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Urologists' Group Issues Updated Guidelines on PSA Test

Title: Urologists' Group Issues Updated Guidelines on PSA Test
Category: Health News
Created: 5/3/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM




nes

Joblessness an Unwanted Side Effect of Chemo for Breast Cancer

Title: Joblessness an Unwanted Side Effect of Chemo for Breast Cancer
Category: Health News
Created: 4/28/2014 9:35:00 AM
Last Editorial Review: 4/28/2014 12:00:00 AM




nes

Single Motherhood Doesn't Seem to Hinder Happiness

Title: Single Motherhood Doesn't Seem to Hinder Happiness
Category: Health News
Created: 4/26/2014 10:35:00 AM
Last Editorial Review: 4/28/2014 12:00:00 AM




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Kids' Happiness Doesn't Depend on 2 Natural Parents, Says Study

Title: Kids' Happiness Doesn't Depend on 2 Natural Parents, Says Study
Category: Health News
Created: 4/25/2014 2:35:00 PM
Last Editorial Review: 4/28/2014 12:00:00 AM




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Poor Fitness in Middle Age Tied to Early Death Risk in Study

Title: Poor Fitness in Middle Age Tied to Early Death Risk in Study
Category: Health News
Created: 4/30/2014 9:35:00 AM
Last Editorial Review: 4/30/2014 12:00:00 AM




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With Kids In Car, Parents Still Likely to Use Cellphones

Title: With Kids In Car, Parents Still Likely to Use Cellphones
Category: Health News
Created: 5/2/2014 12:36:00 PM
Last Editorial Review: 5/2/2014 12:00:00 AM




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Trampolines Linked to More Than 1 Million ER Visits Over a Decade

Title: Trampolines Linked to More Than 1 Million ER Visits Over a Decade
Category: Health News
Created: 5/2/2014 12:35:00 PM
Last Editorial Review: 5/2/2014 12:00:00 AM




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Pediatricians Issue New Guidelines for Hospital Release of Newborns

Title: Pediatricians Issue New Guidelines for Hospital Release of Newborns
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM




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Very Young Kids Often Use Tablets, Smartphones, Study Finds

Title: Very Young Kids Often Use Tablets, Smartphones, Study Finds
Category: Health News
Created: 4/26/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM




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Study Challenges Salt Guidelines for Kids

Title: Study Challenges Salt Guidelines for Kids
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM




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Focus on Healthy Foods, Not Avoiding 'Bad' Ones, for Heart Health: Study

Title: Focus on Healthy Foods, Not Avoiding 'Bad' Ones, for Heart Health: Study
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM




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New Guidelines Issued on Breast, Genital Plastic Surgery for Teen Girls

Title: New Guidelines Issued on Breast, Genital Plastic Surgery for Teen Girls
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM




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Businesses Should Be Mindful of Zika Danger to Workers, CDC Says

Title: Businesses Should Be Mindful of Zika Danger to Workers, CDC Says
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM




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Mindfulness Therapy May Help Ease Recurrent Depression

Title: Mindfulness Therapy May Help Ease Recurrent Depression
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/28/2016 12:00:00 AM




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Two Genes May Raise Odds for Fraternal Twin Pregnancies

Title: Two Genes May Raise Odds for Fraternal Twin Pregnancies
Category: Health News
Created: 4/28/2016 12:00:00 AM
Last Editorial Review: 4/29/2016 12:00:00 AM




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Brineura Approved for Rare Genetic Illness Affecting Kids

Title: Brineura Approved for Rare Genetic Illness Affecting Kids
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM




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Most Seniors Use Cellphones While Behind the Wheel

Title: Most Seniors Use Cellphones While Behind the Wheel
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM




nes

Seniors Often Have Trouble Managing Money, Medicines

Title: Seniors Often Have Trouble Managing Money, Medicines
Category: Health News
Created: 4/28/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM




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Are Smartphones Helping or Harming Kids' Mental Health?

Title: Are Smartphones Helping or Harming Kids' Mental Health?
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM




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Measles Outbreak in Minnesota Grows to 34 Cases

Title: Measles Outbreak in Minnesota Grows to 34 Cases
Category: Health News
Created: 5/4/2017 12:00:00 AM
Last Editorial Review: 5/5/2017 12:00:00 AM




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College Kids May Be Learning, Even When Checking Smartphones

Title: College Kids May Be Learning, Even When Checking Smartphones
Category: Health News
Created: 4/27/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM




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Scientists Pinpoint Dozens of Genes That Increase Risk of Depression

Title: Scientists Pinpoint Dozens of Genes That Increase Risk of Depression
Category: Health News
Created: 4/27/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM




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'What's That Word?' Fitness Helps Seniors Find It

Title: 'What's That Word?' Fitness Helps Seniors Find It
Category: Health News
Created: 4/30/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM




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U.S. Illnesses Tied to Ticks, Mosquitoes Are Soaring

Title: U.S. Illnesses Tied to Ticks, Mosquitoes Are Soaring
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM




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Health Tip: Getting Enough Magnesium

Title: Health Tip: Getting Enough Magnesium
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM




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FDA Puts Tough Warning Label on Ambien, Lunesta, Other Sleep Aids

Title: FDA Puts Tough Warning Label on Ambien, Lunesta, Other Sleep Aids
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM




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Newly Discovered Illness May Cause Nearly 1 in 5 Dementias, Experts Say

Title: Newly Discovered Illness May Cause Nearly 1 in 5 Dementias, Experts Say
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM




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Was Dyslexia the Secret to Leonardo da Vinci's Greatness?

Title: Was Dyslexia the Secret to Leonardo da Vinci's Greatness?
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM




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Rare, Serious Illness May Occur in Children With COVID-19

Title: Rare, Serious Illness May Occur in Children With COVID-19
Category: Health News
Created: 4/28/2020 12:00:00 AM
Last Editorial Review: 4/28/2020 12:00:00 AM




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Coronavirus Crisis Has Fewer Kids Getting Needed Vaccines

Title: Coronavirus Crisis Has Fewer Kids Getting Needed Vaccines
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM




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Trump Says Federal Guidelines on Social Distancing Set to Expire

Title: Trump Says Federal Guidelines on Social Distancing Set to Expire
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM




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CDC Draft Guidelines For Reopening U.S. Being Reviewed by White House

Title: CDC Draft Guidelines For Reopening U.S. Being Reviewed by White House
Category: Health News
Created: 5/1/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM




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More Airlines to Make Passenger Face Coverings Mandatory

Title: More Airlines to Make Passenger Face Coverings Mandatory
Category: Health News
Created: 5/1/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM




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Pregnancy Guidelines During COVID-19 Pandemic

Title: Pregnancy Guidelines During COVID-19 Pandemic
Category: Health News
Created: 4/2/2020 12:00:00 AM
Last Editorial Review: 4/2/2020 12:00:00 AM




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Sometimes, Aspirin May Be Enough to Ease Migraines

Title: Sometimes, Aspirin May Be Enough to Ease Migraines
Category: Health News
Created: 12/10/2019 12:00:00 AM
Last Editorial Review: 12/10/2019 12:00:00 AM




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FDA Approves New Type of Drug to Treat Migraines

Title: FDA Approves New Type of Drug to Treat Migraines
Category: Health News
Created: 12/23/2019 12:00:00 AM
Last Editorial Review: 12/24/2019 12:00:00 AM




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Could Smartphones Be Making Migraines Even Tougher to Treat?

Title: Could Smartphones Be Making Migraines Even Tougher to Treat?
Category: Health News
Created: 3/4/2020 12:00:00 AM
Last Editorial Review: 3/5/2020 12:00:00 AM




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10 New Weapons in the War on Migraines

Title: 10 New Weapons in the War on Migraines
Category: Health News
Created: 3/10/2020 12:00:00 AM
Last Editorial Review: 3/11/2020 12:00:00 AM




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Trial Finds Acupuncture May Help Prevent Migraines

Title: Trial Finds Acupuncture May Help Prevent Migraines
Category: Health News
Created: 3/26/2020 12:00:00 AM
Last Editorial Review: 3/27/2020 12:00:00 AM




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New Drug Could Help Stop Blindness From Thyroid Eye Disease

Title: New Drug Could Help Stop Blindness From Thyroid Eye Disease
Category: Health News
Created: 1/22/2020 12:00:00 AM
Last Editorial Review: 1/23/2020 12:00:00 AM




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On Some Farms, Washing Machines Give Leafy Greens a Spin -- But Is That Safe?

Title: On Some Farms, Washing Machines Give Leafy Greens a Spin -- But Is That Safe?
Category: Health News
Created: 4/24/2020 12:00:00 AM
Last Editorial Review: 4/24/2020 12:00:00 AM




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Study Confirms Safety, Effectiveness of Children's Vaccines

Title: Study Confirms Safety, Effectiveness of Children's Vaccines
Category: Health News
Created: 4/23/2020 12:00:00 AM
Last Editorial Review: 4/24/2020 12:00:00 AM




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Drinking Takes Toll on Bones of People With HIV: Study

Title: Drinking Takes Toll on Bones of People With HIV: Study
Category: Health News
Created: 3/6/2020 12:00:00 AM
Last Editorial Review: 3/9/2020 12:00:00 AM




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AHA News: Make Mother's Day Last All Year With Wellness and Appreciation

Title: AHA News: Make Mother's Day Last All Year With Wellness and Appreciation
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM




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How Dangerous Is General Anesthesia?

Title: How Dangerous Is General Anesthesia?
Category: Procedures and Tests
Created: 3/5/2020 12:00:00 AM
Last Editorial Review: 4/7/2020 12:00:00 AM




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Mindfulness a Powerful Tool for Aging

Title: Mindfulness a Powerful Tool for Aging
Category: Health News
Created: 4/2/2020 12:00:00 AM
Last Editorial Review: 4/3/2020 12:00:00 AM




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When Booze Labels Carry Health Warnings, Drinking Declines: Study

Title: When Booze Labels Carry Health Warnings, Drinking Declines: Study
Category: Health News
Created: 5/4/2020 12:00:00 AM
Last Editorial Review: 5/4/2020 12:00:00 AM




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Skipping Sleep to Watch Sports is The Real March Madness

Title: Skipping Sleep to Watch Sports is The Real March Madness
Category: Health News
Created: 3/6/2020 12:00:00 AM
Last Editorial Review: 3/6/2020 12:00:00 AM




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Challenges with Adherence to Clinical Practice Guidelines: Lessons for Implementation Science




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SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation [Research Articles]

Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement.