U.S. President Donald Trump on Thursday described a valet of his reportedly testing positive for the coronavirus as "one of those things" and said that he and Vice President Mike Pence have since been tested and they are both negative.

A U.S. federal judge dismissed a lawsuit brought by former "Empire" actor Jussie Smollett who accused the city of Chicago of malicious prosecution in concluding that his claim to having been the victim of a racist and homophobic beating was a hoax.

The United States' Federal Aviation Administration (FAA) is investigating an incident in which actor Harrison Ford was piloting a small plane that wrongly crossed a runway where another aircraft was landing, U.S. media reported late on Wednesday citing an FAA statement.

Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Disease, says all of the Zika infections in the United States were contracted outside the country. Rough Cut (no reporter narration)

A European coalition is forming around an approach to using smartphone technology to trace coronavirus infections which, it's hoped, will enable borders to reopen. Joe Davies reports.

Some dogs and cats may be passing gut microbes to their owners that withstand last-resort antibiotics, which can be needed to fight off pneumonia from a coronavirus infection

Covid-19 contact tracers are part healthcare worker, part detective and part call centre operative. But what is the job really like? New Scientist spoke to one in Ireland to find out

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app

We are already seeing the pandemic's effects on mental health, and we need to act urgently to avoid a full-blown crisis, says Sam Howells  

The UK government has refused to say how many covid-19 contact tracers it has employed, with less than three weeks to go until its target of recruiting 18,000 of them by mid-May

Vampire bats are social creatures that build relationships through grooming and food-sharing, but when they feel ill, they self-isolate and call out for contact far less

The UK government will begin trials of its coronavirus contact-tracing app this week, but what impact it will have on slowing the spread of covid-19 is unclear

Our best mathematical theory of consciousness is sparking a rethink of one of science’s hardest problems – how simple matter gives rise to a complex mind

U.S. President Donald Trump on Thursday described a valet of his reportedly testing positive for the coronavirus as "one of those things" and said that he and Vice President Mike Pence have since been tested and they are both negative.

U.S. President Donald Trump on Thursday said it's "one of those things" after he learned that a White House valet tested positive for the coronavirus, noting contact with that person was limited. Gavino Garay has more.

Title: Common Treatment May Not Help Seniors With Underactive Thyroid
Category: Health News
Created: 5/4/2020 12:00:00 AM
Last Editorial Review: 5/5/2020 12:00:00 AM

Title: 'Healthy Bones' Shot Could Cut Women's Fracture Risk
Category: Health News
Created: 5/3/2007 2:00:00 AM
Last Editorial Review: 5/3/2007 12:00:00 AM

Title: Health Tip: Risk Factors for Gestational Diabetes
Category: Health News
Created: 5/2/2008 2:00:00 AM
Last Editorial Review: 5/2/2008 12:00:00 AM

Title: Cancer Drug Seems to Work by Activating Virus
Category: Health News
Created: 4/23/2010 2:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Many in U.S. Have at Least 1 Heart Risk Factor
Category: Health News
Created: 4/27/2010 10:36:00 AM
Last Editorial Review: 4/27/2010 10:36:05 AM

Title: What Are the Riskiest Food-Bacteria Combos?
Category: Health News
Created: 4/29/2011 11:00:00 AM
Last Editorial Review: 4/29/2011 12:00:00 AM

Title: Health Tip: Reducing Your Risk of Stress Fractures
Category: Health News
Created: 4/29/2014 7:35:00 AM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: Doctor Salaries and Job Satisfaction: New Survey
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

Title: Beijing Olympics Study Hints at Smog's Impact on Birth Weights
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: ER Practices Key to Helping Those Addicted to Painkillers: Study
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Title: Health Tip: Spotting Signs of Urinary Tract Infection
Category: Health News
Created: 5/1/2015 12:00:00 AM
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Title: More Active Kids Could Save U.S. Billions in Health Costs: Study
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM

Title: Sleeping Pills Boost Danger of Falls, Fractures in Older Users
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Created: 5/2/2017 12:00:00 AM
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Title: Health Tip: Get Active
Category: Health News
Created: 5/1/2018 12:00:00 AM
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Title: Caterpillar Invasion in London Puts People at Risk of Deadly Allergic Reactions
Category: Health News
Created: 4/30/2018 12:00:00 AM
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Title: Skin's 'Good' Bacteria May Be Promising Weapon Against Eczema
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Created: 5/3/2018 12:00:00 AM
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Title: Vaginal Bacteria Could Help Predict Risk of Premature Birth: Study
Category: Health News
Created: 4/8/2020 12:00:00 AM
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Title: Many Seniors Think They See Better Than They Actually Do
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Title: FDA OKs Farxiga for Heart Failure With Reduced Ejection Fraction
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Title: Bacteria May Be a Player in Diabetes Among Very Obese
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Title: Obesity Is Biggest Type 2 Diabetes Risk Factor
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Title: Laser Process May Kill Bacteria on Metal Surfaces
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Title: Pneumonia More Deadly Than Hip Fractures for Hospitalized Seniors
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Title: Vitamin D Might Aid Seniors' Recovery From Hip Fracture: Study
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Title: Active Older Vets More Likely to Fall, But Less Likely to Get Hurt: Study
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Title: Lasix Side Effects, Warnings, and Drug Interactions
Category: Medications
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Title: Promacta (eltrombopag)
Category: Medications
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Title: High Testosterone Levels Have Different Health Impact for Men and Women
Category: Health News
Created: 2/10/2020 12:00:00 AM
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Title: Bacterial Blood Infections Tied to Heightened Colon Cancer Risk
Category: Health News
Created: 4/22/2020 12:00:00 AM
Last Editorial Review: 4/23/2020 12:00:00 AM

There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor–targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase II processivity as an approach to improve the activity and limit the toxicity of the EWS-FLI1–targeted small molecule, mithramycin, for Ewing sarcoma. The clinical activity of mithramycin for Ewing sarcoma is limited by off-target liver toxicity that restricts the serum concentration to levels insufficient to inhibit EWS-FLI1. In this study, we perform an siRNA screen of the druggable genome followed by a matrix drug screen to identify mithramycin potentiators and a synergistic "class" effect with cyclin-dependent kinase 9 (CDK9) inhibitors. These CDK9 inhibitors enhanced the mithramycin-mediated suppression of the EWS-FLI1 transcriptional program leading to a shift in the IC₅₀ and striking regressions of Ewing sarcoma xenografts. To determine whether these compounds may also be liver protective, we performed a qPCR screen of all known liver toxicity genes in HepG2 cells to identify mithramycin-driven transcriptional changes that contribute to the liver toxicity. Mithramycin induces expression of the BTG2 gene in HepG2 but not Ewing sarcoma cells, which leads to a liver-specific accumulation of reactive oxygen species (ROS). siRNA silencing of BTG2 rescues the induction of ROS and the cytotoxicity of mithramycin in these cells. Furthermore, CDK9 inhibition blocked the induction of BTG2 to limit cytotoxicity in HepG2, but not Ewing sarcoma cells. These studies provide the basis for a synergistic and less toxic EWS-FLI1–targeted combination therapy for Ewing sarcoma.

2-fluorofucose (2FF) inhibits protein and cellular fucosylation. Afucosylation of IgG antibodies enhances antibody-dependent cell-mediated cytotoxicity by modulating antibody affinity for FcRIIIa, which can impact secondary T-cell activation. Immune responses toward most common solid tumors are dominated by a humoral immune response rather than the presence of tumor-infiltrating cytotoxic T cells. IgG antibodies directed against numerous tumor-associated proteins are found in the sera of both patients with breast cancer and transgenic mice bearing mammary cancer. We questioned whether 2FF would have antitumor activity in two genetically distinct transgenic models; TgMMTV-neu (luminal B) and C3(1)-Tag (basal) mammary cancer. 2FF treatment significantly improved overall survival. The TgMMTV-neu doubled survival time compared with controls [P < 0.0001; HR, 7.04; 95% confidence interval (CI), 3.31–15.0], and survival was significantly improved in C3(1)-Tag (P = 0.0013; HR, 3.36; 95% CI, 1.58–7.14). 2FF treated mice, not controls, developed delayed-type hypersensitivity and T-cell responses specific for syngeneic tumor lysates (P < 0.0001). Serum IgG from 2FF-treated mice enhanced tumor lysis more efficiently than control sera (P = 0.004). Administration of 2FF for prophylaxis, at two different doses, significantly delayed tumor onset in both TgMMTV-neu; 20 mmol/L (P = 0.0004; HR, 3.55; 95% CI, 1.60–7.88) and 50 mmol/L (P = 0.0002; HR: 3.89; 95% CI, 1.71–8.86) and C3(1)-Tag; 20 mmol/L (P = 0.0020; HR, 2.51; 95% CI, 1.22–5.18), and 50 mmol/L (P = 0.0012; HR, 3.36; 95% CI, 1.57–7.18). Mammary cancer was prevented in 33% of TgMMTV-neu and 26% of C3(1)-Tag. 2FF has potent antitumor effects in mammary cancer models. The agent shows preclinical efficacy for both cancer treatment and prevention.

Dental students’ ability to critique team performance in dental school team clinics is a key component of dental education. The aim of this study was to determine if students’ perceptions of their team leaders’ openness of communication, cooperative decision making, and well-defined goals were positively related to the students’ improvement-oriented voice behavior and willingness to raise concerns in the clinical environment. This study used a voluntary 12-question survey, distributed via email to all 311 students at the University of Nevada, Las Vegas School of Dental Medicine after completion of the spring 2017 semester. Eighty-seven students responded, for a response rate of 28%. Responses were stratified by team, class year, and gender, and the quantitative distribution of answers to each question was correlated with each other. Team leader collaborative qualities, which included openness for communication, cooperative decision making, and well-defined goals, were found to have a significant positive relationship with students’ willingness to both raise concerns and make suggestions. Additionally, when measured by class year and gender, team differences in voice behavior assessment by students across the teams were found to be independent of class year, and no significant differences were found by gender. These results suggested that, to maintain high levels of communication, proper reporting of concerns, and a high standard of care, dental schools should encourage team leaders to enhance their capacity to present active collaborative behaviors in the school’s clinic. The study also highlighted potential opportunities for further study of faculty traits and development in the dental school team model.

The aim of this cross-sectional study was to examine the faculty mentoring practices in seven dental schools in the U.S. A 34-item survey was administered electronically to dental faculty members of all ranks, tracks, and job categories in seven dental schools using faculty listservs. Survey questions addressed current mentoring practices in which the faculty members were involved; their perceptions of those mentoring practices; their perceived characteristics of an ideal mentoring program, mentor, and mentee; perceived best practices; and respondents’ demographics. The survey was conducted from October 2017 to February 2018. A total of 154 surveys were completed (response rate 22%). Over 58% (90/154) of the respondents reported receiving no mentoring; 31.9% (49/154) said they received informal mentoring; and 9.7% (15/154) received formal mentoring. Of the 64 respondents who received mentoring, both formal and informal, 92.2% (59/64) were full-time faculty, and 7.8% (5/64) were part-time faculty (p=0.001). Approximately 39% of the respondents indicated that their mentoring program was not overseen by anyone and that participation was voluntary. The top three perceived benefits of mentoring were increased overall professional development, development of a career plan, and increased professional networks. The three most important characteristics of an ideal mentoring program for the respondents were a program based on the needs of the mentee, a mentor who has the desire to help the mentee, and a mentee who is eager to learn. The results of this study showed a very low level of formal or informal faculty mentoring programs in the dental schools surveyed. Future studies are needed to determine best practices and strategies to expand and enhance mentoring of faculty members.

Despite advances in oral health care, inequalities in oral health outcomes persist due to problems in access. With proper training, primary care providers can mitigate this inequality by providing oral health education, screening, and referral to advanced dental treatment. Diverging sets of oral health competencies and guidelines have been released or endorsed by multiple primary care disciplines. The aim of this study was to transform multiple sets of competencies into Entrustable Professional Activities (EPAs) for oral health integration into primary care training. A scoping review of the literature between January 2000 and December 2016 was conducted according to PRISMA methodology to identify all existing sets of competencies. The following primary care disciplines were included in the search: allopathic/osteopathic medical schools and residency programs in family medicine, internal medicine, and pediatrics; physician assistant programs; and nurse practitioner programs. Competencies were compared using the Health Resources and Services Administration Integration of Oral Health and Primary Care Practice competencies as the foundational set and translated into EPAs. The resulting EPAs were tested with a reactor panel. The scoping review produced 1,466 references, of which 114 were selected for full text review. Fourteen competencies were identified as being central to the integration of oral health into primary care. These were converted to seven EPAs for oral health integration into primary care and were mapped onto Accreditation Council for Graduate Medical Education residency competency domains as well to the Association of American Medical Colleges EPAs for graduating medical students. The resulting EPAs delineate the essential, observable work required of primary care providers to ensure that oral health is treated as a critical determinant of overall health.