The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components.

The invention is a decanter centrifuge for separating a first substance and a second substance with different densities, comprising a bowl rotating in use around a horizontal axis of rotation in a direction of rotation, said axis of rotation extending in a longitudinal direction of said bowl, a radial direction extending perpendicular to the longitudinal direction, a base plate provided at one longitudinal end of said bowl, said base plate having an internal side and an external side, an outlet opening provided in said base plate for discharge of one of said substances. A slide valve body is adapted for covering an adjustable part of the outlet opening to delimit an effective area of the outlet opening.

An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture.

Methods and apparatuses for activating colorant in selected regions of an article in which the colorant is incorporated are described. The colorant activation can create various desired visual aspects.

Methods to produce pH-sensitive microparticles that have an active agent dispersed in a polymer matrix have certain advantages over microcapsules with an active agent encapsulated in an interior compartment/core inside of a polymer wall. The current invention relates to pH-sensitive microparticles that have a corrosion-detecting or corrosion-inhibiting active agent or active agents dispersed within a polymer matrix of the microparticles. The pH-sensitive microparticles can be used in various coating compositions on metal objects for corrosion detecting and/or inhibiting.

A method of color laser marking an article having a polymeric foil with at least one colorless layer containing an infrared absorber, a polymeric binder and a color forming compound; including the steps of:—laser marking the colorless layer with an infrared laser using a first laser operation mode to generate a blue or cyan color; and—laser marking the same colorless layer with an infrared laser using a second laser operation mode to generate a black color, wherein the first laser operation mode applies less energy to the colorless layer than the second laser operation mode. Also disclosed is an article, such as a security document, including a polymeric foil and a colorless layer containing laser marked graphical data having a blue or cyan color and laser marked information having a black color.

A method for preparing a color laser marked article comprising the steps of: a) infrared laser marking a security element including a polymeric support and a color forming layer comprising a color forming compound, an infrared dye and a polymeric binder comprising vinyl acetate and at least 85 wt % of vinyl chloride based on the total weight of the binder; and b) exposing the laser marked security element with light having a wavelength higher than 440 nm. The light exposure of step b) hinders the falsification of an issued security document without significant increase of background density.

The invention is directed to methods for determining clonotypes and clonotype profiles in assays for analyzing immune repertoires by high throughput nucleic acid sequencing of somatically recombined immune molecules. In one aspect, the invention comprises generating a clonotype profile from an individual by generating sequence reads from a sample of recombined immune molecules; forming from the sequence reads a sequence tree representing candidate clonotypes each having a frequency; coalescing with a highest frequency candidate clonotype any lesser frequency candidate clonotypes whenever such lesser frequency is below a predetermined value and whenever a sequence difference therebetween is below a predetermined value to form a clonotype. After such coalescence, the candidate clonotypes is removed from the sequence tree and the process is repeated. This approach permits rapid and efficient differentiation of candidate clonotypes with genuine sequence differences from those with experimental or measurement errors, such as sequencing errors.

A method for computer-aided closed and/or open-loop control of a technical system is provided. A first value of an output quantity is predicted on a data-based model at a current point in time. A second value of the output quantity is determined from an analytical model. The state of the technical system at the current point is assigned a confidence score in the correctness of prediction of the data-based model. A third value of the output quantity is determined from the first and second value as a function of the confidence score for controlling the technical system. A suitable value for the output quantity can be derived from the analytical model even for regions of the technical system in which the quality of prediction of the data-based model is low because of a small set of training data. The technical systems can be turbines, such as gas turbines.

A method of providing data included in a building information modeling (BIM) data file using a server is provided. The method includes retrieving mapping data corresponding to a user request, extracting data corresponding to at least one entity mapped to the mapping data from the BIM data file, and transmitting the extracted data to a client.

A method of applying particles to a backing having a make layer on one of the backing's opposed major surfaces. The method including the steps of: supporting the particles on a feeding member having a feeding surface such that the particles settle into one or more layers on the feeding surface; the feeding surface and the backing being arranged in a non-parallel manner; and translating the particles from the feeding surface to the backing and attaching the particles to the make layer by an electrostatic force.

Devices, systems, and methods for treating a heart of a patient may make use of structures which limit a size of a chamber of the heart, such as by deploying a tensile member to bring a wall of the heart toward (optionally into contact with) a septum of the heart. The implant may include an electrode or other structure for applying pacing signals to one or both ventricles of the heart, for defibrillating the heart, for sensing beating of the heart or the like. A wireless telemetry and control system may allowing the implant to treat congestive heart failure, monitor the results of the treatment, and apply appropriate electrical stimulation.

An implantable medical device lead having a flow measurement sensor mounted thereon is provided with a capsule mounted proximate to the sensor. The capsule is used to house electrical circuitry corresponding to the sensor in order to prevent impedance on conductors of the lead, which gradually decreases over chronic periods, from directly affecting signal transmission between the sensor and the electrical circuitry. The electrical circuitry includes a charge amplifier used for processing signals from the sensor. In some cases, the amplifier can be initially calibrated and periodically tuned so as to have consistent functioning with the sensor over chronic periods.

The present invention provides a closed-loop system for treating neurological disorders, such as epilepsy. In one embodiment the system comprises an input assembly that is adapted to receive one or more signals from a patient that are indicative of a patient's neurological state. The input assembly processes the one or more signals to generate one or more control input signals. An output assembly receives the one or more control input signals from the input assembly and generate a neuromodulation signal that is a function of the patient's neurological state. An electrode array is configured to deliver the neuromodulation signal to a patient's peripheral nerve, such as the vagus nerve.

The burr hole plug comprises a plug base configured for being mounted around a burr hole, and having an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the plug base aperture. The retainer includes a retainer support, a slot formed in the retainer support for receiving the medical device, and a clamping mechanism having a clamping bar and a flange slidably engaged with the retainer support to laterally slide the clamping bar to secure the medical device. A method comprises introducing the medical device through the burr hole, mounting the plug base around the burr hole, mounting the retainer within the plug base aperture, receiving the medical device into the slot, and sliding the slidable flange relative to the retainer support to laterally slide to secure the medical device.

An apparatus of muscle and/or joint exercise adapted to reeducation and/or physical conditioning of a body part of a user, including a hollow body; a mobile member translatable inside the body; a motor-driven means arranged on the bottom of the body and adapted for driving and decelerating in displacement the mobile member in both translatory directions; a cooperating means between the body and a frame, this cooperating means being arranged on the bottom of the body and including: at least one hinge of the body on the frame, the hinge providing at least at least one degree of rotational freedom for the body around an axis of rotation; and a removable means for installing and removing the body, the removable means being designed for removably installing the body on a base slidingly mounted in the frame.

A foot rest including: a foot receptacle, the foot receptacle including a first portion and a second portion, and wherein the first portion intersects the second portion; a cross-member disposed on a first side of the first portion; and a bucket connector disposed on the first side of the first portion of the foot receptacle, wherein the cross-member is proximate an end of the first portion and the bucket connector is distal to the end of the first portion.

A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, and a first port and a second port for conveying liquid.

A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, and a first port and a second port for conveying liquid.

An injection molding machine includes an ejector unit configured to eject a molding product from a mold and a mold release force sensor configured to detect a force to release the molding product from the mold.

An injection molding machine includes an ejector unit configured to eject a molding product from a mold. The ejector unit includes a support provided on a platen to which the mold is attached, a slidable base configured to slide relative to the support, a transmission mechanism supported by the support and configured to convert an input into an output corresponding to the distance between the support and the slidable base and transmit the output to the slidable base, a drive source configured to cause the transmission mechanism to operate, an ejection member configured to move together with the slidable base, and an adjustment mechanism configured to adjust the position of the slidable base relative to the ejection member.

Provided is a technology with which, when producing a resin molded article, the inside of which is provided with an insert component such as a terminal fitting, it is possible to prevent the insert component from being exposed at an inappropriate position, and to ensure the desired positional accuracy. In an injection molding device, the accuracy of the position of a terminal is improved by allowing a core-back mold to move after a terminal, which is an insert component, has been inserted in a terminal tip holding section of a slide mold. By allowing the core-back mold to move by only a prescribed amount prior to injection molding, a resin wall is formed between the core-back mold and the terminal. The inappropriate exposure and shorting of and the adhesion of foreign substances to, and the like, the terminal can thus be prevented.

In a method for producing a cleaning blade, a first composition obtained by causing a reaction of diphenylmethane diisocyanate and a first aliphatic polyester polyol which has a number-average molecular weight of 2000 to 3500 and is used in an amount of 20 to 40 mol % relative to the diphenylmethane diisocyanate and a second composition containing a urethane rubber-synthesizing catalyst and a second aliphatic polyester polyol which has a number-average molecular weight of 2000 to 3500 and is the same as or different from the first aliphatic polyester polyol are mixed so that a relationship between a number of moles (MNCO [mol]) of an NCO group in the first composition and a number of moles (MOH [mol]) of an OH group in the second composition satisfies 0.05≦MOH/MNCO≦0.20.

Disclosed is a positive photosensitive resin composition that includes (A) an alkali soluble resin prepared by a phosphorous-containing diamine represented by the following Chemical Formula 1, (B) a photosensitive diazoquinone compound, and (C) a solvent. A photosensitive resin film prepared using the same and a semiconductor device including the photosensitive resin film are also disclosed. In Chemical Formula 1, each substituent is the same as defined in the detailed description.

For use with a percussion instrument, the combination comprises a clamp base to support the percussion instrument, a clamp jaw, adjustable connector structure connecting the jaw to the base for displacing the jaw toward and away from the base, and clamping structure carried on at least one of the jaw and the base to be clamped against a support member in response to relative clamping displacement of the jaw and base, whereby adjustment of the structure accommodates to clamping of different size support members by clamping structure.

A method for tracking a user's movements between network addresses can include, subsequent to a request for a (current) network address from a user, receiving the network address and an identifier for a region associated with the network address. The method can also include locating a record that contains the identifier for the region and a time that immediately precedes the request for the network address from the user. The record may further contain a prior network address. The method can further include generating an entry for a table that includes the identifier for the region, the current network address, and the prior network address. A server computer or a client computer can generate the entry. Improved accountability and improved user profile accuracy can be obtained with the method. A data processing system readable medium can comprise code that includes instructions for carrying out the method.

A vehicle powertrain has an engine, a driving shaft having a passage defined therein, a driven shaft, a pump, a hydraulic fluid reservoir, and a CVT. A driving pulley of the CVT includes a fixed sheave and a movable sheave disposed on the driving shaft for rotation therewith, a spring biasing a movable sheave away from the fixed sheave, and a CVT chamber fluidly communicating with the passage of the driving shaft. The pump supplies hydraulic fluid from the reservoir to the passage in the driving shaft. The hydraulic fluid flows from the passage to the CVT chamber to create a hydraulic pressure in the CVT chamber. The hydraulic pressure in the CVT chamber biases the movable sheave toward the fixed sheave.

A bicycle transmission control apparatus comprises a control unit that provides a first signal to operate a first derailleur a gear shift distance from a first origin sprocket to a first destination sprocket. The control unit receives a condition signal that indicates a condition resulting from at least one of the first derailleur and a second derailleur; and an adjustment controller moves the first derailleur an adjustment distance less than the gear shift distance in response to the condition signal.

A chain cleaner capable of cleaning dirt and debris from the roller chain of a chain driven vehicle is provided. The chain cleaner is a polymer sheet. The sheet has a leading and a trailing edge, upper and lower surfaces, and a bilateral axis defining a chain line. The chain line extends from the leading to the trailing edge. A clear slot is positioned in the sheet adjacent to the trailing edge. The slot has a predetermined height and width which is at least equal to a respective height and width of the chain to be cleaned. The chain is thereby capable of biased directional travel against the lower and upper surfaces and through the slot, along the chain line when operating the chain drive of the vehicle. The chain cleaner includes an assembly for attaching the sheet to the vehicle adjacent to the leading edge.

An energy harvesting system comprises a first region having a first temperature and a second region. A conduit is located at least partially within the first region. A heat engine configured for converting thermal energy to mechanical energy includes a shape memory alloy forming at least one generally continuous loop. The shape memory alloy is disposed in heat exchange contact with the first region and the second region. The shape memory alloy is driven to rotate around at least a portion of the conduit by the response of the shape memory alloy to the temperature difference between the first region and the second region. At least one pulley is driven by the rotation of the shape memory alloy, and the at least one pulley is operatively connected to a component to thereby drive the component.

A bicycle derailleur adjusting apparatus for adjusting a bicycle derailleur includes a controller. The bicycle derailleur includes a base member adapted to be mounted to a bicycle, a movable member, a linkage coupled between the base member and the movable member, and an actuator configured to move the movable member of the bicycle derailleur among a plurality of derailleur positions. The controller is configured to control the actuator based on a travel value indicative of a travel distance of the movable member between adjacent derailleur positions to update the derailleur positions of the movable member.

A bicycle gear shift control system capable of avoiding frequent gear shifting includes: a power module; a microcomputer electrically connected to the power module for allowing a cyclist to switch between the automatic gear shifting mode and a manual gear shifting mode; a gear shifting driver electrically connected to the microcomputer, substantially connected to a derailleur, and instructed by the microcomputer to drive the derailleur to perform gear shift control; and a manual shifting controller electrically connected to the microcomputer. The microcomputer has an automatic gear shifting logic whereby the microcomputer determines the timing of automatic gear shifting and performs gear shifting. The microcomputer further has a gear shifting delay logic that involves delaying for a delay time interval from commencement of gear shifting according to a gear shifting criterion and ruling out all other gear shifting commands during the delay time interval.

A continuously variable transmission for a vehicle comprises a primary pulley, a secondary pulley, and a belt entrained around both pulleys in an opposite manner between the fixed and movable sheaves thereof. One pulley carries a selectively deployable stop that may be placed into position to mechanically limit the range of motion between the fixed and movable sheaves. This establishes an actual maximum transmission ratio that is larger than the nominal minimum transmission ratio but smaller than the nominal maximum transmission ratio achievable by the transmission during normal operation thereof. When such a transmission is used on a utility vehicle attached to a substance dispensing applicator operatively driven by the vehicle's engine, the application rate stays substantially constant despite changes in engine speed when the user keeps the transmission upshifted to the actual maximum transmission ratio set by the position of the deployed stop.

A rear bicycle sprocket for use with a multi-gear rear cassette is provided. The sprocket includes a chain engaging portion and a mounting portion having generally annular shape about a central axis and a plurality of support arms, integrally formed with the chain engaging portion and with the mounting portion. The sprocket further includes a plurality of space maintaining protrusions, each space maintaining protrusion extending axially forwardly from an axially forward surface of a corresponding support arm and integrally formed therewith. A multi-gear rear cassette having a plurality of sprockets coaxially mounted together wherein the plurality of sprockets includes the rear bicycle sprocket mounted axially rearmost and a bicycle including the multi-gear rear cassette are further provided.

A belt-type continuously variable transmission for a vehicle includes: a primary pulley including a first fixed sheave fixed to an input shaft, and a first movable sheave relatively non-rotatable and relatively movable in axial direction to the input shaft due to spline-fitting of a female spline formed on an inner circumferential portion thereof to a male spline formed on the input shaft; a secondary pulley including a second fixed sheave fixed to an output shaft in parallel with the input shaft, and a second movable sheave relatively non-rotatable and relatively movable in the axial direction to the output shaft due to spline-fitting of a female spline formed on an inner circumferential portion thereof to a male spline formed on the output shaft; and a transmission belt, the belt-type continuously variable transmission for a vehicle disposed with at least one of a first groove width defining portion disposed on the primary pulley for defining a maximum groove width of the first pulley groove and a second groove width defining portion disposed on the secondary pulley for defining a maximum groove width of the second pulley groove, the first groove width defining portion and the second groove width defining portion being disposed on one shaft of the input shaft and the output shaft, and the other shaft having a uniform shaft diameter in an range of sliding of the first movable sheave or the second movable sheave in the axial direction except a site with the male spline formed, the other shaft being disposed on the opposite side to the one shaft.

A vehicle has a motor-gear unit, a trailing wheel of the vehicle being connected the output shaft of the gear and an input shaft of the gear being connected to a motor. The gear has an outer wheel, an inner wheel and a traction means extending between the outer wheel and the inner wheel. A revolving transmitter is also provided which lifts the traction means off the outer periphery of the inner wheel and pushes it against the inner periphery of the outer wheel.

A clip-type mechanism for tensioning slack in a chain. A spring-biased piston is positioned in a bore in a housing. A ratchet rack is positioned on the piston, along with a clip member. A recess in the housing bore has an annular member with a hardened surface to reduce wear.

A chain cleaning and lubricating device for use with chain driven vehicles, such as motorcycles. The chain cleaning and lubricating device includes a lubrication reservoir for storing chain lubricant, a lubrication applicator, and a control lever that is attachable to the handlebars of a motorcycle. A control cable operatively connects the control lever to a control valve that is operatively situated within the lubrication reservoir. The chain cleaning and lubricating device is affixed to a sprocket housing mounted to the frame of the motorcycle. The lubrication applicator includes a plurality of bristles that extend downward from the bottom surface of the lubrication reservoir to continuously engage the rotating chain of the motorcycle to remove debris from the chain. The control lever is selectively operated to regulate the flow of chain lubricant from the lubrication reservoir to the chain of the motorcycle.

A method for electronically controlling a bicycle gearshift comprising at least one derailleur is disclosed, comprising the sequential steps of: a) imparting a movement on the derailleur of the gearshift until the derailleur is in an intended position;b) waiting for a predetermined time period,c) performing a check whether the derailleur is in the intended position, within a possible predetermined tolerance,d) in case said check has a negative outcome, imparting a movement on the derailleur of the gearshift until the derailleur is in the intended position. A derailleur and an electronically servo-assisted bicycle gearshift comprising control electronics comprising modules adapted to carry out the method outlined above are also disclosed.

A derailleur device, particularly a rear derailleur, includes at least one locking device for locking a chain guide at least in one locking position that is different from the starting position in relation to a movable element, and it is provided therein that the locking device includes a locking element displaceable between a passive position, in which the chain guide is released in relation to the movable element, and at least one active position, in which the chain guide is held in the at least one locking position.

A mixer system includes a mixing chamber with a drive panel, open top, discharge opening in a side of the mixing chamber, and door configured to open and close the discharge opening. A first mixing auger is disposed inside the mixing chamber, and a first auger drive is disposed on another side of the drive panel and connected to the first auger through the drive panel and connected to a driveline. A second mixing auger is disposed inside the mixing chamber on the first side of the drive panel, and another auger drive is connected to the second auger through the drive panel. A clutch is connected between the second auger drive and the driveline and configured to mechanically connect and disconnect the second auger drive from the driveline based on an input. A method of sequentially starting different augers within a mixing chamber is provided.

A clay mixing apparatus includes a mixing chamber, a rotor arranged within the mixing chamber, a drive unit arranged to rotate the rotor, an ejecting unit, a pressure reducing unit; and an exhaust flow path. The rotor includes a shaft rotated by the drive unit, an extruding member and a mixing member. The mixing member includes a plurality of arms and a plurality of blades arranged at tip ends of the arms. The exhaust opening is opposed, in a radial direction about the center axis, to a portion of the mixing member lying near the extruding member and/or a portion of the extruding member lying near the mixing member.

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group,RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—,W represents a single bond or a C1-3 alkylene group, andRing B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group,Y represents a nitrogen atom or the formula N+(RF),RF represents a C1-4 alkyl group, andm and n, which may be the same or different, each represent an integer of 0 or 1.

A process for preparing the compound of the following formula (E): wherein Bn represents a benzyl group, and tBu represents a tert-butyl group, the process including: (a) subjecting the following compound (B) to trifluoroacetylation, wherein tBu represents a tert-butyl group to produce the following compound (C): wherein tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; (b) reacting the compound (C) with benzyloxyamine in the presence of a hydroxyl group activating agent to produce the following compound (D): wherein Bn represents a benzyl group, tBu represents a tert-butyl group, and TFA represents a trifluoroacetyl group; and (c) subjecting the compound (D) to detrifluoroacetylation.

This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions.

The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.