For many Welsh speakers, Eryri and Yr Wyddfa are the names they have used all along.

1. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
4. Sunita Williams explains reason behind her changed appearance in space | 'They have routine checks, dedicated surgeons' | Inshorts  Inshorts
5. Inside Sunita Williams' extended mission: What she’s doing in space  India Today

Filed under: Asia, Thailand

Not only are tourists still coming, but they've been arriving in increasing numbers in recent years, according to government data.

Continue reading Demonstrations in Thailand? No Problem, Travelers Say.

Demonstrations in Thailand? No Problem, Travelers Say. originally appeared on Gadling on Mon, 02 Dec 2013 11:26:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States, Hotels and Accommodations

• it's warm and you're not
• former mayor Bob Filner is under house arrest, so there's less of a chance you'll get harassed
• you want to ice skate outside but don't like the cold

Continue reading Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate

Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate originally appeared on Gadling on Tue, 10 Dec 2013 15:32:00 EST. Please see our terms for use of feeds.

Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks originally appeared on Gadling on Mon, 16 Dec 2013 15:07:00 EST. Please see our terms for use of feeds.

Filed under: Asia, Japan, Airlines, News

Continue reading Another Boeing 787 Dreamliner Has a Battery Problem

Another Boeing 787 Dreamliner Has a Battery Problem originally appeared on Gadling on Tue, 14 Jan 2014 14:57:00 EST. Please see our terms for use of feeds.

The 2019 MLB season feels so close now. Spring Training has begun. Players are taking the field. So it's time to rank the best of the best.

It's not rare to see former Major League sons in Major League uniforms, but is it unusual to find four in one clubhouse?

bmj;387/nov12_10/q2481/FAF1faJulia and Malcolm Donaldsondonaldson20241111.f1Malcolm Donaldson was a distinguished paediatric endocrinologist with a string of research publications to his name—but he was also happy to play second fiddle (almost literally) to his wife Julia, the celebrated author of much loved children’s books, including The Gruffalo and Room on the Broom.Malcolm, a talented musician and performer, accompanied his wife as she toured festivals, schools, and libraries in the UK and around the world. Together they performed the stories, with Malcolm acting characters ranging from an accident prone dragon to a comic cattle thief. His star role, in the words of Julia’s literary agent, was “a particularly suave fox” in The Gruffalo.Malcolm met Julia Shields when they were students at the University of Bristol and they married in 1972. Donaldson went on to work in Brighton, London, and Lyon, France, before moving back to Bristol to be a senior registrar in paediatrics. Six...

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.

Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received scant attention, unlike in primates where the glabrous skin has been the focus. The relative activation of different LTMR subtypes carries information about vibrotactile stimuli, as does the rate and temporal patterning of LTMR spikes. Rate coding depends on the probability of a spike occurring on each stimulus cycle (reliability), whereas temporal coding depends on the timing of spikes relative to the stimulus cycle (precision). Using in vivo extracellular recordings in male rats and mice of either sex, we measured the reliability and precision of LTMR responses to tactile stimuli including sustained pressure and vibration. Similar to other species, rodent LTMRs were separated into rapid-adapting (RA) or slow-adapting based on their response to sustained pressure. However, unlike the dichotomous frequency preference characteristic of RA1 and RA2/Pacinian afferents in other species, rodent RAs fell along a continuum. Fitting generalized linear models to experimental data reproduced the reliability and precision of rodent RAs. The resulting model parameters highlight key mechanistic differences across the RA spectrum; specifically, the integration window of different RAs transitions from wide to narrow as tuning preferences across the population move from low to high frequencies. Our results show that rodent RAs can support both rate and temporal coding, but their heterogeneity suggests that coactivation patterns play a greater role in population coding than for dichotomously tuned primate RAs.

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

Headlines for November 13, 2024; ACLU Attorney Lee Gelernt on How Rights Groups Are Preparing to Fight Trump’s Mass Deportations; Immigrant Activist to Biden: Close Deportation Cases Now to Take a Weapon Away from Trump; Trump Taps Fossil Fuel Ally Lee Zeldin to Head EPA, Push “Anti-Environmental Agenda”; Head of U.N. Climate Summit in Azerbaijan Caught on Tape Pushing Oil & Gas Deals

MDT trainees have an opportunity to minister and pray for healing for a lady in Lesotho.

An OM Russia worker helps a young mother and her children living in a desperate situation.

A Dutch team member shares her mission trip experience praying with a man in Siberia.

OM Russia had a great kick-off to the STM summer season by serving in a camp for children with disabilities to hear about Christ.

A Discipleship centre student from an unreached people group meets a girl with the same ethnic background and tells to her about salvation.

A woman from a least-reached group of people accepted Christ during Discipleship Centre student outreach.

From Leyte Island to Northern Cebu to Bohol Island, the Christmas season brought overwhelming joy to many who received provision and care from OM Philippines.

Young Filipinos participate in OM Philippines Alternative Learning System, a learning institution for those who have dropped out of school or failed their exams.

The OM Mozambique team builds a library in Mocuba to support and provide resources for the local community.

Through the ups and downs of starting a new team, millennial workers see fruit when they start asking the right question.

A Christian teacher shares from the Bible with her Muslim headmaster in Turkey.

A new partner ministry broadcasting Urdu-speaking programmes to 360+ million who speak it, is giving them hope for eternity.

Five years ago, seven boys were chosen to be discipled as Honest Boys in Mpulungu, Zambia. They carry the values proudly in their adult lives.

Cecilia dreamt of being able to provide a safe place for at-risk girls. In January 2016 that dream was realised in Hope House.

From trying to survive each day to leading their community in bringing development, the members of a Self Help Group are being transformed drastically.

“…to many host ministries, short-term outreaches can be a blessing or a curse,” shares OMer Ivy. “Here I would like to share some tips that help me feel less like a tour guide and more like I’m helping facilitate an exposure trip for the Kingdom.”

Long-term workers leave Arab world to transition to new opportunity working with the spiritual needs of Syrian refugees in Europe.

Five years of displacement has taken its toll on Syrian refugees living in Lebanon, but many have met Jesus and discovered eternal hope.

The OM Near East Field church planting school prepares students to cross cultural and religious boundaries.

"Although the Kurds feel they are one of the forgotten peoples of the world, they aren’t forgotten by God," an OM worker explains.

By providing holistic care and support to victims of human trafficking, OM hopes to lead them to freedom in Christ.

In January 2013, OM Norway and Norwegian Naval Training Agency agreed on internship programme for deckhands and motormen on board MV Logos Hope.

Bloody feet. Blisters. That wasn’t the expectation of eager Transform participants who left the conference in Rome to join OM Spain on a unique journey.

Michel Di Feliciantonio and three other Italian Christians spent a week in Šid, Serbia, helping refugees on their way into Europe.

A teenage boy's ankle is healed and the Good News is spread through this situation.

Since 2005, Rachel Chua (22) has been involved in TeenStreet Malaysia and she attended OCZ for the 2nd time this year. Her passion is contagious.

A man shares his story of living with HIV at an AIDS workshop aboard Logos Hope, which opened hearts for ministry to others with HIV.

During his years as a heroin addict, Muhamed wrote a song that is now a celebrated worship song in his local church.

Spending the weekend with friends, Mark and Beth quickly learn that their friends’ background does not necessarily mean they follow the practices of that religion.

Claudia Costa, from Brazil, discusses her personal journey to leadership in Europe and the unity believers share in the body of Christ.

A pastor of a small community church was about to resign when God brought new hope through the work of OM El Salvador.

Daniel Ottoson (US), who serves as a site leader at an international congregation in Finland, enjoys seeing Finns and foreigners serving and loving Jesus together.

In postmodern Finland, an international church in Helsinki preaches God’s Word as it is and challenges its congregation to ‘get into the Bible’ daily.

A team of 18 people from Guatemala recently joined forces with OM Ecuador in an outreach to the little-evangelised southern parts of Ecuador.

From a bus break down to the relentless spread of a stomach virus: nothing deterred the medical team from carrying out Gods work.