Human macrophages equipped with chimeric antigen receptor constructs infiltrate solid tumors, ingest malignant tissue, and stimulate adaptive immunity in mouse models. Several new biotech companies are racing to bring the technology into clinical trials.

Thermo Fisher Scientific announced plans in March to acquire Qiagen in a $11.5 billion deal that could bring morediagnostic offeringsand sample-preparation technologies to one of the world's leading manufacturers of scientific instruments, research services, and laboratory consumables.

T cell–expressed PD-L1 exerts tolerogenic effects on tumor immunity in pancreatic cancer.

This study was an analysis of a national sample of U.S. medical office visits from 2014 to 2016, a period when evidence of effectiveness was emerging for a variety of beneficial type 2 diabetes agents with regard to potential reduction in diabetes comorbidities. Ideal therapy was defined as an American Diabetes Association–identified beneficial agent plus metformin. The associations between atherosclerotic cardiovascular disease or obesity and use of these agents were explored.

Background:

The associations of abdominal skeletal muscle mass index (SMI), visceral and subcutaneous adipose tissue (VAT and SAT, respectively), and mortality among patients with stage I–III colorectal cancer may differ for men and women, but only few studies stratified their data into men and women. We investigated associations of abdominal SMI, VAT, and SAT with overall mortality among men and among women with stage I–III colorectal cancer.

Background:

The recent expansion of treatment options in acute myeloid leukemia (AML) has necessitated a greater understanding of patient preferences for treatment benefits, about which little is known.

Colorectal cancer is a growing burden in adults less than 50 years old. In 2018, the American Cancer Society published a guideline update recommending a reduction in the colorectal cancer screening start age for average-risk individuals from 50 to 45. Implementing these recommendations would have important implications for public health. However, the approximate number of people impacted by this change, the average-risk population ages 45–49, is not well-described in the literature. Here, we provide methodology to conservatively estimate the average-risk and screening-eligible population in the United States, including those who would be impacted by a lowered colorectal cancer screening start age. Using multiple data sources, we estimated the current average-risk population by subtracting individuals with symptomatic colorectal cancer, with a family history of colorectal cancer, and with inflammatory bowel disease and hereditary nonpolyposis colorectal cancer from the total population. Within this population, we estimated the number of screening-eligible individuals by subtracting those with previous colorectal cancer screening (45- to 49-year-old) or up to date with colorectal cancer screening (50- to 74-year-old). The total average-risk population is estimated between 102.1 and 106.5 million people, of whom 43.4–45.2 million people are eligible for colorectal cancer screening. Lowering the screening age would add roughly 19 million people to the average-risk population and increase the current number of screening-eligible individuals on immediate implementation by over 60% (from 27 to 44 million). Estimating the population size impacted by lowering the recommended colorectal cancer screening start age enables more accurate decision-making for policymakers and epidemiologists focused on cancer prevention.

BACKGROUND AND PURPOSE:

Conventional nonadhesive liquid embolic agents currently are the criterion standard for endovascular embolization of cerebral AVMs. However, inadequate distal penetration into the nidus and unstable proximal plug formation are the major limitations of this approach and of the currently available embolic materials. The aim of this study was to evaluate the hypothetic efficacy of combining liquid embolic agents with different properties and viscosities for use in endovascular embolization of cerebral AVMs.

BACKGROUND AND PURPOSE:

The use of invasive cerebral angiography with CTA for active treatment of patients with suspected ischemic strokes has been increasing recently. This study aimed to identify the incidence of postcontrast acute kidney injury using baseline renal function when CTA and cerebral angiography were performed sequentially.

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[Having appointment with real estate experts #5] While buying a home is quite easy for high-income households, it is another story for the middle-class. With a wise and specific financial plan, the chances of owning a home can still lie within reach even if an average income.

If you’re excited and in good shape to buy a home, self-made millionaire Barbara Corcoran says these are the five steps for you to take.

Buying a home always need time and effort. Many home buyers can not manage a series of buying steps themselves, so hiring real estate agents to finish the deal quickly and more effectively is a smart decision. If you are still considering whether you should hire an agent or not, the following infographic will show you the benefits of buying a home with an agent:

Business Insider asked real-estate agents across the U.S., and they point out 11 reason that prevent your home from being sold.

Home buyers or sellers normally face many difficulties and obstacles that need time and effort to overcome. To save time, avoid risks and make the purchase faster and smoother, most people hire real estate agents for effective advice and assistance.

Selling home with help from a real estate agent is the ultimate option of many home sellers to promote a fast, smooth sale with a higher price. The following infographic shows the specific benefits you could get when you sell your home with an agent.

A gameplay trailer for a Prince of Persia reboot, called Prince of Persia: Redemption, was posted on YouTube in March 2012 and was discovered this week. 

The LinkedIn profile for the former Ubisoft employee Christophe Prelot revealed he worked on a cancelled Prince of Persia title from April 2010 to 2011 as a 3D level artist. The game was in development for the PlayStation 3, Xbox 360 and Windows PC. 

Ubisoft assistant technical director Marc-Andre Belleau in 2018 left a comment on the video asking, "Where did you get that?!"

View the video below:

Thanks ResetEra.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443408/footage-of-cancelled-prince-of-persia-redemption-from-2012-discovered/

City of Windsor payouts on personal injury and property damage claims totaled $2.1 million in 2019, the lowest number in eight years. The total — for settlements as well as court decisions — was well below the $3 million budgeted for the hundreds of claims made each year against the city for everything from trip-and-falls, […]

An AI based on deepfake technology can translate videos of a person speaking in one language into another. In future, it could help people who don’t speak the same language communicate

An AI search engine takes one-tenth of a second to search more than 2 billion satellite images, identifying natural or built features that look alike, such as forests or military bases

An image-editing program designed by researchers at Abode uses AI to let you quickly transform the shape of objects in images and change the lighting

Telling Lies is a game where you sift through video calls to solve a mystery. Half the time you don't know what you should be doing, but that's part of the fun, says Jacob Aron

Don't analyse them too closely, they didn't have HD in the 1970s.

The hacker in question hasn't even graduated high school yet.

Only the best images are used to create a mosaic of the entire planet, resulting in a super-crisp, high-definition view.

A South Dakota teenager has admitted to slaying a 16-year-old girl who “ran away” from home to live with him after they met on an online dating website, authorities said.

Michael Campbell, 17, pleaded guilty to first-degree manslaughter on Thursday for the death of Shayna Ritthaler, a 16-year-old from Moorcroft, Wyoming, who was reported missing from a local coffee shop on Oct. 3. Less than a week later, her body was found in the basement bedroom of Campbell’s home.

“We got into an argument and then I shot her,” Campbell said during a change-of-plea hearing on Thursday, before referring to the teenager as his girlfriend, according to the Associated Press. “I shot her in the head.”

Read more at The Daily Beast.

The Queen gave a 75th anniversary VE Day speech Friday night that doubled as a rallying cry against coronavirus. “Never give up, never despair, that was the message of VE Day,” she told the British people.

Second World War heroes would “recognize and admire,” the sacrifices the British were making today in the fight against coronavirus, the Queen added. It was her second major coronavirus-themed speech to the nation.

“It may seem hard that we cannot mark this special anniversary as we would wish. Instead we remember from our homes and our doorsteps. But our streets are not empty,” the Queen said, “They are filled with the love and the care that we have for each other.”

Read more at The Daily Beast.

Morningside USA was supposed to be apocalypse-proof. 

A gated, stucco fortress in the southwest corner of Missouri’s Ozark mountains, Morningside is an evangelical Christian community built to rent condos right through the end of the world.

“Where are you going to go when the world's on fire? Where are you going to go? This place is for God's people and this place, we need some farmers to move here,” Morningside’s founder, the disgraced doomsday televangelist Jim Bakker, said in a May 2018 sermon. “Did you know people from the government, from NASA, research from so many of them, they have said in their research, the safest place to live in troubled times is right here?”  

Read more at The Daily Beast.

THE CORONAVIRUS lockdown is now causing serious damage to the UK's economy, Tory MP Steve Baker has warned - stressing he was now "gravely concerned" at the situation

STATE pension age is continually being reviewed and altered by the government. The latest change occurred earlier this week.

A group of astronomers has called for legal action to stop the launch of thousands of satellites designed by companies like SpaceX and OneWeb to beam high-speed internet around the world

There’s nothing like crash-landing on an alien planet. Journey to the Savage Planet doesn't always get it right, but it has echoes of classic Metroid Prime, says Jacob Aron

There is something deeply unsettling about the lionization of Andrew Cuomo and his handling of the epidemic, especially in the light of the raw statistics

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