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Cortando en pedazos a Agag B

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Creciendo en tu fortaleza en Cristo

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Usando tu libertad A

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Usando tu libertad B

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.




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Rice Shortages, High Prices Hit Most Vulnerable

Francis Ndege isn’t sure if his customers in Africa’s largest slum can afford to keep buying rice from him. Prices for rice grown in Kenya soared a while ago because of higher fertilizer prices and a yearslong drought in the Horn of Africa that has reduced production. Cheap rice imported from India had filled the gap, feeding many of the hundreds of thousands of residents in Nairobi's Kibera slum who survive on less than $2 a day. But that is changing. The price of a 25-kilogram (55-pound) bag of rice has risen by a fifth since June. Wholesalers are yet to receive new stocks since India, the world's largest exporter of rice by far, said last month that it would ban some rice shipments. It's an effort by the world’s most populous nation to control domestic prices ahead of a key election year — but it’s left a yawning gap of around 9.5 million metric tons (10.4 tons) of rice that people around the world need, roughly a fifth of global exports. “I’m really hoping the imports keep coming,” said Ndege, 51, who's sold rice for 30 years. He isn’t the only one. Global food security is already under threat since Russia halted an agreement allowing Ukraine to export wheat and the El Nino weather phenomenon hampers rice production. Now, rice prices are soaring — Vietnam’s rice export prices, for instance, have reached a 15-year high — putting the most vulnerable people in some of the poorest nations at risk. The world is at an “inflection point," said Beau Damen, a natural resources officer with the U.N. Food and Agriculture Organization based in Bangkok. Even before India’s restrictions, countries already were frantically buying rice in anticipation of scarcity later when the El Nino hit, creating a supply crunch and spiking prices. What could make the situation worse is if India’s ban on non-basmati rice creates a domino effect, with other countries following suit. Already, the United Arab Emirates has suspended rice exports to maintain its domestic stocks. Another threat is if extreme weather damages rice crops in other countries. An El Nino is a natural, temporary and occasional warming of part of the Pacific Ocean that shifts global weather patterns, and climate change is making them stronger. Scientists expect the one underway to expand to supersized levels, and, in the past, they have resulted in extreme weather ranging from drought to flooding. The impact would be felt worldwide. Rice consumption in Africa has been growing steadily, and most countries are heavily dependent on imports. While nations with growing populations like Senegal have been trying to grow more of their own rice — many are struggling. Amadou Khan, a 52-year-old unemployed father of five in Dakar, says his children eat rice with every meal except breakfast, which they often have to skip when he's out of work. “I am just getting by — sometimes, I’ve trouble taking care of my kids,” he said. Imported rice — 70% of which comes from India — has become prohibitively expensive in Senegal, so he's eating homegrown rice that costs two-thirds as much. Senegal will turn to other trading partners like Thailand or Cambodia for imports, though the West African country is not “far from being self-sufficient" on rice, with over half of its demand grown locally, Agriculture Ministry spokesperson Mamadou Aïcha Ndiaye said. Asian countries, where 90% of the world’s rice is grown and eaten, are struggling with production. The Philippines was carefully managing water in anticipation of less rain amid the El Nino when Typhoon Doksuri battered its northern rice-producing region, damaging $32 million worth of rice crops — an estimated 22% of its annual production. The archipelago nation is the second-largest importer of rice after China, and President Ferdinand Marcos Jr. has underscored the need to ensure adequate buffers. India’s rice restrictions also were motivated by erratic weather: An uneven monsoon along with a looming El Nino meant that the partial ban was needed to stop food prices from rising, Indian food policy expert Devinder Sharma said. The restrictions will take offline nearly half the country's usual rice exports this year, said Ashok Gulati of the Indian Council for Research on International Economic Relation. Repeated restrictions make India an unreliable exporter, he added. “That’s not good for the export business because it takes years to develop these markets,” Gulati said. Vietnam, another major rice exporter, is hoping to capitalize. With rice export prices at a 15-year high and expectations that annual production to be marginally higher than last year, the Southeast Asian nation is trying to keep domestic prices stable while boosting exports. The Agriculture Ministry says it's working to increase how much land in the Mekong Delta is dedicated to growing rice by around 500 square kilometers — an area larger than 90,000 football fields. Already the Philippines is in talks with Vietnam to try to get the grain at lower prices, while Vietnam also looks to target the United Kingdom, which receives much of its rice from India. But exporters like Charoen Laothamatas in neighboring Thailand are wary. The Thai government expects to ship more rice than it did last year, with its exports in the first six months of the year 15% higher than the same period of 2022. But the lack of clarity about what India will do next and concerns about the El Nino means Thai exporters are reluctant to take orders, mill operators are unwilling to sell and farmers have increased the prices of unmilled rice, said Laothamatas, president of the Thai Rice Exporters Association. With prices fluctuating, exporters don't know what prices to quote — because prices may spike again the next day. “And no one wants to take the risk,” Laothamatas said.




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Uncertainty is the winner and incumbents the losers so far in a year of high-stakes global elections

LONDON — Discontented, economically squeezed voters have turned against sitting governments on both right and left during many of the dozens of elections held this year, as global power blocs shift and political certainties crumble. From India to South Africa to Britain, voters dealt blows to long-governing parties. Elections to the European Parliament showed growing support for the continent's far right, while France's centrist president scrambled to fend off a similar surge at home. If there’s a global trend, Eurasia Group president Ian Bremmer said at a summit in Canada in June, it’s that “people are tired of the incumbents.” More than 40 countries have held elections already this year. More uncertainty awaits — nations home to over half the world’s population are going to the polls in 2024. The world is already anxiously turning to November’s presidential election in the U.S., where an acrimonious campaign was dealt a shocking blow by an assassination attempt against Republican nominee and former president, Donald Trump. Unpopular incumbents Aftershocks from the COVID-19 pandemic, conflicts in Africa, Europe and the Middle East, and spiking prices for food and fuel have left dissatisfied voters eager for change. “Voters really, really don’t like inflation,” said Rob Ford, professor of political science at the University of Manchester. “And they punish governments that deliver it, whether they are at fault or not.” Inflation and unemployment are rising in India, the world’s largest democracy, where Prime Minister Narendra Modi’s Hindu nationalist Bharatiya Janata Party unexpectedly lost its parliamentary majority after a decade of dominance. Modi was forced to rely on coalition partners to govern as the opposition doubled its strength in parliament. In South Africa, sky-high rates of unemployment and inequality helped drive a dramatic loss of support for the African National Congress, which had governed ever since the end of the apartheid system of white minority rule in 1994. The party once led by Nelson Mandela lost its parliamentary majority for the first time and was forced to enter a coalition with opposition parties. In Britain, the center-left Labour Party won election in a landslide, ousting the Conservatives after 14 years. As in so many countries, Prime Minister Keir Starmer faces a jaded electorate that wants lower prices and better public services — but is deeply skeptical of politicians’ ability to deliver change. US-China tensions Caught between world powers China and the United States, Taiwan held one of the year's most significant elections. Lai Ching-te, of the Democratic Progressive Party, won a presidential election that was seen as a referendum on the island’s relationship with China, which claims Taiwan as its own. Beijing regards Lai as a separatist and ramped up military pressure with drills in the Taiwan Strait. Lai has promised to strengthen the defenses of the self-governing island, and the U.S. has pledged to help it defend itself, heightening tensions in one of the world’s flashpoints. In Bangladesh, an important partner of the U.S. that has drawn closer to China, Prime Minister Sheikh Hasina won a fourth successive term in an election that opposition parties boycotted. The U.S. and U.K. said the vote was not credible, free or fair. Political dynasties In several countries, family ties helped secure or cement power. Pakistan held messy parliamentary elections – under the eye of the country’s powerful military — that saw well-established political figures vie to become prime minister. The winner, atop a coalition government, was Prime Minister Shehbaz Sharif, younger brother of three-time premier Nawaz Sharif. Opponents say the election was rigged in his favor, with opponent and former prime minister, Imran Khan, imprisoned and blocked from running. The situation remains unstable, with Pakistan’s Supreme Court ruling that Khan’s party was improperly denied some seats. In Indonesia, Southeast Asia’s largest democracy, former Defense Minister Prabowo Subianto was officially declared president more than two months after an election in which he won over 58% of the vote. His two losing rivals alleged fraud and nepotism — Subianto’s vice president-elect is outgoing leader Joko Widodo’s son, and Subianto was the son-in-law of Indonesia’s late dictator, Suharto. The country’s highest court rejected their arguments. Some outcomes were predictable. Russian President Vladimir Putin was reelected to a fifth term in a preordained election that followed his relentless crackdown on dissent. Rwanda's election extended the 30-year rule of President Paul Kagame, an authoritarian leader who ran almost unopposed. Far right's uneven march The far right has gained ground in Europe as the continent experiences economic instability and an influx of migrants from troubled lands. Elections for the parliament of the 27-nation European Union shifted the bloc’s center of gravity, with the far right rocking ruling parties in France and Germany, the EU’s traditional driving forces. The EU election triggered a political earthquake in France. After his centrist, pro-business party took a pasting, President Emmanuel Macron called a risky snap parliamentary election in hope of stemming a far-right surge. The anti-immigration National Rally party won the first round, but alliances and tactical voting by the center and left knocked it down to third place in the second round and left a divided legislature. New faces, daunting challenges A presidential election tested Senegal's reputation as a stable democracy in West Africa, a region rocked by a recent spate of coups. The surprise winner was little-known opposition figure Basirou Diomaye Faye, released from prison before polling day as part of a political amnesty. Faye is Africa’s youngest elected leader, and his rise reflects widespread frustration among Senegal’s youth with the country’s direction. Senegal has made new oil and gas discoveries in recent years, but the population has yet to see any real benefit. Mexico elected Claudia Sheinbaum as the first female president in the country’s 200-year history. A protege of outgoing President Andrés Manuel López Obrador, the 61-year-old former Mexico City mayor vowed to continue in the direction set by the popular leftist leader. She faces a polarized electorate, daunting drug-related violence, an increasingly influential military and tensions over migration with the U.S. Uncertainty is the new normal On July 28, Venezuelan President Nicolás Maduro will seek to extend a decade-plus presidency marked by a complex political, social and economic crisis that has driven millions into poverty or out of the country. Opposition parties have banded together, but the ruling party has tight control over the voting process, and many doubt votes will be counted fairly. South Sudan, the world’s youngest country, is scheduled to hold its long-delayed first elections in December. That would represent a key milestone, but the vote is rife with danger and vulnerable to failure. Looming above all is the choice U.S. voters will make Nov. 5 in a tense and divided country. The July 13 shooting at a Trump rally in Pennsylvania, in which the former president was wounded and a rallygoer was killed, came as Democrats agonize over the fitness of President Joe Biden, who has resisted calls to step aside. The prospect of a second term for Trump, a protectionist wary of international entanglements, is evidence of the world’s shifting power blocs and crumbling political certainties. "The world is in the transition," said Neil Melvin, director of international security at defense think tank the Royal United Services Institute. “There are very broad processes on the way which are reshaping international order," he added. "It’s a kind of anti-globalization. It’s a growing return to the nation state and against multilateralism.”




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Mortality in the Gaza-Israel War

Following the 7 October 2023 attack on Israel by Hamas-led militants, Israel’s response has led to unprecedented high mortality levels in the Gaza Strip. The Palestinian death toll over the twelve month period is believed to be among the highest such civilian casualty rates in the 21st century. During the first seven months of the […]




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Between Harris and Trump, More Doubts Than Certainties for Latin America

Migration, trade, the defence of democracy, the confrontation with China and the collapse of multilateralism are issues that shed more doubts than certainties on Latin America’s expectations of the imminent presidential elections in the United States. Interest and tension have grown after dozens of polls and bookmakers have shown similar chances of victory for Democrat […]




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Africa’s Most Important Election is Underway

Africa has had a terrible record dealing with extreme poverty. The late Adebayo Adedeji, the legendary head of the United Nations Economic Commission for Africa (ECA), campaigned vigorously but unsuccessfully in the 1980s against the IMF and World Bank-imposed structural adjustment programmes, contending that these contributed to poverty’s increase. The continent’s economic growth plummeted rapidly […]




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Germany, Somalia Agree to Step Up Deportations

[Shabelle] Germany and Somalia are to cooperate on stepping up the deportation of migrants from the East African country.




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President Mohamud Vows to Reintegrate Somali Nationals As Germany Agrees On Deportation Plan

[Radio Dalsan] Somalia is prepared to welcome back its nationals from Germany, particularly those without legal residency, following a meeting between Somali President Hassan Sheikh Mohamud and German Chancellor Olaf Scholz on Wednesday.




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Israel’s Moves to Ban UNRWA—Signals Uncertainty for Affected Palestinians

The decision of Israel’s parliament, the Knesset, to adopt two laws that would severely limit or outright ban UNRWA has the potential to set a dangerous precedent, where countries can simply implement their own justification to ban the activity of the United Nations, even if it violates their obligations under international humanitarian law. Even with […]




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Online gambling outperforms the brick-and-mortar scene worldwide

Online gambling platforms are always open, meaning you can gamble when you feel like it




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As Forests Felled Wood Shortage Hits Villagers in Zimbabwe

Linet Makwera (28) has a baby strapped on her back as she totters barefoot, picking tiny pieces of wood on both sides of a dusty and narrow road, peering fearfully at people passing by along the road in Chimanimani’s Mutambara area in Gonzoma village located in Zimbabwe’s Manicaland Province, east of the country. Her fears, […]




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2024 Asian Regional Forum on Investment Management of Foreign Exchange Reserves - Roberta Casali

Opening remarks by Roberta Casali, ADB Vice-President for Finance and Risk Management, at the 2024 Asian Regional Forum on Investment Management of Foreign Exchange Reserves, 25 September 2024, Japan




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Trump on Day 1: Begin deportation push, pardon Jan. 6 rioters and make his criminal cases vanish

Donald Trump has said he wouldn’t be a dictator — “except for Day 1.” According to his own statements, he’s got a lot to do on that first day in the White House.






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Broncos OLB Nik Bonitto has transformed into pass rushing star in Year 3: “He’s certainly made the leap”

Nik Bonitto's production has steadily increased since being taken in the second round out of Oklahoma in the 2022 draft by the Denver Broncos.




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Five of the most important International Space Station experiments

From artificial retinas to ageing mice, here are five of the most promising results from research performed on the ISS – and what they might mean for humans on Earth and in space




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Why relaxation is as important as sleep - and six ways to do it better

We instinctively know that relaxing feels good, but we are now figuring out what it does to the brain and uncovering the best ways to unwind to maximise its benefits




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Do certain foods suppress inflammation and help you live longer?

Recent research shows that anti-inflammatory diets are not as faddish as they might sound, with the power to reduce the risk of heart attacks and some cancers




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Can we really balance our hormones by eating certain foods?

Diets that claim to control excess oestrogen or stress hormones are all the rage on Instagram and TikTok. They could be good for us, just not for the reasons claimed




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Could when you eat be as important as what you eat?

Peaks in appetite and metabolism driven by our body's inbuilt clocks mean that eating at the wrong time can have consequences for our health and waistline




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Certain quantum systems may be able to defy entropy's effects forever

A mathematical proof shows that some quantum states can resist nature’s tendency to disorder – but only under very specific conditions




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Do certain foods suppress inflammation and help you live longer?

Recent research shows that anti-inflammatory diets are not as faddish as they might sound, with the power to reduce the risk of heart attacks and some cancers




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Can we really balance our hormones by eating certain foods?

Diets that claim to control excess oestrogen or stress hormones are all the rage on Instagram and TikTok. They could be good for us, just not for the reasons claimed




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Could when you eat be as important as what you eat?

Peaks in appetite and metabolism driven by our body's inbuilt clocks mean that eating at the wrong time can have consequences for our health and waistline




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Can Certain Foods Affect Your Thyroid?

Title: Can Certain Foods Affect Your Thyroid?
Category: Health and Living
Created: 6/2/2022 12:00:00 AM
Last Editorial Review: 6/2/2022 12:00:00 AM




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Do Certain Foods Affect Your Thyroid?

Title: Do Certain Foods Affect Your Thyroid?
Category: Health and Living
Created: 6/24/2022 12:00:00 AM
Last Editorial Review: 6/24/2022 12:00:00 AM




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Alcohol May Raise Risk for Certain Breast Cancers

Title: Alcohol May Raise Risk for Certain Breast Cancers
Category: Health News
Created: 8/23/2010 6:10:00 PM
Last Editorial Review: 8/24/2010 12:00:00 AM




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Survival Rates Better for Certain Heart Transplant Patients

Title: Survival Rates Better for Certain Heart Transplant Patients
Category: Health News
Created: 8/24/2010 6:10:00 PM
Last Editorial Review: 8/25/2010 12:00:00 AM




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Pump Placed in Aorta Doesn't Improve Angioplasty Outcomes: Study

Title: Pump Placed in Aorta Doesn't Improve Angioplasty Outcomes: Study
Category: Health News
Created: 8/24/2010 4:10:00 PM
Last Editorial Review: 8/25/2010 12:00:00 AM




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New Drug Approved for Lack of Certain White Blood Cells

Title: New Drug Approved for Lack of Certain White Blood Cells
Category: Health News
Created: 8/30/2012 2:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM




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Study Questions Value of Certain Knee Surgeries

Title: Study Questions Value of Certain Knee Surgeries
Category: Health News
Created: 8/25/2014 12:36:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM




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Early Virus Raises Asthma Risk in Certain Kids: Study

Title: Early Virus Raises Asthma Risk in Certain Kids: Study
Category: Health News
Created: 8/26/2016 12:00:00 AM
Last Editorial Review: 8/26/2016 12:00:00 AM




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A Little Wine & Certain Foods Could Help Keep Blood Pressure Healthy

Title: A Little Wine & Certain Foods Could Help Keep Blood Pressure Healthy
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/25/2021 12:00:00 AM




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Certain Painkillers Raise Heart Failure Risk in People With Type 2 Diabetes

Title: Certain Painkillers Raise Heart Failure Risk in People With Type 2 Diabetes
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




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Using Primary Health Care Electronic Medical Records to Predict Hospitalizations, Emergency Department Visits, and Mortality: A Systematic Review

Introduction:

High-quality primary care can reduce avoidable emergency department visits and emergency hospitalizations. The availability of electronic medical record (EMR) data and capacities for data storage and processing have created opportunities for predictive analytics. This systematic review examines studies which predict emergency department visits, hospitalizations, and mortality using EMR data from primary care.

Methods:

Six databases (Ovid MEDLINE, PubMed, Embase, EBM Reviews (Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials, Cochrane Methodology Register, Health Technology Assessment, NHS Economic Evaluation Database), Scopus, CINAHL) were searched to identify primary peer-reviewed studies in English from inception to February 5, 2020. The search was initially conducted on January 18, 2019, and updated on February 5, 2020.

Results:

A total of 9456 citations were double-reviewed, and 31 studies met the inclusion criteria. The predictive ability measured by C-statistics (ROC) of the best performing models from each study ranged from 0.57 to 0.95. Less than half of the included studies used artificial intelligence methods and only 7 (23%) were externally validated. Age, medical diagnoses, sex, medication use, and prior health service use were the most common predictor variables. Few studies discussed or examined the clinical utility of models.

Conclusions:

This review helps address critical gaps in the literature regarding the potential of primary care EMR data. Despite further work required to address bias and improve the quality and reporting of prediction models, the use of primary care EMR data for predictive analytics holds promise.




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Ensuring availability of respiratory medicines in times of European drug shortages

Extract

It is of utmost importance that medicines are available at all times for our patients. Historically, medication unavailability has typically, if not exclusively, affected low- and middle-income countries [1]. More recently however, drug shortages have also been reported in high-income European countries [2]. Drug shortages have negative health consequences for patients [3], and a profound economic impact, with the need to resort to more expensive alternatives and demands on healthcare professionals’ time to find, prescribe and dispense alternatives [4].




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Low-Field (64 mT) Portable MRI for Rapid Point-of-Care Diagnosis of Dissemination in Space in Patients Presenting with Optic Neuritis [CLINICAL PRACTICE]

BACKGROUND AND PURPOSE:

Low-field 64 mT portable brain MRI has recently shown diagnostic promise for MS. This study aimed to evaluate the utility of portable MRI (pMRI) in assessing dissemination in space (DIS) in patients presenting with optic neuritis and determine whether deploying pMRI in the MS clinic can shorten the time from symptom onset to MRI.

MATERIALS AND METHODS:

Newly diagnosed patients with optic neuritis referred to a tertiary academic MS center from July 2022 to January 2024 underwent both point-of-care pMRI and subsequent 3T conventional MRI (cMRI). Images were evaluated for periventricular (PV), juxtacortical (JC), and infratentorial (IT) lesions. DIS was determined on brain MRI per 2017 McDonald criteria. Test characteristics were computed by using cMRI as the reference. Interrater and intermodality agreement between pMRI and cMRI were evaluated by using the Cohen . Time from symptom onset to pMRI and cMRI during the study period was compared with the preceding 1.5 years before pMRI implementation by using Kruskal-Wallis with post hoc Dunn tests.

RESULTS:

Twenty patients (median age: 32.5 years [interquartile range {IQR}, 28–40]; 80% women) were included, of whom 9 (45%) and 5 (25%) had DIS on cMRI and pMRI, respectively. Median time interval between pMRI and cMRI was 7 days (IQR, 3.5–12.5). Interrater agreement was very good for PV (95%, = 0.89), and good for JC and IT lesions (90%, = 0.69 for both). Intermodality agreement was good for PV (90%, = 0.80) and JC (85%, = 0.63), and moderate for IT lesions (75%, = 0.42) and DIS (80%, = 0.58). pMRI had a sensitivity of 56% and specificity of 100% for DIS. The median time from symptom onset to pMRI was significantly shorter (8.5 days [IQR 7–12]) compared with the interval to cMRI before pMRI deployment (21 days [IQR 8–49], n = 50) and after pMRI deployment (15 days [IQR 12–29], n = 30) (both P < .01). Time from symptom onset to cMRI in those periods was not significantly different (P = .29).

CONCLUSIONS:

In patients with optic neuritis, pMRI exhibited moderate concordance, moderate sensitivity, and high specificity for DIS compared with cMRI. Its integration into the MS clinic reduced the time from symptom onset to MRI. Further studies are warranted to evaluate the role of pMRI in expediting early MS diagnosis and as an imaging tool in resource-limited settings.




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The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer [PRECISION MEDICINE IN PRACTICE]

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib treatment. Case 2 describes a 6-yr-old boy with a thalamic tumor that underwent multiple resections, with no actionable driver detected using targeted next-generation sequencing. Whole-genome and RNA-seq analysis identified an internal tandem duplication in FGFR1 and RAS pathway activation. Future management options include FGFR1 inhibitors. These cases demonstrate the importance of escalating molecular diagnostics for pediatric brain cancer, advocating for early reflexing to integrative whole-genome sequencing and transcriptomic profiling when targeted panels are uninformative. Identifying molecular drivers can significantly impact treatment decisions and improve patient outcomes.




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Healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality: a longitudinal community-based study

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.




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Can&#x2019;t prescribe, can&#x2019;t dispense: the challenge of medicine shortages




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Evaluation of the Importance of Capsule Transparency in Dry Powder Inhalation Devices [Research Briefs]

The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule (P <0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.




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[Evolutionary Biology] How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?

The strength of reproductive isolation (RI) between two or more lineages during the process of speciation can vary by the ecological conditions. However, most speciation research has been limited to studying how ecologically dependent RI varies among a handful of broadly categorized environments. Very few studies consider the variability of RI and its effects on speciation at finer scales—that is, within each environment due to spatial or temporal environmental heterogeneity. Such variation in RI across time and/or space may inhibit speciation through leaky reproductive barriers or promote speciation by facilitating reinforcement. To investigate this overlooked aspect of speciation research, we conducted a literature review of existing studies of variation in RI in the field and then conducted individual-based simulations to examine how variation in hybrid fitness across time and space affects the degree of gene flow. Our simulations indicate that the presence of variation in hybrid fitness across space and time often leads to an increase in gene flow compared to scenarios where hybrid fitness remains static. This observation can be attributed to the convex relationship between the degree of gene flow and the strength of selection on hybrids. Our simulations also show that the effect of variation in RI on facilitating gene flow is most pronounced when RI, on average, is relatively low. This finding suggests that it could serve as an important mechanism to explain why the completion of speciation is often challenging. While direct empirical evidence documenting variation in extrinsic RI is limited, we contend that it is a prevalent yet underexplored phenomenon. We support this argument by proposing common scenarios in which RI is likely to exhibit variability and thus influence the process of speciation.





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Switch Comfortably Best-Seller - Japan Hardware Estimates for October 2024

The Nintendo Switch was the best-selling console in Japan with 241,803 units sold for October 2024, according to VGChartz estimates. The Nintendo Switch has now sold an estimated 34.30 million units lifetime in Japan.

The PlayStation 5 sold an estimated 49,056 units to bring its lifetime sales to 6.12 million units. The Xbox Series X|S sold 5,862 units to bring their lifetime sales to 0.64 million units. The PlayStation 4 sold an estimated 162 units to bring its lifetime sales to 9.68 million units.

PS5 sales compared to the same month for the PS4 in 2017 are down by nearly 53,000 units, while the Xbox Series X|S compared to the same month for the Xbox One are up by over 5,000 units. PS4 sold 101,851 units for the month of October 2017 and Xbox One sales were at 563 units.

Nintendo Switch sales compared to the same month a year ago are down by 41,368 units (-14.6%). PlayStation 5 sales are down by 17,208 (-26.0%) and Xbox Series X|S sales are down by 2,294 units (-28.1%). The PlayStation 4 is down by 5,362 units (-97.1%) year-over-year.

Looking at sales month-on-month, Nintendo Switch sales are down up nearly 67,000 units, the PlayStation 5 sales are down by over 4,000 units, and Xbox Series X|S sales are up by over 2,000 units.

2024 year-to-date, the Nintendo Switch has sold an estimated 2.47 million units, the PlayStation 5 has sold 1.16 million units, and the Xbox Series X|S has sold 0.09 million units.

Monthly Sales:

Japan hardware estimates for October 2024 (Followed by lifetime sales):

  1. Switch - 241,803 (34,300,699)
  2. PlayStation 5 - 49,056 (6,121,649)
  3. Xbox Series X|S - 5,862 (636,764)
  4. PlayStation 4 - 162 (9,679,626)

Weekly Sales:

Japan October 12, 2024 hardware estimates:

  1. Switch - 55,097
  2. PlayStation 5 - 11,810
  3. Xbox Series X|S - 429
  4. PlayStation 4 - 31

Japan October 19, 2024 hardware estimates:

  1. Switch - 58,866
  2. PlayStation 5 - 11,324
  3. Xbox Series X|S - 1,612
  4. PlayStation 4 - 36

Japan October 26, 2024 hardware estimates:

  1. Switch - 67,736
  2. PlayStation 5 - 11,951
  3. Xbox Series X|S - 1,207
  4. PlayStation 4 - 40

Japan November 2, 2024 hardware estimates:

  1. Switch - 60,104
  2. PlayStation 5 - 13,971
  3. Xbox Series X|S - 2,614
  4. PlayStation 4 - 55

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463008/switch-comfortably-best-seller-japan-hardware-estimates-for-october-2024/




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