What you need to know As part of the response to COVID-19 the Government has delayed the introduction of the new IR35 rules (which extend the current IR35 rules that apply to public sector bodies to medium and large private sector organisations) unt...

In line with the Federal Ministry of Finance's press release dated 3 April 2020, Germany and Austria have concluded a mutual agreement for Covid 19-related home office activities on 15 April 2020, which relates to the application of the Double Tax ...

Relief through extension of filing deadlines for employers in the Corona crisis In a letter dated 23 April 2020, the Federal Ministry of Finance has provided tax relief by extending the filing deadlines for preliminary wage tax returns (Lohnsteuer-A...

Authorities across the globe are rapidly employing short-term protective measures against the economic impacts of COVID-19. The efforts include measures support businesses and their employees. Our team of tax lawyers is actively monitoring global r...

As part of the EU’s general clampdown on certain forms of aggressive tax planning, Directive 2011/16/EU (commonly known as DAC6) will soon require taxpayers and intermediaries across the EU to start reporting information in relation to certain...

With the continued economic impact of the Covid-19, amendments and updates were published on 1 May 2020 to address various tax relief measures that are available to qualifying taxpayers. The initial measures contained in the draft Disaster Managemen...

With increasing numbers of working parents comes a sharper focus on employer support for childcare arrangements.  On 6 April 2005, the Government is to introduce new tax incentives in relation to childcare arrangements which are intended t...

As of the 20th August 2014, businesses in Hungary are required to pay tax in connection with their advertising activities. The new legislation applies to individuals or organisations that publish adverts (“Publishers”);and place orders f...

Speed brief: On 11 July 2019, the UK Government published legislation confirming its intention to introduce a digital services tax (DST). The key features of this DST are as follows: • 2% tax on revenues (not profit) generated from UK users &bu...

Last Thursday, July 11, 2019, the French Parliament definitively enacted the so-called "GAFA tax” initiated by the French government in early March 2019, making France one of the first countries to tax the turnover of digital giants. Context D...

The UK is changing the way in which it taxes share options and share awards held by employees who move between countries. Some employees will gain and some employees will lose. As an employer, if you have employees on assignment from overseas or you...

The General Court of the European Union annulled on 14 February the European Commission’s decision of 11 January 2016 (Decision (EU) 2016/1699), in which it had found that Belgium’s excess profit exemption scheme was incompatible with EU...

The Seattle City Council will...

Gas tax revenue in Illinois could plummet by hundreds of millions of dollars this year because coronavirus restrictions are keeping drivers off the road, possibly delaying some major road and ......

Those in the diversified industrials sector will have seen that the Chancellor announced in the recent budget that the government is going ahead with its plans to introduce a world leading plastic packaging tax. The tax will be set at a flat rate of...

OFFSHORE gaming operators and their service providers must settle all their tax liabilities before resuming operations, Finance Secretary Carlos Dominguez 3rd reiterated on Friday. “In order for POGO (Philippine offshore gaming operators) service providers to be allowed to operate, they must pay their 2019 income tax liabilities, or in the case of POGO franchisees, the […]

Prague Daily Monitor

According to a story run in Deník N, a blind woman going out for a morning walk ran into a nightmare scenario on Monday in Prague's trendy Žižkov area.

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Revenue projections have suffered a serious hit as a result of virus pandemic.

A tax on migrating workers compensates the exporting country for loss of the human capital created by its education and skills development programs.

Singapore’s carbon tax is designed to maximize green investments while minimizing negative effects on the overall economy.

The Nagpur Municipal Corporation (NMC) has proposed a penalty of threefold property tax on residential structures lacking the Occupancy Certificate (OC). As the Nagpur Municipal Corporation (NMC) plans to levy threefold property tax on residential structures lacking the Occupancy Certificates (OCs), it may affect as many as 90 percent of the buildings in the city. Tukaram Mundhe, Commissioner, NMC, avers that the occupancy certificate is mandatory as per the building byelaws stated under the Maharashtra Regional and Town Planning (MRTP) Act, 1966. Therefore, all the building owners should obtain OC to avoid penalties. Nagpur has around 3,000 buildings that were served notices under the MRTP Act, but penalties were not levied until […]

Rawalpindi: Pakistan Businessmen and Intellectuals Forum President Mian Zahid Hussain has said that sales tax should be withdrawn on cottonseed, oil cake, etc. while withholding tax refunds stuck since a decade should be released.He said the largest foreign exchange earning sector is in trouble,...

Central Excise Commissioner waives Rs 24.34 crore tax, affected plot owners hail decision Tribune News Service Chandigarh, February 6 In a relief to the converted plot holders in Industrial Area, Phase I, and Phase II, the Commissioner, Customs and Central Excise Department, has ruled that there will be not service tax on conversion of plots. This order will imply on those who have converted their plots from industrial to commercial. Besides, the Commissioner has also waived Rs 24.34 crore service tax. A show-cause notice for the service tax was issued to the UT Estate Office in July 2013 for not depositing service tax. The department had issued notice of Rs […]

Alastair Hughes, CEO (Asia Pacific) of Jones Lang LaSalle (JLL), who was in Bangalore to hold a board meeting of the Asia Pacific region comprising China, Japan, Australia, South East Asia and India, spoke to BusinessLine to share the real estate market sentiment and key issues on corporate leasing. How is the realty market in India as compared to other countries in Asia Pacific ? India has seen a dramatic recovery. The hangover did not last very long as it had in 2010-2011. The market is very dynamic here right now. While Asia-Pacific began to recover in 2012-2013, India went through a lull, largely due to lack of business confidence, […]

HOWRAH: With an eye on boosting revenue, the Howrah Municipal Corporation announced a partial waiver for property and commercial tax on Tuesday. Under the waiver scheme, no penalty or interest need to be paid. The KMC has already enforced such a scheme and has benefited greatly, said Howrah mayor Rathin Chakraborty. He said the last board, controlled by the Left Front, bungled in tax collection, resulting in tax default of around Rs 200 crore. “The state is supporting us, but we must be self-sufficient. The tax outstanding will be collected without burdening civilians,” the mayor added. http://timesofindia.indiatimes.com/city/kolkata/Howrah-Municipal-Corporation-announces-partial-waiver-of-property-and-commercial-tax/articleshow/31431111.cms

Kolkata is all set to turn into a blue-and-white city during the Mamata government. The Kolkata Municipal Corporation (KMC) announced Monday that if you paint your house’ exterior blue-and-white, you will be fully exempted from paying property tax to the government. The Trinamool Congress-run KMC has come up with a proposal to waive the property tax for 2014-15 if a residential building or house is painted in the party’s favorite color combination — white and sky blue. “We will allow full waiver of property tax for 2014-15 if anybody wishes to paint his/her house or even apartment buildings, of course residential, in white and sky blue – the theme color […]

PUNE: Across the city, the rush to pay the annual property tax in advance and avail the discount has swelled the Pune Municipal Corporation coffers. Over 4.50 lakh property owners, who paid the tax before May 31 and availed of the 10% discount, helped the civic body collect Rs 400 crore in two months. “More than 50% of property owners paid the tax in the first two months of the new financial year. The good response to the scheme is due to the awareness programmes the administration undertook. The efforts to provide bills at the doorstep of residents helped boost collection. A maximum number of bills were sent to the […]

Title: Chicago's Short-Lived 'Soda Tax' Cut Consumption, Boosted Health Care Funds
Category: Health News
Created: 2/24/2020 12:00:00 AM
Last Editorial Review: 2/25/2020 12:00:00 AM

Objective

To investigate the pattern of progression of neurologic impairment in Friedreich ataxia (FRDA) and identify patients with fast disease progression as detected by clinical rating scales.

Objective

To describe the clinical and molecular genetic findings in a family segregating a novel mutation in the AIFM1 gene on the X chromosome.

Objective

To investigate the pathogenicity of the TGM6 variant for spinocerebellar ataxia 35 (SCA35), which was previously reported to be caused by pathogenic mutations in the gene TGM6.

Objective

To specifically report on ataxic-hypotonic cerebral palsy (CP) using registry data and to directly compare its features with other CP subtypes.

Paclitaxel has been considered to cause OATP1B-mediated drug-drug interactions at therapeutic doses; however, its clinical relevance has not been demonstrated. This study aimed to elucidate in vivo inhibition potency of paclitaxel against OATP1B1 and OATP1B3 using endogenous OATP1B biomarkers. Paclitaxel is an inhibitor of OATP1B1 and OATP1B3, with K_i of 0.579 ± 0.107 and 5.29 ± 3.87 μM, respectively. Preincubation potentiated its inhibitory effect on both OATP1B1 and OATP1B3, with K_i of 0.154 ± 0.031 and 0.624 ± 0.183 μM, respectively. Ten patients with non–small cell lung cancer who received 200 mg/m² of paclitaxel by a 3-hour infusion were recruited. Plasma concentrations of 10 endogenous OATP1B biomarkers—namely, coproporphyrin I, coproporphyrin III, glycochenodeoxycholate-3-sulfate, glycochenodeoxycholate-3-glucuronide, glycodeoxycholate-3-sulfate, glycodeoxycholate-3-glucuronide, lithocholate-3-sulfate, glycolithocholate-3-sulfate, taurolithocholate-3-sulfate, and chenodeoxycholate-24-glucuronide—were determined in the patients with non–small cell lung cancer on the day before paclitaxel administration and after the end of paclitaxel infusion for 7 hours. Paclitaxel increased the area under the plasma concentration-time curve (AUC) of the endogenous biomarkers 2- to 4-fold, although a few patients did not show any increment in the AUC ratios of lithocholate-3-sulfate, glycolithocholate-3-sulfate, and taurolithocholate-3-sulfate. Therapeutic doses of paclitaxel for the treatment of non–small cell lung cancer (200 mg/m²) will cause significant OATP1B1 inhibition during and at the end of the infusion. This is the first demonstration that endogenous OATP1B biomarkers could serve as surrogate biomarkers in patients.

Viruses and mobile genetic elements are molecular parasites or symbionts that coevolve with nearly all forms of cellular life. The route of virus replication and protein expression is determined by the viral genome type. Comparison of these routes led to the classification of viruses into seven "Baltimore classes" (BCs) that define the major features of virus reproduction. However, recent phylogenomic studies identified multiple evolutionary connections among viruses within each of the BCs as well as between different classes. Due to the modular organization of virus genomes, these relationships defy simple representation as lines of descent but rather form complex networks. Phylogenetic analyses of virus hallmark genes combined with analyses of gene-sharing networks show that replication modules of five BCs (three classes of RNA viruses and two classes of reverse-transcribing viruses) evolved from a common ancestor that encoded an RNA-directed RNA polymerase or a reverse transcriptase. Bona fide viruses evolved from this ancestor on multiple, independent occasions via the recruitment of distinct cellular proteins as capsid subunits and other structural components of virions. The single-stranded DNA (ssDNA) viruses are a polyphyletic class, with different groups evolving by recombination between rolling-circle-replicating plasmids, which contributed the replication protein, and positive-sense RNA viruses, which contributed the capsid protein. The double-stranded DNA (dsDNA) viruses are distributed among several large monophyletic groups and arose via the combination of distinct structural modules with equally diverse replication modules. Phylogenomic analyses reveal the finer structure of evolutionary connections among RNA viruses and reverse-transcribing viruses, ssDNA viruses, and large subsets of dsDNA viruses. Taken together, these analyses allow us to outline the global organization of the virus world. Here, we describe the key aspects of this organization and propose a comprehensive hierarchical taxonomy of viruses.

Despite the importance of the Bering Sea for subarctic oceanography and climate, relatively little is known of the foraminifera from the extensive Aleutian Basin. We report the occurrence of modern deep-water agglutinated foraminifera collected at seven sites cored during Integrated Ocean Drilling Program (IODP) Expedition 323 in the Bering Sea. Assemblages collected from core-top samples contained 32 genera and 50 species and are described and illustrated here for the first time. Commonly occurring species include typical deep-water Rhizammina, Reophax, Rhabdammina, Recurvoides and Nodulina. Assemblages from the northern sites also consist of accessory Cyclammina, Eggerelloides and Glaphyrammina, whilst those of the Bowers Ridge sites consist of other tubular genera and Martinottiella. Of the studied stations with the lowest dissolved oxygen concentrations, the potentially Bering Sea endemic Eggerelloides sp. 1 inhabits the northern slope, which has the highest primary productivity, and the potentially endemic Martinottiella sp. 3 inhabits Bowers Ridge, which has the lowest oxygen concentrations but relatively low annual productivity. Martinottiella sp. 3, with open pores on its test surface, has previously been reported in Pliocene to Recent material from Bowers Ridge. Despite relatively small sample sizes, ecological constraints may imply that the Bering Sea experienced high productivity and reduced oxygen at times since at least the Pliocene. We note the partially endemic nature of the agglutinated foraminiferal assemblages, which may at least in part be due to basin restriction, the geologically long time period of reduced oxygen, and high organic carbon flux. Our results indicate the importance of gathering further surface sample data from the Aleutian Basin.

As home sellers commonly propose to state a lower price in the sale contract than the actual transaction value, home buyers have to bear additional risks from such real estate transactions.

Tech firms are making record profits but paying little tax. Now global leaders are discussing ways to make them pay their fair share

The state accuses the ride-hailing apps of flouting a labor law by classifying drivers as independent contractors instead of employees.

Data showed the domestic equity market gave up half the gains that it had amassed.

No major Hollywood film since has attempted anything quite like Cast Away.

A sharp decline in economic activity as well as tax cuts approved by lawmakers added to the decline.

Billionaire property developer Huang Xiangmo publishes a lengthy and scathing attack at the ATO, which is pursuing him over a $141 million tax bill, and ASIO, which revoked his permanent residency.

A Federal Court judge rules Chinese property developer Huang Xiangmo should declare his overseas assets as the ATO which alleges the billionaire has an unpaid $141 million tax debt closes in.

Thousands of Australian expats fear they could be hit with large capital gains tax bills because they've been unable to return home due to COVID-19 travel restrictions, before a June 30 deadline that would have allowed them to sell their property to avoid liabilities.

Westpac joins ANZ in deferring its interim dividend as it braces for the financial impact of COVID-19, but mounting issues around money laundering and tax reporting may cost it almost as much.

HOBART taxi driver Mikahil Ahmed is reeling from a brutal racial attack that left him hospitalised and badly damaged his cab.

The Government's proposed JobKeeper payment is set to move the goalposts in desperate negotiations between sporting codes and their players amid the coronavirus pandemic.

WASHINGTON – November 14, 2017 – As the Senate begins debate on a tax reform bill, the clinical research industry hopes that...