012-01-01 Joseph LargayJan 1, 2012; 30:25-26Case Studies Full Article
y Hypoglycemia? Low Blood Glucose? Low Blood Sugar? By clinical.diabetesjournals.org Published On :: 2012-01-01 Jan 1, 2012; 30:38-38Patient Information Full Article
y Standards of Medical Care in Diabetes--2018 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2018-01-01 American Diabetes AssociationJan 1, 2018; 36:14-37Position Statements Full Article
y Case Study: Treating Hypertension in Patients With Diabetes By clinical.diabetesjournals.org Published On :: 2004-07-01 Evan M. BenjaminJul 1, 2004; 22:137-138Case Studies Full Article
y Diabetes and Erectile Dysfunction By clinical.diabetesjournals.org Published On :: 2001-01-01 Neelima V. ChuJan 1, 2001; 19:Practical Pointers Full Article
y Inpatient Management of Hyperglycemia and Diabetes By clinical.diabetesjournals.org Published On :: 2011-01-01 Vasudev MagajiJan 1, 2011; 29:3-9Feature Articles Full Article
y Case Study: Diabetic Ketoacidosis in Type 2 Diabetes: "Look Under the Sheets" By clinical.diabetesjournals.org Published On :: 2004-10-01 Brian J. WelchOct 1, 2004; 22:198-200Case Studies Full Article
y Diabetes and Your Joints By clinical.diabetesjournals.org Published On :: 2001-07-01 Jul 1, 2001; 19:Patient Information Full Article
y Obesity in America: It's Getting Worse By clinical.diabetesjournals.org Published On :: 2004-01-01 Jennifer B. MarksJan 1, 2004; 22:Editorials Full Article
