GUNWHARF Quays are celebrating the New Year by opening a new dining area.

IT WAS time to go Down Mexico Way - with a visit to the Lone Star State thrown in.

In her new filing for the court-ordered protection, Esther Campbell claims that Steve Harwell is not taking his bipolar disorder medication, and has been verbally and mentally abusive toward her.

A baleen whale off California almost swallowed a sea lion that got in the way during an anchovy feeding frenzy, in an encounter rarely seen let alone caught on film.

Locals at the heart of a devastating fish kill say politicians lack the vision or intent to overcome water management deficiencies, as the ABC visits towns from Goolwa to Menindee to find out who, if anyone, is in control of the Murray-Darling Basin.

A group of scientists is pushing for Exmouth Gulf, next to Ningaloo Reef in remote Western Australia, to be protected from industry saying its biodiversity is of global significance.

A trial is underway to determine if two former senior staff from the Shire of Exmouth in WA falsified records in relation to a $1 million aquarium purchase.

Snakes have been known to wrap their jaws around crocodiles, kangaroos and goats so why would one give up on a bird?

Maggots were found in the mouth of a patient with advanced dementia by visiting family members, the Royal Commission into Aged Care sitting in WA has been told.

Australian woolgrowers are set to benefit from the suspension of wool exports from South Africa to China due to an outbreak of foot-and-mouth disease.

A disease that could potentially wipe out Australia's multi-billion-dollar livestock industry has been detected at Australian airports.

The first round of the FA Cup takes place this weekend.

Through his personal streaming platform, IndyCar veteran Conor Daly's Twitch offers fans a front-row seat to a driver's race-day mind.

(Dartmouth College) Annual award supports the research and teaching careers of talented young faculty in the chemical sciences.

When Dr. Gil Rivera became a dentist, he had no idea his career would take him to the bloodied and bruised front lines of the NHL, but nearly 18 years later, he continues to treat the ravaged mouths of professional hockey players as the team dentist of the Tampa Bay Lightning.

Intellectual property -- History.

Edinburgh : Young J. Pentland, 1886.

In a new twist on oral history, University of Alberta paleontologists have discovered that an Argentinian reptile from 95 million years ago developed a type of tooth enamel that is common in humans and other mammals but rare among reptiles.

STYLE AND SUBSTANCE

A couple launches a monthly class for children and their parents despite low numbers. Through prayer and free advertising, more begin to come.

Title: Allergy-Linked Mouth Breathing Spells Trouble for Kids
Category: Health News
Created: 4/23/2010 12:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Health Tip: Use a Mouthguard
Category: Health News
Created: 4/27/2016 12:00:00 AM
Last Editorial Review: 4/27/2016 12:00:00 AM

Title: Health Tip: Prevent Hand, Foot and Mouth Disease
Category: Health News
Created: 4/30/2018 12:00:00 AM
Last Editorial Review: 4/30/2018 12:00:00 AM

Upon infection, the highly structured 5' untranslated region (5' UTR) of picornavirus is involved in viral protein translation and RNA synthesis. As a critical element in the 5' UTR, the internal ribosome entry site (IRES) binds to various cellular proteins to function in the processes of picornavirus replication. Foot-and-mouth disease virus (FMDV) is an important member in the family Picornaviridae, and its 5' UTR contains a functional IRES element. In this study, the cellular heterogeneous nuclear ribonucleoprotein L (hnRNP L) was identified as an IRES-binding protein for FMDV by biotinylated RNA pulldown assays, mass spectrometry (MS) analysis, and determination of hnRNP L-IRES interaction regions. Further, we found that hnRNP L inhibited the growth of FMDV through binding to the viral IRES and that the inhibitory effect of hnRNP L on FMDV growth was not due to FMDV IRES-mediated translation, but to influence on viral RNA synthesis. Finally, hnRNP L was demonstrated to coimmunoprecipitate with RNA-dependent RNA polymerase (3D^pol) in an FMDV RNA-dependent manner in the infected cells. Thus, our results suggest that hnRNP L, as a critical IRES-binding protein, negatively regulates FMDV replication by inhibiting viral RNA synthesis, possibly by remaining in the replication complex.

IMPORTANCE Picornaviruses, as a large family of human and animal pathogens, cause a bewildering array of disease syndromes. Many host factors are implicated in the pathogenesis of these viruses, and some proteins interact with the viral IRES elements to affect function. Here, we report for the first time that cellular hnRNP L specifically interacts with the IRES of the picornavirus FMDV and negatively regulates FMDV replication through inhibiting viral RNA synthesis. Further, our results showed that hnRNP L coimmunoprecipitates with FMDV 3D^pol in a viral RNA-dependent manner, suggesting that it may remain in the replication complex to function. The data presented here would facilitate further understanding of virus-host interactions and the pathogenesis of picornavirus infections.

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You've been doing it all wrong

Bournemouth have reversed their decision to furlough staff amid the coronavirus lockdown, the club has confirmed.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

Welcome to the Evening Standard's LIVE coverage as the coronavirus crisis continues to heavily impact sport across the globe.

The Department has entered into a consent decree with the City of Portsmouth, Va., that, if approved by the court, will resolve the Department’s complaint that the City of Portsmouth engaged in a pattern or practice of employment discrimination against African Americans in its hiring of entry-level firefighters, in violation of Title VII of the Civil Rights Act of 1964 (Title VII).

Deborah Clark, 52, of Portsmouth, Va., pleaded guilty before U.S. District Judge Henry C. Morgan Jr.

A bail bondsman in Portsmouth, Va., pleaded guilty today in the Eastern District of Virginia for bribing public officials in exchange for receiving favorable treatment.

A bail bondsman in Portsmouth, Va., was sentenced today to serve 30 months in prison for bribing public officials in exchange for receiving favorable treatment, announced Assistant Attorney General Lanny A. Breuer of the Justice Department’s Criminal Division and U.S. Attorney for the Eastern District of Virginia Neil H. MacBride.

A former sergeant of the Portsmouth Sheriff’s Office (PSO) was sentenced to serve 15 months in prison today for accepting bribes in exchange for favors and referrals. Acting Assistant Attorney General Mythili Raman of the Justice Department’s Criminal Division and Acting U.S. Attorney Dana J. Boente of the Eastern District of Virginia made the announcement.

This is candy in its purest form -- certified organic ingredients, zero artificial colors and flavors, no preservatives or GMOs.

Help Kids Defeat the Mouth Monsters