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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Frequent traffic snarls pose hardship to motorists in Tiruchi

It is common to see vehicles lining up for a long distance from the traffic signal near Cauvery bridge to Anna Statue.




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547: WordPress and GraphQL with Jason Bahl

Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more.




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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569: Apple’s Web Apps, Meta Quest and Vision Pro, and Missing Sticky Headers

How do you point out things in a UI? Are Arc Boosts the end of the web? What do you think of VR and AR / Vision Pro and Meta Quest? And what do you do when the sticky header goes missing?




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572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




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588: Elliott Marquez on Web Components and Lit

Elliot Marquez talks with us about the history of Polymer and Lit, why you should pick Lit, working with web components, the shadow dom, managing state, and how Material design is built with web components.




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638: Q&A About Copyright, Jekyll, Joomla, Statamic, and More!

Dave's designing a new tshirt, questions for lawyers about copyrights for code projects, what does the copyright in the footer actually do, what do Dave and Chris require for personal web projects, does Jekyll get updated anymore, the Bob from Hell UX pattern, viewing ads on CNN, what about Joomla or Statamic, and how do paid fonts on the web work?




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Improve quality of indoor air

Outdoor air pollutants are impacting the indoor environment and builders have to take remedial measures, says M.A. Siraj




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Here comes the squeeze

While a dip in prices can be good news for home buyers, there is always a risk in investing too early.




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Building digital trust with quantum tech

QNu Labs devises qubit-powered solutions for the ‘trillion-dollar cyber-attack problem’ 




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Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill

The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024




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Delhi enveloped in toxic haze, AQI in severe zone in some areas

Data from the CPCB's Sameer app, which provides hourly AQI updates, showed that out of the 38 monitoring stations, 13 were in the severe category with readings above 400




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Chairman of Waqf Bill committee taking unilateral decisions, Opposition MPs tell Speaker

Will continue to attend JPC meetings, says Opposition after submitting memorandum to Birla




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Air quality 'very poor' in Delhi

Delhi’s air quality remains “very poor” with some areas in the “severe” category, despite a slight improvement




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Delhi's air quality remains 'very poor', AQI at 367

The minimum temperature in Delhi was recorded at 18.0 degrees Celsius, 3.7 notches warmer than usual.




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Leaves taken by doctors during RG Kar protest to be adjusted against their official quota: AIIMS Delhi




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Delhi's air quality remains 'very poor' on November 8

Meanwhile, a thick layer of morning mist and smog blanketed the city as the minimum temperature dropped to 18.1 degrees Celsius, 3.8 degrees above normal; AQI stood at 387




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Delhi’s air quality remains ‘very poor’, layer of smog over city for ninth day post-Diwali

Delhi’s air quality reaches severe levels, blamed on stubble-burning, Diwali fireworks, and low wind speed




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Delhi air quality ‘very poor’ on November 10

The National Capital wakes up to toxic air with AQI at 334, ‘very poor’ air quality due to stubble-burning, Diwali fireworks, and low wind speed




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Delhi’s air quality ‘very poor’ to ‘severe’ on November 11

Delhi’s air quality persists in the ‘very poor’ category more than a week post-Deepavali




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BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife




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Can India arrest income inequality?

Thomas Piketty’s prescriptions are too radical. Dattopant Thengadi’s vision is more useful for us




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With Alyque on your mind 

The book has some of Alyque’s craziest ideas but it ends up falling between a bunch of stools 




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International conference to recommend policies to address gender inequality at farms

“The conference aims to promote the sharing of cutting-edge knowledge on gender and inclusion in agri-food systems.”




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Study unravels the recipe that gives mushk budiji rice its unique aroma

Researchers say the rice variety’s export potential can be maximised by cultivating it in places where its flavour compounds are expressed the most




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Chittoor farmers worried about frequent crop-raiding by jumbos

A herd of 16 elephants raided the paddy and tomato fields at Irikipenta village of Somala mandal on Saturday




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More aquatic animals were farmed than fished in 2022, for the first time ever

The total amount of aquatic animals captured in the wild fell to 91 million tonnes and the global production rose to 94.4 million in 2022, the FAO said




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Paddy MSP up 5.35% to ₹2,300 per quintal as Cabinet clears MSP hikes for 14 kharif crops

MSPs for bajra, arhar dal, maize offer highest margins above production costs; Cabinet nod for Varanasi airport expansion, new Maharashtra port, wind energy projects in Gujarat and T.N., forensic infrastructure development




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Climate-resilient agriculture is prerequisite for sustainable development, says ICAR chief

Tobacco industry contributes ₹32,516 crore annually to national economy through exports and excise tax reviews and sustains employment for 45.7 million people, says Director General of ICAR




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The certainty trap [electronic resource] : why we need to question ourselves more--and how we can judge others less / Ilana Redstone ; foreword by Joe Walsh.

Durham, North Carolina : Pitchstone Publishing, [2024]




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Observability and mathematics [electronic resource] : Quantum Yang-Mills theory and modelling / Boris Khots.




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Net profit nearly doubles in Q4




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GlaxoSmithKline Pharma March quarter net at Rs. 106 cr.




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Aditya Birla Fashion to acquire Forever 21 India




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Mphasis Q4 net profit declines 13% to Rs. 155 crore




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Foreign investors reduce holdings in top 200 companies in March quarter




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Shree Cement Q4 net profit surges 87%




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Blue Star Q4 net at Rs. 72 crore




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Mahindra rides on higher demand, Q4 net up 14 per cent




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Quality of farm loans by Indian banks won’t weaken: Moody’s




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Why the monsoon is a big deal for your equity portfolio

Is the idea of a dry monsoon beginning to parch your appetite for investing?




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Jabong sales up 14% in March quarter




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E-commerce soaks up 2 m sqft of warehouse realty in 2015




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India will outperform global equity markets: Morgan Stanley




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Startup Grex gets new CEO after founders squabble




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Rupee drops to lowest value ever against U.S. dollar due to equity outflows, oil prices

The currency's decline past the 84 handle is significant as the RBI had been defending that level.




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FPIs take out ₹58,711 crore from equities in October on geopolitical crisis, strong Chinese stocks

The outflow came following a nine-month high investment of ₹57,724 crore in September