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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation




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Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




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Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance




or

Spies Are Fighting a Shadow War Against the Coronavirus

Calder Walton describes four ways how intelligence services are certain to contribute to defeating COVID-19 and why pandemic intelligence will become a central part of future U.S. national security.




or

No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




or

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




or

This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




or

Romney's Reckless China Rhetoric Risks New Cold War

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.




or

The United States Forgot Its Strategy for Winning Cold Wars

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.




or

Maxwell Taylor's Cold War: From Berlin to Vietnam

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.




or

Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




or

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance




or

Spies Are Fighting a Shadow War Against the Coronavirus

Calder Walton describes four ways how intelligence services are certain to contribute to defeating COVID-19 and why pandemic intelligence will become a central part of future U.S. national security.




or

No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




or

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




or

This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




or

Romney's Reckless China Rhetoric Risks New Cold War

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.




or

The United States Forgot Its Strategy for Winning Cold Wars

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.




or

Maxwell Taylor's Cold War: From Berlin to Vietnam

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.




or

Washington Should Take Action on AI or Stay Out of the Way

Federal and local regulations are part of the solution to tough issues related to Artificial Intelligence, writes K. Gretchen Greene, but no regulatory approach on its own can fully answer these questions today. "Finding answers will require significant investments in research and development, collaboration, negotiation, and experimentation, deep and careful thought across many fields and leadership at all levels, across and between governments. The U.S. federal government is well positioned to lead, but if it won't, it should at least stay out of the way."




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In Memoriam: Patricia McLaughlin

Patricia (Pat) McLaughlin, our beloved colleague and friend at the Center since 2001, passed away in February after a brief illness. Hired as Faculty Assistant to John Holdren, Co-Director of the Center’s Science, Technology, and Public Policy Program (STPP) nearly 20 years ago, she continued to work with STPP and with John until her illness.




or

Bruce Schneier on Cybersecurity in the Age of Coronavirus

Is Zoom secure? What about your home computer? Cyber expert Bruce Schneier says that we all need to be aware of the things cyber criminals thrive on during the confusion caused by coronavirus.




or

Washington Should Take Action on AI or Stay Out of the Way

Federal and local regulations are part of the solution to tough issues related to Artificial Intelligence, writes K. Gretchen Greene, but no regulatory approach on its own can fully answer these questions today. "Finding answers will require significant investments in research and development, collaboration, negotiation, and experimentation, deep and careful thought across many fields and leadership at all levels, across and between governments. The U.S. federal government is well positioned to lead, but if it won't, it should at least stay out of the way."




or

In Memoriam: Patricia McLaughlin

Patricia (Pat) McLaughlin, our beloved colleague and friend at the Center since 2001, passed away in February after a brief illness. Hired as Faculty Assistant to John Holdren, Co-Director of the Center’s Science, Technology, and Public Policy Program (STPP) nearly 20 years ago, she continued to work with STPP and with John until her illness.




or

Bruce Schneier on Cybersecurity in the Age of Coronavirus

Is Zoom secure? What about your home computer? Cyber expert Bruce Schneier says that we all need to be aware of the things cyber criminals thrive on during the confusion caused by coronavirus.




or

Innovations in dialysis membranes for improved kidney replacement therapy




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SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2




or

The ethics of genetic testing for kidney diseases




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Targeting inflammation in AKI by P2Y14 receptor inhibition in mice




or

How to Topple Dictators and Transform Society

Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements.




or

What Makes for a Moral Foreign Policy?

Joseph Nye's new book rates the efforts of presidents from FDR to Trump.




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Lebanon has formed a controversial new government in a polarised, charged atmosphere, and protesters are not going to be easily pacified by its promises, explains Rami Khoury.

The fourth consecutive month of Lebanon's unprecedented political and economic crisis kicked off this week with three dramatic developments that will interplay in the coming months to define the country's direction for years to come: Escalating protests on the streets, heightened security measures by an increasingly militarising state, and now, a new cabinet of controversial so-called "independent technocrats" led by Prime Minister-designate Hassan Diab.

Seeking to increase pressure on the political elite to act responsibly amid inaction vis-a-vis the slow collapse of the economy, the protesters had launched the fourth month of their protest movement, which had begun on 17 October last year, with a 'Week of Anger', stepping up their tactics and targeting banks and government institutions.




or

Grow Up About Dictators, America!

The U.S. Democratic primary has exposed an obsession with morality when it comes to foreign policy that is harmful to strategic and moral objectives alike, Stephen M. Walt writes.




or

How Do Past Presidents Rank in Foreign Policy?

How do presidents incorporate morality into decisions involving the national interest? Moral considerations explain why Truman, who authorized the use of nuclear weapons in Japan during World War II, later refused General MacArthur's request to use them in China during the Korean War. What is contextual intelligence, and how does it explain why Bush 41 is ranked first in foreign policy, but Bush 43 is found wanting? Is it possible for a president to lie in the service of the public interest? In this episode, Professor Joseph S. Nye considers these questions as he explores the role of morality in presidential decision-making from FDR to Trump.




or

Enabling anti-tumor immunity by unleashing ILC2




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Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer




or

A β-galactosidase kiss of death for senescent cells




or

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases




or

Molecular architecture of the luminal ring of the <i>Xenopus laevis</i> nuclear pore complex




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Structure of the cytoplasmic ring of the <i>Xenopus laevis</i> nuclear pore complex by cryo-electron microscopy single particle analysis




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Insight 219: Singapore in the Global Energy Transition

For decades, Singapore has been a premier refinery hub and gatekeeper between Asia and the Middle East, but its position is increasingly threatened as producer countries are shifting into the downstream activities that helped make Singapore the “Houston of Asia”. Oil and petrochemicals drive about one quarter of Singapore’s net exports. Greater competition in the global oil and gas value chain could take a heavy toll on the city-state’s national budget and economic growth prospects.




or

Why the U.S. Withdrawal from the Paris Climate Accord is a Mistake

The authors explain why the Trump administration's reiteration of its intent to finalize U.S. withdrawal from the Paris Agreement is a tragic mistake that will weaken us as a nation.




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Study Group on Energy Innovation and the Transition to a Low-Carbon Economy: Advising Fortune 500 Companies

This study group will explore the role of the private sector in evolving energy systems, and how corporations might change in a climate constrained world. 




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Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World

To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures.

What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past.




or

Urban Waste to Energy Recovery Assessment Simulations for Developing Countries

In this paper, a quantitative Waste to Energy Recovery Assessment (WERA) framework is used to stochastically analyze the feasibility of waste-to-energy systems in selected cities in Asia.




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Harvard Business School Professor Rebecca Henderson Outlines Ways Organizations are Changing in Response to the Coronavirus Pandemic and Climate Change in New Edition of "Environmental Insights"

Rebecca Henderson, the John and Natty McArthur University Professor at Harvard University, shared her perspectives on how large organizations are changing in response to the coronavirus pandemic and climate change in the newest episode of "Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program," a podcast produced by the Harvard Environmental Economics Program. Listen to the interview here. Listen to the interview here.




or

Organizational Responses to COVID-19 and Climate Change: A Conversation with Rebecca Henderson

Rebecca Henderson, the John and Natty McArthur University Professor at Harvard University, shared her perspectives on how large organizations are changing in response to the coronavirus pandemic and climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




or

No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




or

Low Prices, Full Storage Tanks: What's Next for the Oil Industry

When the economy slows, so does the demand for oil. Prices have plummeted and storage tanks are filled to capacity. We look at the future of the oil industry.




or

Modeling and comparing central and room air conditioning ownership and cold-season in-home thermal comfort using the American Housing Survey