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The Lancet: New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial

A two-week course of antiviral therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin, started within 7 days of showing COVID-19 symptoms, is safe and more effective at reducing the duration of viral shedding than lopinavir-ritonavir alone in patients with mild to moderate illness, according to the first randomized trial of this triple combination therapy involving 127 adults (aged 18 and older) from six public hospitals in Hong Kong.




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Stroke evaluations drop by nearly 40% during COVID-19 pandemic

A study from Washington University School of Medicine in St. Louis has found that stroke evaluations fell by nearly 40% during a period of the COVID-19 pandemic, suggesting that many stroke patients are not seeking potentially life-saving medical treatment.




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Joe Biden, nearly invisible during pandemic, has plenty to smile about

The 77-year old is never going to be an electrifying nominee, but Joe Biden has a lot to feel good about seven months out from election day.




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Response from Eddie, AFL not nearly enough

THERE'S so much wrong about the Eddie McGuire-James-Brayshaw-Danny Frawley pack mentality attack of Caroline Wilson. As was the AFL's insipid response on Monday.




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Young people dominate nearly 800,000 job losses since COVID-19 crisis escalated

The COVID-19 pandemic resulted in a 5.5 per cent slump in jobs in the first week after extensive business shutdowns and social-distancing limits were introduced to contain the virus, new ABS figures show.




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Hundreds of thousands granted early access to $3.8b in superannuation

Nearly half a million Australians have had applications for early access to their superannuation approved, totalling $3.8 billion in early payments, Treasurer Josh Frydenberg says.




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Superannuation early withdrawal risks collapsing retirement system

Super funds and prominent professional investors warn that the mass withdrawal of funds from superannuation during the COVID-19 crisis risks undermining the whole retirement income system.




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This university student pulls in nearly double his usual earnings thanks to JobKeeper

Thanks to a loophole in the Federal Government's JobKeeper legislation, Lewis Mullins has been earning far more than he did before the coronavirus pandemic. But the same can no longer be said for his younger colleagues.




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US economy 'on life support' as unemployment soars to nearly 15 per cent

The US economy lost a staggering 20.5 million jobs in April, the steepest plunge in payrolls since the Great Depression, but President Donald Trump says "all those jobs will be back" very soon.




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Banks an early drag on stocks

The sharemarket opened lower as weak banking stocks failed to support a strong rally in energy shares.




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Statistics Canada to investigate after official job numbers leaked early

Statistics Canada has launched an investigation after a media outlet reported its latest job-loss figures more than a half hour before the data was officially released.




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Canada lost nearly 2 million jobs in April amid COVID-19 crisis: Statistics Canada

Canada lost almost two million jobs during the month of April, a record high, as the impact of COVID-19 on the economy made itself known.




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Broadway star Nick Cordero showing 'early signs' of waking up from COVID-19 coma

Dancer Amanda Kloots offered a hopeful update Wednesday on her husband, Nick Cordero, who has been in a medically induced coma after contracting COVID-19.




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Three Early Signs That COVID-19 Could Disrupt the Buy-and-Bill Channel

Will home infusion growth be a long-overdue correction for the buy -and-bill channel or a temporary blip that will soon vanish?

For some time, I have been tracking the evolution of the buy-and-bill system for provider-administered drugs. The data have shown that hospital outpatient departments have been displacing physician offices. Amid this shift, home infusion providers have accounted for a minority of commercial medical benefit spending and a tiny share of Medicare Part B spending.

However, the coronavirus pandemic is triggering new growth in home infusion for buy-and-bill products. Below, I highlight the early signs of a marketplace change. I believe that some of these short-term shifts in the buy-and-bill market will persist even after we have recovered from COVID-19. They may even slow the runaway growth of the 340B Drug Pricing Program.

If not, then I suppose we'll just keep living in a world with limited home infusion over and over.

In early May, Drug Channels Institute will host two live video webinars: Industry Update and COVID-19 Impact: Retail & Specialty Pharmacies (May 1) and Industry Update and COVID-19 Impact: PBMs & Payers (May 8). CLICK HERE TO LEARN MORE AND SIGN UP. DCI will donate 20% of all profits from these events to The Center for Disaster Philanthropy’s COVID-19 Response Fund. Watch my video invitation below.

Read more »
        




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Early Detection: A New Front in the War on Cancer

Blood tests that find malignancies before they spread could transform our approach to treatment

-- Read more on ScientificAmerican.com




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Remdesivir: early findings on experimental coronavirus drug offer 'quite good news'

Preliminary results of US government trial show patients who received drug recovered faster than others

Hopes of an effective drug treatment for coronavirus patients have risen following positive early results from a trial of remdesivir, a drug first tried in Ebola patients.

Data from the trial on more than 1,000 severely ill patients in 75 hospitals around the world show that patients put on the drug recovered 31% faster than similar patients who were given a placebo drug instead. Remdesivir cut recovery time from a median of 15 days to 11.

Related: World's stock markets soar on coronavirus treatment hopes

Continue reading...




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Italy to relax COVID-19 lockdown in early May

Italy has outlined its plans to ease the lockdown restrictions that were implemented across the country 7 weeks ago to combat the COVID-19 coronavirus pandemic.




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Nearly half of Americans believe COVID-19 was created in a lab, according to a new survey

Almost half of Americans believe that the coronavirus was created in a lab, according to an April survey of 6,300 people.




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Phase 3 Libtayo monotherapy trial halted early due to strong benefit in advanced non-small cell lung cancer

A Phase 3 study of Sanofi and Regeneron’s Libtayo (cemiplimab) as a monotherapy for advanced or metastatic non-small cell lung cancer (NSCLC) has been stopped early after showing strong overall survival benefit, it has emerged.




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Seattle Genetics, Astellas' bladder cancer med Padcev blows early expectations out of the water

Even a pandemic can’t slow down Seattle Genetics and Astellas' new bladder cancer treatment Padcev, which "blew out sales expectations" for the first quarter, analysts said. And now, they're jacking up their long-term sales estimates for the drug as a result.




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Early missteps, transparency questions dog U.S. government's remdesivir rollout: reports

When Gilead Sciences scored a groundbreaking FDA emergency use authorization for COVID-19 therapy remdesivir, the company made the unusual move of handing distribution rights to the U.S. government. But the federal rollout has gotten off to a rocky start. 




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Roche's Kadcyla wins NICE backing in early breast cancer use

Unlike its first U.K. reimbursement negotiations, Roche’s HER2 antibody-drug conjugate has won quick National Institute for Health and Care Excellence backing for routine NHS coverage to prevent HER2-positive breast cancer from returning after surgery in the so-called adjuvant setting.




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BP Products to Pay Nearly $180 Million to Settle Clean Air Violations at Texas City Refinery

BP Products North America Inc. has agreed to spend more than $161 million on pollution controls, enhanced maintenance and monitoring, and improved internal management practices to resolve Clean Air Act violations at its Texas City, Texas, refinery.



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International Criminal Figure Pleads Guilty to $138 Million Fuel Tax Scheme After Nearly 13 Years as a Fugitive

After nearly 13 years as a fugitive, a former New Jersey resident has been returned to the United States, and pleaded guilty today to conspiring to committing one of the nation’s largest known motor fuel excise tax schemes. Aaron Misulovin a/k/a Albert Friedman, a/k/a Valery Vibornov, pleaded guilty before U.S. District Judge Joseph E. Irenas in Camden, N.J., to one count of conspiracy, three counts of wire fraud, three counts of money laundering and three counts of tax evasion.



  • OPA Press Releases

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Former State Department Official and Wife Arrested for Serving as Illegal Agents of Cuba for Nearly 30 Years

A former State Department official and his wife have been arrested on charges of serving as illegal agents of the Cuban government for nearly 30 years and conspiring to provide classified U.S. information to the Cuban government.



  • OPA Press Releases

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Indiana Home Health Agency Pays Nearly $2 Million to Settle False Claims Act Allegations

“With the nation’s focus on health care, this settlement demonstrates the Justice Department’s commitment to ensuring that federal health care dollars are spent appropriately,” said Tony West, Assistant Attorney General for the Civil Division.



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Syracuse Mortgage Underwriter to Pay United States Nearly $679,000 to Resolve Mortgage Fraud Allegations

Robert Corp, a mortgage underwriter in Syracuse, N.Y., has agreed to pay the United States close to $679,000 to settle allegations that he defrauded the U.S. Department of Housing and Urban Development (HUD).



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Los Angeles Business Owner Pleads Guilty to Submitting Nearly $1 Million in False and Fraudulent Claims to Medicare

The owner and operator of a Los Angeles durable medical equipment (DME) company pleaded guilty today to submitting nearly $1 million in false claims to Medicare.



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Los Angeles Business Owner Pleads Guilty to Submitting Nearly Half a Million Dollars in False and Fraudulent Claims to Medicare

The owner and operator of a Los Angeles durable medical equipment (DME) company pleaded guilty today to submitting nearly one half of a million dollars in false claims to Medicare.



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Alaska Department of Transportation and Public Facilities to Pay Nearly $1 Million for Alleged Clean Water Act Violations

The Alaska Department of Transportation and Public Facilities has agreed to pay nearly $1 million to resolve allegations that it violated the Clean Water Act at numerous sites in Alaska



  • OPA Press Releases

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Heart Device Manufacturer in Minnesota and Hospitals in Ohio & Kentucky to Pay Nearly $4 Million to Resolve Fraud Allegations

St. Jude Medical Inc., a heart device manufacturer; Parma Community General Hospital; and Norton Healthcare have paid the United States $3,898,300 to resolve false claim allegations that St. Jude paid illegal kickbacks to two hospitals to secure heart-device business.



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Former State Department Official Sentenced to Life in Prison for Nearly 30-year Espionage Conspiracy

Walter Kendall Myers, a former State Department official, and his wife, Gwendolyn Steingraber Myers, have been sentenced to life in prison without the possibility of parole and 81 months in prison, respectively, for their roles in a nearly 30-year conspiracy to provide highly-classified U.S. national defense information to the Republic of Cuba.



  • OPA Press Releases

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Texas Chemical Plant to Pay Nearly $1.5 Million to Resolve Violations in the Transferring of Acid Waste

Air Products LLC has agreed to pay $1.485 million in civil penalties to resolve hazardous waste mismanagement violations at its Pasadena, Texas, chemical manufacturing facility.



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Employee of U.S. Embassy in Baghdad Convicted of Stealing Nearly $250,000

An employee of the U.S. Embassy in Baghdad, Iraq, was found guilty today by a jury in Alexandria, Va., of stealing nearly $250,000 intended for the payment of shipping and customs services for the embassy.



  • OPA Press Releases

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Former Employee of U.S. Embassy in Baghdad Sentenced to 42 Months in Prison for Stealing Nearly $250,000

A former employee of the U.S. Embassy in Baghdad, Iraq, was sentenced today in U.S. District Court in Alexandria, Va., to 42 months in prison for stealing nearly $250,000 intended for the payment of shipping and customs services for the embassy.



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Natural Resource Trustees for the Deepwater Horizon Oil Spill Announce $1 Billion Agreement to Fund Early Gulf Coast Restoration Projects

Under an unprecedented agreement announced today by the Natural Resource Trustees for the Deepwater Horizon oil spill, BP has agreed to provide $1 billion toward early restoration projects in the Gulf of Mexico to address injuries to natural resources caused by the spill.



  • OPA Press Releases

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Justice Department Reaches Settlement with Connecticut Early Learning Center to Ensure Equal Opportunity for Children with Autism

The Justice Department today announced a settlement agreement with Beach Babies Learning Center LLC, located in Old Saybrook, Conn., to resolve allegations that the center terminated the enrollment of a then two-year-old child from its program because the child has autism.



  • OPA Press Releases

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“Project Delirium” Results in Nearly 2,000 Arrests During 20-Month Operation, Seizures of More Than 12 Tons of Drugs and $62 Million in U.S. Currency

Approximately 1,985 individuals have been arrested on narcotics-related charges as part of a 20-month multi-agency law enforcement investigation known as “Project Delirium,” which targeted the La Familia Michoacana drug cartel.



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Nearly 40 Members and Associates of Bandido Outlaw Motorcycle Gang Charged in Three Districts for Alleged Drug and Firearm Offenses

Nearly 40 members and associates of the Bandido Outlaw Motorcycle Gang (BOMG) were arrested yesterday and today on various firearms and drug-related charges in three judicial districts as part of a coordinated law enforcement effort.



  • OPA Press Releases

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Former Department of Defense Employee Pleads Guilty to Submitting False Travel Claims Totaling Nearly $500,000

John R. Brock, 52, of Crofton, Md., pleaded guilty today before U.S. District Court Judge Robert L. Wilkins in U.S. District Court for the District of Columbia to a criminal information charging him with one count of making a false claim against the United States.



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Georgia Man Sentenced to Nearly Four Years in Prison in Plot to Supply Iran with U.S. Military Aircraft Components

Michael Edward Todd, a U.S. national who is president of The Parts Guys LLC, a company in Port Orange, Fla., that maintains a warehouse at the Middle Georgia Municipal Airport in Macon, was sentenced this morning in federal court in the Middle District of Georgia.



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Magyar Telekom and Deutsche Telekom Resolve Foreign Corrupt Practices Act Investigation and Agree to Pay Nearly $64 Million in Combined Criminal Penalties

The department filed a criminal information against Magyar Telekom and a two-year deferred prosecution agreement in U.S. District Court for the Eastern District of Virginia today.



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Former Department of Defense Employee Sentenced to 30 Months in Prison for Submitting False Travel Claims Totaling Nearly $500,000

John R. Brock, 52, of Crofton, Md., was sentenced by U.S. District Judge Robert L. Wilkins in the District of Columbia.



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South San Francisco Food Processing Factory Will Pay Nearly $700,000 in Penalties, Spend $6 Million to Update Refrigeration System Safety

Columbus Manufacturing Inc., a wholly owned subsidiary of Columbus Foods LLC, has agreed to pay a penalty and make significant upgrades to settle Clean Air Act violations.



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Former IRS Employee from Texas Sentenced to Nearly Nine Years in Prison on Theft of Government Property and Aggravated Identity Theft Convictions

Thomas W. Richardson was sentenced Thursday by U.S. District Judge Jane J. Boyle in Dallas to 105 months in prison and ordered to pay $30,649 in restitution, following his guilty plea in August 2011 to one count of theft of government property and one count of aggravated identity theft, the Justice Department announced today.



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Health Care Fraud Prevention and Enforcement Efforts Result in Record-breaking Recoveries Totaling Nearly $4.1 Billion

Attorney General Eric Holder and Department of Health and Human Services (HHS) Secretary Kathleen Sebelius today released a new report showing that the government’s health care fraud prevention and enforcement efforts recovered nearly $4.1 billion in taxpayer dollars in Fiscal Year (FY) 2011.



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Dallas Doctor Arrested for Alleged Role in Nearly $375 Million Health Care Fraud Scheme

A physician and the office manager of his medical practice, along with five owners of home health agencies, were arrested today on charges related to their alleged participation in a nearly $375 million health care fraud scheme involving fraudulent claims for home health services.



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Kansas Refinery to Pay Nearly $1 Million Penalty for Environmental Violations Related to Air Emissions

Coffeyville Resources Refining & Marketing (CRRM) has agreed to pay a civil penalty of more than $970,000 and invest more than $4.25 million in new pollution controls and $6.5 million in operating costs to resolve alleged violations of air, Superfund and community right-to-know laws at its Coffeyville, Kan., refinery.



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Former Grant Administrator and Legal Assistant of American Samoa Non-profit Legal Aid Corporation Sentenced for Stealing Nearly $160,000 in Federal Grant Funds

Julie Matau, 49, and her daughter, Andrea Matau, 28, each were sentenced yesterday in Oakland, Calif., for their participation in the theft of nearly $160,000 in federal grant funds from a now-defunct nonprofit American Samoa legal services corporation.



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ATK Launch Systems Inc. Settles False Claims Product Substitution Case for Nearly $37 Million

ATK has agreed to pay the United States $21 million in cash and provide necessary in-kind services worth $15,967,160 to fix the 76,000 unsafe para-flares remaining in the government’s inventory. The settlement resolves a False Claims Act suit filed in the U.S. District Court for the District of Utah.



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