aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

aircrack-ng is a set of tools for auditing wireless networks. It's an enhanced/reborn version of aircrack. It consists of airodump (an 802.11 packet capture program), aireplay (an 802.11 packet injection program), aircrack (static WEP and WPA-PSK cracking), airdecap (decrypts WEP/WPA capture files), and some tools to handle capture files (merge, convert, etc.).

The Chinese government recently issued a whitepaper on the status and prospects of the hydrogen fuel and fuel cell sectors, indicating that energy derived from hydrogen will become an important part of the Chinese energy network.

The addition of hydropower generating capacity to an irrigation network in northern Japan is one step closer to completion. Several sites have been identified for the installation of VLH turbines, with a total capacity of 1.433 MW.

The Chinese government recently issued a whitepaper on the status and prospects of the hydrogen fuel and fuel cell sectors, indicating that energy derived from hydrogen will become an important part of the Chinese energy network.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

Vistra Energy, a Texas-based power generation firm, recently underwent a network transformation project. CISO Paul Reyes, joined by Zscaler's Dan Shelton, opens up on how to make the move to cloud-based models and what it can do to support your business.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

Vistra Energy, a Texas-based power generation firm, recently underwent a network transformation project. CISO Paul Reyes, joined by Zscaler's Dan Shelton, opens up on how to make the move to cloud-based models and what it can do to support your business.

The Bangladesh eGovernment Computer Incident Response Team, or CIRT, is taking several steps to strengthen cybersecurity, including building a sensor network to help enable all banks to share threat intelligence, says Tawhidur Rahman, CIRT's head of digital security and diplomacy.

Two chance encounters propelled remote direct memory access from a good but obscure idea for fast networks into the jet fuel for the world’s more powerful supercomputers. The lucky breaks launched the fortunes of an Israel-based startup that staked its fortunes on InfiniBand, a network based on RDMA. Later, that startup, Mellanox Technologies, helped steer Read article >

The post How RDMA Became the Fuel for Fast Networks appeared first on The Official NVIDIA Blog.

Cloud data centers are evolving to an architecture that is accelerated, disaggregated and software-defined to meet the exponential growth in AI and high performance computing. To build these modern data centers, HPC and networking hardware and software must go hand in hand. NVIDIA provides the leading accelerated computing platform. Mellanox is the high-performance networking leader, Read article >

The post Riding a Cloud: NVIDIA Acquires Network-Software Trailblazer Cumulus appeared first on The Official NVIDIA Blog.

NVIDIA is expanding its long-standing collaboration with IBM to accelerate the deployment of edge networks. Businesses are deploying these networks around the world as they switch on IoT sensors and extract real-time insights from the masses of data they generate. Today, IBM announced new solutions for edge computing including the IBM Edge Application Manager on Read article >

The post Taking Point: IBM, NVIDIA Collaborate at the Network’s Edge appeared first on The Official NVIDIA Blog.

Cloud data centers are evolving to an architecture that is accelerated, disaggregated and software-defined to meet the exponential growth in AI and high performance computing. To build these modern data centers, HPC and networking hardware and software must go hand in hand. NVIDIA provides the leading accelerated computing platform. Mellanox is the high-performance networking leader, Read article >

The post Riding a Cloud: NVIDIA Acquires Network-Software Trailblazer Cumulus appeared first on The Official NVIDIA Blog.

NVIDIA is expanding its long-standing collaboration with IBM to accelerate the deployment of edge networks. Businesses are deploying these networks around the world as they switch on IoT sensors and extract real-time insights from the masses of data they generate. Today, IBM announced new solutions for edge computing including the IBM Edge Application Manager on Read article >

The post Taking Point: IBM, NVIDIA Collaborate at the Network’s Edge appeared first on The Official NVIDIA Blog.

Background - The 2018 Periodic Review The Office of Rail and Road (“ORR”) has recently published its conclusions (the “Conclusions”) following its initial consultation in relation to the creation of the 2018 Periodic Review ...

What is the purpose of the Consultation? The Office of Rail and Road (the “ORR”) is engaged in the 2018 regulatory review of Network Rail, known as the 2018 Periodic Review or “PR18”. PR18 will determine what Network Rail mus...

Background As part of the 2018 periodic review (“PR18”) of Network Rail, the Office of Rail and Road (“ORR”) is reviewing the way in which the charges that operators pay to access the rail network are calculated. This review ...

Background The Office of Rail and Road (the “ORR”) has issued its final determination (“Final Determination”) on the regulatory review of Network Rail (“NR”), known as the 2018 Periodic Review (“PR18”)...

Background On 16 October 2019 the Department for Transport (“DfT”) issued its “Rail Network Enhancements Pipeline Update” for Autumn 2019 (the “Enhancements Pipeline Update”). A copy of the Enhancements Pipeline U...

(MENAFN - CDN Newswire) [To enable links in your articles, contact MENAFN Click here ] aims to cover market size, share, trends, and growth analysis... ......

[Shabelle] Shabelle Media Network [SMN], a privately-owned radio and TV is celebrating its 18th anniversary of existence to mark the day when the Radio first came to air on 6th May 2002 in Marka, the regional capital of Lower Shabelle region.

The Philippines’ largest broadcaster ABS-CBN was forced off the air on Tuesday, the same day Conchita Lopez Taylor turned 90.“We’re used to it,” she said in a phone interview from her home in California.“We” referred to the large Lopez clan who owns the company, which had been forced to shut once before.Taylor was a 42-year-old mother of seven when ABS-CBN’s facilities were seized in 1972 by the clan’s former political ally, then-President Ferdinand Marcos. Her husband, former ABS-CBN chairman…

French police have dismantled smuggling networks trying to take advantage of a rush to buy medical supplies including face masks to tackle the coronavirus epidemic, the interior minister said Friday.

The project’s targeted outcome was improved access to social and economic facilities in the project areas, particularly in education and health services, and transport hubs in Timor-Leste. These were to (i) rehabilitate 232 kilometers (km) of priority roads; (ii) develop and implement a new road maintenance program; (iii) improve border post facilities; and (iv) provide consulting services and technical assistance (TA) in all aspects of project development and implementation.

Microchip Delivers 50 Millionth MOST® Technology 50 Mbps Automotive Intelligent Network Interface Controller

Martha Wells's action-packed novel Network Effect puts you inside the head of a Murderbot. It raises fascinating questions you will think about for a long time, says Sally Adee

ABSTRACT

Host-associated microbial communities are shaped by extrinsic and intrinsic factors to the holobiont organism. Environmental factors and microbe-microbe interactions act simultaneously on the microbial community structure, making the microbiome dynamics challenging to predict. The coral microbiome is essential to the health of coral reefs and sensitive to environmental changes. Here, we develop a dynamic model to determine the microbial community structure associated with the surface mucus layer (SML) of corals using temperature as an extrinsic factor and microbial network as an intrinsic factor. The model was validated by comparing the predicted relative abundances of microbial taxa to the relative abundances of microbial taxa from the sample data. The SML microbiome from Pseudodiploria strigosa was collected across reef zones in Bermuda, where inner and outer reefs are exposed to distinct thermal profiles. A shotgun metagenomics approach was used to describe the taxonomic composition and the microbial network of the coral SML microbiome. By simulating the annual temperature fluctuations at each reef zone, the model output is statistically identical to the observed data. The model was further applied to six scenarios that combined different profiles of temperature and microbial network to investigate the influence of each of these two factors on the model accuracy. The SML microbiome was best predicted by model scenarios with the temperature profile that was closest to the local thermal environment, regardless of the microbial network profile. Our model shows that the SML microbiome of P. strigosa in Bermuda is primarily structured by seasonal fluctuations in temperature at a reef scale, while the microbial network is a secondary driver.

IMPORTANCE Coral microbiome dysbiosis (i.e., shifts in the microbial community structure or complete loss of microbial symbionts) caused by environmental changes is a key player in the decline of coral health worldwide. Multiple factors in the water column and the surrounding biological community influence the dynamics of the coral microbiome. However, by including only temperature as an external factor, our model proved to be successful in describing the microbial community associated with the surface mucus layer (SML) of the coral P. strigosa. The dynamic model developed and validated in this study is a potential tool to predict the coral microbiome under different temperature conditions.

ABSTRACT

Legionella pneumophila is an important cause of pneumonia. It invades alveolar macrophages and manipulates the immune response by interfering with signaling pathways and gene transcription to support its own replication. MicroRNAs (miRNAs) are critical posttranscriptional regulators of gene expression and are involved in defense against bacterial infections. Several pathogens have been shown to exploit the host miRNA machinery to their advantage. We therefore hypothesize that macrophage miRNAs exert positive or negative control over Legionella intracellular replication. We found significant regulation of 85 miRNAs in human macrophages upon L. pneumophila infection. Chromatin immunoprecipitation and sequencing revealed concordant changes of histone acetylation at the putative promoters. Interestingly, a trio of miRNAs (miR-125b, miR-221, and miR-579) was found to significantly affect intracellular L. pneumophila replication in a cooperative manner. Using proteome-analysis, we pinpointed this effect to a concerted downregulation of galectin-8 (LGALS8), DExD/H-box helicase 58 (DDX58), tumor protein P53 (TP53), and then MX dynamin-like GTPase 1 (MX1) by the three miRNAs. In summary, our results demonstrate a new miRNA-controlled immune network restricting Legionella replication in human macrophages.

IMPORTANCE Cases of Legionella pneumophila pneumonia occur worldwide, with potentially fatal outcome. When causing human disease, Legionella injects a plethora of virulence factors to reprogram macrophages to circumvent immune defense and create a replication niche. By analyzing Legionella-induced changes in miRNA expression and genomewide chromatin modifications in primary human macrophages, we identified a cell-autonomous immune network restricting Legionella growth. This network comprises three miRNAs governing expression of the cytosolic RNA receptor DDX58/RIG-I, the tumor suppressor TP53, the antibacterial effector LGALS8, and MX1, which has been described as an antiviral factor. Our findings for the first time link TP53, LGALS8, DDX58, and MX1 in one miRNA-regulated network and integrate them into a functional node in the defense against L. pneumophila.

BACKGROUND AND OBJECTIVES:

Early diagnosis of cerebral palsy (CP) is critical in obtaining evidence-based interventions when plasticity is greatest. In 2017, international guidelines for early detection of CP were published on the basis of a systematic review of evidence. Our study aim was to reduce the age at CP diagnosis throughout a network of 5 diverse US high-risk infant follow-up programs through consistent implementation of these guidelines.

The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior skeletal elements in hindlimbs. The Sall4; Plzf double knockout exhibits severe defects in the femur, tibia, and anterior digits, distinct defects compared to other allelic series of Sall4; Plzf. We found that Sall4 regulates Plzf expression prior to hindlimb outgrowth. Further expression analysis indicated that Hox10 genes and GLI3 are severely downregulated in the Sall4; Plzf double knockout hindlimb bud. In contrast, PLZF expression is reduced but detectable in Sall4; Gli3 double knockout limb buds, and SALL4 is expressed in the Plzf; Gli3 double knockout limb buds. These results indicate that Plzf, Gli3, and Hox10 genes downstream of Sall4, regulate femur and tibia development. In the autopod, we show that Sall4 negatively regulates Hedgehog signaling, which allows for development of the most anterior digit. Collectively, our study illustrates genetic systems that regulate development of the proximal-anterior skeletal elements in hindlimbs.

The Bcl-2 (B cell lymphoma 2)-related protein Nr-13 plays a major role in the regulation of cell death in developing avian B cells. With over 65% sequence similarity to the chicken Nr-13, herpesvirus of turkeys (HVT) vNr-13, encoded by the HVT079 and HVT096 genes, is the first known alphaherpesvirus-encoded Bcl-2 homolog. HVT-infected cells were reported to be relatively more resistant to serum starvation, suggested that vNr-13 could be involved in protecting the cells. Here, we describe CRISPR/Cas9-based editing of exon 1 of the HVT079 and HVT096 genes from the HVT genome to generate the mutant HVT-vNr-13 to gain insights into its functional roles. Overall, wild-type HVT and HVT-vNr-13 showed similar growth kinetics; however, at early time points, HVT-vNr-13 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2-fold-lower growth of cell-free virus. In transfected cells, HVT vNr-13 showed a mainly diffuse cytoplasmic distribution with faint nuclear staining. Further, vNr-13 localized to the mitochondria and endoplasmic reticulum (ER) and disrupted mitochondrial network morphology in the transfected cells. In the wild-type HVT-infected cells, vNr-13 expression appeared to be directly involved in the disruption of the mitochondrial network, as the mitochondrial network morphology was substantially restored in the HVT-vNr-13-infected cells. IncuCyte S3 real-time apoptosis monitoring demonstrated that vNr-13 is unequivocally involved in the apoptosis inhibition, and it is associated with an increase of PFU, especially under serum-free conditions in the later stages of the viral replication cycle. Furthermore, HVT blocks apoptosis in infected cells but activates apoptosis in noninfected bystander cells.

IMPORTANCE B cell lymphoma 2 (Bcl-2) family proteins play important roles in regulating apoptosis during homeostasis, tissue development, and infectious diseases. Several viruses encode homologs of cellular Bcl-2-proteins (vBcl-2) to inhibit apoptosis, which enable them to replicate and persist in the infected cells and to evade/modulate the immune response of the host. Herpesvirus of turkeys (HVT) is a nonpathogenic alphaherpesvirus of turkeys and chickens that is widely used as a live vaccine against Marek’s disease and as recombinant vaccine viral vectors for protecting against multiple avian diseases. Identical copies of the HVT genes HVT079 and HVT096 encode the Bcl-2 homolog vNr-13. While previous studies have identified the potential ability of vNr-13 in inhibiting apoptosis induced by serum deprivation, there have been no detailed investigations on the functions of vNr-13. Using CRISPR/Cas9-based ablation of the vNr-13 gene, we demonstrated the roles of HVT vNr-13 in early stages of the viral replication cycle, mitochondrial morphology disruption, and apoptosis inhibition in later stages of viral replication.

Tumor cells can spread to distant sites through their ability to switch between mesenchymal and amoeboid (bleb-based) migration. Because of this difference, inhibitors of metastasis must account for each migration mode. However, the role of vimentin in amoeboid migration has not been determined. Because amoeboid leader bleb–based migration (LBBM) occurs in confined spaces and vimentin is known to strongly influence cell-mechanical properties, we hypothesized that a flexible vimentin network is required for fast amoeboid migration. To this end, here we determined the precise role of the vimentin intermediate filament system in regulating the migration of amoeboid human cancer cells. Vimentin is a classic marker of epithelial-to-mesenchymal transition and is therefore an ideal target for a metastasis inhibitor. Using a previously developed polydimethylsiloxane slab–based approach to confine cells, RNAi-based vimentin silencing, vimentin overexpression, pharmacological treatments, and measurements of cell stiffness, we found that RNAi-mediated depletion of vimentin increases LBBM by ∼50% compared with control cells and that vimentin overexpression and simvastatin-induced vimentin bundling inhibit fast amoeboid migration and proliferation. Importantly, these effects were independent of changes in actomyosin contractility. Our results indicate that a flexible vimentin intermediate filament network promotes LBBM of amoeboid cancer cells in confined environments and that vimentin bundling perturbs cell-mechanical properties and inhibits the invasive properties of cancer cells.

Leukocyte recruitment is a universal feature of tissue inflammation and regulated by the interactions of chemokines with their G protein–coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CC chemokine ligand 2 (CCL2), plays a central role in recruitment of monocytes in several inflammatory diseases. In this study, we used phosphoproteomics to conduct an unbiased characterization of the signaling network resulting from CCL2 activation of CCR2. Using data-independent acquisition MS analysis, we quantified both the proteome and phosphoproteome in FlpIn-HEK293T cells stably expressing CCR2 at six time points after activation with CCL2. Differential expression analysis identified 699 significantly regulated phosphorylation sites on 441 proteins. As expected, many of these proteins are known to participate in canonical signal transduction pathways and in the regulation of actin cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activating proteins. Moreover, we identified regulated phosphorylation sites in numerous proteins that function in the nucleus, including several constituents of the nuclear pore complex. The results of this study provide an unprecedented level of detail of CCR2 signaling and identify potential targets for regulation of CCR2 function.