b Talk Evidence - Talking about harms By feeds.bmj.com Published On :: Fri, 13 Dec 2019 18:18:10 +0000 In this special edition of talk evidence, Helen Macdonald and Carl Henneghan talk about creating an evidence base from harms. We hear from a member of the pubic who experienced harm from a drug, and now advises the FDA. A former regulator who explains why reporting harms is so important. And finally, an investigative journalist who explains what... Full Article
b Talk Evidence - digital clubbing, osteoarthritis & sustainable EBM By feeds.bmj.com Published On :: Mon, 16 Dec 2019 19:36:54 +0000 We’re back for the December Talk Evidence, and this month we’re being very digital Firstly,(1.20) Helen tells us about arthritic fingers - should we be using prednisolone for treatment when people have painful osteoarthritis of the hand Then (13.30) Carl gets us all to check our fingers for clubbing, and we find out how useful it is as a test... Full Article
b Michael West - GMC Report On Wellbeing By feeds.bmj.com Published On :: Fri, 10 Jan 2020 15:02:33 +0000 Michael West is professor of organisational psychology, at Lancaster University, and co-author of a new GMC report into the wellbeing of NHS staff. The review he led together with the clinical psychiatrist Denise Coia, focused on primary interventions related to workplace factors and the systems that doctors work in, rather than secondary... Full Article
b Is it possible to have fair pricing for medicines By feeds.bmj.com Published On :: Fri, 17 Jan 2020 17:50:54 +0000 Is it possible to have a fair price for medicines? Yes, according to a new collection just published on bmj.com. The authors set out to evaluate how we could improve the functioning of the market for medicines, to honestly compensate industry for innovation, whilst allowing the poorest to afford them. Suerie Moon, co-director of global health at... Full Article
b Talk Evidence - Sepsis, talc and blindsided by blinding By feeds.bmj.com Published On :: Wed, 22 Jan 2020 17:40:40 +0000 Welcome to the festive talk evidence, giving you a little EBM to take you into the new year. As always Duncan Jarvies is joined by Helen Macdonald (resting GP and editor at The BMJ) and Carl Heneghan (active GP, director of Oxford University’s CEBM and editor of BMJ Evidence)* This month: (1.20) Carl tells us about new research on treating... Full Article
b Prevalence and treatment of precocious puberty By feeds.bmj.com Published On :: Tue, 28 Jan 2020 17:19:40 +0000 Precocious puberty, that is puberty that starts before age 8 in girls and 9 in boys seems to be on the rise, but whether that’s because of an increase in incidence, or greater attention is unknown - what we do know that precocious puberty in girls is commonly idiopathic, while in boys is a red flag for pathology. But either way ther first point of... Full Article
b Big Tan - Is the sunbed industry targeting research? By feeds.bmj.com Published On :: Mon, 10 Feb 2020 17:42:30 +0000 In 2012, Eleni Linos, professor of dermatology at Stanford university, published a systematic review and meta-analysis of the link between non-melanoma cancer and sun-beds. That bit of pretty standard research, and a particular rapid response to it, has kicked of years of work - and in this podcast I talk to Eleni and her colleagues Stanton... Full Article
b Talk Evidence - Building an evidence base for covid-19 By feeds.bmj.com Published On :: Mon, 17 Feb 2020 15:22:17 +0000 We're taking a break from the usual Talk Evidence to focus on the new corona virus that has emerged in China. With a brand new disease, we have to build our evidence base from scratch - basic virology, epidemiology, pathogenicity, transmissibility, and ultimately treatment are all unknowns. In this episode of Talk Evidence, we're trying to get... Full Article
b Born equal - the launch of The BMJ special issue on race in medicine By feeds.bmj.com Published On :: Fri, 21 Feb 2020 18:18:08 +0000 Last week the BMJ published it’s first special edition into Racism in Medicine. The issues tacked ranged from differential attainment in medical school, to the physiological effects that experiencing everyday discrimination has. The issue was guest edited by Victor Adebowale, the Chief Executive of the social care enterprise Turning Point, and... Full Article
b Why we are failing patients with multimorbidity By feeds.bmj.com Published On :: Thu, 05 Mar 2020 14:54:02 +0000 We know that the number of people living with multiple health conditions is rising year on year, and yet training, guidelines, organisations and physical spaces in healthcare still largely focus on single diseases or organ systems. The means that patients in the NHS are often treated as if their conditions exist in isolation, and that their care... Full Article
b Cycling - Does the health benefit outweigh the accident risk (in the UK) By feeds.bmj.com Published On :: Thu, 12 Mar 2020 16:22:11 +0000 We all know we should be doing more exercise, and one way to do that is by active commuting - journeying to work on foot or by bike. One thing preventing people from taking up cycling is the fear of being involved in road traffic accidents, and that the risk isn't worth the benefit of the extra exercise. It’s even more confusing when air... Full Article
b Wellbeing - Some advice on working in PPE By feeds.bmj.com Published On :: Wed, 08 Apr 2020 17:38:56 +0000 Wellbeing might not seem the obvious place to talk about PPE - but lack of appropriate PPE is causing healthcare staff a great deal of stress now. Mary Brindle is a pediatric surgeon and the director of The EQuIS (Efficiency Quality Innovation and Safety) Research platform at Alberta Children’s hospital. In this podcast she reflects on the use... Full Article
b The public health response to covid - 19 By feeds.bmj.com Published On :: Sun, 12 Apr 2020 19:40:26 +0000 As part of our response to the covid-19 pandemic, we’re going to be running a series of discussions with experts about some of the big issues arising from the virus. In this one, we’re asking about the public health response to an outbreak - what’s necessary, and is it possible to go to far. Joining us are Martin Mckee - professor of european... Full Article
b Wellbeing - some advice for telehealth in secondary care By feeds.bmj.com Published On :: Thu, 16 Apr 2020 18:30:00 +0000 We’ve published info on Telehealth in primary care - and have been overwhelmed by the response from GPs who are finding it useful. But it’s not only primary care that is dramatically shifting to remote care - routine hospital care is moving online too, so we’ve asked Rowena McCash - GP and out of hours triage trainer joins us to give some tips... Full Article
b Wellbeing – advice from a military medic to frontline clinicians By feeds.bmj.com Published On :: Wed, 22 Apr 2020 11:53:26 +0000 There is no doubt that anxiety levels that clinicians are feeling during this pandemic are high. One military medic believes the current situation is comparable to his experience when posted during British campaigns in Afghanistan and Iraq. Cormac Doyle offers advice on how to deal with high-stress conditions, both in a work and at home, as... Full Article
b Public Health Vs The Economy By feeds.bmj.com Published On :: Tue, 28 Apr 2020 17:49:55 +0000 Around the world, as the covid pandemic plays out, and some countries are starting to ease their restrictions, this narrative of the economy and public health being opposing weights on a set of scales keeps returning - they need to be balanced. But before this, a healthy population is very much seen as being supportive of the economy. So is a... Full Article
b Wellbeing – how one junior doctor found a way to support frontline staff By feeds.bmj.com Published On :: Wed, 29 Apr 2020 17:17:18 +0000 How can we help frontline clinicians? Sometimes medics may feel uneasy or even guilty and that they could be doing more. That was what a junior doctor in Abergavenny in Wales felt and she did something about it. In this podcast, we speak to Josie Cheetham about how she started her initiative to provide support boxes in hospitals for her... Full Article
b Talk Evidence covid-19 update - lack of testing transparency, how to give good debate By feeds.bmj.com Published On :: Mon, 04 May 2020 16:25:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give you... Full Article
b Coping with Covid with Monica Schoch-Spana and Jud Brewer By feeds.bmj.com Published On :: Wed, 06 May 2020 23:27:26 +0000 In this week’s episode, we discuss bystander guilt, convergence, brain hacks and “how you can sneeze on someone’s brain from anywhere in the world”. How can GPs cope with the myriad worries around treating patients during the current pandemic, both on the frontline and in general practice? How do we recognise and break unhelpful anxious behaviour... Full Article
b Wellbeing – coping with Covid fatigue By feeds.bmj.com Published On :: Fri, 08 May 2020 10:00:46 +0000 We are more than six weeks into the lockdown and if you were to gauge the mood of the nation, it would be one of fatigue. It started as an all-hands-on-deck emergency situation, but it now transpires that the current work situation for healthcare professionals is not going to change any time soon. This is a marathon rather than a sprint. So how... Full Article
b Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy By diabetes.diabetesjournals.org Published On :: 2006-01-01 Katalin SusztakJan 1, 2006; 55:225-233Complications Full Article
b C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study By diabetes.diabetesjournals.org Published On :: 2002-05-01 Dilys J. FreemanMay 1, 2002; 51:1596-1600Complications Full Article
b The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects By diabetes.diabetesjournals.org Published On :: 2002-10-01 Joseph G. YuOct 1, 2002; 51:2968-2974Obesity Studies Full Article
b Diabetes and Cardiovascular Disease: The "Common Soil" Hypothesis By diabetes.diabetesjournals.org Published On :: 1995-04-01 Michael P SternApr 1, 1995; 44:369-374Perspectives in Diabetes Full Article
b Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study By diabetes.diabetesjournals.org Published On :: 1974-02-01 Mariano J GarciaFeb 1, 1974; 23:105-111Original Contribution Full Article
b Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles By diabetes.diabetesjournals.org Published On :: 1997-11-01 Shane ReaNov 1, 1997; 46:1667-1677Perspectives in Diabetes Full Article
b High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity By diabetes.diabetesjournals.org Published On :: 2009-07-01 Masayuki SaitoJul 1, 2009; 58:1526-1531Metabolism Full Article
b Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-01-01 Cindy J.M. LoomansJan 1, 2004; 53:195-199Complications Full Article
b Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes By diabetes.diabetesjournals.org Published On :: 1996-12-01 Alan R SaltielDec 1, 1996; 45:1661-1669Perspectives in Diabetes Full Article
b Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells By diabetes.diabetesjournals.org Published On :: 1997-11-01 Markus TiedgeNov 1, 1997; 46:1733-1742Original Article Full Article
b Are the {beta}-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM? By diabetes.diabetesjournals.org Published On :: 1996-03-01 Marc PrentkiMar 1, 1996; 45:273-283Original Article Full Article
b Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of {beta}-Cell Death By diabetes.diabetesjournals.org Published On :: 2001-01-01 Christophe BonnyJan 1, 2001; 50:77-82Islet Studies Full Article
b Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study By diabetes.diabetesjournals.org Published On :: 2003-03-01 Joachim SprangerMar 1, 2003; 52:812-817Pathophysiology Full Article
b A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm By diabetes.diabetesjournals.org Published On :: 1996-02-01 Franz M MatschinskyFeb 1, 1996; 45:223-241Banting Lecture 1995 Full Article
b Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents By diabetes.diabetesjournals.org Published On :: 1999-08-01 G PerseghinAug 1, 1999; 48:1600-1606Articles Full Article
b NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older By diabetes.diabetesjournals.org Published On :: 2003-05-01 Charles M. AlexanderMay 1, 2003; 52:1210-1214Complications Full Article
b Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
b Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome By diabetes.diabetesjournals.org Published On :: 2001-08-01 Giulio MarchesiniAug 1, 2001; 50:1844-1850Pathophysiology Full Article
b Tumor Necrosis Factor {alpha}: A Key Component of the Obesity-Diabetes Link By diabetes.diabetesjournals.org Published On :: 1994-11-01 Gökhan S HotamisligilNov 1, 1994; 43:1271-1278Perspectives in Diabetes Full Article
b Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships By diabetes.diabetesjournals.org Published On :: 2000-12-01 D DabeleaDec 1, 2000; 49:2208-2211Articles Full Article
b Insulin Action, Diabetogenes, and the Cause of Type II Diabetes By diabetes.diabetesjournals.org Published On :: 1994-08-01 C. Ronald KahnAug 1, 1994; 43:1066-1085Banting Lecture Full Article
b From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2009-04-01 Ralph A. DeFronzoApr 1, 2009; 58:773-795Banting Lecture Full Article
b Protein kinase C activation and the development of diabetic complications By diabetes.diabetesjournals.org Published On :: 1998-06-01 D KoyaJun 1, 1998; 47:859-866Articles Full Article
b Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications By diabetes.diabetesjournals.org Published On :: 1995-08-01 Roger H UngerAug 1, 1995; 44:863-870Perspectives in Diabetes Full Article
b Diet-Induced Type II Diabetes in C57BL/6J Mice By diabetes.diabetesjournals.org Published On :: 1988-09-01 Richard S SurwitSep 1, 1988; 37:1163-1167Original Article Full Article
b Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and I{kappa}B-{alpha} By diabetes.diabetesjournals.org Published On :: 2002-07-01 Samar I. ItaniJul 1, 2002; 51:2005-2011Rapid Publications Full Article
b Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats By diabetes.diabetesjournals.org Published On :: 1999-12-01 G XuDec 1, 1999; 48:2270-2276Articles Full Article
b Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2002-01-01 J. Denis McGarryJan 1, 2002; 51:7-18Banting Lecture 2001 Full Article
b Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study By diabetes.diabetesjournals.org Published On :: 2002-04-01 Andreas FestaApr 1, 2002; 51:1131-1137Complications Full Article
b Hypoglycemia in the Diabetes Control and Complications Trial By diabetes.diabetesjournals.org Published On :: 1997-02-01 The Diabetes Control and Complications Trial Research GroupFeb 1, 1997; 46:271-286Original Article Full Article