or

Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




or

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




or

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




or

Short-term NAD<sup>+</sup> supplementation prevents hearing loss in mouse models of Cockayne syndrome




or

Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




or

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians




or

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging




or

High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




or

Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




or

Oral health in allogeneic hematopoietic stem cells transplantation survivors




or

Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




or

Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




or

Safety and efficacy of chimeric antigen receptor T-cell therapy in relapsed/refractory multiple myeloma with renal impairment




or

NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




or

Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




or

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




or

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




or

LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




or

MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer

Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers.




or

Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




or

Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




or

RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.




or

Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




or

VEGF receptor (VEGFR)

Zebrafish studies suggest VEGFR inhibitors could help treat tuberculosis.




or

Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




or

Sortilin 1 (SORT1)

Mouse studies suggest inhibiting SORT1 in macrophages and T cells could help treat atherosclerosis.




or

Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




or

Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




or

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




or

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




or

Transcription factors in ferroptotic cell death




or

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




or

In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




or

Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




or

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




or

High-purity orbital angular momentum states from a visible metasurface laser




or

Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




or

Strain creates a trion factory




or

Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




or

Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




or

Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




or

An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




or

Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




or

Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




or

Head-to-head trials in inflammatory bowel disease: past, present and future




or

Microbiota and colorectal cancer: colibactin makes its mark




or

Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




or

Universal screening for hepatitis C virus infection should be linked to universal treatment access




or

Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




or

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys