After a month-long vacation, Russ Collins made his return to the WEMU studio for Cinema Chat! Along with a few travel stories, Russ shared what's coming to the silver screen in the coming days with WEMU's David Fair.

Our Clients are independent and multi platinum artist(s) Seeking high quality, energetic trap, pop, & R&B style beats for production placement on upcoming releases. We are looking for industry quality production to shop throughout our network, as well as to consider signing new talent for production management opportunity. We will provide you with feedback & rate your submissions!

: Please submit your best work. Songs will go through the review process and if selected you will receive negotiated compensation. We look forward to hearing what you have to offer. 
- The Administration

Deal Type: Producer / Production Management Decision Maker: We are the final decision makers Deal Structure: Negotiable Compensation: Negotiable Song Quality: Rough Mixes, Fully Mastered, Broadcast Ready Similar Sounding Artist: Future, Migos, The Weeknd, Drake, Ty Dolla Sign, 2Chainz, Gucci Mane, Tory Lanez, Chris Brown, Cardi B, Lil Baby

Congresistas discutieron su se justifica que Colombia sea el segundo país de América Latina en gasto militar con USD $9.200 millones en el 2020.

http://www.musicxray.com/xrays/2672430 neuromaster - Shady Back in The Trap

http://www.musicxray.com/xrays/2672480 KadoMane - 17 shot talk (Trap)

http://www.musicxray.com/xrays/2672497 KadoMane - Trap Serious #

http://www.musicxray.com/xrays/2672501 KadoMane - Madd Loud (Trap)

¿Qué pasa si nos excedemos en los alimentos ultraprocesados?

Curso de milagros: un libro que contrapone el amor y el miedo.

Curso de milagros: un libro que contrapone el amor y el miedo.

La Luciérnaga se enciende para hablar de la suspensión de operaciones de la Ultra Air. Además, le contamos sobre las expectativas del turismo durante la semana santa. También, Despedimos a Maleja Villamizar.La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

En 10AM Hoy por Hoy de Caracol Radio estuvo Yesid Galvis Sánchez, Líder de la Asociación de Trapiches Paneleros de Villeta, hblando sobre el proceso de producción de este alimento.

El director de la UNGRD aclaró en 6AM que los recursos de la entidad fueron girados a varias personas, a “los lugares donde estaban sus amigos políticos”.

En 6AM habló Brigitte Anzola, colombiana que se encuentra atrapada en el Líbano, luego de irse de viaje

Well that Well, that escalated quickly.quickly.

Cybersecurity researchers have flagged a new malware campaign that infects Windows systems with a Linux virtual instance containing a backdoor capable of establishing remote access to the compromised hosts. The "intriguing" campaign, codenamed CRON#TRAP, starts with a malicious Windows shortcut (LNK) file likely distributed in the form of a ZIP archive via a phishing email. "What makes the CRON#

Ulrich Rothbauer
Feb 1, 2008; 7:282-289
Research

Jesper V. Olsen
Dec 1, 2005; 4:2010-2021
Technology

Myosins generate force and motion by precisely coordinating their mechanical and chemical cycles, but the nature and timing of this coordination remains controversial. We utilized a FRET approach to examine the kinetics of structural changes in the force-generating lever arm in myosin V. We directly compared the FRET results with single-molecule mechanical events examined by optical trapping. We introduced a mutation (S217A) in the conserved switch I region of the active site to examine how myosin couples structural changes in the actin- and nucleotide-binding regions with force generation. Specifically, S217A enhanced the maximum rate of lever arm priming (recovery stroke) while slowing ATP hydrolysis, demonstrating that it uncouples these two steps. We determined that the mutation dramatically slows both actin-induced rotation of the lever arm (power stroke) and phosphate release (≥10-fold), whereas our simulations suggest that the maximum rate of both steps is unchanged by the mutation. Time-resolved FRET revealed that the structure of the pre– and post–power stroke conformations and mole fractions of these conformations were not altered by the mutation. Optical trapping results demonstrated that S217A does not dramatically alter unitary displacements or slow the working stroke rate constant, consistent with the mutation disrupting an actin-induced conformational change prior to the power stroke. We propose that communication between the actin- and nucleotide-binding regions of myosin assures a proper actin-binding interface and active site have formed before producing a power stroke. Variability in this coupling is likely crucial for mediating motor-based functions such as muscle contraction and intracellular transport.

Thomas O. Gallouët, Andrea Natale and Gabriele Todeschi
Math. Comp. 93 (), 2769-2810.
Abstract, references and article information

Climbing out of the Chinese debt trap The World Today mhiggins.drupal 1 August 2022

Beijing must play a pivotal role in soothing African economic distress, says Alex Vines.

Poorer countries across the world – including many in Africa – are facing $35 billion in debt-service payments in 2022. According to the World Bank, around 40 per cent of this total is owed to China.

Across the African continent, the economic impacts of the coronavirus pandemic have increased rates of extreme poverty and inequality. Since early 2022 the situation has worsened even further, due to the knock-on effects of spiking inflation and interest rates following the Russian invasion of Ukraine. Shortages of fuel and foodstuffs have caused prices to leap upwards. Urban unrest is on the rise, and African governments are having to make tough economic choices as their budgets are squeezed ever more tightly.

Across the continent, progress on the UN’s Sustainable Development Goals is being jeopardized, and non-energy-producing lower and lower-middle income African governments are struggling to repay their loans.

During the Covid pandemic, the G20 assisted 31 out of 36 eligible African countries with its Debt Service Suspension Initiative (DSSI). Established in May 2020, the DSSI helped countries concentrate their resources on fighting the pandemic and safeguarding the lives and livelihoods of millions of the most vulnerable people before it expired at the end of 2021. From 2022, it has been replaced by the G20’s Common Framework for Debt Treatments.

As the second-largest economy in the world after the United States, and the dominant lender for many African states, China has an important role to play in such initiatives. Beijing still tries to keep a low profile and renegotiate its terms on a bilateral basis – although it did support Angola’s early call for G20 action on an initiative that would fulfil what the DSSI delivered. The challenge is to encourage more consistency and trust in such initiatives, as Chinese officials consider them to be too western-oriented. 
 

China’s lending to Africa peaked in 2016

Contemporary views of Chinese lending in Africa remain coloured by the rapid expansion of Chinese finance from the early 2000s to resource-rich African states, and oil producers in particular. The reality is that much of China’s lending has evolved, and is neither intrinsically predatory nor problematic for African partners – and China increasingly prefers to do business with states it considers to be better run.

In fact, as commodity prices and growth rates declined from 2015, Chinese lending to Africa fell significantly, from a peak of $29.5 billion in 2016 to $7.6 billion in 2019. The socio-economic impact of the pandemic has made this situation worse.

That China has attracted criticism is often due to a lack of transparency in its investments, especially those in Kenya and Zambia. This reputation has not been helped by opaque lending arrangements imposed by Chinese state-owned banks, requiring borrowers to prioritize them for repayment. This could lead to cutbacks in key areas of social spending, with direct impacts on African communities.

Over the past two decades, Chinese finance has contributed to an infrastructure boom in many African countries. Angola, for example, was able to undertake a rapid post-conflict reconstruction of its infrastructure, with new roads and bridges being built across the country. New models of financing are being developed: in Kenya, the new Nairobi expressway was constructed under a $600 million Build-Operate-Transfer model that provides for ownership to revert to the national government after a 30-year concession period.

Chinese companies have helped African countries build and upgrade over 10,000km of railway, around 100,000km of highway, 1,000 bridges and 100 ports, as well as power plants, hospitals and schools.

China’s involvement in African debt has varied considerably between countries and over time. Although in recent years this involvement has been framed in the context of the Belt and Road Initiative, it has for the most part been uncoordinated and unplanned, with credit being offered by competing lenders with links to different elements of the Chinese state.

In recent years, as reports have emerged around the poor quality of some of China’s past lending, the authorities in Beijing have sought greater control over new development lending and have imposed new sustainability requirements. At the same time, African countries have sought to diversify sources of supply for infrastructure contracts beyond China. Loans are generally now on a smaller, more manageable scale.

With the introduction of its Global Development Initiative in September 2021, there are indications that China is moving to a ‘new development paradigm’, with the emphasis on providing flows of foreign direct investment rather than loans and a focus on supporting small and medium-sized enterprises, human capital investments and green development.
 

African debt distress

A paper drawing on expertise from Chatham House’s Africa, Asia and Global Economy and Finance experts will be published before the G20 summit in Bali in November 2022. It examines seven African countries that the World Bank deemed in 2020 to be in most debt distress or at risk of debt distress because of their Chinese stock – Angola, Cameroon, Republic of Congo, Djibouti, Ethiopia, Kenya and Zambia. Two countries – Côte d’Ivoire and South Africa – have received new loans from China and are not in any distress.

The paper observes that a lack of transparency over the nature of the terms agreed by these African governments has led to intense domestic criticism and international accusations that China is seeking control over strategic assets.

In fact, in Angola and Zambia, China may have accidently fallen into its own debt trap through profligate and uncoordinated lending.

Zambia became the first pandemic-era default in 2020 and is seeking relief on $17 billion of external debt. After holding general elections in August 2022, Angola and Kenya will also seek additional debt relief, but both may also seek more funds from the private commercial market because of the slow progress of the G20’s Common Framework – something flagged as a concern by China.

All seven of the countries that are most indebted to China are actively seeking to reduce this financial reliance on Beijing in the future.

China has a pivotal role to play in finding effective solutions to these and other African countries’ debt distress. Improved coordination and cooperation between creditors in China and in other parts the world could enhance the positive impact of multilateral initiatives, such as the Common Framework, which has aimed to bring China and India to the negotiating table along with the IMF, the Paris Club group of creditor nations and private creditors.

So far, Chad, Ethiopia and Zambia are the only African countries to have signed up to the framework since its launch in 2020. Although China is suspicious of the IMF, if African states collectively encouraged Beijing to engage with the Common Framework, it could be improved so as to provide debt relief to those African countries finding it difficult to repay their loans.

The analysis of T cell lipid raft proteome is challenging due to the highly dynamic nature of rafts and the hydrophobic character of raft-resident proteins. We explored an innovative strategy for bottom-up lipid raftomics based on suspension-trapping (S-Trap) sample preparation. Mouse T cells were prepared from splenocytes by negative immunoselection, and rafts were isolated by a detergent-free method and OptiPrep gradient ultracentrifugation. Microdomains enriched in flotillin-1, LAT, and cholesterol were subjected to proteomic analysis through an optimized protocol based on S-Trap and high pH fractionation, followed by nano-LC-MS/MS. Using this method, we identified 2,680 proteins in the raft-rich fraction and established a database of 894 T cell raft proteins. We then performed a differential analysis on the raft-rich fraction from nonstimulated versus anti-CD3/CD28 T cell receptor (TCR)-stimulated T cells. Our results revealed 42 proteins present in one condition and absent in the other. For the first time, we performed a proteomic analysis on rafts from ex vivo T cells obtained from individual mice, before and after TCR activation. This work demonstrates that the proposed method utilizing an S-Trap-based approach for sample preparation increases the specificity and sensitivity of lipid raftomics.

Nephron Pharmaceuticals, a drug manufacturing company in West Columbia, S.C., recently hired 650 current and retired teachers through a new program designed to provide educators with additional income.

Researchers are able to track Venus flytrap plants that were stolen from protected areas

A "staggering array" of markings have been hiding in plain sight carved into the walls of Gainsborough Old Hall, a 500-year-old home in Lincolnshire, England

New Solution Helps Designers Calculate and Reduce the Environmental Impact of Their Materials, Production Methods

Behind the glow of city lights, a group of people easily go unnoticed—lost sheep in desperate need of the hope of the gospel.

With new Delaware hunting licenses going on sale this week, DNREC announced the 2024/25 Delaware Hunting and Trapping Guide is now available in hard copy from license agents throughout the state, at DNREC's recreational licensing office in the Richardson & Robbins Building at 89 Kings Highway in Dover and in a readily referenced online edition.

A solar energy absorber that uses quartz to trap heat reached 1050°C in tests and could offer a way to decarbonise the production of steel and cement

Purpose Health care professionals (HCPs) working collaboratively can improve patient outcomes and also increase their understanding of each other’s professional roles. This descriptive study aimed to explore dental hygienists’ perceptions of collaboration with dentists and intraprofessional educational (IntraPE) experiences.Methods A convenience sampling method was used to assess DHs perceptions of collaboration with dentists using the Interprofessional Collaboration Scale (ICS), a validated scale that measures perceptions of communication, accommodation, and isolation among HCPs. One open-ended question was added to explore IntraPE. Demographics, work characteristics and responses from the ICS were analyzed using frequency, mean, standard deviation, Pearson’s correlation, t-test, ANOVA, and multivariable regression. Responses from the open-ended question were transcribed, organized, and coded. Themes were identified using the Delve Qualitative Analysis Tool.Results Of the 264 participants, the average age was 38.9, and most identified as female (98.9%). Data analysis revealed that DHs had positive perceptions of collaboration with dentists. Significant relationships were found between ICS factor accommodation and the average number of patients treated per day (rs = −0.242, p<0.001), dentists’ age (rs = −.145, p<0.05). Isolation showed a significant negative correlation with the average number of patients treated per day (rs = −0.156, p<0.05). Most reported having no opportunities for IntraPE education experiences with dentists. Five categories of themes were identified from the open-ended question: shared academic setting, clinic dentist, externships, desire for more shared learning, and shared patient experiences.Conclusion Dental hygienists in this study had an overall more positive than negative perception of collaboration with dentists. Dental and dental hygiene programs should focus on intraprofessional education experiences to continue to enhance collaboration.

Intrapatient intermetastatic heterogeneity (IIH) has been demonstrated in metastatic castration-resistant prostate cancer (mCRPC) patients and is of the utmost importance for radiopharmaceutical therapy (RPT) eligibility. This study was designed to determine the prevalence of IIH and RPT eligibility in mCRPC patients through a triple-tracer PET imaging strategy. Methods: This was a multisite prospective observational study in which mCRPC patients underwent both ¹⁸F-FDG and ⁶⁸Ga-prostate-specific membrane antigen (PSMA)–617 PET/CT scans. A third scan with ⁶⁸Ga-DOTATATE, a potential biomarker of neuroendocrine differentiation, was performed if an ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found. Per-tracer lesion positivity was defined as having an uptake at least 50% above that of the liver. IIH prevalence was defined as the percentage of participants having at least 2 lesions with discordant features on multitracer PET. Results: IIH was observed in 81 patients (82.7%), and at least 1 ¹⁸F-FDG–positive/⁶⁸Ga-PSMA–negative lesion was found in 45 patients (45.9%). Of the 37 participants who also underwent ⁶⁸Ga-DOTATATE PET/CT, 6 (16.2%) had at least 1 ⁶⁸Ga-DOTATATE–positive lesion. In total, 12 different combinations of lesion imaging phenotypes were observed. On the basis of our prespecified criteria, 52 (53.1%) participants were determined to be eligible for PSMA RPT, but none for DOTATATE RPT. Patients with IIH had a significantly shorter median overall survival than patients without IIH (9.5 mo vs. not reached; log-rank P = 0.03; hazard ratio, 2.7; 95% CI, 1.1–6.8). Conclusion: Most mCRPC patients showed IIH, which was associated with shorter overall survival. On the basis of a triple-tracer PET approach, multiple phenotypic combinations were found. Correlation of these imaging phenotypes with genomics and treatment response will be relevant for precision medicine.

More than 80 per cent of B.C.'s water basins are experiencing level 4 or 5 drought conditions, with salmon in many parts of the province struggling to make it to their spawning grounds.

Стартап Trasec развивает язык программирования TrapC, представляющий собой диалект языка Си, обеспечивающий безопасную работу с памятью. Для блокирования ошибок при работе с памятью, таких как выход за границы выделенного буфера и обращение к уже освобождённой памяти, в TrapC применяется фундаментально иной способ работы с указателями и специальный механизм перехвата ошибок на основе обработчиков исключений (trap). Исходный код компилятора для TrapC планируют открыть в 2025 году.

New rule requires businesses to make subscribing and cancelling subscriptions equally simple.

Bootstrap Icons v1.10.0 is here with nearly 150 new icons. This release includes tons of new variants for person, building, and database icons, plus new brands, rockets, road signs, globes, and many more. We’re now at over 1,900 icons!

150 new icons

Here’s a quick look at all the new icons in v1.10.0:

Some highlights for the new icons include:

• 22 new person icons
• 26 new house icons
• 24 new building icons, including a renamed building to buildings
• 22 new database icons
• 24 new street sign icons
• New globe icons
• New EV, taxi, bus, and scooter transportation icons
• New rockets
• and more!

We also fixed the fill rules for several some issues across the docs, including:

We’ve deviated from developing v5.3.0 to ship a new patch release, Bootstrap v5.2.3, with a handful of more urgent bug fixes.

Highlights

• Added the missing :root CSS variables to our utilities bundle
• Fixed the deprecation warning with Sass 1.56.0
• Fixed the RTL translate() direction for carousels
• Fixed tooltip and popover disposal inconsistencies

We’re heading right back to it with v5.3.0 with support for color modes, new utilities, and more. Look for a pre-release of that soon.

It’s a Christmas miracle—Bootstrap v5.3.0-alpha1 has arrived just in time for the holiday break! This release brings new color mode support, an expanded color palette with variables and utilities, and more.

We’re keeping things short and simple in this blog post with deeper dives into the new color modes and more coming in future posts. For now, we want you to enjoy the holiday break and come back next year feeling refreshed and rejuvenated. Keep reading for what’s new and we’ll see you next year!

Our second alpha release of v5.3.0 has landed with a ton of enhancements and bug fixes for our new color modes! There’s still more to come, but we’ve held off shipping until we ironed out enough issues. Huzzah, we have!

This v5.3.0 release is a monumental update for Bootstrap 5. It’s big enough that it could’ve been a v6 on its own, but we wanted to do right by the community and get color modes out the door without the massive major release upgrade. We’re getting super close now, so bear with us as we continue to chip away at this.

Hot on the heels of our second alpha, we’re releasing a third (and unexpected) alpha for v5.3.0 today with some fixes for some Node Sass compilation errors. In addition, we’ve added a handful of other updates. We’re still on target to ship our stable release soon!

Once again, if you’re new to the v5.3.0 alpha releases, please read through the Migration guide for the first alpha and last month’s second alpha.

Here’s a look at what’s changed in this quick release:

It’s official, the final stable release of v5.3.0 has landed! It’s been a monumental effort to revamp our codebase for CSS variables and color modes, one that will see continued changes leading up to an eventual Bootstrap 6. And we’re so excited to finally ship it!

On top of all the work that’s gone into this release, a lot has happened behind the scenes since we shipped our pre-releases. Keep reading to learn everything that’s new in v5.3.0.

Bootstrap v5.3.1 is here with bug fixes, documentation improvements, and more follow-up enhancements for color modes. Keep reading for the highlights!

• Color modes:
  • Increased color contrast for dark mode by replacing $gray-500 with $gray-300 for the body color
  • Added our color mode switcher JavaScript to our examples ZIP download
• Components:
  • Improved disabled styling for all .nav-links, providing .disabled and :disabled for use with anchors and buttons
  • Add support for Home and End keys for navigating tabs by keyboard
  • Added some basic styling to toggle buttons when no modifier class is present
  • Fixed carousel colors in dark mode
• Forms:
  • Fixed floating label disabled text color
• Utilities:
  • .text-bg-* utilities now use CSS variables
• Sass:
  • Add new $navbar-dark-icon-color Sass variable
  • Removed duplicate $alert Sass variables
  • Added a new variable for $vr-border-width to customize the vertical rule helper width
• Documentation:
  • Added search to our homepage
  • Improved responsive behavior on Dashboard example
  • Improved dark mode rendering of Cheatsheet examples

Get the release

Head to https://getbootstrap.com for the latest. It’s also been pushed to npm:

Bootstrap Icons v1.11.0 has arrived with 100 new icons—including new floppy disk icons, additional brand icons, new person icons, new emojis, some birthday cake, a few new science icons, and more. We’re now at over 2,000 icons!

100 new icons

Here’s a quick look at all the new icons in v1.11.0:

Check out the pull request for all the details on which icons were added and which were updated.

Bootstrap v5.3.2 is here with bug fixes, documentation improvements, and more follow-up enhancements for color modes. Keep reading for the highlights!

Highlights

• Passing a percentage unit to the global abs() is deprecated since Dart Sass v1.65.0. It resulted in a deprecation warning when compiling Bootstrap with Dart Sass. This has been fixed internally by changing the values passed to the divide() function. The divide() function has not been fixed itself so that we can keep supporting node-sass cross-compatibility. In v6, this won’t be an issue as we plan to drop support for node-sass.
• Using multiple ids in a collapse target wasn’t working anymore and has been fixed.

Color modes

• Increased color contrast of form range track background in light and dark modes.
• Fixed table state rendering for color modes with a focus on the striped table in dark mode to increase color contrast.
• Allow <mark> color customization for color modes.

Docs

• Added alternative CDNs section in Getting started -> Download.
• Added Discord and Bootstrap subreddit links in README and Getting started -> Introduction:
  • Discord maintained by the community
  • Bootstrap subreddit

Get the release

Head to https://getbootstrap.com for the latest. It’s also been pushed to npm:

Bootstrap v5.3.3 is here with bug fixes, documentation improvements, and more follow-up enhancements for color modes. Keep reading for the highlights!

Highlights

• Fixed a breaking change introduced with color modes where it was required to manually import variables-dark.scss when building Bootstrap with Sass. Now, _variables.scss will automatically import _variables-dark.scss. If you were already importing _variables-dark.scss manually, you should keep doing it as it won’t break anything and will be the way to go in v6.
• Fixed a regression in the selector engine that wasn’t able to handle multiple IDs anymore.

Color modes

• Badges now use the .text-bg-* text utilities to be certain that the text is always readable (especially when the customized colors are different in light and dark modes).
• Fixed our color-modes.js script to handle the case where the OS is set to light mode and the auto color mode is used on the website. If you copied the script from our docs, you should apply this change to your own script.
• Fixed color schemes description in the color modes documentation to show that color-scheme() only accept light and dark values as parameters.

Miscellaneous

• Allowed <dl>, <dt> and <dd> in the sanitizer.
• Dropped evenly items distribution for modal and offcanvas headers.
• Fixed the accordion CSS selectors to avoid inheritance issues when nesting accordions.
• Fixed the focus box-shadow for the validation stated form controls.
• Fixed the focus ring on focused checked buttons.
• Fixed the product example mobile navbar toggler.
• Changed the RTL processing of carousel control icons.

Docs

• Dropped unnecessary right margin for example code blocks.
• Fixed emphasis text utilities usage in background utilities examples section.
• Added an technical explanation on how to render an accordion expanded by default.
• Changed Vite config path import in Vite guide.
• Enhanced the card image description of the .card-img-* classes.
• Mentioned shift-color() function in the Sass customization page among tint-color() and shade-color().
• Added missing type="button" attribute to the Cheatsheet examples navigation buttons.
• Updated the colors table in the customization page to be responsive.

Get the release

Head to https://getbootstrap.com for the latest. It’s also been pushed to npm:

The ongoing debt crisis in the Global South is severely undermining efforts to combat the medlinkAIDS/medlink epidemic, as per a recent report. Nations

Everyone is blabbing about the metaverse. But what does this future digital world look like? WSJ’s Joanna Stern checked into a hotel and strapped on a VR headset for the day. She went to work meetings, hung out with new avatar friends and attended virtual shows. Photo illustration: Tammy Lian/The Wall Street Journal