The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.

The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and treatment of disease.

The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof. wherein m and n each independently represent 1 or 0;R represents a hydrogen atom or an alkyl group;Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; andZ1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, orZ1 and Z2 jointly form a methylene group.

Suspension concentrate compositions are disclosed for delivering S-(+)-Abscisic acid either alone or in combination with a second plant growth regulator to crop seed prior to planting as well as for foliar, soil drench, in-furrow and sprench (foliar spray and soil drench) applications are disclosed. The compositions, when properly combined in an aqueous carrier and processed through wet milling to achieve the desired particle size, will result in stable compositions that are desirable for treating crop seeds.

An inhibitor for tobacco axillary bud growth, the inhibitor containing one or more cell division inhibitors selected from pyridine-based compounds and benzamide-based compounds. This inhibitor may further include an aliphatic alcohol having 6 to 20 carbon atoms in combination with the one or more cell division inhibitors.

Methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models can be used for determining mechanical property parameters of a sample. An exemplary method includes applying acoustic energy to a sample to apply a mechanical force to the sample, measuring a response by the sample during the application of the acoustic energy, measuring a recovery response of the sample following cessation of the application of the acoustic energy, and determining a value for at least one additional mechanical property parameter of the sample based on the response measured during application of the acoustic energy and the recovery response measured following cessation of the application of acoustic energy.

An electrostatic coating plant coats components with a coating agent that is electrically charged by high voltage device. A first operating variable of a high voltage device may be determined and compared to a limit value. A safety measure may be initiated if the comparison between the first operating variable and the limit value indicates a disturbance in the electrostatic coating plant. The limit value may be flexibly adjusted depending on the operation mode.

A sensor information acquisition section acquires angular velocity information (GX, GY, GZ) around three axes acquired by three angular velocity sensors, and acceleration information (AX, AY, AZ) in three axial directions acquired by three acceleration sensors. A posture information calculation section calculates a posture angle and position coordinates in a virtual three-dimensional space based on the angular velocity information (GX, GY, GZ) and the acceleration information (AX, AY, AZ). The posture information calculation section calculates a fixed coordinate system velocity vector based on an inertial coordinate system acceleration vector (A) obtained from the acceleration information (AX, AY, AZ), and calculates position coordinates in a virtual three-dimensional space corresponding to the fixed coordinate system velocity vector.

A system for testing a plurality of transistors on a wafer having a storage device or personal computer connected via a bus to a plurality of drivers. Each of the voltage drivers having a microcontroller adapted to receive test parameters and provide test data from a plurality of voltage drivers. By utilizing a bus structure, the personal computer can look on one bus for flags indicating test data is available from a driver and receive the data. In addition a bus may be used to provide test parameters to the drivers. In this manner, multiple drivers may be run at the same time incorporating multiple tests. When data is available it is transferred to the personal computer, for providing test parameters to a plurality of drivers, and connected via a second bus for receiving test results from the plurality of drivers.

Described herein is a system and method for detecting underutilized capacity within a storage system environment. The technique comprises collecting performance data of various storage objects within a storage system environment for various performance measures at designated time intervals. The collected performance data may be formatted and stored to a database. One or more parameters may be received specifying at least one performance measure, at least one threshold value, and/or at least one time period. The performance data for target storage objects may be analyzed according to the received parameters to determine any underutilized storage objects. A report may be generated according to the parameters listing the storage objects and address locations of any underutilized storage objects. The report may comprise various information corresponding to the underutilized storage object, such as the business units, tiers, data centers, and levels of service they are associated with.

An asset health monitoring system (AHMS) can assign a confidence indicator to some or all the services of a computing service provider. In response to drops in the confidence indicators, the AHMS can automatically initiate testing of services and/or computing assets associated with the services in order to raise confidence that a particular service and its computing assets will perform correctly. Further, the AHMS can automatically initiate remediation procedures for the particular service and/or specific computing assets that fail the confidence testing. By automatically triggering testing and/or remediation procedures, the AHMS can increase reliability of the computing service provider by preemptively identifying problems.

There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1):wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, andwherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic cation or a metal cation,

A description is given of a photoreactive polymer preparable by radical polymerization using at least one photoreactive monomer, where the photoreactive monomer has at least one radically polymerizable C—C double bond, at least one hydrophilic group selected from an ethylene glycol group and polyethylene glycol groups having at least 2 ethylene glycol units, and at least one photoreactive group, the photoreactive group being a photoenolizable carbonyl group.

The present invention relates to the use of polymeric photoinitiators based on polyalkyletherurethane backbones in the production of hydrophilic gels, in particular hydrogels. The invention relates to methods for manufacturing hydrophilic gels using said polymeric photoinitiators, and the hydrophilic gels thus obtained.

A centrifugal separator comprising: a driving portion; and a swing rotor including, a rotor body, a through-hole passing through the rotor body, pin insert grooves which are provided parallel to the through-hole so as to oppose each other and only partially penetrate the rotor body, and a bucket including, a bucket body that has a contact surface which is configured to contact the rotor body during centrifugal separation, and a cap assembly that seals the bucket body and has a swing shaft extending in a direction perpendicular to an longitudinal direction of the bucket, wherein the swing rotor is rotated when the bucket is inserted into the through-hole, to swing the bucket, and the swing shaft can be moved in the longitudinal direction of the bucket relative to the bucket body and rotated about a longitudinal central axis of the bucket.

An apparatus and method for separating a mixed flow into a higher-density component and a lower-density component is provided. The apparatus may include a casing having a fluid entrance assembly, a fluid outlet assembly, and a drain. The apparatus may also include a plurality of rotary separators disposed in the casing. Each of the plurality of rotary separators may include an inlet in fluid communication with the fluid entrance assembly, a discharge in fluid communication with the fluid outlet assembly, and an outlet passage in communication with the drain. At least one of the plurality of rotary separators may include a stationary housing and a rotatable drum disposed at least partially in the stationary housing. The stationary housing may define a slot at least partially providing the outlet passage, and the rotatable drum may be configured to centrifuge the mixed flow.

A separator includes a centrifugal drum having a vertical axis of rotation and a feed line for material to be centrifuged. A drive spindle for the centrifugal drum is rotatably mounted on a housing via a bearing, the housing being supported elastically on a machine frame. A drive device includes a motor housing and an electric motor having a stator and an armature which is aligned with the drive spindle. The drive device and the motor housing move with the drive spindle as co-vibrating units during an operation of the separator. The drive device is connected to the machine frame below the bearing at a lower axial end of the bearing via one or more joint elements.

A locking system for axially securing a rotor onto a rotatably mounted shaft. The arrangement includes a plurality of locking levers which are each pivotably mounted about axes extending perpendicularly to the shaft between a locking position and an unlocking position in planes containing the axes. The locking levers can each be automatically transferred between an unlocking position and a locking position depending on rotational speed. The locking levers are mounted on the rotor and an annular groove is provided on the shaft and engages with the locking levers in the locking position, wherein the locking levers are prestressed in the unlocking position. Advantageously, the rotor can be both installed and removed without tools by merely placing the rotor onto or removing the rotor from the shaft, in each case depending on rotational speed.

The spinning disc centrifuge rotor includes a sample holder formed from a cylindrical disc body and a cover plate that are made from a transparent material, such as polycarbonate. The disc-shaped body has two concentric or coaxial recesses defined therein. The first recess forms a cylindrical well or sample chamber for receiving a generally cylindrical rock sample. The second recess has a larger diameter than the first recess, and is shallower, forming a fluid collection area above the sample well, the second recess forming an annular ring extending around the top edge or rim of the sample well. An O-ring snugly within the outer wall of the second recess and forms a seal between the cover plate and the floor of the second recess, preventing fluid leakage. A rotor shaft extends from the bottom face of the cylindrical disc.

A centrifuge includes a rotor configured to receive sample containers; a drive shaft operatively coupled to the rotor; and a motor. The motor includes a housing; a plurality of substantially parallel fins integral with the housing, each fin having a free end spaced from the housing, wherein the free ends of the plurality of fins are disposed in a common cylindrical plane; and a plurality of substantially parallel grooves, each groove disposed between a pair of adjacent fins and having a groove depth defined by a distance between the common cylindrical plane and the housing. Wherein the plurality of grooves includes a first multitude of grooves having a common groove depth and a second multitude of grooves having a groove depth that is not the same as the common groove depth, wherein the first and second multitude of grooves are interleaved.

A separator method and apparatus that includes a rotatable drum defining an annular passageway therein, a plurality of blades coupled to the rotatable drum and located in the annular passageway, each of the plurality of blades including a leading section, a trailing section, a concave surface, and a convex surface, the concave and convex surfaces extending from the leading section to the trailing section, each of the plurality of blades disposed circumferentially adjacent to at least another one of the plurality of blades so as to define blade flowpaths therebetween, and a housing at least partially surrounding the rotatable drum and defining a fluid collection chamber fluidly communicating with the annular passageway.

A vertical centrifugal separator includes a casing, a bowl that is rotatably housed in the casing and provided to separate a solution to be processed which is supplied to an interior of the bowl into a liquid and a solid by an action of centrifugal force and discharge the liquid and the solid, and a discharge assembly that is rotatably housed in the bowl and provided to discharge the solid in the bowl. The bowl and the discharge assembly each have an engagement portion that is engaged or disengaged when the bowl and the discharge assembly are moved relative to each other in an axial direction and a position adjustment mechanism for adjusting a phase between the discharge assembly and the bowl relative to a rotation axis, for example, at a single relative position.

A separation cone (30) is mounted into the interior chamber of a centrifugal separator rotor (10), which comprises a cover (14) releasably connected to a base (16), in order to provide a frusto-conical wall subdividing the chamber into upper and lower regions. This slows the passage of fluid from the upper to the lower region, which takes place via openings (24) and/or via a gap between the inner rim (32) of the cone (30) and the axial inlet tube (12). The separation cone (30) is connected to the cover (14) by a releasable snap fit arrangement, such as by deflectable tabs (38) around the periphery of the separation cone (30) engaging into a groove (15) around the interior surface adjacent a lower edge of the cover (14). This allows there to be a predetermined sequence of servicing operations and ensures that the separation cone (30) will reliably stay with the cover (14) when the cover is removed.

The invention describes a color-developing composition that contains at least three major components: (1) a leuco dye or a combination of leuco dyes, (2) an color-developer or a combination of color-developers that can form colored complexes with the leuco dyes, and (3) a desensitizer to temporarily remove the effect of the developer so the leuco dye appears in its colorless form. An optional binder may be included so that the composition may be applied to a substrate as an ink. The ink composition may be applied to synthetic polymeric substrates and other substrates that are incorporated into absorbent articles or personal care products.

There is disclosed an indicator composition, the application thereof to substrates, and related products. The indicator composition comprises an organic solvent soluble polymer and a redox sensitive material which displays different visible properties in the oxidized and reduced forms. The organic solvent soluble polymer can be at least partially sulfonated polystyrene. The indicator composition can be dissolved in organic solvents such as acetone, ethanol and ethyl acetate to form inks which can be used in a variety of printing processes. The indicator composition can be used to detect oxidizing agents, oxygen, water, reducing agents, UV light, temperature and the passage of time.

This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

Disclosed is a humidity indicator which contains no heavy metal and has good visibility of a color change that occurs when the humidity is increased. The humidity indicator can be produced by applying an aqueous coating comprising a leuco dye, an acidic compound which is in a solid state at ambient temperature, a deliquescent substance and an aqueous resin emulsion onto a substrate such as a resin film, a nonwoven fabric or a paper, and heating and drying the resulting product.

The invention discloses an improved multistage fischer tropsch process scheme for the production of hydrocarbon fuels comprising feeding gaseous phase syngas and liquid stream hydrocarbons in a counter current manner such as herein described into the reaction vessel at a number of stages containing reaction catalysts; wherein fresh syngas enters into the stage where the product liquid stream leaves and the fresh liquid stream enters into the stage where the unreacted syngas leaves; wherein further the temperature of each stage can be controlled independently. More particularly the invention relates to improving the heat release in different reactors, product selectivity and reactor productivity of FT reactors.

Disclosed is a process for converting a reactant composition comprising H2 and CO to a product comprising at least one aliphatic hydrocarbon having at least about 5 carbon atoms, the process comprising: flowing the reactant composition through a microchannel reactor in contact with a Fischer-Tropsch catalyst to convert the reactant composition to the product, the microchannel reactor comprising a plurality of process microchannels containing the catalyst; transferring heat from the process microchannels to a heat exchanger; and removing the product from the microchannel reactor; the process producing at least about 0.5 gram of aliphatic hydrocarbon having at least about 5 carbon atoms per gram of catalyst per hour; the selectivity to methane in the product being less than about 25%. Also disclosed is a supported catalyst comprising Co, and a microchannel reactor comprising at least one process microchannel and at least one adjacent heat exchange zone.

A synthesis gas conversion process and system are disclosed. Fresh syngas from a methane reformer is used as a sweep zone gas feed which is caused to flow across a water permselective membrane in a membrane reactor. The water permselective membrane is adjacent a synthesis gas conversion reaction zone in which synthesis gas is contacted with a catalyst and converted to effluent including water. Water is removed from the reaction zone through the membrane and passes out of the reactor with the sweep zone gas. The water is then removed from the sweep zone gas forming a modified gas feed which is fed to the reaction zone. The modified gas feed has a preferred H2/CO ratio to feed into the reaction zone.

Disclosed herein is a method for determining a trajectory for a transfer of a spacecraft from a starting space body to a target space body with respect to a given central space body, wherein the determined trajectory is optimal with respect to a given space mission requirement to be met by the transfer of the spacecraft. The method comprises providing, according to the Pontryagin maximum principle, a physical-mathematical model relating model quantities and physical quantities representing the transfer of the spacecraft with respect to the given central space body.

A production simulator (2), for simulating a mature hydrocarbon field, providing quantity produced (Qφktb) per phase, per well, per layer (or group of layers) and per time as a function of production parameters (PP), wherein the production simulator (2) matches history data (HD) of the mature hydrocarbon field and verifies a Vapnik condition.

A system for intelligent monitoring and management of an electrical system is disclosed. The system includes a data acquisition component, a power analytics server and a client terminal. The data acquisition component acquires real-time data output from the electrical system. The power analytics server is comprised of a real-time energy pricing engine, virtual system modeling engine, an analytics engine, a machine learning engine and a schematic user interface creator engine. The real-time energy pricing engine generates real-time utility power pricing data. The virtual system modeling engine generates predicted data output for the electrical system. The analytics engine monitors real-time data output and predicted data output of the electrical system. The machine learning engine stores acid processes patterns observed from the real-time data output and the predicted data output to forecast an aspect of the electrical system.

The present invention aims to simulate a response more similar to a actual machine while inhibiting load increase in analog operation. Program configuration of the present invention is a component of a simulation program for circuit design, which is executed by a computer. The computer includes an operation portion, a storage portion, a manipulation portion, and a display portion, so that the computer exerts a function of a circuit design simulator, and as a macro model of an operational amplifier for use in the circuit design simulator, enabling the computer to act by simulating a response of the operational amplifier on the circuit design simulator. The macro model of the operational amplifier includes a control portion (LMT1) for generating output exception in the event of input exception or power supply exception of the operational amplifier.

The embodiments relate to modeling resistance in a multi-fin multi-gate field effect transistor (MUGFET). In these embodiments, a design for a multi-fin MUGFET comprises a gate structure with a horizontal portion traversing multiple semiconductor fins and comprising a plurality of first resistive elements connected in series, with vertical portions adjacent to opposing sides of the semiconductor fins and comprising second resistive elements connected in parallel by the horizontal portion, and with contact(s) comprising third resistive element(s). The total gate resistance is determined based on resistance contributions from the first resistive elements, the second resistive elements and the third resistive element(s), particularly, where each resistive contribution is based on a resistance value of the resistive element, a first fraction of current from the semiconductor fins entering the resistive element and a second fraction of the current from the semiconductor fins exiting the resistive element.

Disclosed are polysulfone-based materials that can be used as active and/or passive components in various electronic, optical, and optoelectronic devices, particularly, metal-oxide-semiconductor field-effect transistors. For example, various metal-oxide-semiconductor field-effect transistors can include a dielectric layer and/or a passivation layer prepared from such polysulfone-based materials and exhibit good device performance.

Embodiments of the present invention include an apparatus and method for treatment of pain by a device that provides transcutaneous electrical nerve stimulation. The device includes an applicator equipped with an electric pulse provider that sends an electric pulse to a set of electrodes disposed in an applicator head. The device is placed onto the skin of a patient's body at the point where the patient experiences pain and such that the electrodes of the device contact the skin of the patient while an insulating land area between the electrodes compresses the nerve during transmittal of the electric pulse through the electrodes and into the patient's body.

It is critical in an inductively link medical implant, such as a visual prosthesis or other neural stimulator, to adjust the external coil to a location to maximize communication between the external coil and internal coil. Converting the signal strength between the coils to a signal easily discernible by a clinician, preferably an audible tone, facilitates the adjustment of the external coil to a preferred location.

Some embodiments provide a method of providing ultrasound energy having a stable power output. The method can comprise providing ultrasound energy from a ultrasound transducer; determining a power level threshold of the ultrasound energy; monitoring a power level of the ultrasound energy over time of the ultrasound energy; communicating a power level to a controller; adjusting the frequency of the ultrasound energy upon a change in the power level; and maintaining the power level threshold of the ultrasound energy.

A skin graft applicator with a handle member and a roller member is described for use in applying a skin graft to a patient. The skin graft applicator has a manipulator pad for positioning the skin graft, and a roller member for forcing air and fluid from underneath the skin graft ensuring the proper bond between graft and tissue.

A vibratory assembly is provided that incorporates a vibratory mechanism worn by a sexual participant on one or more digits of an articulating member for the sexual exploration and stimulation of erogenous zones. A modular erogenous stimulation system including the vibratory assembly is also provided along with a kit for providing erogenous stimulation to at least one participant.

A structure for separating a discharge nozzle of an oral irrigator includes a first discharge path formed in one side of the irrigator body, a water pressure control lever rotatably arranged above the first discharge path and having a second discharge path in the other side of the irrigator body, a release button section provided on an upper portion of the water pressure control lever and into which the discharge nozzle is inserted and engaged, and configured, when pushed, to be bent so as to release the engaged discharge nozzle, and a locking section provided in the release button section and water pressure control lever to control a pushing operation of the release button section depending upon whether the first discharge path is open or blocked.

An injection molding machine includes an ejector unit configured to eject a molding product from a mold and a mold release force sensor configured to detect a force to release the molding product from the mold.

An apparatus for fabricating a semiconductor package may include a mold and a molding plate. The mold may define a mold cavity with the mold being configured to receive a circuit board in the mold cavity, and the circuit board may include a semiconductor chip mounted thereon. A molding plate may be moveable in the mold cavity with the molding plate being configured to adjust a volume of the mold cavity. Related methods are also discussed.

A burner and an improved heat recuperator for a burner. The heat recuperator has a tubular body including a plurality of fins extending radially outward from the tubular body. The plurality of fins are disposed in a plurality of segments arranged longitudinally along the tubular body with the plurality of fins in each segment being disposed about a circumference of the tubular body. Adjacent segments of fins being circumferentially offset with one another.

A torch includes a tank adapted to contain a fuel, a firebowl atop the tank defining a fill opening, and an operating device that fits over the firebowl as a snuffer. A closing device may be fitted into the fill opening. The closing device may be movable between a lowered closed position and a raised open position. The closing device defines at least one recess for receiving a portion of an operating device that moves the closing device between the open and closed positions.

Integrated polymeric-ceramic membrane-based oxy-fuel combustor. The combustor includes a polymer membrane structure for receiving air at an input and for delivering oxygen-enriched air at an outlet. An oxygen transport reactor including a ceramic ion transport membrane receives the oxygen-enriched air from the polymer membrane structure to generate oxygen for combustion with a fuel introduced into the oxygen transport reactor.

A combustor includes an end cap having an upstream surface axially separated from a downstream surface. A cap shield circumferentially surrounds the upstream and downstream surfaces, tubes extend from the upstream surface through the downstream, and a plenum is inside the end cap. A first baffle extends radially across the plenum toward the cap shield, and a plate extends radially inside the plenum between the first baffle and the upstream surface. A method for supplying fuel to a combustor includes flowing a working fluid through tubes, flowing a fuel into a plenum between upstream and downstream surfaces, radially distributing the fuel along a first baffle, and axially flowing the fuel across a plate that extends radially inside the plenum.

In a gas turbine engine that includes a compressor and a combustor, wherein the combustor includes a primary fuel injector within a fuel nozzle and a secondary fuel injector that is upstream of the fuel nozzle and configured to inject fuel into a flow annulus of the combustor, a method for detecting a flame holding condition about a fuel injector. The method may include the steps of: detecting an upstream pressure upstream of the secondary fuel injector; detecting a downstream pressure downstream of the secondary fuel injector; determining a measured pressure difference between the upstream pressure and the downstream pressure; and comparing the measured pressure difference to an expected pressure difference.

A combustor includes a casing that surrounds at least a portion of the combustor and includes an end cover at one end of the combustor. An end cap axially separated from the end cover is configured to extend radially across at least a portion of the combustor and includes an upstream surface axially separated from a downstream surface. A plurality of tubes extends from the upstream surface through the downstream surface to provide fluid communication through the end cap. A cap shield extends axially from the end cover and circumferentially surrounds and supports the end cap.