Who better to kick off a series on all things health and evidence than the exceptional and erudite Editor-in-Chief of The BMJ, Dr Fiona Godlee. In this episode, Fiona chats to Ray about the BMJ's ongoing and often controversial campaigns to change medicine - and broader society - for the better. She also looks to a future that addresses the...

Healthy self confidence has an important role in surgery, but what came first - the surgeon or the ego? In this conversation, Christopher Myers, Yemeng Lu-Myers, and Amir Ghaferi join us to talk about the (very few) surgeons who behave badly in theatre, and why that behaviour has persisted, and can be detrimental. Read their full...

From Trash to Treasure is an intensely honest account of a life powerfully redeemed and is a demonstration of the goodness of God. Lee Habbershaw's journey to recovery from sexual abuse moved me to tears - sometimes in compassion, but often in joy. The book is rich with the landmark of life events and Biblical truths which, layer by layer, led Lee into the powerful teaching and counselling ministry she operates in today. This book could change your life (page 7)

Bible. Genesis -- Criticism, interpretation, etc

Paris : V. Masson, 1867.

Goettingae : Litteris Ioann. Christ. Dieterich, Acad. Typogr, [1781]

Se vend à Paris (rue St. Jacques au dessus de la rue des Mathurins) : chez le S.r Duchange graveur ordinaire du Roy. Avec privilege du Roy, [1708?]

A Paris (rue St. Jacques audessus de la rue des Mathurins) : chez G. Duchange graveur du Roy. Avec privilege du Roy, [1708?]

London (46 Pall Mall) : Pub.d by R. Bowyer & M. Parkes, 1st Jan.y 1830.

Stochastic gradient Langevin dynamics (SGLD) is a fundamental algorithm in stochastic optimization. Recent work by Zhang et al. (2017) presents an analysis for the hitting time of SGLD for the first and second order stationary points. The proof in Zhang et al. (2017) is a two-stage procedure through bounding the Cheeger's constant, which is rather complicated and leads to loose bounds. In this paper, using intuitions from stochastic differential equations, we provide a direct analysis for the hitting times of SGLD to the first and second order stationary points. Our analysis is straightforward. It only relies on basic linear algebra and probability theory tools. Our direct analysis also leads to tighter bounds comparing to Zhang et al. (2017) and shows the explicit dependence of the hitting time on different factors, including dimensionality, smoothness, noise strength, and step size effects. Under suitable conditions, we show that the hitting time of SGLD to first-order stationary points can be dimension-independent. Moreover, we apply our analysis to study several important online estimation problems in machine learning, including linear regression, matrix factorization, and online PCA.

We study the problem of parameter estimation for a non-ergodic Gaussian Vasicek-type model defined as $dX_t=(mu+ heta X_t)dt+dG_t, tgeq0$ with unknown parameters $ heta>0$ and $muinR$, where $G$ is a Gaussian process. We provide least square-type estimators $widetilde{ heta}_T$ and $widetilde{mu}_T$ respectively for the drift parameters $ heta$ and $mu$ based on continuous-time observations ${X_t, tin[0,T]}$ as $T ightarrowinfty$.

Our aim is to derive some sufficient conditions on the driving Gaussian process $G$ in order to ensure that $widetilde{ heta}_T$ and $widetilde{mu}_T$ are strongly consistent, the limit distribution of $widetilde{ heta}_T$ is a Cauchy-type distribution and $widetilde{mu}_T$ is asymptotically normal. We apply our result to fractional Vasicek, subfractional Vasicek and bifractional Vasicek processes. In addition, this work extends the result of cite{EEO} studied in the case where $mu=0$.

Penney, Anna -- Travels.

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular

During differentiation, oligodendrocyte precursor cells (OPCs) extend a network of processes that make contact with axons and initiate myelination. Recent studies revealed that actin polymerization is required for initiation of myelination whereas actin depolymerization promotes myelin wrapping. Here, we used primary OPCs in culture isolated from neonatal rat cortices of both sexes and young male and female mice with oligodendrocyte-specific deletion of mechanistic target of rapamycin (mTOR) to demonstrate that mTOR regulates expression of specific cytoskeletal targets and actin reorganization in oligodendrocytes during developmental myelination. Loss or inhibition of mTOR reduced expression of profilin2 and ARPC3, actin polymerizing factors, and elevated levels of active cofilin, which mediates actin depolymerization. The deficits in actin polymerization were revealed in reduced phalloidin and deficits in oligodendrocyte cellular branching complexity at the peak of morphologic differentiation and a delay in initiation of myelination. We further show a critical role for mTOR in expression and localization of myelin basic protein (Mbp) mRNA and MBP protein to the cellular processes where it is necessary at the myelin membrane for axon wrapping. Mbp mRNA transport deficits were confirmed by single molecule RNA FISH. Moreover, expression of the kinesin family member 1B, an Mbp mRNA transport protein, was reduced in CC1+ cells in the mTOR cKO and in mTOR inhibited oligodendrocytes undergoing differentiation in vitro. These data support the conclusion that mTOR regulates both initiation of myelination and axon wrapping by targeting cytoskeletal reorganization and MBP localization to oligodendrocyte processes.

SIGNIFICANCE STATEMENT Myelination is essential for normal CNS development and adult axon preservation and function. The mechanistic target of rapamycin (mTOR) signaling pathway has been implicated in promoting CNS myelination; however, there is a gap in our understanding of the mechanisms by which mTOR promotes developmental myelination through regulating specific downstream targets. Here, we present evidence that mTOR promotes the initiation of myelination through regulating specific cytoskeletal targets and cellular process expansion by oligodendrocyte precursor cells as well as expression and cellular localization of myelin basic protein.

Researchers lifted the ancient Egyptian mummy out of her coffin for the first time in 100 years and, to their surprise, uncovered the ancient artworks

New research indicates that Iron Age Britons venerated brown hares and chickens long before modern Easter celebrations

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

An OM worker in Cambodia shares about how a new training she is attending is transforming the way she does ministry.

The Art Zone is a place where teens can creatively express themselves and their worship for God. For Saskia, art is a way to quiet her mind and let God speak.

The purpose of suffering may be mysterious, but the search for meaning is obligatory.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Rosario, Argentina :: Crewmembers with experience working with least-reached people share a message of unity between churches.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

An OM worker in Cambodia shares about how a new training she is attending is transforming the way she does ministry.

Peeking out our windows, we see America shriveling.

God transforms the hearts of teens from two people groups, who normally do not interact, to bring them together for worship, Bible study and friendship.

Robbie and Angela from OM in Montenegro take every opportunity to bring God's love into the lives of lonely elderly people in a care home.

A woman and her husband accept the Lord after hearing the gospel from an OM team visiting the island of Sante Marie.

Hanta, a committed young Christian from a rural village in Madagascar, learns that if she’s willing to obey God, He provides a way.

OMer Gyöngyi served around the world, then the Riverboat led her back home to Hungary.

No matter people’s struggles, the counselling ministry focuses on a right relationship with God as the beginning of the healing process.

A group of people open to the Holy Spirit's leading find an open door for ministry in Nazareth.

Slight miscommunication between OM workers in Israel leads to an unplanned chance to share the Gospel with a railway attendant.

A Bible study led by OM team members prompts a special prayer...and God answers!

Marcela (Argentina) experienced the power of God working through her while on a mission trip in Israel.

When specific medicine is not available during a medical outreach, OM Guatemala sees God miraculously provide for one mother in need.

After years of prayer and patience, God answers the missionaries of OM Guatemala and sends an English teacher to give free classes.

A group of artists brings hope and joy to destitute children and families.

What do a puppet show, a healed old man, a re-thatched house and rains in the desert have in common? Answer: The OM Africa Trek!

In spite of difficult circumstances and a change in plans, the Freedom Climbers did what they set out to do.

CNA Staff, May 8, 2020 / 07:00 am (CNA).- A new “dial-a-Mass” service enabling Catholics with no internet connection to listen to Sunday Masses is proving a success, an English bishop has said. 

Bishop Terence Drainey of Middlesbrough said that 100 people used the Mass-by-Phone service when it launched May 3.  

Public Masses were suspended in England from March 20 and churches ordered to close days later. The government has not indicated when churches will be allowed to reopen. 

The Diocese of Middlesbrough, in northern England, decided to introduce the phone line -- believed to be the first of its kind in England -- when it became clear that some Catholics were unable to follow livestream Masses because they didn’t have smartphones or Wi-Fi.

Bishop Drainey told CNA: “We’re trying to reach out to as many people as possible. But it became obvious to us that there are some people who aren’t on the internet and they are being completely missed and also wanting to somehow take part in the Mass.”

“As a result of that, talking to our communications people, we came up with this idea of having a ‘dial-a-Mass’ system.”

When Catholics call the service, they hear a brief message welcoming them to St Mary’s Cathedral in Middlesbrough. A recording of the Sunday Mass then begins. 

The Knights of St Columba Council 29 is funding the service, which the diocese believes is the first in England that doesn’t require special access codes.

Bishop Drainey said the line was part of the Church’s creative response to restrictions imposed by the government to prevent the spread of COVID-19.

“One of the things that this crisis situation has brought out is people’s imagination: how to initiate new ways of praying, new ways of getting in touch with the larger Church, participating virtually in liturgical celebrations,” he said.

He added that the service was likely to continue after the crisis passed. He recalled that an 86-year-old woman had phoned him just before the lockdown to talk about livestreamed Masses:

“I said we’re about to do it. ‘That’s fine, great,’ she said. ‘But when all this is finished, you need to continue livestreaming. People like me who can no longer get out, we long to be able to somehow be in contact with the Mass. So promise me there you'll really encourage livestreaming after this has all passed.' And I said: 'Yes, absolutely. I agree.'”

In addition to livestreaming Masses and Mass-by-Phone, the diocese is planning to hold a virtual pilgrimage to Lourdes after it was forced to postpone its regular trip to the French shrine at the end of May. The online pilgrimage will include services on Facebook as well as special prayers and reflections. 
 

OM’s new Director in Hong Kong, Sonia Yip, shares why she’s passionate about seeing young people find their place in God’s kingdom.