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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pact for third ro-ro vessel of Kochi Corporation signed

The third vessel will serve as a standby for the two vessels that are owned by Kochi Corporation




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No roadmap yet for better traffic signage system in Kozhikode city

Emergency signboards and lane markings near roundabouts have not yet been introduced to streamline the traffic management




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This week's sponsor: O’REILLY DESIGN CONFERENCE

O’REILLY DESIGN CONFERENCE - get the skills and insights you need to design the products of the future. Save 20% with code ALIST




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Bulldozer demolition chilling sight, executive cannot replace judiciary: SC

Destroying family homes, leaving entire families homeless, amount to anarchy: Justice Gavai




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Expert Shares Insight on 30 Years of 'The Magic School Bus'

September marked 30 years of "The Magic School Bus" television series. Led by the eccentric Ms. Frizzle, the show sparked a sense of wonder with every adventure -- from transporting children inside the human body to the outer reaches of space. But the television series wouldn't have been possible without its best-selling source material.




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Quantitative elemental mapping of granulite-facies monazite: textural insights and implications for petrochronology

Weller, O M; Jackson, S; Miller, W G R; St-Onge, M R; Rayner, N. Journal of Metamorphic Geology vol. 38, issue 8, 2020 p. 853-880, https://doi.org/10.1111/jmg.12552
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200020.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200020.jpg" title="Journal of Metamorphic Geology vol. 38, issue 8, 2020 p. 853-880, https://doi.org/10.1111/jmg.12552" height="150" border="1" /></a>




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Element and isotopic signature of re-fertilized mantle peridotite as determined by nanopowder and olivine LA-ICPMS analyses

Lawley, C J M; Pearson, D G; Waterton, P; Zagorevski, A; Bédard, J H; Jackson, S E; Petts, D C; Kjarsgaard, B A; Zhang, S; Wright, D. Chemical Geology vol. 536, 119464, 2020 p. 1-17, https://doi.org/10.1016/j.chemgeo.2020.119464
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20190600.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20190600.jpg" title="Chemical Geology vol. 536, 119464, 2020 p. 1-17, https://doi.org/10.1016/j.chemgeo.2020.119464" height="150" border="1" /></a>




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A reassessment of Mesozoic-Cenozoic seabed samples of bedrock from the western Davis Strait and eastern Baffin Island margin, offshore Nunavut: new insights into their lithology, age, and paleoenvironment of deposition

Dafoe, L T; Williams, G L. Geological Survey of Canada, Open File 8702, 2020, 41 pages, https://doi.org/10.4095/321758
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8702.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8702.jpg" title="Geological Survey of Canada, Open File 8702, 2020, 41 pages, https://doi.org/10.4095/321758" height="150" border="1" /></a>




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Tectonic significance of the Virgin River shear zone of the Canadian Shield and implications for the origin of the Snowbird tectonic zone of Laurentia

Card, C D; Bethune, K M; Rayner, N; Ashton, K E. Precambrian Research vol. 361, 106241, 2021 p. 1-22, https://doi.org/10.1016/j.precamres.2021.106241
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210185.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210185.jpg" title="Precambrian Research vol. 361, 106241, 2021 p. 1-22, https://doi.org/10.1016/j.precamres.2021.106241" height="150" border="1" /></a>




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Early Paleozoic seas of offshore eastern Canada: insights from the lithology and palynology of lower Paleozoic strata from the Labrador Margin

Bingham-Koslowski, N. GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 40
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210167.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210167.jpg" title="GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 40" height="150" border="1" /></a>




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Paleoenvironmental analyses and revised lithostratigraphic assignments for 28 wells of the Hopedale and Saglek basins, offshore eastern Canada

Dafoe, L T. Geological Survey of Canada, Open File 8810, 2021, 209 pages (28 sheets), https://doi.org/10.4095/328477
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328477.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328477.jpg" title="Geological Survey of Canada, Open File 8810, 2021, 209 pages (28 sheets), https://doi.org/10.4095/328477" height="150" border="1" /></a>




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Regional stagnation of the western Keewatin ice sheet and the significance of meltwater corridors and eskers, northern Canada

Sharpe, D R; Lesemann, J -E; Knight, R D; Kjarsgaard, B A. Canadian Journal of Earth Sciences vol. 58, issue 10, 2021 p. 1-22, https://doi.org/10.1139/cjes-2020-0136
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200745.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200745.jpg" title="Canadian Journal of Earth Sciences vol. 58, issue 10, 2021 p. 1-22, https://doi.org/10.1139/cjes-2020-0136" height="150" border="1" /></a>




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Assessment of the Amaruq gold deposit signature in glacial sediments using multivariate geochemical data analysis and indicator minerals

de Bronac de Vazelhes, V; McMartin, I; Côté-Mantha, O; Boulianne-Verschelden, N. Journal of Geochemical Exploration vol. 228, 106800, 2021 p. 1-17, https://doi.org/10.1016/j.gexplo.2021.106800
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200684.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200684.jpg" title="Journal of Geochemical Exploration vol. 228, 106800, 2021 p. 1-17, https://doi.org/10.1016/j.gexplo.2021.106800" height="150" border="1" /></a>




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New insights into Keewatin glacial landsystems

McMartin, I. GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 213
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200633.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200633.jpg" title="GAC®-MAC 2021, London, Canada: Exploring Geosciences Through Time and Space/GAC®-MAC 2021, London, Canada : Explorer les géosciences à travers le temps et l'espace; Geological Association of Canada-Mineralogical Association of Canada, Joint Annual Meeting, Abstracts Volume vol. 44, 2021 p. 213" height="150" border="1" /></a>




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Cordilleran magmatism in Yukon and northern British Columbia: characteristics, temporal variations, and significance for the tectonic evolution of the northern Cordillera

Zagorevski, A; van Staal, C R. Northern Cordillera geology: a synthesis of research from the Geo-mapping for Energy and Minerals program, British Columbia and Yukon; by Ryan, J J (ed.); Zagorevski, A (ed.); Geological Survey of Canada, Bulletin 610, 2021 p. 95-122, https://doi.org/10.4095/326063




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Overview of Cordilleran oceanic terranes and their significance for the tectonic evolution of the northern Cordillera

Zagorevski, A; van Staal, C R; Bédard, J H; Bogatu, A; Canil, D; Coleman, M; Golding, M; Joyce, N L; Lawley, C; McGoldrick, S; Mihalynuk, M G; Milidragovic, D; Parsons, A; Schiarizza, P. Northern Cordillera geology: a synthesis of research from the Geo-mapping for Energy and Minerals program, British Columbia and Yukon; by Ryan, J J (ed.); Zagorevski, A (ed.); Geological Survey of Canada, Bulletin 610, 2021 p. 21-65, https://doi.org/10.4095/326053




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The Emeishan large igneous province eruption triggered coastal perturbations and the Capitanian mass extinction: Insights from mercury in Permian bauxite beds

Ling, K; Wen, H; Grasby, S E; Zhao, H; Deng, C; Yin, R. Chemical Geology (Isotope Geoscience Section) vol. 617, 121243, 2022 p. 1-9, https://doi.org/10.1016/j.chemgeo.2022.121243
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220564.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220564.jpg" title="Chemical Geology (Isotope Geoscience Section) vol. 617, 121243, 2022 p. 1-9, https://doi.org/10.1016/j.chemgeo.2022.121243" height="150" border="1" /></a>




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Deformation history and tectonic significance of the Sanagak Lake shear zone, Boothia Peninsula, Nunavut

Drayson, D; Camacho, A; Sanborn-Barrie, M; Regis, D; Larson, K; Osinchuk, A; DuFrane, S A. Canadian Journal of Earth Sciences 2022 p. 1-22, https://doi.org/10.1139/cjes-2022-0046
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220231.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220231.jpg" title="Canadian Journal of Earth Sciences 2022 p. 1-22, https://doi.org/10.1139/cjes-2022-0046" height="150" border="1" /></a>




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Magnetic and gravity models, northern half of the Taltson Magmatic Zone, Rae Craton, Northwest Territories: insights into upper crustal structure

Thomas, M D. Geological Survey of Canada, Current Research (Online) 2022-1, 2022, 22 pages, https://doi.org/10.4095/328244
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328244.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328244.jpg" title="Geological Survey of Canada, Current Research (Online) 2022-1, 2022, 22 pages, https://doi.org/10.4095/328244" height="150" border="1" /></a>




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Exhuming the Canadian Shield: preliminary interpretations from low-temperature thermochronology and significance for the sedimentary succession of the Hudson Bay Basin

Re-release; McDannell, K T; Pinet, N; Issler, D R. Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 287-322, https://doi.org/10.4095/326100
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326100.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326100.jpg" title="Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential; by Lavoie, D (ed.); Dewing, K (ed.); Geological Survey of Canada, Bulletin 609, 2022 p. 287-322, https://doi.org/10.4095/326100" height="150" border="1" /></a>




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Sedimentary basins of northern Canada: contributions to a 1000 Ma geological journey and insight on resource potential

Re-release; Lavoie, D (ed.); Dewing, K (ed.). Geological Survey of Canada, Bulletin 609, 2022, 322 pages, https://doi.org/10.4095/326074
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326074.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_326074.jpg" title="Geological Survey of Canada, Bulletin 609, 2022, 322 pages, https://doi.org/10.4095/326074" height="150" border="1" /></a>




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Stratigraphy of western Baffin Bay: a review of existing knowledge and some new insights

Dafoe, L T; Dickie, K; Williams, G L. Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 219-246, https://doi.org/10.4095/321846
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321846.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_321846.jpg" title="Geological synthesis of Baffin Island (Nunavut) and the Labrador-Baffin Seaway; by Dafoe, L T (ed.); Bingham-Koslowski, N (ed.); Geological Survey of Canada, Bulletin 608, 2022 p. 219-246, https://doi.org/10.4095/321846" height="150" border="1" /></a>




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The tectonic evolution of Laurentia and the North American continent: new datasets, insights, and models

Whitmeyer, S J; Kellett, D A; Tikoff, B; Williams, M L. Laurentia: turning points in the evolution of a continent; Geological Society of America, Memoir vol. 220, 2023 p. 7-16, https://doi.org/10.1130/2022.1220(001)
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210545.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210545.jpg" title="Laurentia: turning points in the evolution of a continent; Geological Society of America, Memoir vol. 220, 2023 p. 7-16, https://doi.org/10.1130/2022.1220(001)" height="150" border="1" /></a>




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Crustal architecture and evolution of the central Thelon tectonic zone, Nunavut: insights from Sm-Nd and O isotope analysis, U-Pb zircon geochronology, and targeted bedrock mapping

Berman, R G; Taylor, B E; Davis, W J; Sanborn-Barrie, M; Whalen, J B. Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 115-158, https://doi.org/10.4095/332497
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332497.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_332497.jpg" title="Canada's northern Shield: new perspectives from the Geoscience for Energy and Minerals Program; Geological Survey of Canada, Bulletin 612, 2024 p. 115-158, https://doi.org/10.4095/332497" height="150" border="1" /></a>




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DHL eCommerce makes two key appointments to aid “significant growth plans”

 DHL eCommerce UK has made two new appointments to its management team, drawing on experience from the retail industry to further align DHL’s services to the evolving eCommerce market.




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DHL Group: we were able to significantly increase revenue in the third quarter

DHL Group increased its revenue by 6.2 percent to EUR 20.6 billion in the third quarter of 2024 (Q3 2023: EUR 19.4 billion) despite the persistently weak global economy.




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Aramex Q3: Domestic express gained volumes and significantly improved profitability

Aramex announced its financial results for the third quarter  and first nine months of the year ending 30 September 2024, revealing double-digit revenue growth across all product lines.




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InPost: Resignation of Chairman of the Board

The Supervisory Board of InPost S.A. has announced that Mark Robertshaw has decided to step down from the Company's Supervisory Board, due to personal family reasons, effective July 1, 2024.




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Bettermile Research: Significant Gap Between US Consumer’s Expectations and Carrier Capabilities

Bettermile, a Berlin-based provider of last-mile delivery software-as-a-service (SaaS), today announced the findings of its latest study, The State of Last Mile Tracking in the USA.




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DHL Supply Chain: our AI applications are designed to unlock greater value for our customers

DHL Supply Chain has launched a significant project in the field of generative AI with the support of Boston Consulting Group (BCG).




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Burgundy Biker Jacket Ladies Peter Sign

Experience Luxury with the burgundy biker jacket ladies! This exceptional jacket combines authentic leather that ages beautifully with a soft yet durable viscose lining. Perfect for any wardrobe, it’s on winter sale now! Get it while supplies last and make a statement that will last a lifetime.




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Steve Brenner - Signals (1985) [full album]

А вот это неиллюзорно шедевр
https://www.youtube.com/watch?v=pP4Cct_1di8
Steve Brenner - Signals (1985) [full album]
https://stevebrenner.bandcamp.com/album/s-i-g-n-a-l-s

Типа имитация Tangerine Dream синхронного периода,
но сильно лучше, чем все, что они сделали после 1984,
причем записано (в домашней студии, насколько я понимаю)
на порядок чище и яснее, чем TD писали, со всеми их сотнями
тысяч долларов, вбуханных в аппаратуру.

Я долго тыкался в биографию автора, пытаясь выяснить,
1985 это не мистификация ли, так и не понял. В принципе,
что сейчас подобной ретрофутуристической музыки пишут
очень много, с реверансами в сторону 1970-х и 1980-х,
лепят на альбом фальшивую датировку, и выкладывают на ютюб,
зарабатывая миллионы прослушиваний.

Вообще Ютюб разрушил централизованную систему музыкальной
критики и прессы, раньше люди шли читать про группы в
Питчфорк или Wire, и покупали альбом, а сейчас тыкают
в рекоммендации Ютюба. Это породило с десяток новых жанров,
свободных от кураторства музкритика, с изобретенной
(и часто целиком фальсифицированной) историей. Походу
появилась масса "групп", датированных на 30-40 лет
раньше, чем на самом деле, и зачастую сгенерированных
через AI, с имитацией всякого ретро; наиболее смешной
образчик вот, с ним-то все яснее ясного

https://bannedvinyl.bandcamp.com/
https://www.youtube.com/watch?v=VcDeZWIF1kY
https://www.youtube.com/@bannedvinyl

но вообще имитаций-мистификаций на ютюбе появилось
очень много, спасибо AI, и в основном оно весьма трудно распознается.

В любом случае, "Signals" Бреннера, безотносительно
к его аутентичности, совершенно прекрасен; особенно
если вы послушали весь доступный Танжерин Дрим и
желаете еще.

Привет




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World Diabetes Day 2024: Early signs of high blood sugar level you should not ignore - India TV News

  1. World Diabetes Day 2024: Early signs of high blood sugar level you should not ignore  India TV News
  2. World Diabetes Day 2024  PIB
  3. World Diabetes Day: Why diabetes is more than abnormal blood sugar level  The Times of India
  4. World Diabetes Day 2024: 10 Foods That Are Secretly Increasing Your Risk Of Diabetes  NDTV
  5. World Diabetes Day 2024: 5 ways to detect diabetes quickly  Health shots









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Church at precarious moment after Welby resignation

Justin Welby behaved like a politician and in some ways has faced the downfall of one, writes religion editor Aleem Maqbool.






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Environment may play significant role in multiple sclerosis




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The miracle of sight

Rachel's personal transformation through Jesus inspires her to serve the women in her community.




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Transform 2016: A refugee’s prayer - An insight into short-term refugee ministry

Meeting Christian refugees praying for European governments made a deep impression on a Transform participant. For another, the term ‘refugee’ got a whole new meaning.




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Resigning is not an option

A pastor of a small community church was about to resign when God brought new hope through the work of OM El Salvador.