1. Tata Steel Chess India Day 1: Abdussatorov Leads Carlsen, So, Narayanan  Chess.com
2. Magnus Carlsen interview: I probably will have the most fun playing Gukesh  Hindustan Times
3. Tata Steel Chess India - Live!  Chess News | ChessBase
4. Abdusattorov Nodirbek leads, Magnus Carlsen close behind in India Open chess  The Times of India
5. Indian chess has come a long way, courtesy Anand: Carlsen  The Hindu

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks originally appeared on Gadling on Mon, 16 Dec 2013 15:07:00 EST. Please see our terms for use of feeds.

Familiar sounds of encouragement and needling filled a practice field at Salt River Fields at Talking Stick on Monday as Nolan Arenado, Trevor Story and the infielders took grounders and Charlie Blackmon and the outfielders gathered their bats and spikes. Only a few faces that always seemed to be around are missing as Spring Training begins.

Rockies third baseman Nolan Arenado said Thursday he won't make Opening Day a hard deadline for negotiations on a possible multiyear contract.

Raimel Tapia has renewed opportunity with the Rockies in 2019, along with a need to deliver.

bmj;387/nov12_10/q2481/FAF1faJulia and Malcolm Donaldsondonaldson20241111.f1Malcolm Donaldson was a distinguished paediatric endocrinologist with a string of research publications to his name—but he was also happy to play second fiddle (almost literally) to his wife Julia, the celebrated author of much loved children’s books, including The Gruffalo and Room on the Broom.Malcolm, a talented musician and performer, accompanied his wife as she toured festivals, schools, and libraries in the UK and around the world. Together they performed the stories, with Malcolm acting characters ranging from an accident prone dragon to a comic cattle thief. His star role, in the words of Julia’s literary agent, was “a particularly suave fox” in The Gruffalo.Malcolm met Julia Shields when they were students at the University of Bristol and they married in 1972. Donaldson went on to work in Brighton, London, and Lyon, France, before moving back to Bristol to be a senior registrar in paediatrics. Six...

At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.

Australian outreach participant Kathryn Jenkin testifies to how God used her prayers while on outreach in Lesotho.

Twenty students graduate OM Russia’s Discipleship programme with a heart for missions.

OM Russia’s Student Christian Centre, in partnership with the local Evangelical Church, reaches universities in Novosibirsk. The project leader shares about plans for this year.

Dorothea, from Germany, joins the one-year programme with OM Russia, which includes visiting Siberian villages to help churches and sharing the Gospel with locals.

OM Russia's short-term outreach team travels across Russia sharing about Christ with as many travellers as possible.

OM Russia and partner organisations work to thwart two killers picking off the younger generation in Russia: drugs and HIV and AIDS.

OM Russia leader Colin Cleaver discusses why he values the involvement of families in OM Russia’s ministry and encourages other families to consider missions.

A team member from the USA who participated in a short-term trip on the Trans-Siberian railroad across Russia shares her experience.

A group of Russians participates in an OM Moldova summer outreach for children.

OM Philippines partners with the local church to provide water and food in areas hit by the 7.2 magnitude earthquake on 15 October.

An Uzbek girl living in Istanbul, Turkey enters into relationship with Jesus after having a dream.

OM worker joins a new Arabic-speaking ministry among Syrians in Turkey.

An OM ministry team in the UK has been reaching out to Iranian and Afghan refugees since May 2012 and praying for growth.

In Tongwa village husbands and wives don't know how to love each other. A young couple is working to change that.

Tabitha Initiative in Kabwe, Zambia, gives business training and small loans to vulnerable women, empowering them to start sustainable businesses in their communities.

Foundations for Farming is changing lives in Zambia by reaching out with God's truth and practical training.

OM worker rejoices her friend's baptism in Greece.

In 2008, the Greek Evangelical Church in Athens opened a community centre, in a suburb where many Albanians live. OM worker Martha describes how she and other staff are reaching out with God's love to local young people.

Instead of the two families they had hoped for, seven families from Katerini attend the Christian camp for Albanians in Greece.

Work of OM Romania, partnering with the church

OM founder George Verwer speaks at the Romanian Brethren Assembly about living a pure life and standing against the issue of abortion.

Since 2007, the Bus4Life has visited 150 locations, welcomed 10,000 visitors and touched many lives, including one Romanian teen who comes back to God.

Surprises await Bus4Life coordinator Esko when visiting a Romanian village: Meeting orphaned girls saved on a visit 26 years ago, and the former Chief of Police from the Communist era.

Joe, a long-term OM worker and ministry leader, shares a glimpse into the work of God inside the war-torn Syria.

Ten years ago, Lydia* arrived on the field as a single woman. Now married and with two kids, her method of ministry has changed entirely.

Global crises provide unprecedented opportunities for OM workers to share truth with least-reached people from Syria, Somalia and Sudan.

Driven apart by the Syrian civil war, an extended family experiences miraculous healing and dreams and believes in Jesus.

Since the Syrian war began, OM workers have served alongside locals, including Muslim background believers, to spread hope amongst desperate people.

OM workers from Latin America discuss the similarities and differences to Arab culture.

Syrian Kurdish refugee families profess faith in Jesus Christ.

Danish students gain perspective and experience with OM Italy.

Artists present visual and performing arts during the international art Festival Week hosted by OM Arts International’s Incarnate programme.

In the 1960s, when OM accepted untrained people for short-term campaigns, it was unheard of. Today, it has become a gateway into missions.

“This publication is a tool to help those who will join Goran in sharing the gospel among Gurbet-speaking Roma, and lays the foundation for future Christian materials.”