Topics in this issue include:

• Support for Non-Consecutive Month CSOs - November 18 ^New
• Price Precision Extension - 2018

New - Support for Non-Consecutive Month CSOs

Effective Sunday, November 18 (trade date Monday, November 19), to simplify the submission of trade entry reports, CME ClearPort will support trade entry for Calendar Spread Options (CSOs) on products, typically Agricultural, that do not list consecutive monthly contracts.

This enhancement will be available in New Release for customer testing on Wednesday, November 7.

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Price Precision Extension

CME Group is implementing end-to-end technology changes to support increased price granularity. Currently, CME Group systems support a maximum of 7 decimals. With this initiative, products with up to 9 decimals may be listed and traded. Effective Sunday, January 13 (trade date Monday, January 14), pending regulatory approval, the 2 Year Treasury Note futures and spreads will move from 7 decimals to 8 to support trading at 1/8 of 1/32.

Customers are encouraged to move to support 9 decimals now; but there are no plans to list a product that uses the 9th decimal at this time.

For more on impacted products and CME Globex, iLink messaging, Drop Copy and Market Data impacts, view the CME Globex Client Impact Assessment.

These enhancements are currently available for testing in New Release.

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German translation of the BIS Quarterly Review, March 2018

German translation of the BIS press release about the BIS Quarterly Review, March 2018

German translation of the BIS Quarterly Review, June 2018

German translation of the Annual Economic Report 2018 of the BIS, June 2018 - Die politischen Entscheidungsträger können dem gegenwärtigen Wirtschaftsaufschwung eine nachhaltige Basis verleihen, schreibt die BIZ in ihrem Wirtschaftsbericht. Dazu sollten sie strukturpolitische Maßnahmen ergreifen, mit Blick auf künftige Risiken wieder für größeren Handlungsspielraum in der Geld- und Fiskalpolitik sorgen und die Umsetzung der Regulierungsreformen vorantreiben. ...

German translation of the BIS Quarterly Review, September 2018

German translation of the BIS Quarterly Review, December 2018

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director.

OM Director's Update from Lawrence Tong, International Director

OM Update from Lawrence Tong, International Director

OM Director's Update from Lawrence Tong, International Director

OM Director's Update by Lawrence Tong, International DIrector

OM Director's Update from Lawrence Tong

The sixth-generation 9.7-inch iPad with 128GB of storage and cellular connectivity would normally set you back $559, but is currently marked down to just $349.

Europe's top competition for amateur players returns for 2018/19 with 39 nations discovering the fate of their eventual representatives in the preliminary and intermediate round draws.

UEFA's technical observers have selected their all-star squad from the 2018/19 UEFA Women's Champions League.

Capacity-building work of bodies established under the Convention and its Kyoto Protocol. Compilation and synthesis report by the secretariat.

Adaptation in human settlements: key findings and way forward. Report by the secretariat.

Provisional agenda and annotations. Note by the Executive Secretary.

Provisional agenda and annotations. Note by the Executive Secretary.

Technical workshop on ways to increase the efficiency and transparency of the budget process. Report by the secretariat.

Agenda and annotations. Note by the Executive Secretary.

Capacity-building work of bodies established under the Convention and its Kyoto Protocol. Compilation and synthesis report by the secretariat. Addendum. Compilation of capacity-building activities undertaken by bodies established under the Convention and its Kyoto Protocol

The 33rd meeting of the Least Developed Countries Expert Group. Report by the secretariat.

Implementation of the framework for capacity-building in developing countries. Synthesis report by the secretariat.

Arrangements for Intergovernmental Meetings. Note by the Executive Secretary.

Outcomes of work under the Nairobi work programme on impacts, vulnerability and adaptation to climate change since May 2016. Synthesis report by the secretariat.

United Nations Environment Programme response to the independent review of the Climate Technology Centre and Network.

Status of submission and review of seventh national communications and third biennial reports. Note by the secretariat.

Ceftobiprole medocaril is an advanced-generation cephalosporin prodrug that has qualified infectious disease product status granted by the US-FDA and is currently being evaluated in phase 3 clinical trials in patients with acute bacterial skin and skin structure infections (ABSSSIs) and in patients with Staphylococcus aureus bacteremia. In this study, the activity of ceftobiprole and comparators was evaluated against more than 7,300 clinical isolates collected in the United States from 2016 through 2018 from patients with skin and skin structure infections. The major species/pathogen groups were S. aureus (53%), Enterobacterales (23%), Pseudomonas aeruginosa (7%), β-hemolytic streptococci (6%), Enterococcus spp. (4%), and coagulase-negative staphylococci (2%). Ceftobiprole was highly active against S. aureus (MIC_50/90, 0.5/1 mg/L; 99.7% susceptible by EUCAST criteria; 42% methicillin-resistant S. aureus [lsqb]MRSA[rsqb]). Ceftobiprole also exhibited potent activity against other Gram-positive cocci. The overall susceptibility of Enterobacterales to ceftobiprole was 84.8% (>99.0% susceptible for isolate subsets that exhibited a non-extended-spectrum β-lactamase [lsqb]ESBL[rsqb]-phenotype). A total of 74.4% of P. aeruginosa, 100% of β-hemolytic streptococci and coagulase-negative staphylococci, and 99.6% of Enterococcus faecalis isolates were inhibited by ceftobiprole at ≤4 mg/L. As expected, ceftobiprole was largely inactive against Enterobacterales that contained ESBL genes and Enterococcus faecium. Overall, ceftobiprole was highly active against most clinical isolates from the major Gram-positive and Gram-negative skin and skin structure pathogen groups collected at U.S. medical centers participating in the SENTRY Antimicrobial Surveillance Program during 2016–2018. The broad-spectrum activity of ceftobiprole, including potent activity against MRSA, supports its further evaluation for the potential ABSSSI indication.

BACKGROUND:

Orphan drug development is crucial for children, who are disproportionately affected by rare diseases. Data are lacking on the number, nature, and benefit of recently approved pediatric orphan indications.

The 55-vehicle Volkswagen fleet which will transport players and officials at UEFA Futsal EURO 2018 has been handed over to the tournament organisers.

Hosts Slovenia have been handed a tough group with Italy and Serbia while France's debut finals match will be against holders Spain after the draw was made in Ljubljana.

We look at the 12 teams that will compete in Slovenia between 30 January and 10 February – from champions Spain and former winners Italy and Russia to debutants France.

UEFA Futsal EURO 2018 runs until 10 February in Ljubljana with 12 teams aiming for the title: we give you the key pointers to following a tournament full of skill and passion.

You can watch UEFA Futsal EURO 2018 across Europe and the world thanks to UEFA's broadcast partners and the live streaming of games on UEFA.com and our YouTube channel UEFA.tv.

See all the results and highlights from UEFA Futsal EURO 2018 at Ljubljana's Stožice Arena.

Ricardinho, Taynan, Douglas Junior, Pola and Georgi Zamtaradze have been named the best five players of the 2018 finals and are also in the 14-strong selection for the Team of the Tournament.

The 2018/19 UEFA European Under-19 Championship qualifying round draw has been made in Nyon, starting the road to the July 2019 finals in Armenia.

The waterproof Kindle Paperwhite offers more for your money than any other ebook reader on the market.

The 2018 UEFA Super Cup will be played on 15 August of next year at Tallinn's Lilleküla Stadium, the first senior UEFA final in Estonia in the centenary of that republic's creation.

Real Madrid will take on Atlético in Tallinn, Estonia, on Wednesday.