y Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC. Full Article
y DHS herding people on to an imperfect system in myGov By www.smh.com.au Published On :: Mon, 10 Aug 2015 14:17:52 GMT Over the past few weeks I have been answering calls for the myGov helpdesk. Full Article
y Australian Federal Police walk away from $145 million Israeli crime-fighting software deal By www.smh.com.au Published On :: Wed, 19 Aug 2015 06:25:36 GMT Police walk away from deal with contractor, conceding numerous issues have put project beyond rescue. Full Article
y iiNet CEO David Buckingham leaves company By www.smh.com.au Published On :: Sun, 30 Aug 2015 23:59:15 GMT CEO of Perth-based internet service provider iiNet, David Buckingham, has left the company, according to multiple sources. Full Article
y Public servants warned off internet sex and cheating sites after Ashley Madison hack By www.smh.com.au Published On :: Thu, 03 Sep 2015 13:30:00 GMT Marriage vows are one thing, but the public service Code of Conduct, that's serious. Full Article
y Why we need to stop car crash 'women in tech' panels and actually break the glass ceiling By www.smh.com.au Published On :: Mon, 21 Sep 2015 13:04:36 GMT Women in tech panels seldom have anything to offer besides fortune-cookie wisdom and repackaged logic. Full Article
y Australians are avoiding cash-only businesses: survey By www.smh.com.au Published On :: Thu, 24 Sep 2015 03:39:45 GMT As internet banking and tap-and-go cards become ubiquitous, Australians are beginning to reject businesses that operate on a cash only basis. Full Article
y Sydney start-up Suppertime acquired by food delivery giant By www.smh.com.au Published On :: Mon, 12 Oct 2015 06:29:04 GMT Australian premium restaurant delivery service Suppertime has been snapped by a major international company, as the local food delivery market continues to heat up. Full Article
y St George, Bank of Melbourne and BankSA outage to be fixed on Monday night, St George says By www.smh.com.au Published On :: Mon, 05 Oct 2015 19:22:02 GMT St George, Bank of Melbourne and BankSA customers begin to regain access to their accounts after a system outage. Full Article
y StartupWeek Sydney readies for launch By www.smh.com.au Published On :: Mon, 19 Oct 2015 01:39:13 GMT StartupWeek Sydney 2015 starts on Friday, and 5000 people are expected to attend more than 50 events to celebrate and strengthen the city's thriving start-up community. Full Article
y Cyber security expert issues dire warning over vulnerability of key infrastructure By www.smh.com.au Published On :: Thu, 22 Oct 2015 13:00:00 GMT Data theft and cybercrime is a major source of funding for Islamic State which is likely to have secretly planted insiders "around the world" in positions where critical data could be extracted and exploited, a leading cyber security expert has warned. Full Article
y Centrelink blocks 60,000 calls a day, blames smartphone apps By www.smh.com.au Published On :: Fri, 23 Oct 2015 07:05:35 GMT Centrelink blocked 22m phone calls last year, with smartphone apps blamed for inflating the figures. Full Article
y Cyber thieves target tax time By www.smh.com.au Published On :: Tue, 27 Oct 2015 07:15:12 GMT Tens of thousands of taxpayers forced to wait for refunds amid suspicion of identity theft. Full Article
y Public service to ban paper in boxes: New digital policy to make sweeping reforms across APS By www.smh.com.au Published On :: Sat, 31 Oct 2015 10:34:24 GMT One powerful agency head warns against "tyranny of small person" as sweeping reforms released for public service. Full Article
y Australian public service's 'gap in capability' to deal with digital revolution By www.smh.com.au Published On :: Thu, 29 Oct 2015 00:19:02 GMT State of the Service report outlines the major hurdle to digital reform. Full Article
y Five hundred tax file numbers hacked every day By www.smh.com.au Published On :: Tue, 10 Nov 2015 02:07:05 GMT Identity thieves can now get into employers' payroll systems, but ATO says it's systems are safe. Full Article
y Australian companies targeted by identity thieves for tax frauds By www.smh.com.au Published On :: Tue, 10 Nov 2015 02:08:52 GMT Australian companies are having their identities hijacked by international criminals who use them to try to defraud the Australian Taxation Office. Full Article
y Open government data to public use, and Australia may start to catch up with the world By www.smh.com.au Published On :: Mon, 02 Nov 2015 13:15:00 GMT Public servants need to ditch the control and encourage entrepreneurship. Full Article
y Identity fraudsters attack Tax Office at least 11,000 times in one year By www.smh.com.au Published On :: Tue, 03 Nov 2015 13:55:23 GMT The ATO has been targeted more than 11,000 times by identity fraudsters attempting to steal tax refunds in 2014-15. Full Article
y Australia vulnerable to a cyber-attack disaster By www.smh.com.au Published On :: Fri, 13 Nov 2015 06:06:57 GMT Australian government agencies and organisations are increasingly vulnerable to a major cyber attack yet security has not evolved in more than 20 years, according to an international cybercrime expert. Full Article
y Taxpayer records exposed by serious ATO, myGov security flaw By www.smh.com.au Published On :: Wed, 18 Nov 2015 23:42:04 GMT Taxpayer says he was hung up on twice by call centre staff when trying to report the issue. Full Article
y New website allows youth to report cyber bullying at ACT libraries By www.smh.com.au Published On :: Mon, 07 Dec 2015 02:36:03 GMT A new pilot website will also make it easier for material to be taken off the internet. Full Article
y Anonymous group hacks Islamic State, tells them to chill out: reports By www.smh.com.au Published On :: Fri, 27 Nov 2015 00:42:23 GMT Terrorists' propaganda appears to be shifting to the Dark Web so that it will be harder to shut down. Full Article
y Bureau of Meteorology computers breached, ABC reports By www.smh.com.au Published On :: Wed, 02 Dec 2015 07:51:04 GMT Australia's Bureau of Meteorology has reportedly had its computer systems breached. Full Article
y Delayed Australian data breach notification bill lands By www.smh.com.au Published On :: Fri, 04 Dec 2015 04:27:12 GMT Australians will be informed of certain breaches of their personal information under new laws being proposed by the Turnbull government, but only if the company or organisation breached turns over $3 million in revenue a year. Full Article
y Pro sport and big data: coaches may be more in favour than athletes By www.smh.com.au Published On :: Mon, 14 Dec 2015 13:00:00 GMT Professional sport is still working out how to tackle big data and understand how technology can assist elite athletes, according to top-level sports sports officials in the United States. Full Article
y Centrelink's IT meltdown hits the disability pension By www.smh.com.au Published On :: Mon, 21 Dec 2015 21:45:06 GMT Centrelink's tech woes disrupts Disability Pension medical crackdown. Full Article
y ACT Health bogged down by outdated faxes By www.smh.com.au Published On :: Tue, 05 Jan 2016 11:20:04 GMT Archaic technology wasting time for Canberrans is in the target of new federal agency. Full Article
y Centrelink wrongly hits 70,000 families with bills for up to $726 By www.smh.com.au Published On :: Thu, 07 Jan 2016 07:49:06 GMT Computer glitch blamed as welfare agency hits tens of thousands with bills for money that is not owed. Full Article
y Telstra privacy breach leaves customer's voicemail exposed By www.smh.com.au Published On :: Fri, 22 Jan 2016 05:56:14 GMT Richard Thornton did a factory reset on his second-hand iPhone 5, but the buyer kept receiving his voicemail. Full Article
y Troubled myGov website to be taken from Human Services and given to Digital Transformation Office for streamlining By www.smh.com.au Published On :: Thu, 28 Jan 2016 12:30:00 GMT Malcolm Turnbull's DTO has been critical of myGov, now it has the chance to show it can do better. Full Article
y Remembering the failed Aussie start-ups of yesteryear By www.smh.com.au Published On :: Thu, 18 Feb 2016 00:13:08 GMT Failed start-ups are a dime a dozen. But you wouldn't know it from the Australian market which, unlike that of our American cousins, prefers to hide its failures and slink quietly into that good night instead of exploring the lessons gleaned from failure. Full Article
y Why Hollywood animation powerhouses are resisting the cloud By www.smh.com.au Published On :: Thu, 03 Mar 2016 20:14:05 GMT Despite new performance bottlenecks, the digital animation and visual effects industry is very reluctant to move their productions to the cloud, according to Sydney's Animal Logic. Full Article
y MyGov to feel the audit blowtorch By www.smh.com.au Published On :: Thu, 03 Mar 2016 06:23:08 GMT Human Service to face National Audit Office scrutiny. Again. Full Article
y Apple v FBI: what the fight is about and why you should care By www.smh.com.au Published On :: Fri, 04 Mar 2016 15:27:05 GMT Apple is in the middle of a legal fight with the FBI over creating a 'back door' to unlock a terrorist's iPhone. Full Article
y Recruitment drive for cyber security specialists will bring challenges for government By www.smh.com.au Published On :: Mon, 02 May 2016 19:51:02 GMT Fear government's cyber security recruitment drive will lead to job cuts. Full Article
y Malcolm Turnbull promises $50 million reboot for troubled myGov By www.smh.com.au Published On :: Tue, 21 Jun 2016 22:06:13 GMT Takeover of troubled portal by Digital Transformation Office confirmed Full Article
y Government agencies name cybercrime as their top fraud risk: PwC By www.smh.com.au Published On :: Tue, 26 Jul 2016 14:15:00 GMT The 'typical' corrupt bureaucrat is a male, university-educated middle manager, aged 41 to 50. Full Article
y Call for a cyber security reserve corps to help fight major attacks By www.smh.com.au Published On :: Mon, 15 Aug 2016 14:15:00 GMT Experienced volunteers would help fight major online threats to governments, private industry and civil institutions. Full Article
y Centrelink apologises for new privacy breach By www.smh.com.au Published On :: Sat, 05 Nov 2016 06:37:10 GMT Rookie email error shares hundred of email addresses – twice. Full Article
y ATO fumes after cyber criminals attack myGov portal during last days of Tax Time 2016 By www.smh.com.au Published On :: Thu, 03 Nov 2016 13:15:00 GMT Tensions emerge between Tax Office and Human Services after hackers take down myGov Full Article
y Digital Transformation Agency boss Paul Shetler resigns By www.smh.com.au Published On :: Sun, 02 Jul 2017 22:05:05 GMT Agile government takes a stumble as digital pioneer logs off after just six weeks. Full Article
y Can the government really protect your privacy when it 'de-identifies' public data? By www.smh.com.au Published On :: Mon, 05 Dec 2016 12:45:00 GMT We don't really know to how to use big data and protect personal information at the same time. Full Article
y Brisbane City Council IT contract faces potential $60 million blow-out By www.smh.com.au Published On :: Wed, 25 Jan 2017 05:49:06 GMT A $122 million Brisbane City Council IT contract will be renegotiated after a systems replacement program was delayed by 18 months, with a potential cost blow-out of up to $60 million. Full Article
y Auditor-general exposes weaknesses in ACT government's IT systems By www.smh.com.au Published On :: Mon, 08 May 2017 02:35:19 GMT Electronic sexual health records and the births, deaths and marriages registry have been left exposed. Full Article
y How federal government departments are protecting Australians' data against cyber hack By www.smh.com.au Published On :: Mon, 15 May 2017 10:09:02 GMT Cyber Security Minister Dan Tehan says the government can't rule out vulnerabilities to cyber threats. Full Article
y Australia's Cyber Security Strategy: weaknesses, yes, but we're improving By www.smh.com.au Published On :: Fri, 02 Jun 2017 05:53:07 GMT The online world changes so fast it was always going to be tough to design a four-year strategy. Full Article
y Latest ATO online system failure hits at peak tax time By www.smh.com.au Published On :: Wed, 05 Jul 2017 10:54:02 GMT Outages have hit the Tax Office's IT system on Wednesday. Full Article
y Brisbane City Council terminates $122 million IT contract By www.smh.com.au Published On :: Fri, 28 Jul 2017 12:14:03 GMT Brisbane CIty Council has terminated a $122 million IT contract that had been plagued with cost blow outs and lengthy delays. Full Article
y Quirk's integrity questioned over failure to release "secret" IT report By www.smh.com.au Published On :: Tue, 08 Aug 2017 07:26:04 GMT Opposition councillors have called Brisbane's Lord Mayor Graham Quirk secretive and accused him of putting his integrity at stake over the failure to release an external review into the now terminated $122 million IT contact with Technology One. Full Article
